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Enhancing the regenerative potential of stem cell-laden, clinical-grade implants through laminin engineering

Mogas Barcons, A; Chari, DM; Adams, CF


A Mogas Barcons


Protected delivery of neural stem cells (NSCs; a major transplant population) within bioscaffolds has the potential to improve regenerative outcomes in sites of spinal cord injury. Emergent research has indicated clinical grade bioscaffolds (e.g. those used as surgical sealants) may be repurposed for this strategy, bypassing the long approval processes and difficulties in scale-up faced by laboratory grade materials. While promising, clinical scaffolds are often not inherently regenerative. Extracellular molecule biofunctionalisation of scaffolds can enhance regenerative features such as encapsulated cell survival/distribution, cell differentiation into desired cell types and nerve fibre growth. However, this strategy is yet to be tested for clinical grade scaffolds. Here, we show for the first time that Hemopatch™, a widely used, clinically approved surgical matrix, supports NSC growth. Further, functionalisation of Hemopatch™ with laminin promoted homogenous distribution of NSCs and their daughter cells within the matrix, a key regenerative criterion for transplant cells.


Mogas Barcons, A., Chari, D., & Adams, C. (2021). Enhancing the regenerative potential of stem cell-laden, clinical-grade implants through laminin engineering. Materials Science and Engineering: C, 123,

Journal Article Type Article
Acceptance Date Jan 28, 2021
Publication Date Apr 1, 2021
Publicly Available Date May 30, 2023
Journal Materials Science and Engineering: C
Print ISSN 0928-4931
Electronic ISSN 1873-0191
Publisher Elsevier
Volume 123
Keywords Extracellular matrix, Hemopatch™, Neural stem cell, Spinal cord injury, Surgical materials, Tissue engineering, Cell Differentiation, Humans, Laminin, Neural Stem Cells, Spinal Cord Injuries, Tissue Engineering, Tissue Scaffolds
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