Dietary phytochemicals against COVID‐19: A focus on thymoquinone
(2023)
Journal Article
Outputs (51)
Traditional processing techniques impacted the bioactivities of selected local consumed foods (2023)
Journal Article
Epidemiological and clinical studies have evidenced the crucial role of vegetables and mushrooms for our health. Vegetables and mushrooms are usually cooked before consumption which induces many physicochemical changes in foods. A change in the phyto... Read More about Traditional processing techniques impacted the bioactivities of selected local consumed foods.
Pluripharmacological potential of Mascarene endemic plant leaf extracts (2023)
Journal Article
In vivo antihyperglycaemic and antihyperlipidemic activities and chemical constituents of Solanum anomalum (2022)
Journal Article
Solanum anomalum is a plant used ethnomedically for the treatment of diabetes. The study was aimed to validate ethnomedical claims in rat model and identify the likely antidiabetic compounds. Leaf extract (70–210 mg/kg/day) and fractions (140 mg/kg/d... Read More about In vivo antihyperglycaemic and antihyperlipidemic activities and chemical constituents of Solanum anomalum.
In vitro and in vivo antimalarial activity and chemical profiling of sugarcane leaves. (2022)
Journal Article
Saccharum officinarum Linn. (sugarcane, Family-Poaceae) is employed in Ibibio traditional medicine for the treatment of various infections and diseases such as malaria. We This study aims to assess the antiplasmodial effect of the leaf extract and fr... Read More about In vitro and in vivo antimalarial activity and chemical profiling of sugarcane leaves..
Sesquiterpene Lactones Modulated DNA Methylation through Inhibition of DNMTs in Ovarian Cancer Cells (2022)
Journal Article
Inappropriate DNA methylation of tumour suppressor genes can affect their expression and function, and as such, DNA methylation has been a promising target for anti-cancer therapy. In gynaecological malignancy, ovarian cancer has the highest associat... Read More about Sesquiterpene Lactones Modulated DNA Methylation through Inhibition of DNMTs in Ovarian Cancer Cells.
In Vivo Antibacterial Efficacy of Antimicrobial Peptides Modified Metallic Implants-Systematic Review and Meta-Analysis. (2022)
Journal Article
Biomaterial-associated infection is difficult to detect and brings consequences that can lead to morbidity and mortality. Bacteria can adhere to the implant surface, grow, and form biofilms. Antimicrobial peptides (AMPs) can target and kill bacterial... Read More about In Vivo Antibacterial Efficacy of Antimicrobial Peptides Modified Metallic Implants-Systematic Review and Meta-Analysis..
Biotransformation of artemisinin to a novel derivative via ring rearrangement by Aspergillus niger. (2022)
Journal Article
Artemisinin is a component part of current frontline medicines for the treatment of malaria. The aim of this study is to make analogues of artemisinin using microbial transformation and evaluate their in vitro antimalarial activity. A panel of microo... Read More about Biotransformation of artemisinin to a novel derivative via ring rearrangement by Aspergillus niger..
Identification of foods that affect the anti-cancer activity of pitavastatin in cells (2022)
Journal Article
Statins inhibit the synthesis of mevalonate, a precursor isoprenoid molecule to geranylgeraniol that is necessary for the post-translational modification of several small GTPase oncogenes. Despite numerous preclinical studies suggesting that statins... Read More about Identification of foods that affect the anti-cancer activity of pitavastatin in cells.
Phytochemical characterization, antihyperglycaemic and antihyperlipidemic activities of Setaria megaphylla in alloxan-induced diabetic rats (2022)
Journal Article
Background Setaria megaphylla (Steud) Dur & Schinz (Poaceae), a grass used ethnomedically by herbalists in Nigeria for the treatment of diabetes was evaluated for antidiabetic, hypolipidemic and pancreas protective potentials in rats. Methods So... Read More about Phytochemical characterization, antihyperglycaemic and antihyperlipidemic activities of Setaria megaphylla in alloxan-induced diabetic rats.
