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The Fourth Trimester: Pregnancy as a Predictor of Cardiovascular Disease

Wu, Pensée; Park, Ki; Gulati, Martha

The Fourth Trimester: Pregnancy as a Predictor of Cardiovascular Disease Thumbnail


Ki Park

Martha Gulati


Pregnancy identifies women who may be at a greater risk of cardiovascular disease (CVD), based on the development of adverse pregnancy outcomes (APOs), and may identify women who may benefit from atherosclerotic CVD (ASCVD) risk reduction efforts. APOs are common and although they are separate diagnoses, all these disorders seem to share an underlying pathogenesis. What is not clear is whether the APO itself initiates a pathway that results in CVD or whether the APO uncovers a woman's predisposition to CVD. Regardless, APOs have immediate risks to maternal and foetal health, in addition to longer-term CVD consequences. CVD risk assessment and stratification in women remains complex and, historically, has underestimated risk, especially in young women. Further research is needed into the role of ASCVD risk assessment and the effect of aggressive ASCVD risk modification on CVD outcomes in women with a history of APOs.

Journal Article Type Article
Acceptance Date Jul 10, 2021
Online Publication Date Sep 3, 2021
Publication Date Sep 3, 2021
Publicly Available Date May 30, 2023
Journal European Cardiology Review
Print ISSN 1758-3756
Publisher Radcliffe Medical Media
Peer Reviewed Peer Reviewed
Volume 16
Article Number e31
Publisher URL


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