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Outputs (2202)

The development and validation of a hydrostatic pressure bioreactor for applications in bone tissue engineering
Thesis
Price, J. C. F. A. (2017). The development and validation of a hydrostatic pressure bioreactor for applications in bone tissue engineering

Current orthopaedics treatments of bone defects often involve the use of implanted fixatives and/or autograft procedures to restore function to the afflicted area following injury. Fixatives and implants are usually temporary solutions, since they ar... Read More about The development and validation of a hydrostatic pressure bioreactor for applications in bone tissue engineering.

An evaluation of tailored magnetic nanoparticles in the induction of stem cell differentiation
Thesis
Moise, S. (2016). An evaluation of tailored magnetic nanoparticles in the induction of stem cell differentiation

Improving the differentiation capacity of stem cells by defining the ideal physico-chemical and spatial parameters will enhance the efficiency of stem cell-based clinical therapies. In this thesis the hypothesis that heat shock (elevated temperatures... Read More about An evaluation of tailored magnetic nanoparticles in the induction of stem cell differentiation.

Characterisation of pathogenic T helper and T regulatory cell subsets in relapse and progression in multiple sclerosis
Thesis
Kalra, S. (2017). Characterisation of pathogenic T helper and T regulatory cell subsets in relapse and progression in multiple sclerosis

Multiple Sclerosis (MS) is one of the commonest disabling neurological diseases affecting the young in the developed world. It affects the central nervous system (CNS) and is characterised by inflammation with neuronal demyelination /degeneration and... Read More about Characterisation of pathogenic T helper and T regulatory cell subsets in relapse and progression in multiple sclerosis.

An investigation of the mechanisms underpinning the effect of anti-inflammatory drugs on neural stem cells
Thesis
Al-Mayyahi, R. S. (2017). An investigation of the mechanisms underpinning the effect of anti-inflammatory drugs on neural stem cells

Anti-inflammatory drugs such as corticosteroids (CSs) and minocycline (MINO) are widely used in the treatment of a range of clinical conditions and to suppress graft rejection in stem cell transplantation therapy. However, such treatment is associate... Read More about An investigation of the mechanisms underpinning the effect of anti-inflammatory drugs on neural stem cells.

Time-dependent markers of comorbidity and prognosis in heart failure patients: transitions across the life course
Thesis
Rushton, C. A. (2016). Time-dependent markers of comorbidity and prognosis in heart failure patients: transitions across the life course

Heart failure (HF) disease carries a poor prognosis despite optimisation of cardiovascular (CVD) treatments. Non-CVD comorbid diseases are common and known to influence the HF clinical course. These comorbidities change in severity over time from new... Read More about Time-dependent markers of comorbidity and prognosis in heart failure patients: transitions across the life course.

The aggregation and reduction of iron minerals by the Alzheimer’s disease peptide ß-amyloid (1-42): an X-ray absorption study
Thesis
Everett, J. (2015). The aggregation and reduction of iron minerals by the Alzheimer’s disease peptide ß-amyloid (1-42): an X-ray absorption study

Iron is vital for healthy brain function. However when present in a redox-active form or in excess concentrations it can be toxic. Interestingly, increased levels of redox-active iron biominerals have been shown to exist in Alzheimer’s disease (AD) t... Read More about The aggregation and reduction of iron minerals by the Alzheimer’s disease peptide ß-amyloid (1-42): an X-ray absorption study.

Evaluation of saliva biomarkers in chronic obstructive pulmonary disease: correlation to patient reported outcomes
Thesis
Patel, N. (2016). Evaluation of saliva biomarkers in chronic obstructive pulmonary disease: correlation to patient reported outcomes

COPD is a debilitating chronic respiratory disease with a systemic footprint. COPD is a highly heterogeneous disease but invariably its management involves a one-size fits all approach. This fails to address individual variations in disease progressi... Read More about Evaluation of saliva biomarkers in chronic obstructive pulmonary disease: correlation to patient reported outcomes.

Investigating the chondrogenic phenotype in clinically relevant cells: the effect of hTERT expression
Thesis
Dale, T. P. (2016). Investigating the chondrogenic phenotype in clinically relevant cells: the effect of hTERT expression

Damaged or diseased mature articular cartilage cannot undergo effective tissue repair and due to its avascular, hypocellular nature defects become widespread and painful. No ‘gold standard’ treatment exists for this indication and the ultimate recour... Read More about Investigating the chondrogenic phenotype in clinically relevant cells: the effect of hTERT expression.

The preclinical evaluation of simvastatin and pitavastatin for the treatment of ovarian cancer
Thesis
Robinson, E. (2015). The preclinical evaluation of simvastatin and pitavastatin for the treatment of ovarian cancer

Ovarian cancer is the fifth most common cancer which affects women in the United Kingdom. The 5-year survival rate is less than 45% despite improvements in chemotherapeutic regimens. Platinum-based therapy in combination with other chemotherapy inclu... Read More about The preclinical evaluation of simvastatin and pitavastatin for the treatment of ovarian cancer.