Outputs (1145)

Single-cell profiling of Anopheles gambiae spermatogenesis defines the onset of meiotic silencing and premeiotic overexpression of the X chromosome (2023)
Journal Article
Page, N., Taxiarchi, C., Tonge, D., Kuburic, J., Chesters, E., Kriezis, A., …Galizi, R. (2023). Single-cell profiling of Anopheles gambiae spermatogenesis defines the onset of meiotic silencing and premeiotic overexpression of the X chromosome. Communications Biology, 6(1), Article 850. https://doi.org/10.1038/s42003-023-05224-z

Understanding development and genetic regulation in the Anopheles gambiae germline is essential to engineer effective genetic control strategies targeting this malaria mosquito vector. These include targeting the germline to induce sterility or using... Read More about Single-cell profiling of Anopheles gambiae spermatogenesis defines the onset of meiotic silencing and premeiotic overexpression of the X chromosome.

Cysteamine-mediated blockade of the glycine cleavage system modulates epithelial cell inflammatory and innate immune responses to viral infection (2023)
Journal Article
Fraser-Pitt, D., Mercer, D. K., Francis, M., Toledo-Aparicio, D., Smith, D. W., & O'Neil, D. A. (2023). Cysteamine-mediated blockade of the glycine cleavage system modulates epithelial cell inflammatory and innate immune responses to viral infection. Biochemical and Biophysical Research Communications, 677, 168-181. https://doi.org/10.1016/j.bbrc.2023.08.021

Transient blockade of glycine decarboxylase (GLDC) can restrict de novo pyrimidine synthesis, which is a well-described strategy for enhancing the host interferon response to viral infection and a target pathway for some licenced anti-inflammatory th... Read More about Cysteamine-mediated blockade of the glycine cleavage system modulates epithelial cell inflammatory and innate immune responses to viral infection.

Identification and characterization of two CRISPR-Cas systems associated with the mosquito microbiome (2023)
Journal Article
Hegde, S., Rauch, H. E., Hughes, G. L., & Shariat, N. (in press). Identification and characterization of two CRISPR-Cas systems associated with the mosquito microbiome. Access Microbiology, 5(8), https://doi.org/10.1099/acmi.0.000599.v3

The microbiome profoundly influences many traits in medically relevant vectors such as mosquitoes, and a greater functional understanding of host-microbe interactions may be exploited for novel microbial-based approaches to control mosquito-borne dis... Read More about Identification and characterization of two CRISPR-Cas systems associated with the mosquito microbiome.

Identification and characterization of two CRISPR/Cas systems associated with the mosquito microbiome (2023)
Journal Article
Hegde, S., Rauch, H. E., Hughes, G. L., & Shariat, N. (2023). Identification and characterization of two CRISPR/Cas systems associated with the mosquito microbiome. Access Microbiology, 5(8), https://doi.org/10.1099/acmi.0.000599.v4

The microbiome profoundly influences many traits in medically relevant vectors such as mosquitoes, and a greater functional understanding of host–microbe interactions may be exploited for novel microbial-based approaches to control mosquito-borne dis... Read More about Identification and characterization of two CRISPR/Cas systems associated with the mosquito microbiome.

In-solution and interface study on biological model membranes and their interaction with Prohibitin (2023)
Thesis
Piccinini, A. (2023). In-solution and interface study on biological model membranes and their interaction with Prohibitin. (Thesis). Keele University

Prohibitins (PHB) play a crucial role in premature cellular ageing, tumour suppression, cell cycle regulation, and apoptosis, and their deregulation is involved in viral infections, neurological and cardiovascular diseases and cancer. Despite the ess... Read More about In-solution and interface study on biological model membranes and their interaction with Prohibitin.

