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Outputs (76)

Development and external validation of the eFalls tool: a multivariable prediction model for the risk of ED attendance or hospitalisation with a fall or fracture in older adults. (2024)
Journal Article

Falls are common in older adults and can devastate personal independence through injury such as fracture and fear of future falls. Methods to identify people for falls prevention interventions are currently limited, with high risks of bias in publish... Read More about Development and external validation of the eFalls tool: a multivariable prediction model for the risk of ED attendance or hospitalisation with a fall or fracture in older adults..

Demographic, health, physical activity, and workplace factors are associated with lower healthy working life expectancy and life expectancy at age 50 (2024)
Journal Article

Although retirement ages are rising in the United Kingdom and other countries, the average number of years people in England can expect to spend both healthy and work from age 50 (Healthy Working Life Expectancy; HWLE) is less than the number of year... Read More about Demographic, health, physical activity, and workplace factors are associated with lower healthy working life expectancy and life expectancy at age 50.

2005 How do emergency ambulance clinicians decide what to do for older adults who have fallen? An analysis of qualitative survey data (2024)
Journal Article

Introduction Around 10% of calls received by English ambulance services are for older adults who have fallen1; with an ageing population there are significant care provision needs. Decision-making on the treatment for people who fall, can impact thei... Read More about 2005 How do emergency ambulance clinicians decide what to do for older adults who have fallen? An analysis of qualitative survey data.

2004 How confident are we in decision making? The quantitative analysis of ambulance response to older adult fallers: A pilot survey (2024)
Journal Article

Introduction The number one reason for older people to be taken to hospital emergency departments is a fall1. An “Ambulance Improvement Programme Pillar”2 is trying to reduce conveyance to hospital for falls, however it is not understood how the atte... Read More about 2004 How confident are we in decision making? The quantitative analysis of ambulance response to older adult fallers: A pilot survey.

Chest wall reconstruction reduces hospital mortality following major chest wall trauma: a retrospective cohort study (2023)
Journal Article

Introduction Chest wall reconstruction was introduced for the management of patients with severe chest wall injuries. We undertook a retrospective cohort study to investigate whether the treatment was associated with improved survival compared with... Read More about Chest wall reconstruction reduces hospital mortality following major chest wall trauma: a retrospective cohort study.

Symptom patterns and life with post-acute COVID-19 in children aged 8-17: a mixed methods studyprotocol. (2023)
Journal Article

Background: While there is a substantial body of knowledge about acute COVID-19, less is known about long-COVID, where symptoms continue beyond 4 weeks. Aim: To describe longer-term effects of COVID-19 infection in children and young people (CYP)... Read More about Symptom patterns and life with post-acute COVID-19 in children aged 8-17: a mixed methods studyprotocol..

Factors associated with change in health-related quality of life in people with gout: a 3-year prospective cohort study in primary care (2022)
Journal Article

Objective To describe factors associated with change in health-related quality of life (HRQOL) in people living with gout in primary care. Methods In a UK prospective cohort study, adults with a diagnosis of gout registered with 20 general practices... Read More about Factors associated with change in health-related quality of life in people with gout: a 3-year prospective cohort study in primary care.

Evaluating the long-term effect of allopurinol use in gout using marginal structural models: A primary care electronic health records study (2022)
Presentation / Conference

Background: Allopurinol is intended to be taken for life in the treatment of gout. In UK primary care, treatment is suboptimal with up to 30% of indicated patients being treated within five years of diagnosis and once prescribed allopurinol, treatmen... Read More about Evaluating the long-term effect of allopurinol use in gout using marginal structural models: A primary care electronic health records study.

The effectiveness of corticosteroid injection versus night splints for carpal tunnel syndrome: 24-month follow-up of a randomized trial (2022)
Journal Article

Objectives This follow-up study of the INSTinCTS (INjection vs SplinTing in Carpal Tunnel Syndrome) trial compared the effects of corticosteroid injection (CSI) and night splinting (NS) for the initial management of mild-to-moderate carpal tunnel sy... Read More about The effectiveness of corticosteroid injection versus night splints for carpal tunnel syndrome: 24-month follow-up of a randomized trial.

