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Melanie Holden's Outputs (89)

Individual participant data meta‐analysis to examine linear or non‐linear treatment‐covariate interactions at multiple time‐points for a continuous outcome (2024)
Journal Article
Hattle, M., Ensor, J., Scandrett, K., van Middelkoop, M., van der Windt, D. A., Holden, M. A., & Riley, R. D. (2024). Individual participant data meta‐analysis to examine linear or non‐linear treatment‐covariate interactions at multiple time‐points for a continuous outcome. Research Synthesis Methods, https://doi.org/10.1002/jrsm.1750

Individual participant data (IPD) meta‐analysis projects obtain, harmonise, and synthesise original data from multiple studies. Many IPD meta‐analyses of randomised trials are initiated to identify treatment effect modifiers at the individual level,... Read More about Individual participant data meta‐analysis to examine linear or non‐linear treatment‐covariate interactions at multiple time‐points for a continuous outcome.

Knee braces for knee osteoarthritis: A scoping review and narrative synthesis of interventions in randomised controlled trials (2024)
Journal Article
Holden, M. A., Murphy, M., Simkins, J., Thomas, M. J., Huckfield, L., Quicke, J. G., …Peat, G. (2024). Knee braces for knee osteoarthritis: A scoping review and narrative synthesis of interventions in randomised controlled trials. Osteoarthritis and Cartilage, https://doi.org/10.1016/j.joca.2024.08.010

Objective
To identify and synthesise the content of knee bracing interventions in randomised controlled trials (RCTs) of knee osteoarthritis (OA).

Design
In this scoping review, three electronic databases (PubMed, Web of Science, Cochrane) were... Read More about Knee braces for knee osteoarthritis: A scoping review and narrative synthesis of interventions in randomised controlled trials.

People with short symptom duration of knee osteoarthritis benefit more from exercise therapy than people with longer symptom duration: An individual participant data meta-analysis from the OA trial bank. (2024)
Journal Article
van Middelkoop, M., Schiphof, D., Middelkoop M, V., Hattle, M., D, S., Simkins, J., …SMA, B.-Z. (2024). People with short symptom duration of knee osteoarthritis benefit more from exercise therapy than people with longer symptom duration: An individual participant data meta-analysis from the OA trial bank. Osteoarthritis and Cartilage, https://doi.org/10.1016/j.joca.2024.07.007

To investigate whether duration of knee symptoms influenced the magnitude of the effect of exercise therapy compared to non-exercise control interventions on pain and physical function in people with knee osteoarthritis (OA). We undertook an individu... Read More about People with short symptom duration of knee osteoarthritis benefit more from exercise therapy than people with longer symptom duration: An individual participant data meta-analysis from the OA trial bank..

Exploring Experiences of People With Knee Osteoarthritis Who Received a Physiotherapist-Delivered Dietary Weight Loss and Exercise Intervention: A Mixed Methods Study. (2024)
Journal Article
Lawford, B. J., Allison, K., Nelligan, R., Campbell, P., Hinman, R. S., Jones, S. E., …Bennell, K. L. (2024). Exploring Experiences of People With Knee Osteoarthritis Who Received a Physiotherapist-Delivered Dietary Weight Loss and Exercise Intervention: A Mixed Methods Study. Arthritis Care & Research, https://doi.org/10.1002/acr.25401

Explore the experiences of people with knee osteoarthritis who received a very low energy diet (VLED) and exercise program from a physiotherapist. Mixed methods study involving questionnaires (n=42) and semi-structured interviews (n=22) with randomiz... Read More about Exploring Experiences of People With Knee Osteoarthritis Who Received a Physiotherapist-Delivered Dietary Weight Loss and Exercise Intervention: A Mixed Methods Study..

