Outputs (2202)

Remote activation of Frizzled receptors using magnetic nanoparticles for bone tissue engineering
Thesis
Rotherham, M. (2016). Remote activation of Frizzled receptors using magnetic nanoparticles for bone tissue engineering

The Wnt signalling pathways play crucial roles in development, tissue patterning, and stem cell fate determination. These pathways are therefore an attractive therapeutic target in the field of regenerative medicine and tissue engineering. Magnetic n... Read More about Remote activation of Frizzled receptors using magnetic nanoparticles for bone tissue engineering.

Prevention of pneumonia after stroke: The effect of metoclopramide on aspiration and pneumonia in stroke patients fed via nasogastric tubes
Thesis
metoclopramide on aspiration and pneumonia in stroke patients fed via nasogastric tubes

Introduction: Pneumonia contributes significantly to the morbidity and mortality in stroke patients, especially those fed via nasogastric tubes.

Methods: This project was conducted in two steps;
1. A randomised controlled trial: The efficacy of p... Read More about Prevention of pneumonia after stroke: The effect of metoclopramide on aspiration and pneumonia in stroke patients fed via nasogastric tubes.

Improving Leukaemia diagnosis and management with Selected Ion Flow Tube Mass Spectrometry and vibrational spectroscopy techniques
Thesis
Rashid Siddique, M. (2017). Improving Leukaemia diagnosis and management with Selected Ion Flow Tube Mass Spectrometry and vibrational spectroscopy techniques

Leukaemia is 11th most common cancer worldwide, associated with poor prognosis. The 10 years’ survival for leukaemia is between 44% - 47%. One of the main reasons for this is the disease being diagnosed in late stages. Most of leukaemia screening tec... Read More about Improving Leukaemia diagnosis and management with Selected Ion Flow Tube Mass Spectrometry and vibrational spectroscopy techniques.

Three-Dimensional Structured Hybrid Scaffolds for Enhanced Bone formation
Thesis
Baba Ismail, Y. M. (2016). Three-Dimensional Structured Hybrid Scaffolds for Enhanced Bone formation

The most common clinical treatments for large bone deficiencies resulting from trauma, disease or infection are autograft, allograft or bone graft substitutes (BGS). However, these treatments still have limitations for clinical applications. Thus, th... Read More about Three-Dimensional Structured Hybrid Scaffolds for Enhanced Bone formation.

Novel tissue engineering approaches to enhance natural bone formation
Thesis
Deegan, A. J. (2016). Novel tissue engineering approaches to enhance natural bone formation

The bone tissue engineering community has been striving to develop novel approaches that mimic natural bone formation. The rapid generation of mineralised bone tissue with a capacity for vascularisation and the selection of highly osteogenic cell sou... Read More about Novel tissue engineering approaches to enhance natural bone formation.

Synthesis and biological evaluation of polymer-autotaxin inhibitor conjugates for the treatment of ovarian cancer
Thesis
(2016). Synthesis and biological evaluation of polymer-autotaxin inhibitor conjugates for the treatment of ovarian cancer

Autotaxin is an extracellular phospholipase D that catalyses the hydrolysis of lysophosphatidyl choline (LPC) to bioactive lipid lysophosphatidic acid (LPA). LPA has been implicated in many pathological processes relevant to cancer, including cell mi... Read More about Synthesis and biological evaluation of polymer-autotaxin inhibitor conjugates for the treatment of ovarian cancer.

Phytochemical Composition and Antimicrobial Properties of Four Plants Indicated for Traditional Medicine Use
Thesis
Al-Dulaimi, O. A. A. (2017). Phytochemical Composition and Antimicrobial Properties of Four Plants Indicated for Traditional Medicine Use

The rapid development of seriously drug-resistant pathogen strains has created a dangerous problem to public health. The discovery of new effective antimicrobials remains an urgent task to control microbial resistance. Natural products can offer spec... Read More about Phytochemical Composition and Antimicrobial Properties of Four Plants Indicated for Traditional Medicine Use.

Phytochemical Analysis and Evaluation of Anticancer and Antimalarial Properties of Four Medicinal Plants
Thesis
Uche, F. I. (2017). Phytochemical Analysis and Evaluation of Anticancer and Antimalarial Properties of Four Medicinal Plants

Cancer and malaria are among the most life-threatening diseases globally. Cancer is responsible for about 125,000 annual deaths globally. In 2015, the World Health Organization report estimated that 236000-635000 people died of malaria. These disease... Read More about Phytochemical Analysis and Evaluation of Anticancer and Antimalarial Properties of Four Medicinal Plants.

Clinical validation of near-patient assessment of fluid status in dialysis patients
Thesis
Tan, B. K. (2017). Clinical validation of near-patient assessment of fluid status in dialysis patients

Dialysis patients have an extraordinarily high level of cardiovascular morbidity and mortality. Volume expansion is common among this cohort and this is linked to markers of cardiac dysfunction, inflammation and low plasma albumin, all of which predi... Read More about Clinical validation of near-patient assessment of fluid status in dialysis patients.

A role for the human mesenchymal stem cell secretome in attenuation of cytokine-induced apoptosis in pancreatic beta cells
Thesis
Al-Azzawi, B. (2017). A role for the human mesenchymal stem cell secretome in attenuation of cytokine-induced apoptosis in pancreatic beta cells

Diabetes is a lifelong condition caused by an inability of the body to break down glucose due to a defect in either insulin synthesis or the target cells becoming resistant to secreted insulin. There are two main types of diabetes, type 1 diabetes me... Read More about A role for the human mesenchymal stem cell secretome in attenuation of cytokine-induced apoptosis in pancreatic beta cells.