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Toby Helliwell's Outputs (83)

A person-centred primary care pharmacist-led osteoporosis review for optimising medicines (PHORM): a protocol for the development and co-design of a model consultation intervention (2024)
Journal Article
Sturrock, A., Grabrovaz, M., Bullock, L., Clark, E., Finch, T., Haining, S., …Paskins, Z. (2024). A person-centred primary care pharmacist-led osteoporosis review for optimising medicines (PHORM): a protocol for the development and co-design of a model consultation intervention. BMJ Open, 14(11), https://doi.org/10.1136/bmjopen-2024-085323

Introduction: Adherence to medicines in osteoporosis is poor, with estimated 1 year persistence rates between 16% and 60%. Poor adherence is complex, relating to combinations of fear of side effects, beliefs about medication being unnecessary, doubts... Read More about A person-centred primary care pharmacist-led osteoporosis review for optimising medicines (PHORM): a protocol for the development and co-design of a model consultation intervention.

2236 Emergency department attendance stratified by cause and frailty status: a national cohort study of over 155 million patients (2024)
Journal Article
Sokhal, B., Matetić, A., Protheroe, J., Helliwell, T., Myint, P., Paul, T., …Mamas, M. (2024). 2236 Emergency department attendance stratified by cause and frailty status: a national cohort study of over 155 million patients. Age and ageing, 53(Supplement_3), https://doi.org/10.1093/ageing/afae139.051

Introduction Data are limited on whether the causes of Emergency Department (ED) attendance and clinical outcomes vary by frailty status. Methods Using data from the Nationwide Emergency Department Sample, all ED attendances from 2016 to 2018 were st... Read More about 2236 Emergency department attendance stratified by cause and frailty status: a national cohort study of over 155 million patients.

The Relationship Between Obesity and Patient-Reported Outcome Measures in People with Polymyalgia Rheumatica (2024)
Journal Article
Scott, I. C., Bajpai, R., Hider, S. L., Helliwell, T., Mallen, C. D., & Muller, S. (in press). The Relationship Between Obesity and Patient-Reported Outcome Measures in People with Polymyalgia Rheumatica. Rheumatology Advances in Practice, 8(3), Article rkae081. https://doi.org/10.1093/rap/rkae081

Objective
To examine the association between obesity and patient-reported outcomes measures (PROMs) in a primary care-based cohort of people with polymyalgia rheumatica (PMR).

Methods
The PMR Cohort Study recruited people with incident PMR from... Read More about The Relationship Between Obesity and Patient-Reported Outcome Measures in People with Polymyalgia Rheumatica.

P187 Fatigue in people with polymyalgia rheumatica: a key unmet need? (2024)
Presentation / Conference
Muller, S., Belcher, J., Hider, S., Helliwell, T., & Mallen, C. D. (2024, April). P187 Fatigue in people with polymyalgia rheumatica: a key unmet need?. Poster presented at British Society for Rheumatology Annual Conference 2024

Background/Aims Polymyalgia rheumatica (PMR) is common in older adults, causing severe pain and stiffness, particularly in the shoulder and hip girdles. Glucocorticoids treatment generally focusses on reducing pain and stiffness, but there are other... Read More about P187 Fatigue in people with polymyalgia rheumatica: a key unmet need?.

P185 Anatomical patterns of pain in primary care patients with polymyalgia rheumatica compared to the general population (2024)
Presentation / Conference
Hammad, N., Partington, R., Hider, S., Butt, H., Helliwell, T., Mallen, C., & Muller, S. (2024, April). P185 Anatomical patterns of pain in primary care patients with polymyalgia rheumatica compared to the general population. Poster presented at British Society for Rheumatology Annual Conference 2024

Background/Aims Polymyalgia rheumatica (PMR) is common in older adults, causing severe pain and stiffness, particularly in the shoulder and hip girdles. A tapered course of glucocorticoids is recommended, but not always straightforward, with frequent... Read More about P185 Anatomical patterns of pain in primary care patients with polymyalgia rheumatica compared to the general population.

Designing a primary care pharmacist-led review for people treated with opioids for persistent pain: a multi-method qualitative study (2024)
Journal Article
Woodcock, C., Cornwall, N., Dikomitis, L., Harrisson, S. A., White, S., Helliwell, T., …Jinks, C. (2024). Designing a primary care pharmacist-led review for people treated with opioids for persistent pain: a multi-method qualitative study. British Journal of General Practice Open (BJGP Open), Article BJGPO.2023.0221. https://doi.org/10.3399/BJGPO.2023.0221

Background Opioids are frequently prescribed for persistent non-cancer pain despite limited evidence of long-term effectiveness and risk of harm. Evidence-based interventions to address inappropriate opioid prescribing are lacking.

Aim To explore... Read More about Designing a primary care pharmacist-led review for people treated with opioids for persistent pain: a multi-method qualitative study.

