Anterior cruciate ligament reconstruction in skeletally immature patients is effective: A systematic review

Migliorini, Filippo; Cocconi, Federico; Schäfer, Luise; Memminger, Michael Kurt; Giorgino, Riccardo; Maffulli, Nicola

Abstract

Purpose
The present study evaluated the outcomes of anterior cruciate ligament (ACL) reconstruction in children with open physes. The outcomes of interest were to compare the increase in joint laxity and PROMs from baseline to the last follow-up, the rate and features of the return to sport and the rate of complications.

Methods
This study was conducted according to the 2020 PRISMA guidelines. In October 2023, the following databases were accessed: PubMed, Web of Science, Google Scholar and Embase. All the clinical studies investigating ACL reconstruction in skeletally immature patients were accessed. Only articles which clearly stated that surgeries were conducted in children with open physis were eligible.

Results
Data from 53 studies (1691 procedures) were collected. 35% (597 out of 1691 patients) were women. The mean length of the follow-up was 44.7 ± 31.3 months. The mean age of the patients was 12.7 ± 1.1 years old. All PROMs significantly improved from the baseline values to those at the last follow-up. The mean time to return to sport was 8.3 ± 1.9 months. 89% (690 out of 771 patients) returned to sports, 15% (109 out of 721 patients) reduced their level of sports activity or league, and 84% (651 out of 771 patients) returned to their previous level of sport. 9% (112 out of 1213) of patients experienced re-tear of the reconstructed ACL, and 11% (75 out of 660) of patients underwent a further ACL reoperation. No patients (0 out of 83) demonstrated increased laxity at the last follow-up, and persistent sensation of instability was reported by 5% (11 out of 235) of patients.

Conclusion
ACL reconstruction in skeletally immature patients is effective and safe, and is associated with fast recovery and a high rate of return to sport.

Level of Evidence
Level IV.

Citation

Migliorini, F., Cocconi, F., Schäfer, L., Memminger, M. K., Giorgino, R., & Maffulli, N. (in press). Anterior cruciate ligament reconstruction in skeletally immature patients is effective: A systematic review. Knee Surgery, Sports Traumatology, Arthroscopy, 32(2), 418-431. https://doi.org/10.1002/ksa.12048

• Journal Article Type: Article
• Acceptance Date: Dec 28, 2023
• Online Publication Date: Jan 23, 2024
• Deposit Date: Jan 29, 2024
• Publicly Available Date: Jan 29, 2024
• Journal: Knee Surgery, Sports Traumatology, Arthroscopy
• Print ISSN: 0942-2056
• Publisher: Springer Verlag
• Peer Reviewed: Peer Reviewed
• Volume: 32
• Issue: 2
• Pages: 418-431
• DOI: https://doi.org/10.1002/ksa.12048
• Keywords: ACL, skeletally immature, anterior cruciate ligament, children
• Publisher URL: https://onlinelibrary.wiley.com/doi/10.1002/ksa.12048