All Outputs (70)

A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation (2024)
Journal Article
Campbell, K., Naire, S., & Kuiper, J.-H. (2024). A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation. Journal of Theoretical Biology, Article 111874. https://doi.org/10.1016/j.jtbi.2024.111874

Treating bone-cartilage defects is a fundamental clinical problem. The ability of damaged cartilage to self-repair is limited due to its avascularity. Left untreated, these defects can lead to osteoarthritis. Details of osteochondral defect repair ar... Read More about A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation.

Journal of Theoretical Biology A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation --Manuscript Draft-- Manuscript Number: JTB-D-23-00814R1 (2024)
Journal Article
Kuiper, J., Campbell, K., & Naire, S. (in press). Journal of Theoretical Biology A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation --Manuscript Draft-- Manuscript Number: JTB-D-23-00814R1. Journal of Theoretical Biology,

Treating bone-cartilage defects is a fundamental clinical problem. The ability of damaged cartilage to self-repair is limited due to its avascularity. Left untreated, these defects can lead to osteoarthritis. Details of osteochondral defect repair ar... Read More about Journal of Theoretical Biology A mathematical model of signalling molecule-mediated processes during regeneration of osteochondral defects after chondrocyte implantation --Manuscript Draft-- Manuscript Number: JTB-D-23-00814R1.

Assessment of the effectiveness of weight-adjusted antibiotic administration, for reduced duration, in surgical prophylaxis of primary hip and knee arthroplasty. (2024)
Journal Article
Okoro, T., Wan, M., Mukabeta, T. D., Malev, E., Gross, M., Williams, C., …Murnaghan, J. (in press). Assessment of the effectiveness of weight-adjusted antibiotic administration, for reduced duration, in surgical prophylaxis of primary hip and knee arthroplasty. World Journal of Orthopedics, 15(2), 170-179. https://doi.org/10.5312/wjo.v15.i2.170

Prophylactic antibiotics have significantly led to a reduction in the risk of post-operative surgical site infections (SSI) in orthopaedic surgery. The aim of using antibiotics for this purpose is to achieve serum and tissue drug levels that exceed,... Read More about Assessment of the effectiveness of weight-adjusted antibiotic administration, for reduced duration, in surgical prophylaxis of primary hip and knee arthroplasty..

Circumferential Periosteal Release to Treat Paediatric Leg Length Discrepancy: Medium Term Outcomes. (2023)
Journal Article
Chatterton, B. D., Kuiper, J. H., & Williams, D. P. (2023). Circumferential Periosteal Release to Treat Paediatric Leg Length Discrepancy: Medium Term Outcomes. Strategies in Trauma and Limb Reconstruction, 18(2), 67-72. https://doi.org/10.5005/jp-journals-10080-1591

This study aims to report the medium term outcomes of circumferential periosteal release of the distal femur and distal tibia in treating paediatric leg length discrepancy (LLD). A retrospective case series was performed on all patients undergoing ci... Read More about Circumferential Periosteal Release to Treat Paediatric Leg Length Discrepancy: Medium Term Outcomes..

Comparison of Knee Articular Cartilage Defect Size Between Measurements Obtained on Preoperative MRI Versus During Arthrotomy (2023)
Journal Article
Perry, J., Kuiper, J. H., McCarthy, H. S., Jermin, P., Gallacher, P. D., Tins, B., & Roberts, S. (2023). Comparison of Knee Articular Cartilage Defect Size Between Measurements Obtained on Preoperative MRI Versus During Arthrotomy. Orthopaedic Journal of Sports Medicine, 11(9), Article 23259671231193380. https://doi.org/10.1177/23259671231193380

Background: Treatment decisions for cartilage defects are often based on lesion size. Magnetic resonance imaging (MRI) is widely used to diagnose cartilage defects noninvasively; however, their size estimated from MRI may differ from defect sizes me... Read More about Comparison of Knee Articular Cartilage Defect Size Between Measurements Obtained on Preoperative MRI Versus During Arthrotomy.

