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Toby Helliwell's Outputs (83)

Investigating the usefulness of Automated Check-in Data Collection in general practice (AC DC Study): a multicentre, cross-sectional study in England. (2023)
Journal Article
Lawton, S., Mallen, C., Muller, S., Wathall, S., & Helliwell, T. (2023). Investigating the usefulness of Automated Check-in Data Collection in general practice (AC DC Study): a multicentre, cross-sectional study in England. BMJ Open, 13(1), Article e062389. https://doi.org/10.1136/bmjopen-2022-062389

Objectives: To investigate the usefulness of using automated appointment check-in screens to collect brief research data from patients, prior to their general practice consultation.

Design: A descriptive, cross-sectional study.

Setting: Nine ge... Read More about Investigating the usefulness of Automated Check-in Data Collection in general practice (AC DC Study): a multicentre, cross-sectional study in England..

Immunogenicity and safety of an inactivated whole-virus COVID-19 vaccine (VLA2001) compared with the adenoviral vector vaccine ChAdOx1-S in adults in the UK (COV-COMPARE): interim analysis of a randomised, controlled, phase 3, immunobridging trial (2022)
Journal Article
Lazarus, R., Querton, B., Corbic Ramljak, I., Dewasthaly, S., Jaramillo, J. C., Dubischar, K., …Torku, D. (2022). Immunogenicity and safety of an inactivated whole-virus COVID-19 vaccine (VLA2001) compared with the adenoviral vector vaccine ChAdOx1-S in adults in the UK (COV-COMPARE): interim analysis of a randomised, controlled, phase 3, immunobridging trial. Lancet Infectious Diseases, 22(12), 1716-1727. https://doi.org/10.1016/s1473-3099%2822%2900502-3

Background
The Valneva COVID-19 vaccine (VLA2001; Valneva Austria, Vienna, Austria) is an inactivated whole-virus, adjuvanted SARS-CoV-2 vaccine. We aimed to assess the safety and immunogenicity of primary vaccination with VLA2001 versus the ChAdOx1... Read More about Immunogenicity and safety of an inactivated whole-virus COVID-19 vaccine (VLA2001) compared with the adenoviral vector vaccine ChAdOx1-S in adults in the UK (COV-COMPARE): interim analysis of a randomised, controlled, phase 3, immunobridging trial.

The impact of polymyalgia rheumatica on intimate sexual relationships: findings from the PMR Cohort Study (2022)
Journal Article
Muller, S., Hider, S. L., Hider, S., Ranasinghe, . P., Helliwell, T., Lawton, S. A., …Mallen, C. (2022). The impact of polymyalgia rheumatica on intimate sexual relationships: findings from the PMR Cohort Study. Rheumatology Advances in Practice, 6(3), https://doi.org/10.1093/rap/rkac070

Objectives To determine the impact of polymyalgia rheumatica (PMR) on intimate and sexual relationships over time. Methods The PMR Cohort study (UKCRN ID16477) is a longitudinal study of patients with incident PMR in English primary care. Participant... Read More about The impact of polymyalgia rheumatica on intimate sexual relationships: findings from the PMR Cohort Study.

AB0583 REFERRAL PATTERN AND TREATMENT OF POLYMYALGIA RHEUMATICA IN GENERAL PRACTICE: AN INTERNATIONAL QUESTIONNAIRE BASED STUDY (2022)
Journal Article
Overgaard Donskov, A., Mackie, S., Hauge, E. M., Toro Gutiérrez, C., Hemmig, A., Van der Maas, A., …Keller, K. (2022). AB0583 REFERRAL PATTERN AND TREATMENT OF POLYMYALGIA RHEUMATICA IN GENERAL PRACTICE: AN INTERNATIONAL QUESTIONNAIRE BASED STUDY. Annals of the Rheumatic Diseases, 81(Suppl 1), 1416.2-1417. https://doi.org/10.1136/annrheumdis-2022-eular.1380

Background In most countries polymyalgia rheumatica (PMR) is diagnosed and managed by both general practitioners (GP) and rheumatologists. However, the referral pattern from GP’s to specialist around the world has not been described. The initial pred... Read More about AB0583 REFERRAL PATTERN AND TREATMENT OF POLYMYALGIA RHEUMATICA IN GENERAL PRACTICE: AN INTERNATIONAL QUESTIONNAIRE BASED STUDY.

