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Novel TDP1 Inhibitors: Disubstituted Thiazolidine-2,4-Diones Containing Monoterpene Moieties. (2023)
Journal Article
Reynisson, J. (2023). Novel TDP1 Inhibitors: Disubstituted Thiazolidine-2,4-Diones Containing Monoterpene Moieties. International Journal of Molecular Sciences, https://doi.org/10.3390/ijms24043834

Tyrosyl-DNA-phosphodiesterase 1 (TDP1) is a promising target for antitumor therapy; the use of TDP1 inhibitors with a topoisomerase 1 poison such as topotecan is a potential combination therapy. In this work, a novel series of 3,5-disubstituted thiaz... Read More about Novel TDP1 Inhibitors: Disubstituted Thiazolidine-2,4-Diones Containing Monoterpene Moieties..

Analysis of Heparin Samples by Attenuated Total Reflectance Fourier-Transform Infrared Spectroscopy in the Solid State. (2023)
Journal Article
Devlin, A. J., Mycroft-West, C. J., Turnbull, J. E., Andrade De Lima, M., Guerrini, M., Yates, E. A., & Skidmore, M. A. (2023). Analysis of Heparin Samples by Attenuated Total Reflectance Fourier-Transform Infrared Spectroscopy in the Solid State. ACS Central Science, 9, 381-392. https://doi.org/10.1021/acscentsci.2c01176

Heparin is a polydisperse, heterogeneous polysaccharide of the glycosaminoglycan (GAG) class that has found widespread clinical use as a potent anticoagulant and is classified as an essential medicine by the World Health Organization. The importance... Read More about Analysis of Heparin Samples by Attenuated Total Reflectance Fourier-Transform Infrared Spectroscopy in the Solid State..

Induction of aphid resistance in tobacco by the cucumber mosaic virus CMV?2b mutant is jasmonate-dependent. (2023)
Journal Article
Arinaitwe, W., Tungadi, T. D., Pate, A. E., Joyce, J., Baek, E., Murphy, A. M., & Carr, J. P. (2023). Induction of aphid resistance in tobacco by the cucumber mosaic virus CMV?2b mutant is jasmonate-dependent. Molecular Plant Pathology, 24(4), 391 - 395. https://doi.org/10.1111/mpp.13305

Cucumber mosaic virus (CMV) is vectored by aphids, including Myzus persicae. Tobacco (Nicotiana tabacum 'Xanthi') plants infected with a mutant of the Fny strain of CMV (Fny-CMV?2b, which cannot express the CMV 2b protein) exhibit strong resistance a... Read More about Induction of aphid resistance in tobacco by the cucumber mosaic virus CMV?2b mutant is jasmonate-dependent..

qSanger: Quantification of Genetic Variants in Bacterial Cultures by Sanger Sequencing (2023)
Journal Article
Prakash, S., Racovita, A., Petrucci, T., Galizi, R., & Jaramillo, A. (in press). qSanger: Quantification of Genetic Variants in Bacterial Cultures by Sanger Sequencing. BioDesign Research, 5, Article 0007. https://doi.org/10.34133/bdr.0007

Genetic variations such as mutations and recombinations arise spontaneously in all cultured organisms. Although it is possible to identify nonneutral mutations by selection or counterselection, the identification of neutral mutations in a heterogeneo... Read More about qSanger: Quantification of Genetic Variants in Bacterial Cultures by Sanger Sequencing.

High sensitivity (zeptomole) detection of BODIPY- labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts. (2023)
Journal Article
Maciej-Hulme, M. L., Leprince, A. C., Lavin, A., Guimond, S. E., Turnbull, J. E., Pelletier, J., …Skidmore, M. A. (2023). High sensitivity (zeptomole) detection of BODIPY- labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts. Analytical Methods, 15(11), 1461-1469. https://doi.org/10.1039/d2ay01803a

The fine structure of heparan sulfate (HS), the glycosaminoglycan polysaccharide component of cell surface and extracellular matrix HS proteoglycans, coordinates the complex cell signalling processes that control homeostasis and drive development in... Read More about High sensitivity (zeptomole) detection of BODIPY- labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts..

