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Measurement error and timing of predictor values for multivariable risk prediction models are poorly reported (2018)
Journal Article
Whittle, R., Peat, G., Belcher, J., Collins, G. S., & Riley, R. D. (2018). Measurement error and timing of predictor values for multivariable risk prediction models are poorly reported. Journal of Clinical Epidemiology, 102, 38-49. https://doi.org/10.1016/j.jclinepi.2018.05.008

Objective Measurement error in predictor variables may threaten the validity of clinical prediction models. We sought to evaluate the possible extent of the problem. A secondary objective was to examine whether predictors are measured at the intende... Read More about Measurement error and timing of predictor values for multivariable risk prediction models are poorly reported.

Predicting surgical intervention in patients presenting with carpal tunnel syndrome in primary care (2018)
Journal Article
Burton, C. L., S Chesterton, L., Chen, Y., & Van Der Windt, D. (2018). Predicting surgical intervention in patients presenting with carpal tunnel syndrome in primary care. Clinical Epidemiology, 739 - 748. https://doi.org/10.2147/CLEP.S154409

Purpose: Carpal tunnel syndrome (CTS) is a symptomatic compression neuropathy of the median nerve. This study investigated the value of candidate prognostic factors (PFs) in predicting carpal tunnel release surgery. Patients and methods: This is a re... Read More about Predicting surgical intervention in patients presenting with carpal tunnel syndrome in primary care.

Comparative Effectiveness of Treatment Options for Plantar Heel Pain: A Systematic Review with Network Meta-Analysis (2018)
Journal Article
Babatunde, Van Der Windt, Roddy, & Thomas. (2018). Comparative Effectiveness of Treatment Options for Plantar Heel Pain: A Systematic Review with Network Meta-Analysis. British Journal of Sports Medicine, 53(3), 1-14. https://doi.org/10.1136/bjsports-2017-098998

Objective To evaluate the comparative effectiveness of current treatment options for plantar heel pain (PHP). Design Systematic review and network meta-analysis (NMA). Data sources Medline, EMBASE, CINAHL, AMED, PEDro, Cochrane Database, Web... Read More about Comparative Effectiveness of Treatment Options for Plantar Heel Pain: A Systematic Review with Network Meta-Analysis.

Comparative Effectiveness of Treatment Options for Plantar Heel Pain: A Systematic Review with Network Meta-Analysis (2018)
Journal Article
Babatunde, O., Legha, A., Littlewood, C., Chesterton, L. S., Thomas, M. J., B Menz, H., …Roddy, E. (2018). Comparative Effectiveness of Treatment Options for Plantar Heel Pain: A Systematic Review with Network Meta-Analysis. British Journal of Sports Medicine, 53(3), https://doi.org/10.1136/bjsports-2017-098998

Objective To evaluate the comparative effectiveness of current treatment options for plantar heel pain (PHP). Design Systematic review and network meta-analysis (NMA). Data Sources Medline, EMBASE, CINAHL, AMED, PEDro, Cochrane Database, We... Read More about Comparative Effectiveness of Treatment Options for Plantar Heel Pain: A Systematic Review with Network Meta-Analysis.

Metabolic risk factors and the incidence and progression of radiographic hand osteoarthritis: a population-based cohort study (2018)
Journal Article
Marshall, M., Peat, G., Nicholls, E., Myers, H. L., Mamas, M. A., & Van Der Windt, D. A. (in press). Metabolic risk factors and the incidence and progression of radiographic hand osteoarthritis: a population-based cohort study. Scandinavian Journal of Rheumatology, 48(1), 52-63. https://doi.org/10.1080/03009742.2018.1459831

OBJECTIVE: To determine whether selected metabolic factors are associated with greater amounts of radiographic hand osteoarthritis (OA) incidence and progression. METHODS: The study identified 706 adults, aged 50-69 years, with hand pain and hand rad... Read More about Metabolic risk factors and the incidence and progression of radiographic hand osteoarthritis: a population-based cohort study.

