Skip to main content

Research Repository

Advanced Search

Clinical and Economic Burden of Stroke Among Young, Midlife, and Older Adults in the United States, 2002-2017

Mamas; Rashid

Clinical and Economic Burden of Stroke Among Young, Midlife, and Older Adults in the United States, 2002-2017 Thumbnail


Authors



Abstract

Objective
To assess trends of stroke hospitalization rates, inpatient mortality, and health care resource use in young (aged =44 years), midlife (aged 45-64 years), and older (aged =65 years) adults.

Patients and Methods
We studied the National Inpatient Sample database (January 1, 2002 to December 31, 2017) to analyze stroke-related hospitalizations. We identified data using the International Classification of Diseases, Ninth/Tenth Revision codes.

Results
Of 11,381,390 strokes, 79% (n=9,009,007) were ischemic and 21% (n=2,372,383) were hemorrhagic. Chronic diseases were more frequent in older adults; smoking, alcoholism, and migraine were more prevalent in midlife adults; and coagulopathy and intravenous drug abuse were more common in young patients with stroke. The hospitalization rates of stroke per 10,000 increased overall (31.6 to 33.3) in young and midlife adults while decreasing in older adults. Although mortality decreased overall and in all age groups, the decline was slower in young and midlife adults than older adults. The mean length of stay significantly decreased in midlife and older adults and increased in young adults. The inflation-adjusted mean cost of stay increased consistently, with an average annual growth rate of 2.44% in young, 1.72% in midlife, and 1.45% in older adults owing to the higher use of health care resources. These trends were consistent in both ischemic and hemorrhagic stroke.

Conclusion
Stroke-related hospitalization and health care expenditure are increasing in the United States, particularly among young and midlife adults. A higher cost of stay counterbalances the benefits of reducing stroke and mortality in older patients.

Citation

Mamas, & Rashid. (2021). Clinical and Economic Burden of Stroke Among Young, Midlife, and Older Adults in the United States, 2002-2017. https://doi.org/10.1016/j.mayocpiqo.2021.01.015

Acceptance Date Apr 8, 2021
Publication Date Apr 8, 2021
Journal Mayo Clinic Proceedings: Innovations, Quality & Outcomes
Print ISSN 2542-4548
Pages 431 - 441
DOI https://doi.org/10.1016/j.mayocpiqo.2021.01.015
Publisher URL https://www.sciencedirect.com/science/article/pii/S2542454821000345?via%3Dihub