New insights into the functional role of protein phosphatase 4 regulatory subunit PP4R3A/SMEK1 in the regulation of leukemic cell fate (2023)
Journal Article
Kavousi, N., Tonge, D. P., & Mourtada-Maarabouni, M. (2023). New insights into the functional role of protein phosphatase 4 regulatory subunit PP4R3A/SMEK1 in the regulation of leukemic cell fate. International Journal of Biological Macromolecules, 233, Article 123467. https://doi.org/10.1016/j.ijbiomac.2023.123467

The serine/threonine protein phosphatase 4 holoenzyme consists of a PP4 catalytic subunit (PP4c), which interacts with four different regulatory subunits. Previous studies have shown that PP4c acts as a tumour suppressor. Emerging evidence suggests t... Read More about New insights into the functional role of protein phosphatase 4 regulatory subunit PP4R3A/SMEK1 in the regulation of leukemic cell fate.

Ultrasound modulates neuronal potassium currents via ionotropic glutamate receptors (2023)
Journal Article
Clennell, B., Steward, T. G., Hanman, K., Needham, T., Benachour, J., Jepson, M., …Whitcomb, D. J. (2023). Ultrasound modulates neuronal potassium currents via ionotropic glutamate receptors. Brain Stimulation, 16(2), https://doi.org/10.1016/j.brs.2023.01.1674

Background
Focused ultrasound stimulation (FUS) has the potential to provide non-invasive neuromodulation of deep brain regions with unparalleled spatial precision. However, the cellular and molecular consequences of ultrasound stimulation on neuron... Read More about Ultrasound modulates neuronal potassium currents via ionotropic glutamate receptors.

The disproportionate case–fatality ratio of COVID-19 between countries with the highest vaccination rates and the rest of the world (2023)
Journal Article
Haider, N., Nayeem Hasan, M., Guitian, J., Khan, R. A., McCoy, D., Ntoumi, F., …Kock, R. A. (2023). The disproportionate case–fatality ratio of COVID-19 between countries with the highest vaccination rates and the rest of the world. IJID Regions, 6, 159-166. https://doi.org/10.1016/j.ijregi.2023.01.011

Objectives
The global reported cumulative case–fatality ratios (rCFRs) and excess mortality rates of the 20 countries with the highest coronavirus disease 2019 (COVID-19) vaccination rates, the rest of the world and Sub-Saharan Africa (SSA) were com... Read More about The disproportionate case–fatality ratio of COVID-19 between countries with the highest vaccination rates and the rest of the world.

A sulphated glycosaminoglycan extract from Placopecten magellanicus inhibits the Alzheimer's disease ß-site amyloid precursor protein cleaving enzyme 1 (BACE-1). (2023)
Journal Article
Mycroft-West, C., Devlin, A., Cooper, L., Guimond, S., Procter, P., Miller, G., …Skidmore, M. (2023). A sulphated glycosaminoglycan extract from Placopecten magellanicus inhibits the Alzheimer's disease ß-site amyloid precursor protein cleaving enzyme 1 (BACE-1). Carbohydrate Research, 525, Article 108747. https://doi.org/10.1016/j.carres.2023.108747

The clinically important anticoagulant heparin, a member of the glycosaminoglycan family of carbohydrates that is extracted predominantly from porcine and bovine tissue sources, has previously been shown to inhibit the ß-site amyloid precursor protei... Read More about A sulphated glycosaminoglycan extract from Placopecten magellanicus inhibits the Alzheimer's disease ß-site amyloid precursor protein cleaving enzyme 1 (BACE-1)..

Synthesis of 4-thio-d-glucopyranose and interconversion to 4-thio-d-glucofuranose. (2023)
Journal Article
Porter, J., Lima, M. A., Pongener, I., & Miller, G. (2023). Synthesis of 4-thio-d-glucopyranose and interconversion to 4-thio-d-glucofuranose. Carbohydrate Research, 524, Article 108759. https://doi.org/10.1016/j.carres.2023.108759

Sulfur containing glycosides offer an exciting prospect for inclusion within noncanonical glycan sequences, particularly as enabling probes for chemical glycobiology and for carbohydrate-based therapeutic development. In this context, we required acc... Read More about Synthesis of 4-thio-d-glucopyranose and interconversion to 4-thio-d-glucofuranose..