Long-term use of glucocorticoids for polymyalgia rheumatica: follow-up of the PMR Cohort Study (2022)
Journal Article
Muller, S., Hider, S. L., Sokhal, B. S., Lawton, S. A., Helliwell, T., & Mallen, C. D. (2022). Long-term use of glucocorticoids for polymyalgia rheumatica: follow-up of the PMR Cohort Study. Rheumatology Advances in Practice, 6(2), Article rkac034. https://doi.org/10.1093/rap/rkac034

Objectives PMR is a common inflammatory condition in older adults, characterized by bilateral hip and shoulder pain and stiffness. Reducing oral glucocorticoids, classically used for <= 2 years, are the mainstay of treatment. This study considers the...

Burnout among primary health-care professionals in low- and middle-income countries: systematic review and meta-analysis (2022)
Journal Article
Helliwell, T., Wright, T., Mughal, F., Babatunde, O., Dikomitis, L., & Mallen, C. (2022). Burnout among primary health-care professionals in low- and middle-income countries: systematic review and meta-analysis. Bulletin of the World Health Organization, 385 - 401A. https://doi.org/10.2471/blt.22.288300

Objective
To estimate the prevalence of burnout among primary health-care professionals in low- and middle-income countries and to identify factors associated with burnout.

Methods
We systematically searched nine databases up to February 2022 to... Read More about Burnout among primary health-care professionals in low- and middle-income countries: systematic review and meta-analysis.

Treatment and Outcomes of Acute Myocardial Infarction in Patients With Polymyalgia Rheumatica With and Without Giant Cell Arteritis. (2022)
Journal Article
Sokhal, B., Matetić, A., Bharadwaj, A., Helliwell, T., Abhishek, A., Mallen, C., …Mamas, M. (2022). Treatment and Outcomes of Acute Myocardial Infarction in Patients With Polymyalgia Rheumatica With and Without Giant Cell Arteritis. American Journal of Cardiology, 12-19. https://doi.org/10.1016/j.amjcard.2022.03.034

This study analyzed the characteristics, management, and outcomes of patients with polymyalgia rheumatica (PMR) hospitalized with acute myocardial infarction (AMI), including sensitivity analysis for presence of giant cell arteritis (GCA). Using the... Read More about Treatment and Outcomes of Acute Myocardial Infarction in Patients With Polymyalgia Rheumatica With and Without Giant Cell Arteritis..

Exploring the Impact of the First Wave of COVID-19 on Social Work Practice: A Qualitative Study in England, UK (2021)
Journal Article
Kingstone, T., Campbell, P., Andras, A., Nixon, K., Mallen, C., Dikomitis, L., …Wenning, B. (2021). Exploring the Impact of the First Wave of COVID-19 on Social Work Practice: A Qualitative Study in England, UK. British Journal of Social Work, 52(4), 2043–2062. https://doi.org/10.1093/bjsw/bcab166

The COVID-19 pandemic signalled a radical shift in health and social care services globally. In UK, many of the people with existing social care needs were identified as 'clinically vulnerable' to COVID-19. Those at greatest risk were encouraged to a... Read More about Exploring the Impact of the First Wave of COVID-19 on Social Work Practice: A Qualitative Study in England, UK.

Prevalence of osteoarthritis in lower middle- and low-income countries: a systematic review and meta-analysis (2021)
Journal Article
Yahaya, I., Wright, T., Babatunde, O., Corp, N., Helliwell, T., Dikomitis, L., & Mallen, C. (2021). Prevalence of osteoarthritis in lower middle- and low-income countries: a systematic review and meta-analysis. Rheumatology International, 41, 1221-1231. https://doi.org/10.1007/s00296-021-04838-y

Evidence from the Global Burden of Disease studies suggests that osteoarthritis (OA) is a significant cause of disability globally; however, it is less clear how much of this burden exists in low-income and lower middle-income countries. This study a... Read More about Prevalence of osteoarthritis in lower middle- and low-income countries: a systematic review and meta-analysis.