Identifying carers in general practice (STATUS QUO): a multicentre, cross-sectional study in England (2024)
Journal Article
Lawton, S., Mallen, C., Hussain, Z., Bajpai, R., Muller, S., Holmstrom, C., …Helliwell, T. (2024). Identifying carers in general practice (STATUS QUO): a multicentre, cross-sectional study in England. BMJ Open, 14(4), Article e083816. https://doi.org/10.1136/bmjopen-2023-083816

Objectives: To determine General Practice (GP) recording of carer status and the number of patients self-identifying as carers, while self-completing an automated check-in screen prior to a GP consultation.

Design: A descriptive cross-sectional st... Read More about Identifying carers in general practice (STATUS QUO): a multicentre, cross-sectional study in England.

Risk of adverse outcomes during gabapentinoid therapy and factors associated with increased risk in UK primary care using the clinical practice research datalink: a cohort study (2024)
Journal Article
Muller, S., Bailey, J., Bajpai, R., Helliwell, T., Harrisson, S. A., Whittle, R., …Ashworth, J. (2024). Risk of adverse outcomes during gabapentinoid therapy and factors associated with increased risk in UK primary care using the clinical practice research datalink: a cohort study. PAIN, https://doi.org/10.1097/j.pain.0000000000003239

Growing evidence from pharmacovigilance data and postmortem toxicology reports highlights the misuse potential of gabapentinoids. This study aimed to investigate the risk of serious adverse outcomes (drug misuse, overdose, major trauma), and their ri... Read More about Risk of adverse outcomes during gabapentinoid therapy and factors associated with increased risk in UK primary care using the clinical practice research datalink: a cohort study.

Acceptability of a proposed practice pharmacist-led review for opioid-treated patients with persistent pain: A qualitative study to inform intervention development (2023)
Journal Article
Cornwall, N., Woodcock, C., Ashworth, J., Harrisson, S. A., Dikomitis, L., White, S., …on behalf of the PROMPPT team. (2023). Acceptability of a proposed practice pharmacist-led review for opioid-treated patients with persistent pain: A qualitative study to inform intervention development. British Journal of Pain, https://doi.org/10.1177/20494637231221688

Introduction
Regular review of patients prescribed opioids for persistent non-cancer pain (PCNP) is recommended but not routinely undertaken. The PROMPPT (Proactive clinical Review of patients taking Opioid Medicines long-term for persistent Pain le... Read More about Acceptability of a proposed practice pharmacist-led review for opioid-treated patients with persistent pain: A qualitative study to inform intervention development.

Recommendations for early referral of individuals with suspected polymyalgia rheumatica: an initiative from the international giant cell arteritis and polymyalgia rheumatica study group (2023)
Journal Article
Keller, K. K., Mukhtyar, C. B., Nielsen, A. W., Hemmig, A. K., Mackie, S. L., Sattui, S. E., …Dejaco, C. (in press). Recommendations for early referral of individuals with suspected polymyalgia rheumatica: an initiative from the international giant cell arteritis and polymyalgia rheumatica study group. Annals of the Rheumatic Diseases, ard-2023-225134. https://doi.org/10.1136/ard-2023-225134

Objective: To develop international consensus-based recommendations for early referral of individuals with suspected polymyalgia rheumatica (PMR).

Methods: A task force including 29 rheumatologists/internists, 4 general practitioners, 4 patients a... Read More about Recommendations for early referral of individuals with suspected polymyalgia rheumatica: an initiative from the international giant cell arteritis and polymyalgia rheumatica study group.

Musculoskeletal disorders and pain in agricultural workers in Low- and Middle-Income Countries: a systematic review and meta-analysis (2023)
Journal Article
Shivakumar, M., Welsh, V., Bajpai, R., Helliwell, T., Mallen, C., Robinson, M., & Shepherd, T. (2024). Musculoskeletal disorders and pain in agricultural workers in Low- and Middle-Income Countries: a systematic review and meta-analysis. Rheumatology International, 44, 235–247. https://doi.org/10.1007/s00296-023-05500-5

Agricultural workers constitute two-thirds of the population of Low- and Middle-Income Countries (LMIC) and are at increased risk of developing musculoskeletal disorders (MSD) due to high-risk activities. This systematic review and meta-analysis aim... Read More about Musculoskeletal disorders and pain in agricultural workers in Low- and Middle-Income Countries: a systematic review and meta-analysis.

Exploring the perspectives of community members on use of Nyaope in Tshwane, South Africa (2023)
Journal Article
Nzaumvila, D. K., Mash, R., & Helliwell, T. (in press). Exploring the perspectives of community members on use of Nyaope in Tshwane, South Africa. South African Family Practice, 65(1), https://doi.org/10.4102/safp.v65i1.5715

Background: Substance use is a major public health issue in South Africa. Cocktails, containing two or more low-quality substances, have been reported. Nyaope is one of the most popular and is widely available. It has a significant impact on users an... Read More about Exploring the perspectives of community members on use of Nyaope in Tshwane, South Africa.