Factors associated with foot-and-mouth disease seroprevalence in small ruminants and identification of hot-spot areas in northern Nigeria (2023)
Journal Article
Begovoeva, M., Ehizibolo, D. O., Adedeji, A. J., Oguche, M. O., Oyekan, O., Ijoma, S. I., …Limon, G. (2023). Factors associated with foot-and-mouth disease seroprevalence in small ruminants and identification of hot-spot areas in northern Nigeria. Preventive Veterinary Medicine, 212, Article 105842. https://doi.org/10.1016/j.prevetmed.2023.105842

Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate widespread immune cell recruitment independent of chemokine receptors. (2023)
Journal Article
Gray, A., Karlsson, R., Roberts, A., Ridley, A., Pun, N., Khan, B., …Salanga, C. (2023). Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate widespread immune cell recruitment independent of chemokine receptors. Cell Reports, 111930 - ?. https://doi.org/10.1016/j.celrep.2022.111930

Leukocyte recruitment from the vasculature into tissues is a crucial component of the immune system but is also key to inflammatory disease. Chemokines are central to this process but have yet to be therapeutically targeted during inflammation due to... Read More about Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate widespread immune cell recruitment independent of chemokine receptors..

Systematic review of community engagement approach in research: describing partnership approaches, challenges and benefits (2023)
Journal Article
Abebe, H., Zerihun, Z., Mallen, C., Price, H., Mulugeta, A., & Taffere, G. (2023). Systematic review of community engagement approach in research: describing partnership approaches, challenges and benefits. Journal of Public Health, https://doi.org/10.1007/s10389-022-01799-9

Background
Community engagement in research has gained momentum as people have realised the importance and value it brings to research. However, a lack of standardization in the engagement approach has been reported in the literature. This systemati... Read More about Systematic review of community engagement approach in research: describing partnership approaches, challenges and benefits.

Systematic Alignment Analysis of Neural Transplant Cells in Electrospun Nanofibre Scaffolds (2022)
Journal Article
Barcons, A. M., Chowdhury, F., Chari, D. M., & Adams, C. (2022). Systematic Alignment Analysis of Neural Transplant Cells in Electrospun Nanofibre Scaffolds. Materials, 16, 124 - 124. https://doi.org/10.3390/ma16010124

<jats:p>Spinal cord injury is debilitating with functional loss often permanent due to a lack of neuro-regenerative or neuro-therapeutic strategies. A promising approach to enhance biological function is through implantation of tissue engineered cons... Read More about Systematic Alignment Analysis of Neural Transplant Cells in Electrospun Nanofibre Scaffolds.

Biological control interventions reduce pest abundance and crop damage while maintaining natural enemies in sub-Saharan Africa: a meta-analysis (2022)
Journal Article
Ratto, F., Bruce, T., Chipabika, G., Mwamakamba, S., Mkandawire, R., Khan, Z., …Sait, S. (2022). Biological control interventions reduce pest abundance and crop damage while maintaining natural enemies in sub-Saharan Africa: a meta-analysis. Proceedings of the Royal Society B: Biological Sciences, https://doi.org/10.1098/rspb.2022.1695

Insect pests are a major challenge to smallholder crop production in sub-Saharan Africa (SSA), where access to synthetic pesticides, which are linked to environmental and health risks, is often limited. Biological control interventions could offer a... Read More about Biological control interventions reduce pest abundance and crop damage while maintaining natural enemies in sub-Saharan Africa: a meta-analysis.

Interspecies microbiome transplantation recapitulates microbial acquisition in mosquitoes (2022)
Journal Article
Coon, K., Hegde, S., & Hughes, G. (2022). Interspecies microbiome transplantation recapitulates microbial acquisition in mosquitoes. Microbiome, 10, Article 58. https://doi.org/10.1186/s40168-022-01256-5

Background Mosquitoes harbor microbial communities that play important roles in their growth, survival, reproduction, and ability to transmit human pathogens. Microbiome transplantation approaches are often used to study host-microbe interactions and... Read More about Interspecies microbiome transplantation recapitulates microbial acquisition in mosquitoes.