Skip to main content

Research Repository

Advanced Search

Outputs (95)

An investigation into the functional roles of protein phosphatase 4 regulatory subunits PP4R3A and PP4R3B in leukemic T-cells (2022)
Thesis
Kavousi, N. (2022). An investigation into the functional roles of protein phosphatase 4 regulatory subunits PP4R3A and PP4R3B in leukemic T-cells. (Thesis). Keele University

The serine/threonine protein phosphatase 4 holoenzyme consists of PP4 catalytic subunit (PP4c), which interacts with four different regulatory subunits (PP4R1, PP4R2, PP4R3, PP4R4). Previous studies have shown that PP4c acts as a tumour suppressor an... Read More about An investigation into the functional roles of protein phosphatase 4 regulatory subunits PP4R3A and PP4R3B in leukemic T-cells.

Investigating the interaction between dengue viral envelope proteins and host receptor molecules (2022)
Thesis
Hyatt, J. G. (2022). Investigating the interaction between dengue viral envelope proteins and host receptor molecules. (Thesis). Keele University

Infection of dengue remains to this date a major socio-economic and public health challenge for large parts of the world, especially low- and middle- income countries in the tropics and sub-tropics. Despite the prevalence of the associated neglected... Read More about Investigating the interaction between dengue viral envelope proteins and host receptor molecules.

Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma (2022)
Journal Article
Napolitano, V., Mróz, P., Marciniak, M., Kalel, V. C., Softley, C. A., Janna Olmos, J. D., …Dubin, G. (2022). Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma. European Journal of Medicinal Chemistry, 243, Article 114778. https://doi.org/10.1016/j.ejmech.2022.114778

Trypanosomiases are neglected tropical diseases caused by Trypanosoma (sub)species. Available treatments are limited and have considerable adverse effects and questionable efficacy in the chronic stage of the disease, urgently calling for the identif... Read More about Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma.

Systematic Alignment Analysis of Neural Transplant Cells in Electrospun Nanofibre Scaffolds (2022)
Journal Article
Mogas Barcons, A., Chowdhury, F., Chari, D. M., & Adams, C. (2022). Systematic Alignment Analysis of Neural Transplant Cells in Electrospun Nanofibre Scaffolds. Materials, 16(1), Article 124. https://doi.org/10.3390/ma16010124

Spinal cord injury is debilitating with functional loss often permanent due to a lack of neuro-regenerative or neuro-therapeutic strategies. A promising approach to enhance biological function is through implantation of tissue engineered constructs,... Read More about Systematic Alignment Analysis of Neural Transplant Cells in Electrospun Nanofibre Scaffolds.

Sensitivity threshold of avian magnetic compass to oscillating magnetic field is species-specific (2022)
Journal Article
Bojarinova, J., Kavokin, K., Cherbunin, R., Sannikov, D., Fedorishcheva, A., Pakhomov, A., & Chernetsov, N. (2023). Sensitivity threshold of avian magnetic compass to oscillating magnetic field is species-specific. Behavioral Ecology and Sociobiology, 77(1), https://doi.org/10.1007/s00265-022-03282-7

One of the most unusual features of the avian magnetic compass is its sensitivity to weak oscillating magnetic fields (OMF) in the radiofrequency range. This effect, observed earlier in numerous experiments in European robins Erithacus rubecula and g... Read More about Sensitivity threshold of avian magnetic compass to oscillating magnetic field is species-specific.

Biological control interventions reduce pest abundance and crop damage while maintaining natural enemies in sub-Saharan Africa: a meta-analysis (2022)
Journal Article
Ratto, F., Bruce, T., Chipabika, G., Mwamakamba, S., Mkandawire, R., Khan, Z., …Sait, S. (2022). Biological control interventions reduce pest abundance and crop damage while maintaining natural enemies in sub-Saharan Africa: a meta-analysis. Proceedings of the Royal Society B: Biological Sciences, https://doi.org/10.1098/rspb.2022.1695

Insect pests are a major challenge to smallholder crop production in sub-Saharan Africa (SSA), where access to synthetic pesticides, which are linked to environmental and health risks, is often limited. Biological control interventions could offer a... Read More about Biological control interventions reduce pest abundance and crop damage while maintaining natural enemies in sub-Saharan Africa: a meta-analysis.