Clerodane Diterpenoids from an Edible Plant Justicia insularis: Discovery, Cytotoxicity, and Apoptosis Induction in Human Ovarian Cancer Cells (2021)
Journal Article
Objectives: The toxicity of chemotherapeutic anticancer drugs is a serious issue in clinics. Drug discovery from edible and medicinal plants represents a promising approach towards finding safer anticancer therapeutics. Justicia insularis T. Anderson... Read More about Clerodane Diterpenoids from an Edible Plant Justicia insularis: Discovery, Cytotoxicity, and Apoptosis Induction in Human Ovarian Cancer Cells.
In vivo efficacy and metabolism of the antimalarial cycleanine and improved in vitro antiplasmodial activity of novel semisynthetic analogues. (2020)
Journal Article
Bisbenzylisoquinoline (BBIQ) alkaloids are a diverse group of natural products that demonstrate a range of biological activities. In this study, the in vitro antiplasmodial activity of three BBIQ alkaloids (cycleanine (1), isochondodendrine (2) and 2... Read More about In vivo efficacy and metabolism of the antimalarial cycleanine and improved in vitro antiplasmodial activity of novel semisynthetic analogues..
Methyl gallate – Rich fraction of Syzygium coriaceum leaf extract induced cancer cell cytotoxicity via oxidative stress (2020)
Journal Article
Whilst the pharmacological potential of Syzygium species is well reported in the literature, data on the Mauritian endemic Syzygium species is limited. Thus, the in vitro antioxidant and anti-proliferative properties of three endangered Syzygium spec... Read More about Methyl gallate – Rich fraction of Syzygium coriaceum leaf extract induced cancer cell cytotoxicity via oxidative stress.
Terminalia bentzoë, a Mascarene Endemic Plant, Inhibits Human Hepatocellular Carcinoma Cells Growth In Vitro via G0/G1 Phase Cell Cycle Arrest (2020)
Journal Article
Tropical forests constitute a prolific sanctuary of unique floral diversity and potential medicinal sources, however, many of them remain unexplored. The scarcity of rigorous scientific data on the surviving Mascarene endemic taxa renders bioprospect... Read More about Terminalia bentzoë, a Mascarene Endemic Plant, Inhibits Human Hepatocellular Carcinoma Cells Growth In Vitro via G0/G1 Phase Cell Cycle Arrest.
Synthesis and evaluation of thymoquinone analogues as anti-ovarian cancer agents (2019)
Journal Article
Conference abstract, presented at the 2nd Molecules Medicinal Chemistry Symposium (MMCS): Facing Novel Challenges in Drug Discovery, Barcelona, Spain, 15–17 May 2019.
Discovery, synthesis and antibacterial evaluation of phenolic compounds from Cylicodiscus gabunensis (2019)
Journal Article
BACKGROUND Cylicodiscus gabunensis Harms (Family Leguminosae) (CG) is an African medicinal plant used as a treatment of various ailments including malaria, liver diseases, and gastrointestinal disturbances. Its extracts showed potent in vitro antiba... Read More about Discovery, synthesis and antibacterial evaluation of phenolic compounds from Cylicodiscus gabunensis.
Isolation, identification and evaluation of anticancer compounds from unexplored Rutidea parviflora (2019)
Presentation / Conference
Palmatine from Unexplored Rutidea parviflora Showed Cytotoxicity and Induction of Apoptosis in Human Ovarian Cancer Cells (2019)
Journal Article
Ovarian cancer ranks amongst the deadliest cancers in the gynaecological category of cancers. This research work aims to evaluate in vitro anti-ovarian cancer activities and identify phytochemical constituents of a rarely explored plant speciesRutide... Read More about Palmatine from Unexplored Rutidea parviflora Showed Cytotoxicity and Induction of Apoptosis in Human Ovarian Cancer Cells.
