Outputs (114)

Can analyses of electronic patient records be independently and externally validated? The effect of statins on the mortality of patients with ischaemic heart disease: a cohort study with nested case-control analysis (2014)
Journal Article
(2014). Can analyses of electronic patient records be independently and externally validated? The effect of statins on the mortality of patients with ischaemic heart disease: a cohort study with nested case-control analysis. BMJ Open, e004952 - e004952. https://doi.org/10.1136/bmjopen-2014-004952

Objective To conduct a fully independent and external validation of a research study based on one electronic health record database, using a different electronic database sampling the same population.

Design Using the Clinical Practice Research Da... Read More about Can analyses of electronic patient records be independently and externally validated? The effect of statins on the mortality of patients with ischaemic heart disease: a cohort study with nested case-control analysis.

Gelatin-Based Materials in Ocular Tissue Engineering (2014)
Journal Article
(2014). Gelatin-Based Materials in Ocular Tissue Engineering. Materials, 3106 - 3135. https://doi.org/10.3390/ma7043106

Gelatin has been used for many years in pharmaceutical formulation, cell culture and tissue engineering on account of its excellent biocompatibility, ease of processing and availability at low cost. Over the last decade gelatin has been extensively e... Read More about Gelatin-Based Materials in Ocular Tissue Engineering.

Product ion distributions for the reactions of NO(+) with some physiologically significant aldehydes obtained using a SRI-TOF-MS instrument (2014)
Journal Article
(2014). Product ion distributions for the reactions of NO(+) with some physiologically significant aldehydes obtained using a SRI-TOF-MS instrument. International Journal of Mass Spectrometry, 23 - 31. https://doi.org/10.1016/j.ijms.2014.02.016

Product ion distributions for the reactions of NO(+) with 22 aldehydes involved in human physiology have been determined under the prevailing conditions of a selective reagent ionization time of flight mass spectrometry (SRI-TOF-MS) at an E/N in the... Read More about Product ion distributions for the reactions of NO(+) with some physiologically significant aldehydes obtained using a SRI-TOF-MS instrument.

Characterisation of radicals formed by the triazine 1,4-dioxide hypoxia-activated prodrug, SN30000 (2014)
Journal Article
Anderson, R. F., Yadav, P., Patel, D., Reynisson, J., Tipparaju, S. R., Guise, C. P., …Hay, M. P. (in press). Characterisation of radicals formed by the triazine 1,4-dioxide hypoxia-activated prodrug, SN30000. Organic and Biomolecular Chemistry, 12(21), 3386-3392. https://doi.org/10.1039/c4ob00236a

The radical species underlying the activity of the bioreductive anticancer prodrug, SN30000, have been identified by electron paramagnetic resonance and pulse radiolysis techniques. Spin-trapping experiments indicate both an aryl-type radical and an... Read More about Characterisation of radicals formed by the triazine 1,4-dioxide hypoxia-activated prodrug, SN30000.

Nesprins: tissue-specific expression of epsilon and other short isoforms (2014)
Journal Article
(2014). Nesprins: tissue-specific expression of epsilon and other short isoforms. PloS one, e94380 -?. https://doi.org/10.1371/journal.pone.0094380

Nesprin-1-giant and nesprin-2-giant regulate nuclear positioning by the interaction of their C-terminal KASH domains with nuclear membrane SUN proteins and their N-terminal calponin-homology domains with cytoskeletal actin. A number of short isoforms... Read More about Nesprins: tissue-specific expression of epsilon and other short isoforms.

Vibrational spectroscopy in stem cell characterisation: is there a niche? (2014)
Journal Article
Sulé-Suso, J., Forsyth, N., Untereiner, V., & Sockalingum, G. (2014). Vibrational spectroscopy in stem cell characterisation: is there a niche?. Trends in Biotechnology, 32(5), 254-262. https://doi.org/10.1016/j.tibtech.2014.03.002

Vibrational spectroscopy using both infrared and Raman spectroscopies has been used in recent years with the aim to aid clinicians in disease diagnosis. More recently, these techniques have been applied to study stem cell differentiation and to deter... Read More about Vibrational spectroscopy in stem cell characterisation: is there a niche?.

Similarities and differences between the perspectives of healthy living champions and pharmacists on the healthy living pharmacy initiative: a qualitative study (2014)
Presentation / Conference
White, S., Brooks, D., & Hopps, A. (2014, April). Similarities and differences between the perspectives of healthy living champions and pharmacists on the healthy living pharmacy initiative: a qualitative study. Presented at Health Services Research & Pharmacy Practice Conference, University of Aberdeen, Aberdeen, UK

The Healthy Living Pharmacy (HLP) initiative has improved public access to health and wellbeing services and increased the quality of services in community pharmacy.1 This appears to be at least partly due to the quality and performance criteria for... Read More about Similarities and differences between the perspectives of healthy living champions and pharmacists on the healthy living pharmacy initiative: a qualitative study.

Sustained PDGF-BB release from PHBHHx loaded nanoparticles in 3D hydrogel/stem cell model (2014)
Journal Article
(2014). Sustained PDGF-BB release from PHBHHx loaded nanoparticles in 3D hydrogel/stem cell model. Journal of Biomedical Materials Research Part A, 282 -288. https://doi.org/10.1002/jbm.a.35149

This study aimed to design a growth factor loaded copolyester of 3-hydroxybutyrate and 3-hydroxyhexanoate (PHBHHx) nanoparticles containing 3D collagen matrix to achieve growth factor sustained release for long-term stimulation of human mesenchymal s... Read More about Sustained PDGF-BB release from PHBHHx loaded nanoparticles in 3D hydrogel/stem cell model.

Aberrant GDF9 Expression and Activation Are Associated With Common Human Ovarian Disorders (2014)
Journal Article
Simpson, C. M., Robertson, D. M., Al-Musawi, S. L., Heath, D. A., McNatty, K. P., Ritter, L. J., …Stanton, P. G. (2014). Aberrant GDF9 Expression and Activation Are Associated With Common Human Ovarian Disorders. The Journal of Clinical Endocrinology & Metabolism, 99(4), E615-E624. https://doi.org/10.1210/jc.2013-3949

Context:
Growth differentiation factor 9 (GDF9) is a central regulator of folliculogenesis and ovulation rate. Fourteen mutations in human (h) GDF9 have been reported in women with premature ovarian failure or polycystic ovarian syndrome as well as... Read More about Aberrant GDF9 Expression and Activation Are Associated With Common Human Ovarian Disorders.

Dysregulation of ubiquitin homeostasis and ß-catenin signaling promote spinal muscular atrophy (2014)
Journal Article
Wishart, T., Becker, C., Wirth, B., Gillingwater, T., Parson, S., Skehel, P., …Morris, G. (2014). Dysregulation of ubiquitin homeostasis and ß-catenin signaling promote spinal muscular atrophy. Journal of Clinical Investigation, 1821 -1834. https://doi.org/10.1172/JCI71318

The autosomal recessive neurodegenerative disease spinal muscular atrophy (SMA) results from low levels of survival motor neuron (SMN) protein; however, it is unclear how reduced SMN promotes SMA development. Here, we determined that ubiquitin-depend... Read More about Dysregulation of ubiquitin homeostasis and ß-catenin signaling promote spinal muscular atrophy.