Alternative models to support weight loss in chronic musculoskeletal conditions: effectiveness of a physiotherapist-delivered intensive diet programme for knee osteoarthritis, the POWER randomised controlled trial (2024)
Journal Article
Allison, K., Jones, S., Hinman, R. S., Pardo, J., Li, P., DeSilva, A., …Bennell, K. L. (2024). Alternative models to support weight loss in chronic musculoskeletal conditions: effectiveness of a physiotherapist-delivered intensive diet programme for knee osteoarthritis, the POWER randomised controlled trial. British Journal of Sports Medicine, 58(10), 538-547. https://doi.org/10.1136/bjsports-2023-107793

Objectives: To determine if physiotherapists can deliver a clinically effective very low energy diet (VLED) supplementary to exercise in people with knee osteoarthritis (OA) and overweight or obesity.

Methods: 88 participants with knee OA and bod... Read More about Alternative models to support weight loss in chronic musculoskeletal conditions: effectiveness of a physiotherapist-delivered intensive diet programme for knee osteoarthritis, the POWER randomised controlled trial.

818 NEITHER ANALYSIS APPROACH NOR RISK OF BIAS EXPLAIN THE LIMITED OVERALL BENEFIT OF THERAPEUTIC EXERCISE FOR KNEE AND/OR HIP OSTEOARTHRITIS IN INDIVIDUAL PARTICIPANT DATA META-ANALYSIS (2024)
Presentation / Conference
Runhaar, J., Holden, M., Hattle, M., Quicke, J., Healey, E. L., van der Windt, D., …Foster, N. (2024, April). 818 NEITHER ANALYSIS APPROACH NOR RISK OF BIAS EXPLAIN THE LIMITED OVERALL BENEFIT OF THERAPEUTIC EXERCISE FOR KNEE AND/OR HIP OSTEOARTHRITIS IN INDIVIDUAL PARTICIPANT DATA META-ANALYSIS. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

783 FEASIBILITY OF A COMORBIDITY-TAILORED EXERCISE AND EDUCATION INTERVENTION FOR PEOPLE AGED 80 YEARS OR OLDER WITH HIP OR KNEE OSTEOARTHRITIS. (2024)
Presentation / Conference
Nicolson, P., Holden, M., Marian, I., Saeedi, E., Williamson, E., Hopewell, S., & Lamb, S. (2024, April). 783 FEASIBILITY OF A COMORBIDITY-TAILORED EXERCISE AND EDUCATION INTERVENTION FOR PEOPLE AGED 80 YEARS OR OLDER WITH HIP OR KNEE OSTEOARTHRITIS. Poster presented at 24 OARSI World Congress on Osteoarthritis, Vienna, Austria

768 STAKEHOLDER CO-DESIGN OF AN EXTENDED COMMUNITY PHARMACY ROLE AND SERVICE DELIVERY MODEL FOR PROVIDING OSTEOARTHRITS CARE: THE PHARMOA MODEL (2024)
Presentation / Conference
Holden, M., Stanford, C., Simkins, J., Babatunde, O. O., White, S., O'Brien, N., …Healey, E. L. (2024, April). 768 STAKEHOLDER CO-DESIGN OF AN EXTENDED COMMUNITY PHARMACY ROLE AND SERVICE DELIVERY MODEL FOR PROVIDING OSTEOARTHRITS CARE: THE PHARMOA MODEL. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

767 EXPLORING THE POTENTIAL EXTENDED ROLE OF COMMUNITY PHARMACY IN THE MANAGEMENT OF OSTEOARTHRITIS: SURVEYS AND INTERVIEWS WITH COMMUNITY PHARMACY STAFF AND OTHER HEALTHCARE PROFESSIONALS (2024)
Presentation / Conference
Simkins, J., Holden, M., Babatunde, O. O., White, S., Nicholls, E., Long, A., …O'Brien, N. (2024, April). 767 EXPLORING THE POTENTIAL EXTENDED ROLE OF COMMUNITY PHARMACY IN THE MANAGEMENT OF OSTEOARTHRITIS: SURVEYS AND INTERVIEWS WITH COMMUNITY PHARMACY STAFF AND OTHER HEALTHCARE PROFESSIONALS. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

Exploring the potential extended role of community pharmacy in the management of osteoarthritis: A multi‐methods study with pharmacy staff and other healthcare professionals (2024)
Journal Article
Simkins, J., Holden, M. A., Babatunde, O., White, S., Nicholls, E., Long, A., …O’Brien, N. (2024). Exploring the potential extended role of community pharmacy in the management of osteoarthritis: A multi‐methods study with pharmacy staff and other healthcare professionals. Musculoskeletal Care, 22(1), Article e1873. https://doi.org/10.1002/msc.1873

Introduction
Osteoarthritis is the commonest form of chronic joint pain, which patients often self-manage before seeking healthcare advice. Patients frequently seek advice from community pharmacies, and a recent policy has recommended integrating co... Read More about Exploring the potential extended role of community pharmacy in the management of osteoarthritis: A multi‐methods study with pharmacy staff and other healthcare professionals.