Mauritian Endemic Medicinal Plant Extracts Induce G2/M Phase Cell Cycle Arrest and Growth Inhibition of Oesophageal Squamous Cell Carcinoma in Vitro (2019)
Journal Article
Terrestrial plants have contributed massively to the development of modern oncologic drugs. Despite the wide acceptance of Mauritian endemic flowering plants in traditional medicine, scientific evidence of their chemotherapeutic potential is lacking.... Read More about Mauritian Endemic Medicinal Plant Extracts Induce G2/M Phase Cell Cycle Arrest and Growth Inhibition of Oesophageal Squamous Cell Carcinoma in Vitro.
Modification of metal surfaces using TCM-derived cyclotides: an antibacterial and antibiofilm study (2018)
Presentation / Conference
Synthesis of (aminoalkyl)cycleanine analogues: cytotoxicity, cellular uptake, and apoptosis induction in ovarian cancer cells (2018)
Journal Article
Our previous studies demonstrated that cycleanine, a macrocyclic bisbenzylisoquinoline (BBIQ) alkaloid, showed potent anti-ovarian cancer activity via apoptosis induction. Here, we synthesized two novel (aminoalkyl) cycleanine analogues (2 and 3) thr... Read More about Synthesis of (aminoalkyl)cycleanine analogues: cytotoxicity, cellular uptake, and apoptosis induction in ovarian cancer cells.
Coupling Plant-Derived Cyclotides to Metal Surfaces: An Antibacterial and Antibiofilm Study (2018)
Journal Article
Modification of metal surfaces with antimicrobial peptides is a promising approach to reduce bacterial adhesion. Here, cyclic peptides or cycloids, possessing remarkable stability and antimicrobial activities, were extracted and purified from Viola p... Read More about Coupling Plant-Derived Cyclotides to Metal Surfaces: An Antibacterial and Antibiofilm Study.
Investigation of the antibiofilm capacity of peptide-modified stainless steel (2018)
Journal Article
Biofilm formation on surfaces is an important research topic in ship tribology and medical implants. In this study, dopamine and two types of synthetic peptides were designed and attached to 304 stainless steel surfaces, aiming to inhibit the formati... Read More about Investigation of the antibiofilm capacity of peptide-modified stainless steel.
The synthesis and evaluation of thymoquinone analogues as anti-ovarian cancer and antimalarial agents (2018)
Journal Article
Thymoquinone (TQ), 2-isopropyl-5-methyl-1,4-benzoquinone, a natural product isolated from Nigella sativa L., has previously been demonstrated to exhibit antiproliferative activity in vitro against a range of cancers as well as the human malarial para... Read More about The synthesis and evaluation of thymoquinone analogues as anti-ovarian cancer and antimalarial agents.
P31 Role of sesquiterpene lactones against human ovarian cancer (2017)
Journal Article
Background: Overexpression of microRNA-31 (miR-31) is implicated in the pathogenesis of esophageal squamous cell carcinoma (ESCC), a deadly disease associated with dietary zinc deficiency. Using a rat model that recapitulates features of human ESCC,... Read More about P31 Role of sesquiterpene lactones against human ovarian cancer.
Identification and evaluation of anticancer compounds from three Nigerian plants used in traditional medicines (2017)
Presentation / Conference
Ovarian cancer is the second leading cause of death among women in the gynaecological category of cancers. The current post surgery treatment which involves the use of platinum-based therapy with its attendant adverse drug-resistance often results in... Read More about Identification and evaluation of anticancer compounds from three Nigerian plants used in traditional medicines.
Isochondodendrine and 2-norcocsuline: additional alkaloids from Triclisia subcordata induce cytotoxicity and apoptosis in ovarian cancer cell lines (2017)
Journal Article
Triclisia subcordata Oliv (Menispermeaceae) is used in herbal medicine for the treatment of cancer and other diseases in Africa. This study aims to isolate minor alkaloids present in this plant and assay their cytotoxic activities. Isochondodendrine... Read More about Isochondodendrine and 2-norcocsuline: additional alkaloids from Triclisia subcordata induce cytotoxicity and apoptosis in ovarian cancer cell lines.