Long-term conditions and the National Diabetes Audit (2018)
Journal Article
Heald, A., Stedman, M., Farman, S., Fryer, A., Bailey, S., & Gadsby, R. (2018). Long-term conditions and the National Diabetes Audit. British Journal of General Practice (BJGP), 68(672), 320.2-320. https://doi.org/10.3399/bjgp18x697637

The management of long-term conditions1 in primary care has hit the headlines thanks to a report from the Academy of Medical Sciences,2 which highlighted the clustering of different physical and mental health conditions in a single patient, and estim... Read More about Long-term conditions and the National Diabetes Audit.

Noninvasive imaging of nanoparticle-labeled transplant populations within polymer matrices for neural cell therapy (2018)
Journal Article
Tickle, J. A., Poptani, H., Taylor, A., & Chari, D. M. (2018). Noninvasive imaging of nanoparticle-labeled transplant populations within polymer matrices for neural cell therapy. Nanomedicine, 13(11), 1333-1348. https://doi.org/10.2217/nnm-2017-0347

Aim: To develop a 3D neural cell construct for encapsulated delivery of transplant cells; develop hydrogels seeded with magnetic nanoparticle (MNP)-labeled cells suitable for cell tracking by MRI. Materials & methods: Astrocytes were exogenously labe... Read More about Noninvasive imaging of nanoparticle-labeled transplant populations within polymer matrices for neural cell therapy.

THE RISK OF KC IN PSORIASIS PATIENTS RECEIVING BIOLOGICS COMPARED TO CONVENTIONAL SYSTEMIC THERAPIES (2018)
Presentation / Conference
Mason, K. (2018, June). THE RISK OF KC IN PSORIASIS PATIENTS RECEIVING BIOLOGICS COMPARED TO CONVENTIONAL SYSTEMIC THERAPIES. Poster presented at 5th World Psoriasis & Psoriatic Arthritis Conference, Stockholm, Sweden

Introduction: Whether psoriasis patients exposed to biologic therapies have an elevated risk of keratinocyte carcinoma (KC), including basal cell carcinoma (BCC) or cutaneous squamous cell carcinoma (cSCC) remains uncertain. Objective:The aim of t... Read More about THE RISK OF KC IN PSORIASIS PATIENTS RECEIVING BIOLOGICS COMPARED TO CONVENTIONAL SYSTEMIC THERAPIES.

Early Clinical Outcomes, Patterns of Failure, and Acute Haematologic Toxicity of Image-Guided Volumetric Modulated Arc Therapy (IG-VMAT) in the Definitive Treatment of Locally Advanced Carcinoma Cervix (2018)
Journal Article
Ahmad, I., Chufal, K. S., Bashir, I., Bhatt, C. P., Bajpai, R., Sharma, L., & Rathour, S. (2018). Early Clinical Outcomes, Patterns of Failure, and Acute Haematologic Toxicity of Image-Guided Volumetric Modulated Arc Therapy (IG-VMAT) in the Definitive Treatment of Locally Advanced Carcinoma Cervix. Clinical Medicine Insights: Oncology, 12, 1-10. https://doi.org/10.1177/1179554918783990

Purpose:To evaluate clinical outcomes and failure patterns in patients with locally advanced cervical cancer (LACC) treated definitively using image-guided volumetric-modulated arc therapy (IG-VMAT).Methods and materials:This retrospective review inc... Read More about Early Clinical Outcomes, Patterns of Failure, and Acute Haematologic Toxicity of Image-Guided Volumetric Modulated Arc Therapy (IG-VMAT) in the Definitive Treatment of Locally Advanced Carcinoma Cervix.