Survival analysis in nonagenarian patients with non-hip lower limb fractures. (2023)
Journal Article
Narayana Murthy, S., Cheruvu, M. S., Siddiqui, R. S., Sharma, N., Dass, D., & Ali, A. (in press). Survival analysis in nonagenarian patients with non-hip lower limb fractures. World Journal of Orthopedics, 14(8), 621-629. https://doi.org/10.5312/wjo.v14.i8.621

The United Kingdom has an aging population with nearly 1 in 5 being over the age of 65, and over 0.5 million over the age of 90. The treatment of acute fractures of the lower limb in the nonagenarian cohort of patients poses a technical challenge to... Read More about Survival analysis in nonagenarian patients with non-hip lower limb fractures..

Mid-term outcome of superior capsular reconstruction using doubled acellular human dermal allograft for irreparable rotator cuff tear (2023)
Journal Article
Snow, M., Kuiper, J. H., Thimmegowda, A., Ramsingh, V., Haikal, M., & Amit, P. (2023). Mid-term outcome of superior capsular reconstruction using doubled acellular human dermal allograft for irreparable rotator cuff tear. Journal of Shoulder and Elbow Surgery, https://doi.org/10.1016/j.jse.2023.06.007

Purpose Thicker (folded) facia lata autografts have been shown to be superior to thinner grafts and single-layered acellular human dermal (HD) allografts for superior capsular reconstruction (SCR) in biomechanical studies. The aim of this study was... Read More about Mid-term outcome of superior capsular reconstruction using doubled acellular human dermal allograft for irreparable rotator cuff tear.

Functional outcomes after Medial Patellofemoral Ligament Reconstruction show inverted J-shaped relation with Body Mass Index (2023)
Journal Article
Sharma, N., Al-Mouazzen, L., Kuiper, J. H., Gallacher, P., & Barnett, A. (in press). Functional outcomes after Medial Patellofemoral Ligament Reconstruction show inverted J-shaped relation with Body Mass Index. Knee Surgery, Sports Traumatology, Arthroscopy, https://doi.org/10.1007/s00167-023-07391-2

Purpose Medial patellofemoral ligament reconstruction (MPFL-R) is a recognised surgical procedure for the treatment of recurrent patellofemoral instability with excellent outcomes reported. The aim of this study is to determine if body mass index ca... Read More about Functional outcomes after Medial Patellofemoral Ligament Reconstruction show inverted J-shaped relation with Body Mass Index.

A pilot randomised controlled trial assessing standard versus dermal patch-augmented rotator cuff repair found no adverse effects and suggest future trials need a minimum of 150 patients (2023)
Journal Article
Snow, M., Kuiper, J. H., James, S., Keeling, E., Rich, S., & Amit, P. (in press). A pilot randomised controlled trial assessing standard versus dermal patch-augmented rotator cuff repair found no adverse effects and suggest future trials need a minimum of 150 patients. Knee Surgery, Sports Traumatology, Arthroscopy, https://doi.org/10.1007/s00167-023-07356-5

The aims of this pilot randomised controlled trial (RCT) were to assess the safety and efficacy of a human dermal allograft patch and assess the feasibility of a future RCT comparing retear rate and functional outcome 12 months following standard and... Read More about A pilot randomised controlled trial assessing standard versus dermal patch-augmented rotator cuff repair found no adverse effects and suggest future trials need a minimum of 150 patients.

Relationship Between Activity Level and Knee Function Is Influenced by Negative Affect in Patients Undergoing Cell Therapy for Articular Cartilage Defects in the Knee. (2023)
Journal Article
Kuiper. (2023). Relationship Between Activity Level and Knee Function Is Influenced by Negative Affect in Patients Undergoing Cell Therapy for Articular Cartilage Defects in the Knee. Orthopaedic Journal of Sports Medicine, 23259671231151925 - ?. https://doi.org/10.1177/23259671231151925

BACKGROUND: Increased activity level is generally reported to be positively related to improved knee function after knee surgery. However, little research has been conducted into this relationship on an individual patient basis, or the influence of d... Read More about Relationship Between Activity Level and Knee Function Is Influenced by Negative Affect in Patients Undergoing Cell Therapy for Articular Cartilage Defects in the Knee..

