A novel neuronal circuit: Tanycytes mediate defensive metabolic responses following acute high‐temperature exposure

Chen, Qi; Brüning‐Richardson, Anke; Chen, Ruoli; Zou, Shuang; Lan, Yu‐Long

Abstract

The core body temperature, plays a vital role in influencing metabolic rate, enzyme activity, and various other physiological processes.1 Significant progress has been achieved in unraveling the neural mechanisms responsible for lowering body temperature during illness, commonly observed in conditions like fever.2 It has been established that populations of neurons in the ventral medial preoptic area of the hypothalamus are activated after systemic inflammation. They respond to locally secreted immune molecules such as prostaglandin E2, interleukin-1β (IL-1β), and C-C motif ligand 2 (CCL2), and form connections with other brain areas, some of which known to control pain sensation, thirst or social interactions, contributing to survival during infection.2 However, little is known about how the brain orchestrates responses to dissipate excess heat in response to acute thermal challenges encompassing unavoidable environmental exposure (e.g. air-conditioned environments) and elective exposure (e.g. sauna).

Citation

Chen, Q., Brüning‐Richardson, A., Chen, R., Zou, S., & Lan, Y. (2024). A novel neuronal circuit: Tanycytes mediate defensive metabolic responses following acute high‐temperature exposure. Brain-X, 2(3), 1-3. https://doi.org/10.1002/brx2.70003

• Journal Article Type: Commentary
• Acceptance Date: Sep 1, 2024
• Online Publication Date: Oct 8, 2024
• Publication Date: Sep 1, 2024
• Deposit Date: Oct 18, 2024
• Publicly Available Date: Oct 18, 2024
• Journal: Brain‐X
• Print ISSN: 2835-3153
• Electronic ISSN: 2835-3153
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 2
• Issue: 3
• Article Number: e70003
• Pages: 1-3
• DOI: https://doi.org/10.1002/brx2.70003
• Keywords: feeding, temperature, tanycyte, neural circuit
• Public URL: https://keele-repository.worktribe.com/output/950486