SJ Drabble
Mechanisms of Action of a Web-Based Intervention With Health Professional Support to Increase Adherence to Nebulizer Treatments in Adults With Cystic Fibrosis: Qualitative Interview Study.
Drabble, SJ; O'Cathain, A; Arden, MA; Keating, S; Hutchings, M; Maguire, C; Wildman, M; Scott, AJ
Authors
Abstract
BACKGROUND: Adherence to nebulizer treatments in adults with cystic fibrosis (CF) is often low. A new complex intervention to help adults with CF increase their adherence to nebulizer treatments was tested in a pilot randomized controlled trial (RCT) in 2 UK CF centers. Patients used a nebulizer with electronic monitoring capabilities that transferred data automatically to a digital platform (CFHealthHub) to monitor adherence over time and to a tailored website to display graphs of adherence data and educational and problem-solving information about adherence. A trained interventionist helped patients identify ways to increase their adherence. OBJECTIVE: This study aims to explore the mechanisms of action underpinning the intervention. METHODS: A qualitative interview study was conducted concurrently with a pilot RCT. In total, 25 semistructured interviews were conducted with 3 interventionists at 2 time points, 14 patients in the intervention arm of the trial, and 5 members of the multidisciplinary teams offering wider care to patients. A framework approach was used for the analysis. RESULTS: The intervention was informed by a theoretical framework of behavior change. There was evidence of the expected behavior change mechanisms of action. There was also evidence of additional mechanisms of action associated with effective telehealth interventions for self-management support: relationships, visibility, and fit. Patients described how building a relationship with the interventionist through face-to-face visits with someone who cared about them and their progress helped them to consider ways of increasing adherence to medication. Rather than seeing the visibility of adherence data to clinicians as problematic, patients found this motivating, particularly if they received praise about progress made. The intervention was tailored to individuals, but there were challenges in how the intervention fitted into some patients' busy lives when delivered through a desktop computer. CONCLUSIONS: The mechanisms of action associated with effective telehealth interventions for self-management operated within this new intervention. The intervention was modified to strengthen mechanisms of action based on these findings, for example, delivery through an app accessed via mobile phones and then tested in an RCT in 19 UK CF centers. TRIAL REGISTRATION: International Standard Randomized Controlled Trial Number 13076797; http://www.isrctn.com/ISRCTN13076797.
Citation
Drabble, S., O'Cathain, A., Arden, M., Keating, S., Hutchings, M., Maguire, C., …Scott, A. (2020). Mechanisms of Action of a Web-Based Intervention With Health Professional Support to Increase Adherence to Nebulizer Treatments in Adults With Cystic Fibrosis: Qualitative Interview Study. Journal of Medical Internet Research, e16782 - ?. https://doi.org/10.2196/16782
Acceptance Date | Jun 25, 2020 |
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Publication Date | Oct 6, 2020 |
Journal | Journal of Medical Internet Research |
Print ISSN | 1438-8871 |
Publisher | JMIR Publications |
Pages | e16782 - ? |
DOI | https://doi.org/10.2196/16782 |
Keywords | United Kingdom, adherence, compliance, cystic fibrosis, health behavior, interview, patient portals, process evaluation, psychological theory, qualitative research, telehealth, Adolescent, Adult, Cystic Fibrosis, Feasibility Studies, Female, Humans, Inter |
Publisher URL | https://doi.org/10.2196/16782 |
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