Histological and Radiological Assessment of Endogenously Generated Repair Tissue In Vivo Following a Chondral Harvest (2023)
Journal Article
Gallacher, P., Jermin, P., Richardson, J., Kuiper, J., Roberts, S., McCarthy, H., & Tins, B. (2023). Histological and Radiological Assessment of Endogenously Generated Repair Tissue In Vivo Following a Chondral Harvest. Cartilage, 48-58. https://doi.org/10.1177/19476035221149523

OBJECTIVE: To examine repair tissue formed approximately 15 months after a chondral harvest in the human knee. DESIGN: Sixteen individuals (12 males, 4 females, mean age 36 ± 9 years) underwent a chondral harvest in the trochlea as a pre-requisite fo... Read More about Histological and Radiological Assessment of Endogenously Generated Repair Tissue In Vivo Following a Chondral Harvest.

A Randomized Trial of Autologous Chondrocyte Implantation Versus Alternative Forms of Surgical Cartilage Management in Patients With a Failed Primary Treatment for Chondral or Osteochondral Defects in the Knee (2023)
Journal Article
Snow, M., Middleton, L., Mehta, S., Roberts, A., Gray, R., Richardson, J., …O’Brien, S. (2023). A Randomized Trial of Autologous Chondrocyte Implantation Versus Alternative Forms of Surgical Cartilage Management in Patients With a Failed Primary Treatment for Chondral or Osteochondral Defects in the Knee. American Journal of Sports Medicine, 51(2), 367-378. https://doi.org/10.1177/03635465221141907

BACKGROUND: There are limited randomized controlled trials with long-term outcomes comparing autologous chondrocyte implantation (ACI) versus alternative forms of surgical cartilage management within the knee. PURPOSE: To determine at 5 years after s... Read More about A Randomized Trial of Autologous Chondrocyte Implantation Versus Alternative Forms of Surgical Cartilage Management in Patients With a Failed Primary Treatment for Chondral or Osteochondral Defects in the Knee.

Psoriatic arthritis: review of potential biomarkers predicting response to TNF inhibitors (2022)
Journal Article
Makos, A., Kuiper, J., Kehoe, O., & Amarasena, R. (2022). Psoriatic arthritis: review of potential biomarkers predicting response to TNF inhibitors. Inflammopharmacology, 77-87. https://doi.org/10.1007/s10787-022-01092-x

Psoriatic arthritis (PsA) is a chronic and painful inflammatory immune-mediated disease. It affects up to 40% of people with psoriasis and it is associated with several comorbidities such as obesity, diabetes, metabolic syndrome and hypertension. PsA... Read More about Psoriatic arthritis: review of potential biomarkers predicting response to TNF inhibitors.

Intrathecal morphine in combination with bupivacaine as pre-emptive analgesia in posterior lumbar fusion surgery: a retrospective cohort study (2022)
Journal Article
Kuiper. (2022). Intrathecal morphine in combination with bupivacaine as pre-emptive analgesia in posterior lumbar fusion surgery: a retrospective cohort study. Journal of Orthopaedic Surgery and Research, https://doi.org/10.1186/s13018-022-03124-2

Abstract Background The purpose of this study was to evaluate the efficacy of intrathecal morphine (ITM) in combination with bupivacaine as pre-emptive analgesia in patients undergoing posterior lumbar fusion surgery. This is in comparison with tradi... Read More about Intrathecal morphine in combination with bupivacaine as pre-emptive analgesia in posterior lumbar fusion surgery: a retrospective cohort study.

Evaluating the Feasibility and Reliability of Remotely Delivering and Scoring the North Star Ambulatory Assessment in Ambulant Patients with Duchenne Muscular Dystrophy (2022)
Journal Article
Kuiper. (2022). Evaluating the Feasibility and Reliability of Remotely Delivering and Scoring the North Star Ambulatory Assessment in Ambulant Patients with Duchenne Muscular Dystrophy. Children, 728 - 728. https://doi.org/10.3390/children9050728

Objective: The North Star Ambulatory Assessment (NSAA) is a validated 17-item functional rating scale and widely used to assess motor function in boys with Duchenne muscular dystrophy (DMD). The SARS-CoV-2 pandemic and subsequent Government 'lockdown... Read More about Evaluating the Feasibility and Reliability of Remotely Delivering and Scoring the North Star Ambulatory Assessment in Ambulant Patients with Duchenne Muscular Dystrophy.