Factors influencing oviposition behaviour of the invasive pest, Drosophila suzukii, derived from interactions with other Drosophila species: potential applications for control (2023)
Journal Article
Tungadi, T. D., Powell, G., Shaw, B., & Fountain, M. T. (2023). Factors influencing oviposition behaviour of the invasive pest, Drosophila suzukii, derived from interactions with other Drosophila species: potential applications for control. Pest Management Science, 79(11), 4132-4139. https://doi.org/10.1002/ps.7693

Drosophila suzukii (Matsumura) or spotted wing Drosophila is a worldwide invasive pest of soft‐ and stone‐fruit production. Female D. suzukii lay their eggs in ripening fruit and the hatched larvae damage fruit from the inside, rendering it unmarketa... Read More about Factors influencing oviposition behaviour of the invasive pest, Drosophila suzukii, derived from interactions with other Drosophila species: potential applications for control.

Extracellular vesicles derived from umbilical cord mesenchymal stromal cells show enhanced anti-inflammatory properties via upregulation of miRNAs after pro-inflammatory priming (2023)
Journal Article
Hyland, M., Mennan, C., Davies, R., Wilson, E., Tonge, D. P., Clayton, A., & Kehoe, O. (2023). Extracellular vesicles derived from umbilical cord mesenchymal stromal cells show enhanced anti-inflammatory properties via upregulation of miRNAs after pro-inflammatory priming. Stem Cell Reviews and Reports, 19, 2391–2406. https://doi.org/10.1007/s12015-023-10586-2

Autoimmune conditions, such as rheumatoid arthritis, are characterised by a loss of immune tolerance, whereby the immune cells attack self-antigens causing pain and inflammation. These conditions can be brought into remission using pharmaceutical tre... Read More about Extracellular vesicles derived from umbilical cord mesenchymal stromal cells show enhanced anti-inflammatory properties via upregulation of miRNAs after pro-inflammatory priming.

Parasite exchange and hybridisation at a wild-feral-domestic interface (2023)
Journal Article
Smith, W. J., Jezierski, M. T., Dunn, J. C., & Clegg, S. M. (2023). Parasite exchange and hybridisation at a wild-feral-domestic interface. International Journal for Parasitology, 53(14), 797-808. https://doi.org/10.1016/j.ijpara.2023.06.005

Interactions between wild, feral, and domestic animals are of economic and conservation significance. The pigeon Columba livia is a synanthropic species in a feral form, but it also includes the rare Rock Dove. Columba livia is an important player at... Read More about Parasite exchange and hybridisation at a wild-feral-domestic interface.

Bird species with wider geographical ranges have higher blood parasite diversity but not prevalence across the African-Eurasian flyway (2023)
Journal Article
La Chapelle, M., Ruta, M., & Dunn, J. C. (2023). Bird species with wider geographical ranges have higher blood parasite diversity but not prevalence across the African-Eurasian flyway. International Journal for Parasitology, 53(14), 787-796. https://doi.org/10.1016/j.ijpara.2023.06.002

Avian blood parasites, from the genera Plasmodium, Haemoproteus and Leucocytozoon, are predicted to alter their range and prevalence as global temperatures change, and host and vector ranges shift. Understanding large-scale patterns in the prevalence... Read More about Bird species with wider geographical ranges have higher blood parasite diversity but not prevalence across the African-Eurasian flyway.

Decoding attraction: improving vine weevil monitoring by exploiting key sensory cues. (2023)
Journal Article
Fezza, E., Roberts, J. M., Bruce, T. J. A., Walsh, L. E., Gaffney, M. T., Pope, T. W., …Gaffney, M. T. (in press). Decoding attraction: improving vine weevil monitoring by exploiting key sensory cues. Pest Management Science, 10.1002/ps.7665. https://doi.org/10.1002/ps.7665

Monitoring is an integral component of integrated pest management (IPM) programmes used to inform crop management decisions. Vine weevil, Otiorhynchus sulcatus F. (Coleoptera: Curculionidae), continues to cause economically significant losses in hort... Read More about Decoding attraction: improving vine weevil monitoring by exploiting key sensory cues..