Searching for a prodrome for rheumatoid arthritis in the primary care record: A case-control study in the clinical practice research datalink (2018)
Journal Article
Muller, S., Hider, S., Machin, A., Stack, R., Hayward, R. A., Raza, K., & Mallen, C. (2019). Searching for a prodrome for rheumatoid arthritis in the primary care record: A case-control study in the clinical practice research datalink. Seminars in Arthritis and Rheumatism, 48(5), 815-820. https://doi.org/10.1016/j.semarthrit.2018.06.008

Background Rheumatoid arthritis (RA) has articular and non-articular manifestations. Early, intensive treatment has substantial benefit for both. This requires patients be identified as soon as symptoms develop. Objectives To determine whether s... Read More about Searching for a prodrome for rheumatoid arthritis in the primary care record: A case-control study in the clinical practice research datalink.

Physical and mental determinants of dropout and retention among nursing students: protocol of the SPRiNG cohort study. (2018)
Journal Article
(2018). Physical and mental determinants of dropout and retention among nursing students: protocol of the SPRiNG cohort study. BMC Nursing, 27 - ?. https://doi.org/10.1186/s12912-018-0296-9

Background: The shortage of nursing professionals is of growing concern. The causes of this include the demanding physical and mental workload, leading to a dropout of nurses that may start during their education. However, it is unclear to what exten... Read More about Physical and mental determinants of dropout and retention among nursing students: protocol of the SPRiNG cohort study..

Advancing practice for back pain through stratified care (STarT Back) (2018)
Journal Article
Sowden, G., Hill, J., Morso, L., Louw, Q., & Foster, N. E. (in press). Advancing practice for back pain through stratified care (STarT Back). Brazilian Journal of Physical Therapy, 22(4), 255-264. https://doi.org/10.1016/j.bjpt.2018.06.003

Background Low back pain (LBP) is common, however research comparing the effectiveness of different treatments over the last two decades conclude either no or small differences in the average effects of different treatments. One suggestion to explai... Read More about Advancing practice for back pain through stratified care (STarT Back).

Representativeness of a digitally engaged population and a patient organisation population with rheumatoid arthritis and their willingness to participate in research: a cross-sectional study. (2018)
Journal Article
(2018). Representativeness of a digitally engaged population and a patient organisation population with rheumatoid arthritis and their willingness to participate in research: a cross-sectional study. RMD Open, e000664 - ?. https://doi.org/10.1136/rmdopen-2018-000664

Objectives: To describe (1) the representativeness of (a) users of an online health community (HealthUnlocked.com (HU)) with rheumatoid arthritis (RA) and (b) paid members of an RA patient organisation, the National Rheumatoid Arthritis Society (NRAS... Read More about Representativeness of a digitally engaged population and a patient organisation population with rheumatoid arthritis and their willingness to participate in research: a cross-sectional study..

Temporal Changes in Comorbidity Burden in Patients Having Percutaneous Coronary Intervention and Impact on Prognosis (2018)
Journal Article
Potts, J., Kwok, C., Ensor, J., Rashid, M., Kadam, U., Kinnaird, T., …Mamas, M. (2018). Temporal Changes in Comorbidity Burden in Patients Having Percutaneous Coronary Intervention and Impact on Prognosis. American Journal of Cardiology, 122(5), 712-722. https://doi.org/10.1016/j.amjcard.2018.05.003

This study aims to evaluate the impact of comorbidity burden on outcomes among patients who undergo percutaneous coronary intervention (PCI). We used the Nationwide Inpatient Sample to identify all PCI procedures undertaken in the United States betwe... Read More about Temporal Changes in Comorbidity Burden in Patients Having Percutaneous Coronary Intervention and Impact on Prognosis.

Trends in the prevalence, incidence and surgical management of carpal tunnel syndrome between 1993 and 2013: an observational analysis of UK primary care records (2018)
Journal Article
Burton, C., Chen, Y., Chesterton, L. S., & Van Der Windt, D. (2018). Trends in the prevalence, incidence and surgical management of carpal tunnel syndrome between 1993 and 2013: an observational analysis of UK primary care records. BMJ Open, Article e020166. https://doi.org/10.1136/bmjopen-2017-020166

OBJECTIVES: To describe the prevalence, incidence and surgical management of carpal tunnel syndrome (CTS), between 1993 and 2013, as recorded in the Clinical Practice Research Datalink (CPRD). DESIGN: We completed a series of cross-sectional epidemio... Read More about Trends in the prevalence, incidence and surgical management of carpal tunnel syndrome between 1993 and 2013: an observational analysis of UK primary care records.