Isolation, identification and anti-cancer activity of minor alkaloids from Triclisia subcordata (2017)
Journal Article
No abstract
Advanced glycation products' levels and mechanical properties of vaginal tissue in pregnancy (2017)
Journal Article
Objectives Non-enzymatic glycation is closely associated with altered mechanical properties of connective tissue. Pregnancy, marked with high levels of female hormones, confers unique alteration to the mechanical properties of pelvic connective tiss... Read More about Advanced glycation products' levels and mechanical properties of vaginal tissue in pregnancy.
Antibacterial and antibiotic potentiating activities of tropical marine sponge extracts (2017)
Journal Article
Increasing prevalence of antibiotic resistance has led research to focus on discovering new antimicrobial agents derived from the marine biome. Although ample studies have investigated sponges for their bioactive metabolites with promising prospects... Read More about Antibacterial and antibiotic potentiating activities of tropical marine sponge extracts.
A characterization of the antimalarial activity of the bark of Cylicodiscus gabunensis Harms (2017)
Journal Article
Ethnopharmacological relevance and aim A decoction of the bark of Cylicodiscus gabunensis Harms is used as a traditional medicine in the treatment of malaria in Nigeria. This study aims to validate the antimalarial potency of this decoction in vitro... Read More about A characterization of the antimalarial activity of the bark of Cylicodiscus gabunensis Harms.
Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine (2016)
Journal Article
Ovarian cancer remains one of the main causes of death in all gynecologic malignancies [1]. Natural products continue to be important sources of clinically approved anti-cancer drugs [2, 3]. Triclisia subcordata Oliv (Menispermeaceae) is a medicinal... Read More about Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine.
Antibacterial effects of the essential oil from flower buds of Magnolia biondii Pamp (2016)
Journal Article
Flower buds of Magnolia biondii Pamp (family Magnoliaceae) is known as Xin-Yi in the Chinese Pharmacopoeia, and is widely used for the treatment of allergic rhinitis, rhinosinusitis, nasal congestion, and headache.1 Bacterial infection caused by Stap... Read More about Antibacterial effects of the essential oil from flower buds of Magnolia biondii Pamp.
Report of the International Symposium on Phytochemicals in Medicine and Food (ISPMF 2015) (2016)
Journal Article
Advances of Plant-Derived Natural Products in Ovarian Cancer Therapy (2016)
Journal Article
Ovarian cancer is the leading cause of death in the gynaecologic cancers within the UK and US. Presently the standard treatment for ovarian cancer entails the use of chemotherapy drugs paclitaxel and carboplatin after aggressive surgical reduction in... Read More about Advances of Plant-Derived Natural Products in Ovarian Cancer Therapy.
Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine (2016)
Journal Article
Triclisia subcordata Oliv (Menispermeaceae) is a medicinal plant traditionally used for the treatment of various diseases in West Africa. The ethanol extract of T.?subcordata and its fractions were screened for in vitro anti-ovarian cancer activities... Read More about Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine.
Cytotoxicity Effects and Apoptosis Induction by Bisbenzylisoquinoline Alkaloids from Triclisia subcordata (2016)
Journal Article
Triclisia subcordata Oliv (Menispermeaceae) is a medicinal plant traditionally used for the treatment of various diseases in West Africa. The ethanol extract of T.?subcordata and its fractions were screened for in vitro anti-ovarian cancer activities... Read More about Cytotoxicity Effects and Apoptosis Induction by Bisbenzylisoquinoline Alkaloids from Triclisia subcordata.
Fingerprint of Tiger Balm® By Thermal Desorption Gas Chromatography Mass Spectrometry (2016)
Journal Article
Introduction: Tiger Balm® is a blend of volatile oils used for many years in control of muscle cramps and headache. Objectives: To establish a quick and accurate method of analysis for Tiger Balm®. Materials and Methods: GC-MS and TD GC-MS were used... Read More about Fingerprint of Tiger Balm® By Thermal Desorption Gas Chromatography Mass Spectrometry.