Acute Myocardial Infarction in Autoimmune Rheumatological Disease: A Nationwide Analysis of Clinical outcomes and Predictors of Management Strategy (2021)
Journal Article
Mamas, Clarson, Roddy, Mallen, & Helliwell. (2021). Acute Myocardial Infarction in Autoimmune Rheumatological Disease: A Nationwide Analysis of Clinical outcomes and Predictors of Management Strategy. Mayo Clinic Proceedings, 388-399. https://doi.org/10.1016/j.mayocp.2020.04.044

Objectives: The present study sought to examine national-level differences in management strategies and outcomes in patients with autoimmune rheumatic disease (AIRD) with acute myocardial infarction (AMI) between 2004 and 2014.
Methods: All AMI hos... Read More about Acute Myocardial Infarction in Autoimmune Rheumatological Disease: A Nationwide Analysis of Clinical outcomes and Predictors of Management Strategy.

Insights into back pain through linkage of digital patient generated data with electronic health records (2020)
Presentation / Conference
Martinez De Pinillos, A., Helliwell, T., Cooper, M., Mullane, M., Meleck, S., O'hanlon, S., …Dhanjal, J. (2020, September). Insights into back pain through linkage of digital patient generated data with electronic health records. Paper presented at 36th International Conference on Pharmacoepidemiology & Therapeutic Risk Management, Virtual

Background: Back pain affects up to 80% of the population in industrialised countries and is the largest cause of disability in the UK. Physician and patient engagement are critical to ensure timely and multidisciplinary collection of back pain event... Read More about Insights into back pain through linkage of digital patient generated data with electronic health records.

Mortality Among Patients With Polymyalgia Rheumatica: A Retrospective Cohort Study (2020)
Journal Article
Partington, R., Muller, S., Mallen, C. D., Abdul Sultan, A., & Helliwell, T. (2021). Mortality Among Patients With Polymyalgia Rheumatica: A Retrospective Cohort Study. Arthritis Care and Research, 73(12), 1853-1857. https://doi.org/10.1002/acr.24403

OBJECTIVE: To determine whether a diagnosis of polymyalgia rheumatica (PMR) is associated with premature mortality. METHODS: We extracted anonymised electronic medical records of patients over the age of 40 years, who were eligible for linkage with t... Read More about Mortality Among Patients With Polymyalgia Rheumatica: A Retrospective Cohort Study.

Comorbidities in patients with polymyalgia rheumatica prior to and following diagnosis: A case control and cohort study (2020)
Journal Article
Partington, R., Muller, S., Mallen, C. D., Abdul Sultan, A., & Helliwell, T. (2020). Comorbidities in patients with polymyalgia rheumatica prior to and following diagnosis: A case control and cohort study. Seminars in Arthritis and Rheumatism, 50(4), 663-672. https://doi.org/10.1016/j.semarthrit.2020.05.003

Objectives: To determine the burden of comorbidities, including glucocorticoid (GC) related adverse effects, in patients with polymyalgia rheumatica (PMR) before and after diagnosis.

Methods: We extracted anonymised electronic medical records of p... Read More about Comorbidities in patients with polymyalgia rheumatica prior to and following diagnosis: A case control and cohort study.

THE RELATIONSHIP BETWEEN OBESITY AND OUTCOMES IN PATIENTS WITH POLYMYALGIA RHEUMATICA (2020)
Journal Article
Helliwell, T., Mallen, C. D., Scott, I. C., Bajpai, R., Muller, S., & Hider, S. L. (2020). THE RELATIONSHIP BETWEEN OBESITY AND OUTCOMES IN PATIENTS WITH POLYMYALGIA RHEUMATICA. Rheumatology, 59, 18-18. https://doi.org/10.1093/RHEUMATOLOGY/KEAA110.037

Background
Obesity predisposes to a pro-inflammatory state. Studies have reported worse clinical outcomes in patients with inflammatory arthritis who are obese. The relationship between obesity and outcomes in patients with polymyalgia rheumatica (P... Read More about THE RELATIONSHIP BETWEEN OBESITY AND OUTCOMES IN PATIENTS WITH POLYMYALGIA RHEUMATICA.

