Invasive Hemodynamic Monitoring in Cardiogenic Shock Is Associated With Lower In‐Hospital Mortality

Osman, Mohammed; Syed, Moinuddin; Patel, Brijesh; Munir, Muhammad Bilal; Kheiri, Babikir; Caccamo, Marco; Sokos, George; Balla, Sudarshan; Basir, Mir Babar; Kapur, Navin K.; Mamas, Mamas A.; Bianco, Christopher M.

Abstract

BackgroundThere is increasing utilization of cardiogenic shock treatment algorithms. The cornerstone of these algorithms is the use of invasive hemodynamic monitoring (IHM). We sought to compare the in‐hospital outcomes in patients who received IHM versus no IHM in a real‐world contemporary database.Methods and ResultsPatients with cardiogenic shock admitted during October 1, 2015 to December 31, 2018, were identified from the National Inpatient Sample. Among this group, we compared the outcomes among patients who received IHM versus no IHM. The primary end point was in‐hospital mortality. Secondary end points included vascular complications, major bleeding, need for renal replacement therapy, length of stay, cost of hospitalization, and rate of utilization of left ventricular assist devices and heart transplantation. Propensity score matching was used for covariate adjustment. A total of 394 635 (IHM=62 565; no IHM=332 070) patients were included. After propensity score matching, 2 well‐matched groups were compared (IHM=62 220; no IHM=62 220). The IHM group had lower in‐hospital mortality (24.1% versus 30.6%,P<0.01), higher percentages of left ventricular assist devices (4.4% versus 1.3%,P<0.01) and heart transplantation (1.3% versus 0.7%,P<0.01) utilization, longer length of hospitalization and higher costs. There was no difference between the 2 groups in terms of vascular complications, major bleeding, and the need for renal replacement therapy.ConclusionsAmong patients with cardiogenic shock, the use of IHM is associated with a reduction in in‐hospital mortality and increased utilization of advanced heart failure therapies. Due to the observational nature of the current study, the results should be considered hypothesis‐generating, and future prospective studies confirming these findings are needed.

Citation

Osman, M., Syed, M., Patel, B., Munir, M. B., Kheiri, B., Caccamo, M., …Bianco, C. M. (2021). Invasive Hemodynamic Monitoring in Cardiogenic Shock Is Associated With Lower In‐Hospital Mortality. Journal of the American Heart Association, 10(18), https://doi.org/10.1161/jaha.121.021808

• Journal Article Type: Article
• Acceptance Date: Jul 19, 2021
• Online Publication Date: Sep 13, 2021
• Publication Date: Sep 21, 2021
• Publicly Available Date: May 30, 2023
• Journal: Journal of the American Heart Association
• Publisher: Wiley Open Access
• Peer Reviewed: Peer Reviewed
• Volume: 10
• Issue: 18
• DOI: https://doi.org/10.1161/jaha.121.021808
• Keywords: Cardiology and Cardiovascular Medicine
• Publisher URL: https://www.ahajournals.org/doi/10.1161/JAHA.121.021808