Wenwu Li's Outputs (52)

Potential of Phytochemicals and their derivatives in the treatment of ovarian cancer (2015)
Book Chapter
Li, W., Johnson-Ajinwo, O. R., & Uche, F. I. (2016). Potential of Phytochemicals and their derivatives in the treatment of ovarian cancer. In Handbook on Ovarian Cancer: Risk Factors, Therapies and Prognosis. Nova Science Publishers

Design, Synthesis, Drug-Likeness and Anti-ovarian Cancer Activity of Thymoquinone Analogues (2015)
Presentation / Conference
Johnson-Ajinwo, O. R., Richardson, A., & Li, W. W. (2015, August). Design, Synthesis, Drug-Likeness and Anti-ovarian Cancer Activity of Thymoquinone Analogues. Paper presented at 2015 PSNA meeting

Anti-Malarial Activities of Margaritaria discoidea and Other Nigerian Medicinal Plants (2015)
Presentation / Conference
Johnson-Ajinwo, O., Ullah, I., Lee, C., Raman, H., Ellerby, N., Horrocks, P., & Li, W. (2015, August). Anti-Malarial Activities of Margaritaria discoidea and Other Nigerian Medicinal Plants. Paper presented at 2015 PSNA Meeting, University of Illinois at Urbana-Champaign, USA

We previously evaluated in vitro anti-cancer activity of a Nigeria medicinal plant—Margaritaria discoidea (Baill.) G.L.Webster [1]. The aim of current study is to investigate crude extracts of ten medicinal plants including M. discoidea for their ant... Read More about Anti-Malarial Activities of Margaritaria discoidea and Other Nigerian Medicinal Plants.

Antimicrobial compounds from Magnolia liliflora Desr (2015)
Presentation / Conference
Al Muzaini, O., Al Dulaimi, O., Al Qahtani, T., & Li, W. W. (2015, January). Antimicrobial compounds from Magnolia liliflora Desr

Cytotoxic effects of stem bark extracts and pure compounds from Margaritaria discoidea on human ovarian cancer cell lines (2014)
Journal Article
Johnson-Ajinwo, O. R., Richardson, A., & Li, W. (2015). Cytotoxic effects of stem bark extracts and pure compounds from Margaritaria discoidea on human ovarian cancer cell lines. Phytomedicine, 22(1), 1-4. https://doi.org/10.1016/j.phymed.2014.09.008

Anti-ovarian cancer activities of alkaloids from Triclisia subcordata olive (Menispermecaea) (2014)
Conference Proceeding
Uche, F., Li, W., Richardson, A., & Greenhough, T. Anti-ovarian cancer activities of alkaloids from Triclisia subcordata olive (Menispermecaea). . https://doi.org/10.1055/s-0034-1382585

This study investigates the anticancer activities of Triclisia subcordata, identifies and elucidates the structure(s) of the bioactive anticancer compound. The evaluation of anticancer activity was done by in vitro sulforhodamine B dye method using A... Read More about Anti-ovarian cancer activities of alkaloids from Triclisia subcordata olive (Menispermecaea).

Anticancer activities of cyclotides from Viola yedeonsis Makino (Violaceae) (2014)
Journal Article
Uche, F., Li, W., Richardson, A., & Greenhough, T. Anticancer activities of cyclotides from Viola yedeonsis Makino (Violaceae). Planta Medica, 80(10), https://doi.org/10.1055/s-0034-1382606

Stable Isotope Dilution Gas Chromatography–Mass Spectrometry for Quantification of Thymoquinone in Black Cumin Seed Oil (2014)
Journal Article
Johnson-Ajinwo, O. R., & Li, W. (2014). Stable Isotope Dilution Gas Chromatography–Mass Spectrometry for Quantification of Thymoquinone in Black Cumin Seed Oil. Journal of Agricultural and Food Chemistry, 62(24), 5466-5471. https://doi.org/10.1021/jf500357x

Black cumin seed (Nigella sativa L.) is a widely used spice and herb, where thymoquinone (2-isopropyl-5-methyl-1,4-benzoquinone) is the major bioactive compound. Here, a stable isotope dilution (SID) gas chromatography–mass spectrometry (GC–MS) techn... Read More about Stable Isotope Dilution Gas Chromatography–Mass Spectrometry for Quantification of Thymoquinone in Black Cumin Seed Oil.

Analysis of volatile compounds in phytomedicines using thermal desorption gas chromatography mass spectroscopy (2013)
Journal Article
Aldulaimi, O., & Li, W. (2013). Analysis of volatile compounds in phytomedicines using thermal desorption gas chromatography mass spectroscopy. Planta Medica, 79(13), https://doi.org/10.1055/s-0033-1352285

Volatile essential oils (EOs) from medicinal plants play an important role in the treatment of various diseases. EOs have been shown to exhibit anti-bacterial, antiviral, antimycotic, antitoxigenic, antiparasitic, and insecticidal properties [1]. Sev... Read More about Analysis of volatile compounds in phytomedicines using thermal desorption gas chromatography mass spectroscopy.

Anti-cancer thymoquinone from Nigella sativa (2013)
Journal Article
Li, W., Rosa, J., Siddique, M., Bajana, B., Sulé-Suso, J., & Richardson, A. Anti-cancer thymoquinone from Nigella sativa. Planta Medica, 79(13), https://doi.org/10.1055/s-0033-1351896

Quinones and phenolic compounds are important bioactive natural products in medicinal and dietary plants [1 – 3]. For example, thymoquinone (2-isopropyl-6-methyl-1,4-benzoquinone, TQ) is the main bioactive compound from Nigella sativa (black cumin) (... Read More about Anti-cancer thymoquinone from Nigella sativa.

Single-Molecule Detection of 5-Hydroxymethylcytosine in DNA through Chemical Modification and Nanopore Analysis (2013)
Journal Article
Li, W., Gong, L., & Bayley, H. (2013). Single-Molecule Detection of 5-Hydroxymethylcytosine in DNA through Chemical Modification and Nanopore Analysis. Angewandte Chemie International Edition, 52(16), 4350-4355. https://doi.org/10.1002/anie.201300413

DNA threading the needle: A new method of single-molecule detection of 5-hydroxymethylcytosine (5hmC) in DNA has been developed. Selective thiol substitution of 5hmC (giving SMC) in a single-step, bisulfite-mediated reaction (see scheme) allows the i... Read More about Single-Molecule Detection of 5-Hydroxymethylcytosine in DNA through Chemical Modification and Nanopore Analysis.

De novo design, synthesis, and characterization of quinoproteins (2006)
Journal Article
Li, W., Hellwig, P., Ritter, M., & Haehnel, W. (2006). De novo design, synthesis, and characterization of quinoproteins. Chemistry - A European Journal, 12(27), 7236-7245. https://doi.org/10.1002/chem.200501212

Quinones and quinoproteins are essential redox components and enzymes in biological systems. Here, we report the de novo design, synthesis, and properties of model four-α-helix bundle quinoproteins. The proteins were designed and constructed from thr... Read More about De novo design, synthesis, and characterization of quinoproteins.