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Outputs (243)

Dibenzoyl-methane Derivatives as a Potential and Exciting New Therapy for the Treatment of Childhood Bone Cancer (2016)
Journal Article
ALMELAH, E., SMITH, D. P. T., MCGOWN, A., AZIZ, A., POTGIETER, H. J., & RAGAZZON, P. (2016). Dibenzoyl-methane Derivatives as a Potential and Exciting New Therapy for the Treatment of Childhood Bone Cancer. Anticancer Research, 36(11), 6043-6050. https://doi.org/10.21873/anticanres.11193

Childhood bone cancer though rare, has very limited treatment choices, with poor survival rates and often involving amputation. We developed a novel molecule, 2’, 4’-dihydroxy-dithion-dibenzoyl-methane and tested it on hepatic, colon, lung and osteob... Read More about Dibenzoyl-methane Derivatives as a Potential and Exciting New Therapy for the Treatment of Childhood Bone Cancer.

Predicting Mortality from Change-over-time in the Charlson Comorbidity Index: A retrospective cohort study in a data-intensive UK health system (2016)
Journal Article
Mamas, M., & Mallen, C. (2016). Predicting Mortality from Change-over-time in the Charlson Comorbidity Index: A retrospective cohort study in a data-intensive UK health system. Medicine, e4973. https://doi.org/10.1097/md.0000000000004973

Multimorbidity is common among older people and presents a major challenge to health systems worldwide. Metrics of multimorbidity are, however, crude: focusing on measuring comorbid conditions at single time-points rather than reflecting the longitud... Read More about Predicting Mortality from Change-over-time in the Charlson Comorbidity Index: A retrospective cohort study in a data-intensive UK health system.

Pluripotent and Multipotent Stem Cells Display Distinct Hypoxic miRNA Expression Profiles (2016)
Journal Article
Agrawal, R., Dale, T. P., Al-Zubaidi, M. A., Benny Malgulwar, P., Forsyth, N. R., & Kulshreshtha, R. (in press). Pluripotent and Multipotent Stem Cells Display Distinct Hypoxic miRNA Expression Profiles. PloS one, 11(10), e0164976. https://doi.org/10.1371/journal.pone.0164976

MicroRNAs are reported to have a crucial role in the regulation of self-renewal and differentiation of stem cells. Hypoxia has been identified as a key biophysical element of the stem cell culture milieu however, the link between hypoxia and miRNA ex... Read More about Pluripotent and Multipotent Stem Cells Display Distinct Hypoxic miRNA Expression Profiles.

Pluripotent and Multipotent Stem Cells Display Distinct Hypoxic miRNA Expression Profiles (2016)
Journal Article
(2016). Pluripotent and Multipotent Stem Cells Display Distinct Hypoxic miRNA Expression Profiles. PloS one, e0164976 -?. https://doi.org/10.1371/journal.+pone.0164976

MicroRNAs are reported to have a crucial role in the regulation of self-renewal and differentiation of stem cells. Hypoxia has been identified as a key biophysical element of the stem cell culture milieu however, the link between hypoxia and miRNA ex... Read More about Pluripotent and Multipotent Stem Cells Display Distinct Hypoxic miRNA Expression Profiles.

Accelerated oral nanomedicine discovery from miniaturized screening to clinical production exemplified by paediatric HIV nanotherapies (2016)
Journal Article
(2016). Accelerated oral nanomedicine discovery from miniaturized screening to clinical production exemplified by paediatric HIV nanotherapies. Nature communications, https://doi.org/10.1038/ncomms13184

Considerable scope exists to vary the physical and chemical properties of nanoparticles, with subsequent impact on biological interactions; however, no accelerated process to access large nanoparticle material space is currently available, hamp... Read More about Accelerated oral nanomedicine discovery from miniaturized screening to clinical production exemplified by paediatric HIV nanotherapies.

Ageing in the musculoskeletal system (2016)
Journal Article
Roberts, S., Colombier, P., Sowman, A., Mennan, C., Rölfing, J. H. D., Guicheux, J., & Edwards, J. R. (2016). Ageing in the musculoskeletal system. Acta orthopaedica, 87(S363), 15- 25. https://doi.org/10.1080/17453674.2016.1244750

The extent of ageing in the musculoskeletal system during the life course affects the quality and length of life. Loss of bone, degraded articular cartilage, and degenerate, narrowed intervertebral discs are primary features of an ageing skeleton, an... Read More about Ageing in the musculoskeletal system.

Coumarin Antifungal Lead Compounds from Millettia thonningii and Their Predicted Mechanism of Action (2016)
Journal Article
Reynisson. (2016). Coumarin Antifungal Lead Compounds from Millettia thonningii and Their Predicted Mechanism of Action. Molecules, https://doi.org/10.3390/molecules21101369

Fungal pathogens continue to pose challenges to humans and plants despite efforts to control them. Two coumarins, robustic acid and thonningine-C isolated from Millettia thonningii, show promising activity against the fungus Candida albicans with min... Read More about Coumarin Antifungal Lead Compounds from Millettia thonningii and Their Predicted Mechanism of Action.

Comparison of the Effects of Incomplete Revascularization on 12-month Mortality in Patients <80 compared to =80 Years of Age Undergoing Percutaneous Coronary Intervention (2016)
Journal Article
Mamas. (2016). Comparison of the Effects of Incomplete Revascularization on 12-month Mortality in Patients

Although randomized trial data suggest that complete revascularization improves outcomes after percutaneous coronary intervention (PCI), the impact of differing revascularization strategies in octogenarians is not well defined. We performed a retrosp... Read More about Comparison of the Effects of Incomplete Revascularization on 12-month Mortality in Patients <80 compared to =80 Years of Age Undergoing Percutaneous Coronary Intervention.

Further development of an in vitro model for studying the penetration of chemicals through compromised skin (2016)
Journal Article
(2016). Further development of an in vitro model for studying the penetration of chemicals through compromised skin. Toxicology in Vitro, 101-107. https://doi.org/10.1016/j.tiv.2016.10.004

A new in vitro model based on the electrical resistance properties of the skin barrier has been established in this laboratory. The model utilises a tape stripping procedure in dermatomed pig skin that removes a specific proportion of the stratum cor... Read More about Further development of an in vitro model for studying the penetration of chemicals through compromised skin.