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Outputs (2247)

Improving the management of lung cancer using mass spectrometry and spectroscopy techniques
Thesis
Rutter, A. V. (2016). Improving the management of lung cancer using mass spectrometry and spectroscopy techniques

Lung cancer is a worldwide health problem associated with poor prognosis. The survival at 5 years remains between 5% and 15% in spite of the development of new drugs. One of the main reasons for this is the disease being diagnosed in late stages when... Read More about Improving the management of lung cancer using mass spectrometry and spectroscopy techniques.

Biomarker profiling in rheumatoid arthritis: an investigation of markers of immune dysfunction and their relationship to disease phenotype
Thesis
Judah, S. M. (2016). Biomarker profiling in rheumatoid arthritis: an investigation of markers of immune dysfunction and their relationship to disease phenotype

Rheumatoid arthritis is an autoimmune disease in which various mediators of immune function play a vital role in the pathological process, influencing its development, progression and severity.

The aim of this study was to investigate the relation... Read More about Biomarker profiling in rheumatoid arthritis: an investigation of markers of immune dysfunction and their relationship to disease phenotype.

A novel in vitro bioluminescence rate-of-kill (BRoK) assay to study the pharmacodynamic properties of antimalarial drug action in Plasmodium falciparum
Thesis
Ullah, I. (2016). A novel in vitro bioluminescence rate-of-kill (BRoK) assay to study the pharmacodynamic properties of antimalarial drug action in Plasmodium falciparum

Massive screens of chemical libraries for antimalarial activity have identified thousands of compounds that exhibit sub-micromolar potency against the blood stage of the malaria parasite Plasmodium falciparum. Triaging these compounds to establish pr... Read More about A novel in vitro bioluminescence rate-of-kill (BRoK) assay to study the pharmacodynamic properties of antimalarial drug action in Plasmodium falciparum.

Local membrane versus systemic consequences of peritoneal dialysis treatment
Thesis
Lambie, M. R. (2015). Local membrane versus systemic consequences of peritoneal dialysis treatment

The primary intent of this thesis is to delineate the relative roles of local membrane and systemic consequences of peritoneal dialysis therapy, with particular reference to the role of inflammation and a severe, uncommon complication, encapsulating... Read More about Local membrane versus systemic consequences of peritoneal dialysis treatment.

Measurement of frailty: development of a primary care framework and validation of an electronic Frailty Index
Thesis
Moody, D. K. (2016). Measurement of frailty: development of a primary care framework and validation of an electronic Frailty Index

Frailty measurement in primary care and at transitions of care is needed to enable timely identification of frailty, guide interventions and support proactive, integrated care. However, there is currently no single tool for frailty measurement in the... Read More about Measurement of frailty: development of a primary care framework and validation of an electronic Frailty Index.

Developing a non-invasive method for in vivo monitoring of forearm flexor tendon excursions during rehabilitation following surgical tendon repair
Thesis
Sharma, R. (2016). Developing a non-invasive method for in vivo monitoring of forearm flexor tendon excursions during rehabilitation following surgical tendon repair

Background: An injury to the wrist and hand can impact different anatomical structures. Any damage or cut to the flexor tendons can leave a devastating impact if not treated well and can therefore compromise our daily physical activities. Surgery and... Read More about Developing a non-invasive method for in vivo monitoring of forearm flexor tendon excursions during rehabilitation following surgical tendon repair.

Role of Cyclin D1 polymorphisms and protein over-expression in clinical outcomes of colorectal cancer
Thesis
Sivakumar, R. (2017). Role of Cyclin D1 polymorphisms and protein over-expression in clinical outcomes of colorectal cancer

Cyclin D1 is a key regulatory protein in the progression of G1-S phase of the cell cycle. Activated Cyclin D1 in turn activates S phase proteins and thereby leading to cell proliferation. Over expression of Cyclin D1 leads S phase cell cycle progress... Read More about Role of Cyclin D1 polymorphisms and protein over-expression in clinical outcomes of colorectal cancer.