The aftermath of war; mental health, substance use and their correlates with social support and resilience among adolescents in a post-conflict region of Sri Lanka (2023)
Journal Article
Dissanayake, L., Jabir, S., Shepherd, T., Helliwell, T., Selvaratnam, L., Jayaweera, K., …Sumathipala, A. (in press). The aftermath of war; mental health, substance use and their correlates with social support and resilience among adolescents in a post-conflict region of Sri Lanka. Child and Adolescent Psychiatry and Mental Health, 17(1), Article 101. https://doi.org/10.1186/s13034-023-00648-1

Background:
Armed conflicts impact on the health and well-being of everyone, but its effect on adolescent mental health is a significant, yet under-explored area in global health. Mental health disorders which develop during adolescence often lead... Read More about The aftermath of war; mental health, substance use and their correlates with social support and resilience among adolescents in a post-conflict region of Sri Lanka.

Proactive review of patients taking opioid medicines for persistent pain led by pharmacists in primary care teams (PROMPPT): A feasibility study (2023)
Presentation / Conference
Ashworth, J., Cornwall, N., Harrisson, S. A., Woodcock, C., Nicholls, E., Laing, L., …Jinks, C. (2023, May). Proactive review of patients taking opioid medicines for persistent pain led by pharmacists in primary care teams (PROMPPT): A feasibility study. Presented at BPS Annual Scientific Meeting 2023, Glasgow, Scotland, UK

P203 Comparison of coding of giant cell arteritis in primary and secondary care records: an observational feasibility study (2023)
Presentation / Conference
Padmanabhan, N., Muller, S., Bailey, J., Helliwell, T., Mackie, S. L., Mallen, C. D., & Roddy, E. (2023, April). P203 Comparison of coding of giant cell arteritis in primary and secondary care records: an observational feasibility study. Poster presented at British Society for Rheumatology Annual Conference 2023, Manchester Central Convention Complex, Manchester, UK

Giant cell arteritis (GCA) is considered a medical emergency, and relapses are common, affecting around 50% of patients. Many of the early symptoms of GCA are non-specific and highly prevalent in older people, making the diagnosis challenging.

The... Read More about P203 Comparison of coding of giant cell arteritis in primary and secondary care records: an observational feasibility study.

Symptom patterns and life with post-acute COVID-19 in children aged 8-17: a mixed methods studyprotocol. (2023)
Journal Article
Faux-Nightingale, A., Burton, C., Twohig, H., Bucknall, M., Carroll, W., Chew-Graham, C., …Welsh, V. (2023). Symptom patterns and life with post-acute COVID-19 in children aged 8-17: a mixed methods studyprotocol. British Journal of General Practice Open (BJGP Open), 7(2), Article BJGPO20220149. https://doi.org/10.3399/bjgpo.2022.0149

Background: While there is a substantial body of knowledge about acute COVID-19, less is known about long-COVID, where symptoms continue beyond 4 weeks.

Aim: To describe longer-term effects of COVID-19 infection in children and young people (CYP)... Read More about Symptom patterns and life with post-acute COVID-19 in children aged 8-17: a mixed methods studyprotocol..

Trends in gabapentinoid prescribing in UK primary care using the Clinical Practice Research Datalink: an observational study (2023)
Journal Article
Ashworth, J., Bajpai, R., Muller, S., Bailey, J., Helliwell, T., Harrisson, S., …Mallen, C. (2023). Trends in gabapentinoid prescribing in UK primary care using the Clinical Practice Research Datalink: an observational study. The Lancet Regional Health Europe, 27, Article ARTN 100579. https://doi.org/10.1016/j.lanepe.2022.100579

Background
The UK government reclassified gabapentin and pregabalin as ‘controlled drugs’ from April 2019. This study aimed to describe the trends in gabapentinoid prescribing before and immediately after reclassification, in the UK Clinical Practic... Read More about Trends in gabapentinoid prescribing in UK primary care using the Clinical Practice Research Datalink: an observational study.

An international survey of current management practices for polymyalgia rheumatica by general practitioners and rheumatologists (2023)
Journal Article
Donskov, A. O., Mackie, S. L., Hauge, E. M., Toro-Gutiérrez, C. E., Hansen, I. T., Hemmig, A. K., …Keller, K. K. (in press). An international survey of current management practices for polymyalgia rheumatica by general practitioners and rheumatologists. Rheumatology, https://doi.org/10.1093/rheumatology/keac713

Objectives
To explore current management practices for PMR by general practitioners (GPs) and rheumatologists including implications for clinical trial recruitment.

Methods
An English language questionnaire was constructed by a working group of... Read More about An international survey of current management practices for polymyalgia rheumatica by general practitioners and rheumatologists.