Child and adolescent musculoskeletal pain (CAM-Pain) feasibility study: testing a method of identifying, recruiting and collecting data from children and adolescents who consult about a musculoskeletal condition in UK general practice (2018)
Journal Article
Michaleff, Z., Campbell, P., Hay, A., Warburton, L., & Dunn, K. (2018). Child and adolescent musculoskeletal pain (CAM-Pain) feasibility study: testing a method of identifying, recruiting and collecting data from children and adolescents who consult about a musculoskeletal condition in UK general practice. BMJ Open, e021116 - ?. https://doi.org/10.1136/bmjopen-2017-021116

OBJECTIVES Test a method of identifying, recruiting and collecting data from children and adolescents who consult their general practitioner about a musculoskeletal condition. DESIGN Prospective cohort feasibility study. SETTING 13 general... Read More about Child and adolescent musculoskeletal pain (CAM-Pain) feasibility study: testing a method of identifying, recruiting and collecting data from children and adolescents who consult about a musculoskeletal condition in UK general practice.

OP0294-PARE Addressing key challenges of lay involvement in musculoskeletal research: co-applicants and trial steering committees (2018)
Presentation / Conference
Higginbottom, A., Blackburn, S., Taylor, R., Rhodes, C., Campbell, L., & Dziedzic, K. (2018, June). OP0294-PARE Addressing key challenges of lay involvement in musculoskeletal research: co-applicants and trial steering committees. Paper presented at Annual European Congress of Rheumatology, EULAR 2018, Amsterdam, 13–16 June 2018

Background Patient and Public Involvement (PPI) in research is a requirement of funding in the UK. It has shown to improve the relevance and quality of research. For over 10 years, a Research User Group (RUG) of over 100 patients with musculoskeletal... Read More about OP0294-PARE Addressing key challenges of lay involvement in musculoskeletal research: co-applicants and trial steering committees.

PREDICTORS AND TEMPORAL TREND OF SEASONAL INFLUENZA VACCINATION IN AUTO-IMMUNE RHEUMATIC DISEASES IN THE UK: A NATIONWIDE PROSPECTIVE COHORT STUDY (2018)
Presentation / Conference
Nakafero, G., Grainge, M., Myles, P., Mallen, C., Zhang, W., Doherty, M., …Abhishek, A. (2018, June). PREDICTORS AND TEMPORAL TREND OF SEASONAL INFLUENZA VACCINATION IN AUTO-IMMUNE RHEUMATIC DISEASES IN THE UK: A NATIONWIDE PROSPECTIVE COHORT STUDY. Poster presented at Annual European Congress of Rheumatology

Background: Autoimmune rheumatic diseases (AIRDs) are associated with an increased risk of influenza and its complications which may be compounded by the use of potent disease modifying anti-rheumatic drugs (DMARDs). In the United Kingdom, seasonal i... Read More about PREDICTORS AND TEMPORAL TREND OF SEASONAL INFLUENZA VACCINATION IN AUTO-IMMUNE RHEUMATIC DISEASES IN THE UK: A NATIONWIDE PROSPECTIVE COHORT STUDY.

AB0212 Diagnostic delay for rheumatoid arthritis: a systematic review (2018)
Presentation / Conference
Hay, C., Prior, J., Scott, I., Raza, K., Hider, S., & Mallen, C. (2018, June). AB0212 Diagnostic delay for rheumatoid arthritis: a systematic review. Paper presented at Annual European Congress of Rheumatology, EULAR 2018, Amsterdam, Netherlands

Background Rheumatoid arthritis (RA) is a common inflammatory condition, affecting 1% of the population and causing pain, stiffness and swelling, leading to significant disability and loss of function[.1 Delays in the diagnosis and treatment of RA ca... Read More about AB0212 Diagnostic delay for rheumatoid arthritis: a systematic review.