Healthy working life expectancy at age 50 for people with and without osteoarthritis in local and national English populations. (2022)
Journal Article

Retirement ages are rising in many countries to offset the challenges of population ageing, but osteoarthritis is an age-associated disease that is becoming more prevalent and may limit capacity to work until older ages. We aimed to assess the impact... Read More about Healthy working life expectancy at age 50 for people with and without osteoarthritis in local and national English populations..

Long-term clinical and socio-economic outcomes following wrist fracture: A systematic review and meta-analysis (2021)
Journal Article

Purpose: To summarise and appraise evidence on the prognosis and long-term clinical and socio-economic outcomes following wrist fracture among adults aged 50 years and over. Methods: Five databases (MEDLINE, EMBASE, AMED, CINAHL-P and PsycINFO) we... Read More about Long-term clinical and socio-economic outcomes following wrist fracture: A systematic review and meta-analysis.

Identifying Long-Term Trajectories of Foot Pain Severity and Potential Prognostic Factors: A Population-Based Cohort Study (2021)
Journal Article

OBJECTIVES: To identify distinct foot pain trajectories over seven years and examine their associations with potential prognostic factors. METHODS: Adults aged =50?years registered with four general practices in North Staffordshire, UK were mailed a... Read More about Identifying Long-Term Trajectories of Foot Pain Severity and Potential Prognostic Factors: A Population-Based Cohort Study.

Predicting pain and function outcomes in people consulting with shoulder pain: the PANDA-S clinical cohort and qualitative study protocol (2021)
Journal Article

INTRODUCTION: People presenting with shoulder pain considered to be of musculoskeletal origin is common in primary care but diagnosing the cause of the pain is contentious, leading to uncertainty in management. To inform optimal primary care for pati... Read More about Predicting pain and function outcomes in people consulting with shoulder pain: the PANDA-S clinical cohort and qualitative study protocol.

A pilot study of a nurse-led integrated care review (the INCLUDE review) for people with inflammatory rheumatological conditions in primary care: feasibility study findings. (2021)
Journal Article

BACKGROUND: People with inflammatory rheumatological conditions such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, polymyalgia rheumatica and giant cell arteritis are at an increased risk of common comorbidities including card... Read More about A pilot study of a nurse-led integrated care review (the INCLUDE review) for people with inflammatory rheumatological conditions in primary care: feasibility study findings..

Population-based estimates of healthy working life expectancy in England at age 50 years: analysis of data from the English Longitudinal Study of Ageing. (2020)
Journal Article

BACKGROUND: Retirement ages are rising in many countries to offset the challenges of population ageing, but people's capacity to work for more years in their later working life (>50 years) is unclear. We aimed to estimate healthy working life expecta... Read More about Population-based estimates of healthy working life expectancy in England at age 50 years: analysis of data from the English Longitudinal Study of Ageing..

Trajectories of foot pain severity over seven years and relationship to potential prognostic factors: the clinical assessment study of the foot (2020)
Journal Article

Background Foot pain is common and disabling in older adults however little is known about its course. The objective of this study was to identify foot pain trajectories over seven years and examine the associations between progressive symptom traje... Read More about Trajectories of foot pain severity over seven years and relationship to potential prognostic factors: the clinical assessment study of the foot.

P142 Factors associated with change in health-related quality of life in people living with gout: a three-year prospective cohort study in primary care (2020)
Journal Article

Background Gout affects 2.5% of adults in the UK but is often poorly managed. It can impair health-related quality of life (HRQOL), yet little is known about which people with gout are at risk of worse outcomes. We investigated factors associated wi... Read More about P142 Factors associated with change in health-related quality of life in people living with gout: a three-year prospective cohort study in primary care.

