Outputs (186)

Drug-Mediated Shortening of Action Potentials in LQTS2 Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. (2017)
Journal Article
Duncan, G., Firth, K., George, V., Duc Hoang, M., Staniforth, A., Smith, G., & Denning, C. (2017). Drug-Mediated Shortening of Action Potentials in LQTS2 Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Stem Cells and Development, 26(23), 1695 -1705. https://doi.org/10.1089/scd.2017.0172

Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) are now a well-established modality for modeling genetic disorders of the heart. This is especially so for long QT syndrome (LQTS), which is caused by perturbation of ion... Read More about Drug-Mediated Shortening of Action Potentials in LQTS2 Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes..

The role of resveratrol on skeletal muscle cell differentiation and myotube hypertrophy during glucose restriction (2017)
Journal Article
(2017). The role of resveratrol on skeletal muscle cell differentiation and myotube hypertrophy during glucose restriction. Molecular and Cellular Biochemistry, https://doi.org/10.1007/s11010-017-3236-1

Glucose restriction (GR) impairs muscle cell differentiation and evokes myotube atrophy. Resveratrol treatment in skeletal muscle cells improves inflammatory-induced reductions in skeletal muscle cell differentiation. We therefore hypothesised that r... Read More about The role of resveratrol on skeletal muscle cell differentiation and myotube hypertrophy during glucose restriction.

Two cases of spinal muscular atrophy type II with eosinophilic oesophagitis (2017)
Journal Article
Fuller, H. R., Shorrock, H. K., Gillingwater, T. H., Pigott, A., Smith, V., Kulshrestha, R., …Willis, T. A. (2017). Two cases of spinal muscular atrophy type II with eosinophilic oesophagitis. Journal of Neuromuscular Diseases, 357-362

Although primarily characterised by loss of motor neurons from the anterior horn of spinal cord and muscle atrophy, spinal muscular atrophy (SMA) is now recognised as a multi-systemic disorder. Here, we report two SMA Type II patients with eosinophil... Read More about Two cases of spinal muscular atrophy type II with eosinophilic oesophagitis.

Development and Application of an NMR-Based Assay for Polyphenol Oxidases (2017)
Journal Article
Li, Y., Zafar, A., Kilmartin, P. A., Reynisson, J., & Leung, I. K. H. (2017). Development and Application of an NMR-Based Assay for Polyphenol Oxidases. ChemistrySelect, 2(32), 10435-10441. https://doi.org/10.1002/slct.201702144

Polyphenol oxidases (PPOs) are enzymes that catalyse the oxidation of phenolic compounds. We report a NMR-based assay that can be used as a screening and validation tool for PPO activity modulators, which was demonstrated using a series of PPO inhibi... Read More about Development and Application of an NMR-Based Assay for Polyphenol Oxidases.

Murine myoblast migration: influence of replicative ageing and nutrition (2017)
Journal Article
(2017). Murine myoblast migration: influence of replicative ageing and nutrition. Biogerontology, https://doi.org/10.1007/s10522-017-9735-3

Cell migration is central to skeletal muscle repair following damage. Leucine and b-Hydroxy bmethylbutyric acid (HMB) are supplements consumed for recovery from muscle damaging exercise in humans, however, their impact on muscle cell migration with a... Read More about Murine myoblast migration: influence of replicative ageing and nutrition.

Longitudinal deformation bench testing using a coronary artery model: a new standard? (2017)
Journal Article
Mamas. (2017). Longitudinal deformation bench testing using a coronary artery model: a new standard?. Open Heart, https://doi.org/10.1136/openhrt-2016-00053

Objectives To compare susceptibility of five different stent platforms with longitudinal stent deformation (LSD) using a clinically relevant bench testing model simulating both short and long malapposed lengths. Background Recent data suggest that de... Read More about Longitudinal deformation bench testing using a coronary artery model: a new standard?.

Advanced glycation end products reduce the calcium transient in cardiomyocytes by increasing production of reactive oxygen species and nitric oxide (2017)
Journal Article
Mamas. (2017). Advanced glycation end products reduce the calcium transient in cardiomyocytes by increasing production of reactive oxygen species and nitric oxide. FEBS Open Bio, 1672 -1685. https://doi.org/10.1002/2211-5463.12284

Advanced glycation end products (AGE) are central to the development of cardiovascular complications associated with diabetes mellitus. AGE may alter cellular function through cross-linking of cellular proteins or by activating the AGE receptor (RAGE... Read More about Advanced glycation end products reduce the calcium transient in cardiomyocytes by increasing production of reactive oxygen species and nitric oxide.

Project Ponder - using clicker technology to encourage in-class engagement (2017)
Journal Article
Pearson, R. (2017). Project Ponder - using clicker technology to encourage in-class engagement. Pharmacy Education,

Background: ‘Project Ponder’ was created to help pharmacy students think more deeply about their chemistry knowledge through the promotion of peer instruction and debate. This work used the author’s past expe... Read More about Project Ponder - using clicker technology to encourage in-class engagement.

Engagement in an e-Health Tool (ORION) predicts opioid-dependent patient likelihood of behavioural change (2017)
Journal Article
Humphris, G., Carra, G., Frisher, M., Neufeind, J., Cecil, J., Scherbaum, N., …Baldacchino, A. (2017). Engagement in an e-Health Tool (ORION) predicts opioid-dependent patient likelihood of behavioural change. Heroin Addiction And Related Clinical Problems, 19(5), 35-44

Background: An eHealth computer-based tool named ORION was constructed to assist patients in the clinic to appreciate the factors responsible for risks of drug overdose. The aim of this study was to investigate the associations between risk perceptio... Read More about Engagement in an e-Health Tool (ORION) predicts opioid-dependent patient likelihood of behavioural change.

Current State-of-the-Art 3D Tissue Models and Their Compatibility with Live Cell Imaging (2017)
Book Chapter
Bardsley, K., Deegan, A. J., El Haj, A., & Yang, Y. (2017). Current State-of-the-Art 3D Tissue Models and Their Compatibility with Live Cell Imaging. In Multi-Parametric Live Cell Microscopy of 3D Tissue Models (3-18). (1). Springer. https://doi.org/10.1007/978-3-319-67358-5_1

Mammalian cells grow within a complex three-dimensional (3D) microenvironment where multiple cells are organized and surrounded by extracellular matrix (ECM). The quantity and types of ECM components, alongside cell-to-cell and cell-to-matrix interac... Read More about Current State-of-the-Art 3D Tissue Models and Their Compatibility with Live Cell Imaging.