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Imidazoline compounds protect against interleukin 1beta-induced beta-cell apoptosis. (2001)
Journal Article
Zaitsev, S. V., Appelskog, I. B., Kapelioukh, I. L., Yang, S. N., Köhler, M., Efendic, S., …Maarabouni, M. (2001). Imidazoline compounds protect against interleukin 1beta-induced beta-cell apoptosis. Diabetes, 50(suppl_1), Article S70. https://doi.org/10.2337/diabetes.50.2007.s70

Imidazoline compounds have been considered for the treatment of type 2 diabetes. We have now investigated the effects of imidazolines on interleukin (IL)-1beta-induced beta-cell apoptosis and the signal transduction pathways involved. Inhibition of C... Read More about Imidazoline compounds protect against interleukin 1beta-induced beta-cell apoptosis..

Effects of imidazoline binding site ligands on the growth and viability of clonal pancreatic β-cells (2000)
Journal Article
Mourtada, M., Elliott, J., Smith, S., & Morgan, N. (2000). Effects of imidazoline binding site ligands on the growth and viability of clonal pancreatic β-cells. Naunyn-Schmiedeberg's Archives of Pharmacology, 361, 146–154. https://doi.org/10.1007/s002109900158

Pancreatic β-cells express imidazoline binding sites which play a role in the regulation of insulin secretion, but it is not known whether ligands for these sites also affect other aspects of β-cell physiology. In the present study, we have investiga... Read More about Effects of imidazoline binding site ligands on the growth and viability of clonal pancreatic β-cells.

Imidazolines and pancreatic hormone secretion (1999)
Journal Article
MORGAN, N. G., CHAN, S. L., MOURTADA, M., MONKS, L. K., & RAMSDEN, C. A. (1999). Imidazolines and pancreatic hormone secretion. Annals of the New York Academy of Sciences, 881(1), 217-228. https://doi.org/10.1111/j.1749-6632.1999.tb09364.x

A range of imidazoline derivatives are known to be effective stimulators of insulin secretion, and this response correlates with closure of ATP-sensitive potassium channels in the pancreatic β-cell. However, mounting evidence indicates that potassium... Read More about Imidazolines and pancreatic hormone secretion.

Effector systems involved in the insulin secretory responses to efaroxan and RX871024 in rat islets of Langerhans (1998)
Journal Article
Mourtada, M., Smith, S. A., & Morgan, N. G. (1998). Effector systems involved in the insulin secretory responses to efaroxan and RX871024 in rat islets of Langerhans. European Journal of Pharmacology, 350(2-3), 251-258. https://doi.org/10.1016/S0014-2999%2898%2900245-3

One component of the mechanism by which imidazoline compounds promote insulin secretion involves closure of ATP-sensitive K+ channels in the β-cell plasma membrane. Recently, however, it has also been proposed that these compounds may exert important... Read More about Effector systems involved in the insulin secretory responses to efaroxan and RX871024 in rat islets of Langerhans.

Insulin secretagogues with an imidazoline structure inhibit arginine-induced glucagon secretion from isolated rat islets of langerhans (1997)
Journal Article
Mourtada, M., Smith, S. A., & Morgan, N. G. (1997). Insulin secretagogues with an imidazoline structure inhibit arginine-induced glucagon secretion from isolated rat islets of langerhans. Biochemical and Biophysical Research Communications, 236(1), 162-166. https://doi.org/10.1006/bbrc.1997.6922

It is well documented that imidazoline compounds such as efaroxan and phentolamine act as potent insulin secretagogues bothin vivoandin vitro,an effect which is mediated principally by blockade of ATP-sensitive potassium channels in the pancreatic B-... Read More about Insulin secretagogues with an imidazoline structure inhibit arginine-induced glucagon secretion from isolated rat islets of langerhans.