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A novel live-attenuated vaccine candidate for mayaro Fever.

Forrester-Soto

A novel live-attenuated vaccine candidate for mayaro Fever. Thumbnail


Authors

Forrester-Soto



Abstract

Mayaro virus (MAYV) is an emerging, mosquito-borne alphavirus that causes a dengue-like illness in many regions of South America, and which has the potential to urbanize. Because no specific treatment or vaccine is available for MAYV infection, we capitalized on an IRES-based approach to develop a live-attenuated MAYV vaccine candidate. Testing in infant, immunocompetent as well as interferon receptor-deficient mice demonstrated a high degree of attenuation, strong induction of neutralizing antibodies, and efficacy against lethal challenge. This vaccine strain was also unable to infect mosquito cells, a major safety feature for a live vaccine derived from a mosquito-borne virus. Further preclinical development of this vaccine candidate is warranted to protect against this important emerging disease.

Citation

Forrester-Soto. (2014). A novel live-attenuated vaccine candidate for mayaro Fever. PLoS Neglected Tropical Diseases, e2969 - e2969. https://doi.org/10.1371/journal.pntd.0002969

Acceptance Date May 22, 2014
Publication Date Aug 7, 2014
Journal PLoS Neglected Tropical Diseases
Publisher Public Library of Science
Pages e2969 - e2969
DOI https://doi.org/10.1371/journal.pntd.0002969
Keywords live-attenuated vaccine, mayaro fever.
Publisher URL https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0002969

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