Anti-Malarial Activities of Margaritaria discoidea and Other Nigerian Medicinal Plants (2015)
Presentation / Conference
We previously evaluated in vitro anti-cancer activity of a Nigeria medicinal plant—Margaritaria discoidea (Baill.) G.L.Webster [1]. The aim of current study is to investigate crude extracts of ten medicinal plants including M. discoidea for their ant... Read More about Anti-Malarial Activities of Margaritaria discoidea and Other Nigerian Medicinal Plants.
Design, Synthesis, Drug-Likeness and Anti-ovarian Cancer Activity of Thymoquinone Analogues (2015)
Presentation / Conference
Antimicrobial compounds from Magnolia liliflora Desr (2015)
Presentation / Conference
Anticancer activities of cyclotides from Viola yedeonsis Makino (Violaceae) (2014)
Journal Article
Anti-ovarian cancer activities of alkaloids from Triclisia subcordata olive (Menispermecaea) (2014)
Conference Proceeding
This study investigates the anticancer activities of Triclisia subcordata, identifies and elucidates the structure(s) of the bioactive anticancer compound. The evaluation of anticancer activity was done by in vitro sulforhodamine B dye method using A... Read More about Anti-ovarian cancer activities of alkaloids from Triclisia subcordata olive (Menispermecaea).
Stable Isotope Dilution Gas Chromatography–Mass Spectrometry for Quantification of Thymoquinone in Black Cumin Seed Oil (2014)
Journal Article
Black cumin seed (Nigella sativa L.) is a widely used spice and herb, where thymoquinone (2-isopropyl-5-methyl-1,4-benzoquinone) is the major bioactive compound. Here, a stable isotope dilution (SID) gas chromatography–mass spectrometry (GC–MS) techn... Read More about Stable Isotope Dilution Gas Chromatography–Mass Spectrometry for Quantification of Thymoquinone in Black Cumin Seed Oil.
Analysis of volatile compounds in phytomedicines using thermal desorption gas chromatography mass spectroscopy (2013)
Journal Article
Volatile essential oils (EOs) from medicinal plants play an important role in the treatment of various diseases. EOs have been shown to exhibit anti-bacterial, antiviral, antimycotic, antitoxigenic, antiparasitic, and insecticidal properties [1]. Sev... Read More about Analysis of volatile compounds in phytomedicines using thermal desorption gas chromatography mass spectroscopy.
Anti-cancer thymoquinone from Nigella sativa (2013)
Journal Article
Quinones and phenolic compounds are important bioactive natural products in medicinal and dietary plants [1 – 3]. For example, thymoquinone (2-isopropyl-6-methyl-1,4-benzoquinone, TQ) is the main bioactive compound from Nigella sativa (black cumin) (... Read More about Anti-cancer thymoquinone from Nigella sativa.
Single-Molecule Detection of 5-Hydroxymethylcytosine in DNA through Chemical Modification and Nanopore Analysis (2013)
Journal Article
DNA threading the needle: A new method of single-molecule detection of 5-hydroxymethylcytosine (5hmC) in DNA has been developed. Selective thiol substitution of 5hmC (giving SMC) in a single-step, bisulfite-mediated reaction (see scheme) allows the i... Read More about Single-Molecule Detection of 5-Hydroxymethylcytosine in DNA through Chemical Modification and Nanopore Analysis.
De novo design, synthesis, and characterization of quinoproteins (2006)
Journal Article
Quinones and quinoproteins are essential redox components and enzymes in biological systems. Here, we report the de novo design, synthesis, and properties of model four-α-helix bundle quinoproteins. The proteins were designed and constructed from thr... Read More about De novo design, synthesis, and characterization of quinoproteins.