The relationship between obesity and outcomes in patients with polymyalgia rheumatica (2020)
Presentation / Conference
Scott, I. C., Bajpai, R., Mallen, C., Muller, S., Helliwell, T., & Hider, S. (2020, April). The relationship between obesity and outcomes in patients with polymyalgia rheumatica. Presented at British Society for Rheumatology Annual Conference 2020, Scottish Event Campus (SEC), Scotland, UK

Background
Obesity predisposes to a pro-inflammatory state. Studies have reported worse clinical outcomes in patients with inflammatory arthritis who are obese. The relationship between obesity and outcomes in patients with polymyalgia rheumatica (P... Read More about The relationship between obesity and outcomes in patients with polymyalgia rheumatica.

P63 The association between presenting clinical features and subsequent diagnosis of giant cell arteritis (2020)
Journal Article
Barnett, L. A., Helliwell, T., Jordan, K. P., & Prior, J. A. (2020). P63 The association between presenting clinical features and subsequent diagnosis of giant cell arteritis. Rheumatology, 59(Supplement_2), https://doi.org/10.1093/rheumatology/keaa111.062

Background
The diagnosis of giant cell arteritis (GCA) remains challenging due to the varied number and type of clinical features (symptoms and comorbidities) that patients with GCA can present with. Prompt diagnosis is important, as if left undiagn... Read More about P63 The association between presenting clinical features and subsequent diagnosis of giant cell arteritis.

O40 Trends in incidence of GCA in the UK (2020)
Journal Article
Barnett, L. A., Helliwell, T., Jordan, K., & Prior, J. (2020). O40 Trends in incidence of GCA in the UK. Rheumatology, 59(Supplement_2), https://doi.org/10.1093/rheumatology/keaa110.039

Background
Giant cell arteritis (GCA) is the most common form of medium and large vessel vasculitis. Diagnosis remains difficult since there are a multitude of symptoms experienced by patients with GCA and if not promptly identified or treated, pati... Read More about O40 Trends in incidence of GCA in the UK.

The Hospital Frailty Risk Score and its association with in-hospital mortality, cost, length of stay and discharge location in patients with heart failure (2020)
Journal Article
Shing Kwok, C., Zieroth, S., Van Spall, H. G. C., Helliwell, T., Clarson, L., Mohamed, M., …Mamas, M. A. (2020). The Hospital Frailty Risk Score and its association with in-hospital mortality, cost, length of stay and discharge location in patients with heart failure. International Journal of Cardiology, 184-190. https://doi.org/10.1016/j.ijcard.2019.09.064

Background:
Little is known about frailty amongst patients hospitalized with heart failure (HF) on a national level.

Methods:
We conducted a retrospective cohort study of patients admitted to hospital for HF in the United States. We examined how... Read More about The Hospital Frailty Risk Score and its association with in-hospital mortality, cost, length of stay and discharge location in patients with heart failure.

Longitudinal clusters of pain and stiffness in polymyalgia rheumatica: 2-year results from the PMR Cohort Study (2019)
Journal Article
Muller, S., Whittle, R., Hider, S. L., Belcher, J., Helliwell, T., Morton, C., …Mallen, C. D. (2020). Longitudinal clusters of pain and stiffness in polymyalgia rheumatica: 2-year results from the PMR Cohort Study. Rheumatology, 59(8), 1906-1915. https://doi.org/10.1093/rheumatology/kez533

Objectives. To investigate potential subgroups of primary care diagnosed patients with polymyalgia rheumatica (PMR) based on self-reported pain and stiffness severity over time.

Methods. 652 people with an incident PMR diagnosis were recruited fro... Read More about Longitudinal clusters of pain and stiffness in polymyalgia rheumatica: 2-year results from the PMR Cohort Study.