All Outputs (6)

An alternative modular 'click-SNAr-click' approach to develop subcellular localised fluorescent probes to image mobile Zn2+ (2019)
Journal Article
Watkinson, M., Fang, L., Trigiante, G., Crespo-Otero, R., Philpott, M. P., & Jones, C. R. (2019). An alternative modular 'click-SNAr-click' approach to develop subcellular localised fluorescent probes to image mobile Zn2+. Organic and Biomolecular Chemistry, 17(47), 10013-10019. https://doi.org/10.1039/c9ob01855g

Zn2+ is involved in a number of biological processes and its wide-ranging roles at the subcellular level, especially in specific organelles, have not yet been fully established due to a lack of tools to image it effectively. We report a new and effic... Read More about An alternative modular 'click-SNAr-click' approach to develop subcellular localised fluorescent probes to image mobile Zn2+.

Endoplasmic reticulum targeting fluorescent probes to image mobile Zn2+ (2019)
Journal Article
Fang, L., Trigiante, G., Crespo-Otero, R., Hawes, C. S., Philpott, M. P., Jones, C. R., & Watkinson, M. (2019). Endoplasmic reticulum targeting fluorescent probes to image mobile Zn2+. Chemical Science, 10(47), 10881-10887. https://doi.org/10.1039/C9SC04300D

Zn2+ plays an important role in the normal function of the endoplasmic reticulum (ER) and its deficiency can cause ER stress, which is related to a wide range of diseases. In order to provide tools to better understand the role of mobile Zn2+ in ER p... Read More about Endoplasmic reticulum targeting fluorescent probes to image mobile Zn2+.

Peptide Cross-Linked Poly(2-oxazoline) as a Sensor Material for the Detection of Proteases with a Quartz Crystal Microbalance (2019)
Journal Article
Watkinson. (2019). Peptide Cross-Linked Poly(2-oxazoline) as a Sensor Material for the Detection of Proteases with a Quartz Crystal Microbalance. Biomacromolecules, 2506-2514. https://doi.org/10.1021/acs.biomac.9b00245

Inflammatory conditions are frequently accompanied by increased levels of active proteases, and there is rising interest in methods for their detection to monitor inflammation in a point of care setting. In this work, new sensor materials for disposa... Read More about Peptide Cross-Linked Poly(2-oxazoline) as a Sensor Material for the Detection of Proteases with a Quartz Crystal Microbalance.

Photoelectrochemical Imaging System for the Mapping of Cell Surface Charges (2019)
Journal Article
Watkinson. (2019). Photoelectrochemical Imaging System for the Mapping of Cell Surface Charges. Analytical Chemistry, 5896 -5903. https://doi.org/10.1021/acs.analchem.9b00304

The surface charge of cells affects cell signaling, cell metabolic processes, adherence to surfaces, and cell proliferation. Our understanding of the role of membrane charges is limited due to the inability to observe changes without interfering, che... Read More about Photoelectrochemical Imaging System for the Mapping of Cell Surface Charges.

Peptide Cross-Linked Poly (Ethylene Glycol) Hydrogel Films as Biosensor Coatings for the Detection of Collagenase (2019)
Journal Article
Watkinson. (2019). Peptide Cross-Linked Poly (Ethylene Glycol) Hydrogel Films as Biosensor Coatings for the Detection of Collagenase. Sensors, https://doi.org/10.3390/s19071677

Peptide cross-linked poly(ethylene glycol) hydrogel has been widely used for drug delivery and tissue engineering. However, the use of this material as a biosensor for the detection of collagenase has not been explored. Proteases play a key role in t... Read More about Peptide Cross-Linked Poly (Ethylene Glycol) Hydrogel Films as Biosensor Coatings for the Detection of Collagenase.

Recent advances in the catalytic oxidation of alkene and alkane substrates using immobilized manganese complexes with nitrogen containing ligands (2019)
Journal Article
Nodzewska, A., Wadolowska, A., & Watkinson, M. (2019). Recent advances in the catalytic oxidation of alkene and alkane substrates using immobilized manganese complexes with nitrogen containing ligands. Coordination Chemistry Reviews, 382, 181-216. https://doi.org/10.1016/j.ccr.2018.12.004

In recent years, many supported manganese catalysts for the oxidative transformations of hydrocarbons by various terminal oxidants have been designed and tested. A vast range of inorganic (e.g. silica, carbon, zeolites), organic (e.g. polymers, dendr... Read More about Recent advances in the catalytic oxidation of alkene and alkane substrates using immobilized manganese complexes with nitrogen containing ligands.