Osteochondral Lesions of the Ankle Treated with Bone Marrow Concentrate with Hyaluronan and Fibrin: A Single-Centre Study. (2022)
Journal Article
Abas, S., Kuiper, J. H., Roberts, S., McCarthy, H., Williams, M., Bing, A., …Makwana, N. (2022). Osteochondral Lesions of the Ankle Treated with Bone Marrow Concentrate with Hyaluronan and Fibrin: A Single-Centre Study. Cells, 11(4), https://doi.org/10.3390/cells11040629

Osteochondral defects of the ankle (OCD) are being increasingly identified as a clinically significant consequence of injury to the ankle, with the potential to lead to osteoarthritis if left untreated. The aim of this retrospective cohort study was... Read More about Osteochondral Lesions of the Ankle Treated with Bone Marrow Concentrate with Hyaluronan and Fibrin: A Single-Centre Study..

Greater trochanteric pain syndrome: focused shockwave therapy versus an ultrasound guided injection: a randomised control trial (2021)
Journal Article
Heaver, C., Pinches, M., Kuiper, J. H., Thomas, G., Lewthwaite, S., Burston, B. J., & Banerjee, R. D. (2023). Greater trochanteric pain syndrome: focused shockwave therapy versus an ultrasound guided injection: a randomised control trial. Hip International, 33(3), 490-499. https://doi.org/10.1177/11207000211060396

Greater trochanteric pain syndrome (GTPS) is a common problem with an incidence of 1.8–5.6 per 1000 population. Physiotherapy, anti-inflammatories, corticosteroid injections and surgery have all been described in the management of GTPS, with limited,... Read More about Greater trochanteric pain syndrome: focused shockwave therapy versus an ultrasound guided injection: a randomised control trial.

Clinical validation of the Oswestry-Bristol Classification as part of a decision algorithm for trochlear dysplasia surgery (2021)
Journal Article
Sharma, N., Rehmatullah, N., Kuiper, J. H., Gallacher, P., & Barnett, A. J. (2021). Clinical validation of the Oswestry-Bristol Classification as part of a decision algorithm for trochlear dysplasia surgery. The Bone & Joint Journal, 103-B(10), 1586-1594. https://doi.org/10.1302/0301-620x.103b10.bjj-2020-1984.r1

The Oswestry-Bristol Classification (OBC) is an MRI-specific assessment tool to grade trochlear dysplasia. The aim of this study is to validate clinically the OBC by demonstrating its use in selecting treatments that are safe and effective.

Contralateral strength training attenuates muscle performance loss following anterior cruciate ligament (ACL) reconstruction: a randomised-controlled trial. (2021)
Journal Article
Kuiper. (2021). Contralateral strength training attenuates muscle performance loss following anterior cruciate ligament (ACL) reconstruction: a randomised-controlled trial. European Journal of Applied Physiology, 3551-3559. https://doi.org/10.1007/s00421-021-04812-3

PURPOSE: To investigate the effects of cross-education (CE) exercise on strength and performance at 10 and 24 weeks post anterior cruciate ligament (ACL) surgery. METHODS: Design: randomised controlled trial. N?=?44 ACL-reconstruction patients, r... Read More about Contralateral strength training attenuates muscle performance loss following anterior cruciate ligament (ACL) reconstruction: a randomised-controlled trial..

Identifying Consensus and Open Questions around Assessing or Predicting the Quality and Success of Cartilage Repair: A Delphi Study (2021)
Journal Article
Kuiper. (2021). Identifying Consensus and Open Questions around Assessing or Predicting the Quality and Success of Cartilage Repair: A Delphi Study. Surgeries, 286 - 302. https://doi.org/10.3390/surgeries2030029

A range of surgical techniques have been developed for the repair or regeneration of lesioned cartilage in the human knee and a corresponding array of scoring systems have been created to assess their outcomes. The published literature displays a wid... Read More about Identifying Consensus and Open Questions around Assessing or Predicting the Quality and Success of Cartilage Repair: A Delphi Study.