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High-volume injections in Achilles tendinopathy: a systematic review (2024)
Journal Article
Hassan, R., Poku, D., Miah, N., & Maffulli, N. (2024). High-volume injections in Achilles tendinopathy: a systematic review. British Medical Bulletin, 1-13. https://doi.org/10.1093/bmb/ldae015

Introduction Achilles tendinopathy (AT) is common, particularly in runners. High-volume injections (HVIs) may be beneficial in the management of AT compared to other conservative management options, including exercise regimens, platelet-rich plasma (... Read More about High-volume injections in Achilles tendinopathy: a systematic review.

ColMA ‐based bioprinted 3D scaffold allowed to study tenogenic events in human tendon stem cells (2024)
Journal Article
Cortella, G., Lamparelli, E. P., Ciardulli, M. C., Lovecchio, J., Giordano, E., Maffulli, N., & Della Porta, G. (in press). ColMA ‐based bioprinted 3D scaffold allowed to study tenogenic events in human tendon stem cells. Bioengineering and Translational Medicine, 1-15. https://doi.org/10.1002/btm2.10723

The advent of bioprinting has enabled the creation of precise three‐dimensional (3D) cell cultures suitable for biomimetic in vitro models. In this study, we developed a novel protocol for 3D printing methacrylated collagen (ColMa, or PhotoCol®) comb... Read More about ColMA ‐based bioprinted 3D scaffold allowed to study tenogenic events in human tendon stem cells.

Manipulation of signaling pathways in bone tissue engineering and regenerative medicine: Current knowledge, novel strategies, and future directions. (2024)
Journal Article
Oryan, A., Afzali, S. A., & Maffulli, N. (in press). Manipulation of signaling pathways in bone tissue engineering and regenerative medicine: Current knowledge, novel strategies, and future directions. Injury, 55(12), Article 111976. https://doi.org/10.1016/j.injury.2024.111976

During osteogenesis, a large number of bioactive molecules, macromolecules, cells, and cellular signals are activated to induce bone growth and development. The activation of molecular pathways leads to the occurrence of cellular events, ultimately r... Read More about Manipulation of signaling pathways in bone tissue engineering and regenerative medicine: Current knowledge, novel strategies, and future directions..

Loss of Consciousness in Judo: Not Always a Concussion (2024)
Journal Article
Singh, K., Malliaropoulos, N., Callan, M., Ikumi, A., & Maffulli, N. (in press). Loss of Consciousness in Judo: Not Always a Concussion. Clinical Journal of Sport Medicine, 1-2. https://doi.org/10.1097/jsm.0000000000001281

INTRODUCTION
All sports carry injury risks. In the event of loss of consciousness (LOC) in judo, and with an appropriate mechanism of injury, concussion is likely to be high on a list of potential causes. The diagnosis and management of concussion h... Read More about Loss of Consciousness in Judo: Not Always a Concussion.

Highest oxygen consumption prediction: introducing variable theoretical proportional factors for different sports (2024)
Journal Article
Lorenzo-Capellá, I., Ramos-Álvarez, J. J., Jiménez-Herranz, M. E., Maffulli, N., de Borba, E. F., Iuliano, E., …Padulo, J. (in press). Highest oxygen consumption prediction: introducing variable theoretical proportional factors for different sports. European Journal of Applied Physiology, https://doi.org/10.1007/s00421-024-05625-w

Purpose
The use of a fixed theoretical-proportional-factor (TPF15) is one of the indirect highest-oxygen-consumptions (HOC) assessment methods, but it may not accurately reflect the physiological differences across various sports (cycling-triathlon-... Read More about Highest oxygen consumption prediction: introducing variable theoretical proportional factors for different sports.

Pediatric wrist fractures: variations in management across countries. An evidence-based summary of evidence (2024)
Journal Article
Labianca, L., Calderaro, C., & Maffulli, N. (in press). Pediatric wrist fractures: variations in management across countries. An evidence-based summary of evidence. British Medical Bulletin, https://doi.org/10.1093/bmb/ldae014

Introduction
Fractures of the distal radius are common in pediatric population, with considerable variation in the management of pediatric wrist fractures across different countries. It is crucial to consider the different approaches to conservative... Read More about Pediatric wrist fractures: variations in management across countries. An evidence-based summary of evidence.