P143 The clinical and cost-effectiveness of corticosteroid injection versus night splints for carpal tunnel syndrome: 24-month follow-up of an open-label, parallel group, randomised controlled trial (2020)
Journal Article

Background Patients with mild-to-moderate carpal tunnel syndrome (CTS) are commonly treated with night splints and/or local corticosteroid injection. In the INSTINCTS (INjection versus SplinTing in Carpal Tunnel Syndrome) trial, we previously report... Read More about P143 The clinical and cost-effectiveness of corticosteroid injection versus night splints for carpal tunnel syndrome: 24-month follow-up of an open-label, parallel group, randomised controlled trial.

The association between anxiety and disease activity and quality of life in rheumatoid arthritis: a systematic review and meta-analysis. (2020)
Journal Article

OBJECTIVES: In people with rheumatoid arthritis (RA), mental health problems are common, but often not recognized or treated, contributing to increased morbidity and mortality. Most studies examining the impact of mental health problems in RA have fo... Read More about The association between anxiety and disease activity and quality of life in rheumatoid arthritis: a systematic review and meta-analysis..

Open-label randomised pragmatic trial (CONTACT) comparing naproxen and low-dose colchicine for the treatment of gout flares in primary care (2019)
Journal Article

OBJECTIVES: To compare the effectiveness and safety of naproxen and low-dose colchicine for treating gout flares in primary care. METHODS: This was a multicentre open-label randomised trial. Adults with a gout flare recruited from 100 general prac... Read More about Open-label randomised pragmatic trial (CONTACT) comparing naproxen and low-dose colchicine for the treatment of gout flares in primary care.

Predictors of pain interference and potential gain from intervention in community dwelling adults with joint pain: A prospective cohort study. (2019)
Journal Article

INTRODUCTION: There is little research on identifying modifiable risk factors that predict future interference of pain with daily activity in people with joint pain, and the estimation of the corresponding population attributable risk (PAR). The pres... Read More about Predictors of pain interference and potential gain from intervention in community dwelling adults with joint pain: A prospective cohort study..

TARGETS FOR REDUCING PREMATURE MORTALITY IN OLDER ADULTS WITH OSTEOARTHRITIS: RESULTS FROM A NOVEL PATH ANALYSIS WITHIN A COX PROPORTIONAL HAZARDS MODEL (2019)
Journal Article

Objectives The objectives of this study were to identify potential mechanisms of the impact of osteoarthritis on mortality and examine the role of modifiable targets (anxiety, depression, insomnia and walking frequency) for health professionals in rh... Read More about TARGETS FOR REDUCING PREMATURE MORTALITY IN OLDER ADULTS WITH OSTEOARTHRITIS: RESULTS FROM A NOVEL PATH ANALYSIS WITHIN A COX PROPORTIONAL HAZARDS MODEL.

088 The impact of anxiety on quality of life and disease activity in rheumatoid arthritis: a systematic review (2019)
Journal Article

Background: Co-morbid anxiety and depression are frequent in patients with rheumatoid arthritis (RA), but are often under-recognised and under-treated, contributing to increased morbidity and mortality. Most studies examining the impact of mood probl... Read More about 088 The impact of anxiety on quality of life and disease activity in rheumatoid arthritis: a systematic review.

252 The prevalence of axial involvement in psoriasis or psoriatic arthritis: a systematic review and meta-analysis (2019)
Journal Article

Background: A significant proportion of patients with psoriasis (PsO) or psoriatic arthritis (PsA) have axial involvement which is associated with more severe peripheral arthritis in PsA. Historically, methods for recognition of axial involvement in... Read More about 252 The prevalence of axial involvement in psoriasis or psoriatic arthritis: a systematic review and meta-analysis.

