Micro RNA in meniscal ailments: current concepts

Migliorini, Filippo; Vecchio, Gianluca; Giorgino, Riccardo; Eschweiler, Jörg; Hildebrand, Frank; Maffulli, Nicola

Abstract

AbstractIntroductionMicro RNAs (miRNAs) are short non-coding RNAs that act primarily in posttranscriptional gene silencing, and are attracting increasing interest in musculoskeletal conditions.Source of dataCurrent scientific literature published in PubMed, Google Scholar, Embase and Web of Science databases.Areas of agreementRecently, the potential of miRNAs as biomarkers for diagnosis and treatment of meniscal injuries has been postulated.Areas of controversyEvaluation of the role of miRNAs in patients with meniscal tears is still controversial.Growing pointsA systematic review was conducted to investigate the potential of miRNA in the diagnosis and management of meniscal damage.Areas timely for developing researchIntra-articular injection of microRNA-210 in vivo may represent a potential innovative methodology for the management of meniscal injuries. Characterization of the miRNAs expression in the synovial fluid could lead to the development of better early diagnosis and management strategies for meniscal tears.

Citation

Migliorini, F., Vecchio, G., Giorgino, R., Eschweiler, J., Hildebrand, F., & Maffulli, N. (2023). Micro RNA in meniscal ailments: current concepts. British Medical Bulletin, 145(1), 141-150. https://doi.org/10.1093/bmb/ldac039

• Journal Article Type: Article
• Acceptance Date: Dec 13, 2022
• Online Publication Date: Jan 29, 2023
• Publication Date: Apr 5, 2023
• Deposit Date: Dec 18, 2023
• Journal: British Medical Bulletin
• Print ISSN: 0007-1420
• Publisher: Oxford University Press
• Peer Reviewed: Peer Reviewed
• Volume: 145
• Issue: 1
• Pages: 141-150
• DOI: https://doi.org/10.1093/bmb/ldac039
• Keywords: General Medicine
• Publisher URL: https://academic.oup.com/bmb/article/145/1/141/7005167