Platelet Lysate and Osteoarthritis of the Knee: A Review of Current Clinical Evidence (2024)
Journal Article
Gupta, A., & Maffulli, N. (2024). Platelet Lysate and Osteoarthritis of the Knee: A Review of Current Clinical Evidence. Pain and Therapy, 13(6), 1377-1386. https://doi.org/10.1007/s40122-024-00661-y

Introduction: Osteoarthritis (OA) of the knee affects millions of people with sizable socioeconomic burden. Conventional treatment modalities are prioritized, turning to surgical intervention only when they have failed. However, these traditional mod... Read More about Platelet Lysate and Osteoarthritis of the Knee: A Review of Current Clinical Evidence.

Bone-patellar tendon-bone, hamstring, and quadriceps tendon autografts for anterior cruciate ligament reconstruction in skeletally immature patients: a systematic review (2024)
Journal Article
Migliorini, F., Cocconi, F., Schäfer, L., Vaishya, R., Kämmer, D., & Maffulli, N. (2024). Bone-patellar tendon-bone, hamstring, and quadriceps tendon autografts for anterior cruciate ligament reconstruction in skeletally immature patients: a systematic review. British Medical Bulletin, 152(1), 16-27. https://doi.org/10.1093/bmb/ldae011

Introduction
Historically, anterior cruciate ligament (ACL) ruptures in the paediatric age group were managed conservatively with bracing, casting, activity modification, and physical therapy. However, most of these patients had to reduce their spor... Read More about Bone-patellar tendon-bone, hamstring, and quadriceps tendon autografts for anterior cruciate ligament reconstruction in skeletally immature patients: a systematic review.

Clinical relevance of patient-reported outcome measures in patients who have undergone total hip arthroplasty: a systematic review (2024)
Journal Article
Migliorini, F., Maffulli, N., Memminger, M. K., Simeone, F., Rath, B., & Huber, T. (in press). Clinical relevance of patient-reported outcome measures in patients who have undergone total hip arthroplasty: a systematic review. Archives of Orthopaedic and Trauma Surgery, https://doi.org/10.1007/s00402-024-05579-w

Introduction
In orthopaedic research, it is crucial to determine changes that are statistically significant and clinically meaningful. One approach to accomplish this is by calculating the Minimal Clinically Important Difference (MCID), the Clinical... Read More about Clinical relevance of patient-reported outcome measures in patients who have undergone total hip arthroplasty: a systematic review.

Sacroiliac joint pain: what treatment and when. (2024)
Journal Article
Cocconi, F., Maffulli, N., Bell, A., Memminger, M. K., Simeone, F., & Migliorini, F. (in press). Sacroiliac joint pain: what treatment and when. Expert Review of Neurotherapeutics, 1-8. https://doi.org/10.1080/14737175.2024.2400682

Spinal and non-spinal pathologies can cause low back pain. Non-spinal sources of low back pain include the sacroiliac joint (SIJ) and the hip. SIJ pain can be treated either conservatively or surgically. Current strategies for managing sacroiliac joi... Read More about Sacroiliac joint pain: what treatment and when..

Rate of revision and wear penetration in different polyethylene liner compositions in total hip arthroplasty: a Bayesian network meta-analysis (2024)
Journal Article
Migliorini, F., Betsch, M., Maffulli, N., Schäfer, L., Hildebrand, F., Kubach, J., & Pasurka, M. (in press). Rate of revision and wear penetration in different polyethylene liner compositions in total hip arthroplasty: a Bayesian network meta-analysis. Scientific Reports, 14(1), Article 21162. https://doi.org/10.1038/s41598-024-71326-1

The present Bayesian network meta-analysis compared different types of polyethylene liners in total hip arthroplasty (THA) in terms of wear penetration (mm/year) and rate of revision. The type of liners compared were the crosslinked ultra-high molecu... Read More about Rate of revision and wear penetration in different polyethylene liner compositions in total hip arthroplasty: a Bayesian network meta-analysis.

Return to Sport Following Arthroscopic Management of Femoroacetabular Impingement: A Systematic Review (2024)
Journal Article
Lucenti, L., Maffulli, N., Bardazzi, T., Saggini, R., Memminger, M., Simeone, F., & Migliorini, F. (in press). Return to Sport Following Arthroscopic Management of Femoroacetabular Impingement: A Systematic Review. Journal of Clinical Medicine, 13(17), https://doi.org/10.3390/jcm13175219

Background: Femoroacetabular impingement (FAI) is common. The present systematic review updates the current evidence on return to sport (RTS) in patients who have undergone arthroscopic surgery for FAI in any of its variants (CAM, pincer, or both). M... Read More about Return to Sport Following Arthroscopic Management of Femoroacetabular Impingement: A Systematic Review.