040 The incidence of anxiety or depression in patients with and without inflammatory rheumatic conditions (2019)
Journal Article

Background: Rheumatoid arthritis (RA) has been linked to several co-morbidities, including anxiety and depression, which can contribute to increased morbidity and mortality. Less literature has examined the association between other inflammatory rheu... Read More about 040 The incidence of anxiety or depression in patients with and without inflammatory rheumatic conditions.

Examining management and research priorities in patients with polymyalgia rheumatica: a primary care questionnaire survey. (2019)
Journal Article

INTRODUCTION/OBJECTIVES: Polymyalgia rheumatica (PMR) is a common inflammatory disorder that is usually managed with oral glucocorticoids, which although effective can cause significant adverse events. Support group survey data suggests length of g... Read More about Examining management and research priorities in patients with polymyalgia rheumatica: a primary care questionnaire survey..

The clinical and cost-effectiveness of corticosteroid injection versus night splints for carpal tunnel syndrome (INSTINCTS trial): an open-label, parallel group, randomised controlled trial. (2018)
Journal Article

Background To our knowledge, the comparative effectiveness of commonly used conservative treatments for carpal tunnel syndrome has not been evaluated previously in primary care. We aimed to compare the clinical and cost-effectiveness of night splint... Read More about The clinical and cost-effectiveness of corticosteroid injection versus night splints for carpal tunnel syndrome (INSTINCTS trial): an open-label, parallel group, randomised controlled trial..

Comorbidity clusters in people with gout: an observational cohort study with linked medical record review (2018)
Journal Article

Objective. To investigate how comorbid conditions cluster in patients with gout in a UK primary care population. Methods. A cross-sectional study was performed using baseline data from a primary-care-based prospective observational cohort of peop... Read More about Comorbidity clusters in people with gout: an observational cohort study with linked medical record review.

Optimal primary care management of clinical osteoarthritis and joint pain in older people: a mixed-methods programme of systematic reviews, observational and qualitative studies, and randomised controlled trials (2018)
Journal Article

Background Osteoarthritis (OA) is the most common long-term condition managed in UK general practice. However, care is suboptimal despite evidence that primary care and community-based interventions can reduce OA pain and disability. Objectives Th... Read More about Optimal primary care management of clinical osteoarthritis and joint pain in older people: a mixed-methods programme of systematic reviews, observational and qualitative studies, and randomised controlled trials.

Risk of fragility fracture among patients with late-onset psoriasis: a United Kingdom population-based study (2018)
Journal Article

This study aimed to examine fracture risk in patients with late-onset psoriasis. A cohort study was conducted using primary care records from the Clinical Practice Research Datalink. Psoriasis patients had a 10% increased risk of fracture compared to... Read More about Risk of fragility fracture among patients with late-onset psoriasis: a United Kingdom population-based study.

Risk of fracture among patients with polymyalgia rheumatica and giant cell arteritis: a population-based study (2018)
Journal Article

Background Glucocorticoids are associated with increased fracture risk and are the mainstay of treatment in polymyalgia rheumatica (PMR) and giant cell arteritis (GCA). However, fracture risk in these conditions has not been previously quantified. T... Read More about Risk of fracture among patients with polymyalgia rheumatica and giant cell arteritis: a population-based study.

The INCLUDE study: INtegrating and improving Care for patients with infLammatory rheUmatological DisordErs in the community; identifying multimorbidity: Protocol for a pilot randomized controlled trial. (2018)
Journal Article

Background: Patients with inflammatory rheumatic conditions such as rheumatoid arthritis, polymyalgia rheumatica and ankylosing spondylitis are at increased risk of common comorbidities such as cardiovascular disease, osteoporosis and anxiety and dep... Read More about The INCLUDE study: INtegrating and improving Care for patients with infLammatory rheUmatological DisordErs in the community; identifying multimorbidity: Protocol for a pilot randomized controlled trial..

