Outputs (6)

Signalling pathways involved in the synergistic effects of human growth differentiation factor 9 and bone morphogenetic protein 15 (2014)
Journal Article
Reader, K. L., Mottershead, D. G., Martin, G. A., Gilchrist, R. B., Heath, D. A., McNatty, K. P., & Juengel, J. L. (2016). Signalling pathways involved in the synergistic effects of human growth differentiation factor 9 and bone morphogenetic protein 15. Reproduction, Fertility and Development, 28(4), 491. https://doi.org/10.1071/rd14099

Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) act synergistically to regulate granulosa cell proliferation and steroid production in several species. Several non-Sma and mothers against decapentaplegic (SMAD) signal... Read More about Signalling pathways involved in the synergistic effects of human growth differentiation factor 9 and bone morphogenetic protein 15.

Bone morphogenetic protein 15 in the pro-mature complex form enhances bovine oocyte developmental competence (2014)
Journal Article
Mottershead. (2014). Bone morphogenetic protein 15 in the pro-mature complex form enhances bovine oocyte developmental competence. PloS one, https://doi.org/10.1371/journal.pone.0103563

Developmental competence of in vitro matured (IVM) oocytes needs to be improved and this can potentially be achieved by adding recombinant bone morphogenetic protein 15 (BMP15) or growth differentiation factor (GDF9) to IVM. The aim of this study was... Read More about Bone morphogenetic protein 15 in the pro-mature complex form enhances bovine oocyte developmental competence.

Mouse GDF9 decreases KITL gene expression in human granulosa cells (2014)
Journal Article
Tuck, A. R., Mottershead, D. G., Fernandes, H. A., Norman, R. J., Tilley, W. D., Robker, R. L., & Hickey, T. E. (2015). Mouse GDF9 decreases KITL gene expression in human granulosa cells. Endocrine, 48(2), 686-695. https://doi.org/10.1007/s12020-014-0335-6

Kit ligand (KITL) is an important granulosa cell-derived growth factor in ovarian folliculogenesis, but its expression and function in human granulosa cells are currently poorly understood. Based on studies performed in animal models, it was hypothes... Read More about Mouse GDF9 decreases KITL gene expression in human granulosa cells.

Aberrant GDF9 Expression and Activation Are Associated With Common Human Ovarian Disorders (2014)
Journal Article
Simpson, C. M., Robertson, D. M., Al-Musawi, S. L., Heath, D. A., McNatty, K. P., Ritter, L. J., …Stanton, P. G. (2014). Aberrant GDF9 Expression and Activation Are Associated With Common Human Ovarian Disorders. The Journal of Clinical Endocrinology & Metabolism, 99(4), E615-E624. https://doi.org/10.1210/jc.2013-3949

Context:
Growth differentiation factor 9 (GDF9) is a central regulator of folliculogenesis and ovulation rate. Fourteen mutations in human (h) GDF9 have been reported in women with premature ovarian failure or polycystic ovarian syndrome as well as... Read More about Aberrant GDF9 Expression and Activation Are Associated With Common Human Ovarian Disorders.

Amphiregulin co-operates with bone morphogenetic protein 15 to increase bovine oocyte developmental competence: effects on gap junction-mediated metabolite supply (2014)
Journal Article
Sugimura, S., Ritter, L. J., Sutton-McDowall, M. L., Mottershead, D. G., Thompson, J. G., & Gilchrist, R. B. (2014). Amphiregulin co-operates with bone morphogenetic protein 15 to increase bovine oocyte developmental competence: effects on gap junction-mediated metabolite supply. Molecular Human Reproduction, 20(6), 499-513. https://doi.org/10.1093/molehr/gau013

This study assessed the participation of amphiregulin (AREG) and bone morphogenetic protein 15 (BMP15) during maturation of bovine cumulus-oocyte complexes (COCs) on cumulus cell function and their impact on subsequent embryo development. AREG treatm... Read More about Amphiregulin co-operates with bone morphogenetic protein 15 to increase bovine oocyte developmental competence: effects on gap junction-mediated metabolite supply.

Effects of differing oocyte-secreted factors during mouse in vitro maturation on subsequent embryo and fetal development (2014)
Journal Article
Sudiman, J., Ritter, L. J., Feil, D. K., Wang, X., Chan, K., Mottershead, D. G., …Gilchrist, R. B. (2014). Effects of differing oocyte-secreted factors during mouse in vitro maturation on subsequent embryo and fetal development. Journal of Assisted Reproduction and Genetics, 31(3), 295-306. https://doi.org/10.1007/s10815-013-0152-5

Purpose
We hypothesised that varying native oocyte-secreted factor (OSF) exposure or using different recombinant OSF peptides would have differential effects on post-in vitro maturation (IVM) embryo and fetal development.

Methods
Mouse cumulus o... Read More about Effects of differing oocyte-secreted factors during mouse in vitro maturation on subsequent embryo and fetal development.