Pharmacological management of secondary chronic spinal cord injury: a systematic review (2024)
Journal Article
Migliorini, F., Cocconi, F., Schäfer, L., Simeone, F., Jeyaraman, M., & Maffulli, N. (2024). Pharmacological management of secondary chronic spinal cord injury: a systematic review. British Medical Bulletin, 151(1), 49–68. https://doi.org/10.1093/bmb/ldae009

Introduction Spinal cord injury (SCI) may bring lifelong consequences for affected patients and a high financial burden to the health care system. Source of data Published peer-reviewed scientific articles identified from EMBASE, Google Scholar, PubM... Read More about Pharmacological management of secondary chronic spinal cord injury: a systematic review.

Osteoinductive potential of graphene and graphene oxide for bone tissue engineering: a comparative study (2024)
Journal Article
Kashte, S. B., Kadam, S., Maffulli, N., Potty, A. G., Migliorini, F., & Gupta, A. (2024). Osteoinductive potential of graphene and graphene oxide for bone tissue engineering: a comparative study. Journal of Orthopaedic Surgery and Research, 19(1), 1-11. https://doi.org/10.1186/s13018-024-05028-9

Background
Bone defects, especially critical-size bone defects, and their repair pose a treatment challenge. Osteoinductive scaffolds have gained importance given their potential in bone tissue engineering applications.

Methods
Polycaprolactone... Read More about Osteoinductive potential of graphene and graphene oxide for bone tissue engineering: a comparative study.

Anodal tDCS improves the effect of neuromuscular training on the feedforward activity of lower extremity muscles in female taekwondo athletes with dynamic knee valgus (2024)
Journal Article
Moshashaei, M. S., Gandomi, F., Amiri, E., & Maffulli, N. (in press). Anodal tDCS improves the effect of neuromuscular training on the feedforward activity of lower extremity muscles in female taekwondo athletes with dynamic knee valgus. Scientific Reports, 14(1), Article 20007. https://doi.org/10.1038/s41598-024-70328-3

Transcranial direct current stimulation (tDCS) can increase cortical excitability of a targeted brain area. This study aimed to investigate the effect of adding anodal-tDCS (a-tDCS) to neuromuscular training (NMT) on the dynamic knee valgus (DKV) and... Read More about Anodal tDCS improves the effect of neuromuscular training on the feedforward activity of lower extremity muscles in female taekwondo athletes with dynamic knee valgus.

Beyond pixel: Superpixel-based MRI segmentation through traditional machine learning and graph convolutional network (2024)
Journal Article
Khatun, Z., Jónsson, H., Tsirilaki, M., Maffulli, N., Oliva, F., Daval, P., …Gargiulo, P. (2024). Beyond pixel: Superpixel-based MRI segmentation through traditional machine learning and graph convolutional network. Computer Methods and Programs in Biomedicine, 256, Article 108398. https://doi.org/10.1016/j.cmpb.2024.108398

Background and Objective:
Tendon segmentation is crucial for studying tendon-related pathologies like tendinopathy, tendinosis, etc. This step further enables detailed analysis of specific tendon regions using automated or semi-automated methods. Th... Read More about Beyond pixel: Superpixel-based MRI segmentation through traditional machine learning and graph convolutional network.

Shoulder balloon spacer for massive irreparable rotator cuff tears results in significant improvements (2024)
Journal Article
Savarese, E., Aicale, R., Romeo, R., & Maffulli, N. (in press). Shoulder balloon spacer for massive irreparable rotator cuff tears results in significant improvements. Knee Surgery, Sports Traumatology, Arthroscopy, https://doi.org/10.1002/ksa.12445

AbstractPurposeThe aim of the present study was to assess the effectiveness of balloon implantation in patients with irreparable supraspinatus tears alone or in combination with other rotator cuff (RC) tendon tears and the effect of several covariabl... Read More about Shoulder balloon spacer for massive irreparable rotator cuff tears results in significant improvements.