Incident acute pseudogout and prior bisphosphonate use: matched case-control study in the UK-Clinical Practice Research Datalink (2017)
Journal Article

Oral bisphosphonates are the most commonly used drugs to treat postmenopausal osteoporosis. Acute pseudogout is anecdotally reported to occur following bisphosphonate initiation but empirical data are lacking. We investigated whether treatment with o... Read More about Incident acute pseudogout and prior bisphosphonate use: matched case-control study in the UK-Clinical Practice Research Datalink.

The clinical and cost effectiveness of steroid injection compared with night splints for carpal tunnel syndrome (2016)
Journal Article

BACKGROUND: Patients diagnosed with idiopathic mild to moderate carpal tunnel syndrome (CTS) are usually managed in primary care and commonly treated with night splints and/or corticosteroid injection. The comparative effectiveness of these intervent... Read More about The clinical and cost effectiveness of steroid injection compared with night splints for carpal tunnel syndrome.

Widespread pain and depression are key modifiable risk factors associated with reduced social participation in older adults: A prospective cohort study in primary care. (2016)
Journal Article

In older adults, reduced social participation increases the risk of poor health-related quality of life, increased levels of inflammatory markers and cardiovascular disease, and increased mortality. Older adults frequently present to primary care, wh... Read More about Widespread pain and depression are key modifiable risk factors associated with reduced social participation in older adults: A prospective cohort study in primary care..

Impairment-targeted exercises for older adults with knee pain: a proof-of-principle study (TargET-Knee-Pain). (2016)
Journal Article

BACKGROUND: Therapeutic exercise is an effective intervention for knee pain and osteoarthritis (OA) and should be individualised. In a preliminary, proof-of-principle study we sought to develop a home exercise programme targeted at specific physical... Read More about Impairment-targeted exercises for older adults with knee pain: a proof-of-principle study (TargET-Knee-Pain)..

Repeated primary care consultations for non-specific physical symptoms in children in UK: a cohort study (2014)
Journal Article

BackgroundNon-specific physical symptoms (NSPS), such as headache and abdominal pain, are common reasons for children to consult primary care. NSPS represent a significant burden not only on society, but also on health care services, through frequent... Read More about Repeated primary care consultations for non-specific physical symptoms in children in UK: a cohort study.

Current evidence on risk factors for knee osteoarthritis in older adults: a systematic review and meta-analysis (2014)
Journal Article

Osteoarthritis (OA) is a leading cause of pain and disability and leads to a reduced quality of life. The aim was to determine the current evidence on risk factors for onset of knee pain/OA in those aged 50 and over. A systematic review and meta-anal... Read More about Current evidence on risk factors for knee osteoarthritis in older adults: a systematic review and meta-analysis.

Bisphosphonates and Risk of Acute Pseudogout: A Case-Control Study in the Clinical Practice Research Datalink (CPRD). (2014)
Presentation / Conference

Background/Purpose: Acute pseudogout is the most dramatic clinical manifestation of calcium pyrophosphate crystal deposition (CPPD). CPPD is most commonly sporadic and age-related but can rarely occur secondary to metabolic diseases or a familial tra... Read More about Bisphosphonates and Risk of Acute Pseudogout: A Case-Control Study in the Clinical Practice Research Datalink (CPRD)..

The association between GP consultations for non-specific physical symptoms in children and parents: a case-control study (2014)
Journal Article

BACKGROUND: Non-specific physical symptoms (NSPS) such as abdominal pain, headache and musculoskeletal pain are widespread in the community, and are common reasons for visiting a general practitioner (GP). Causes of NSPS are multifactorial, but may i... Read More about The association between GP consultations for non-specific physical symptoms in children and parents: a case-control study.

O22. Widespread and Regional Pain Predict Social Participation Restriction in Older Adults: A Prospective Cohort Study (2013)
Presentation / Conference

Background: In older people maintaining social participation (a measure of social function and social roles, such as being a worker, carer or community member), is associated with reduced morbidity and mortality. Social participation restriction resu... Read More about O22. Widespread and Regional Pain Predict Social Participation Restriction in Older Adults: A Prospective Cohort Study.