Co-development and testing of an extended community pharmacy model of service delivery for managing osteoarthritis: protocol for a sequential, multi-methods study (PharmOA) (2024)
Journal Article
Babatunde, O. O., Cottrell, E., White, S., Chudyk, A., Healey, E. L., Edwards, J., …Holden, M. A. (2024). Co-development and testing of an extended community pharmacy model of service delivery for managing osteoarthritis: protocol for a sequential, multi-methods study (PharmOA). BMC Musculoskeletal Disorders, 25(1), Article 54. https://doi.org/10.1186/s12891-023-07105-2

Background
Osteoarthritis is a common, painful and disabling long-term condition. Delivery of high-quality guideline-informed osteoarthritis care that successfully promotes and maintains supported self-management is imperative. However, osteoarthrit... Read More about Co-development and testing of an extended community pharmacy model of service delivery for managing osteoarthritis: protocol for a sequential, multi-methods study (PharmOA).

The cost-effectiveness of adding an ultrasound corticosteroid and local anaesthetic injection to advice and education for hip osteoarthritis (2023)
Journal Article
Kigozi, J., Oppong, R., Paskins, Z., Bromley, K., Lewis, M., Hughes, G., …Roddy, E. (2023). The cost-effectiveness of adding an ultrasound corticosteroid and local anaesthetic injection to advice and education for hip osteoarthritis. Rheumatology, https://doi.org/10.1093/rheumatology/kead659

Objectives. Evidence for the comparative cost-effectiveness of intra-articular corticosteroid injection in people with hip osteoarthritis (OA) remains unclear. This study investigated the cost-effectiveness of best current treatment (BCT) comprising... Read More about The cost-effectiveness of adding an ultrasound corticosteroid and local anaesthetic injection to advice and education for hip osteoarthritis.

CSP2023: 460 Exploring healthcare professionals' perspectives on how community pharmacy could better support people living with osteoarthritis: A qualitative interview study (2023)
Presentation / Conference
Simkins, J., White, S., Babatunde, O., & Holden, M. (2023, November). CSP2023: 460 Exploring healthcare professionals' perspectives on how community pharmacy could better support people living with osteoarthritis: A qualitative interview study. Poster presented at Chartered Society of Physiotherapy (CSP) 2023 Annual Conference, Birmingham Conference and Events Centre, Hill Street, , Birmingham, B5 4EW

Osteoarthritis (OA) is a highly prevalent and painful condition that is commonly managed in primary care by various healthcare professionals (HCPs), including physiotherapists (1). Community pharmacy staff have transferable skills that make them well... Read More about CSP2023: 460 Exploring healthcare professionals' perspectives on how community pharmacy could better support people living with osteoarthritis: A qualitative interview study.

A new measure of exercise adherence: the ATEMPT (Adherence To Exercise for Musculoskeletal Pain Tool) (2023)
Journal Article
Bailey, D. L., Bishop, A., McCray, G., Foster, N. E., & Holden, M. A. (2023). A new measure of exercise adherence: the ATEMPT (Adherence To Exercise for Musculoskeletal Pain Tool). British Journal of Sports Medicine, 58(2), bjsports-2022-106347. https://doi.org/10.1136/bjsports-2022-106347

Objectives: This study aimed to (1) develop a new measure of adherence to exercise for musculoskeletal (MSK) pain (Adherence To Exercise for Musculoskeletal Pain Tool: ATEMPT) based on previously conceptualised domains of exercise adherence, (2) repo... Read More about A new measure of exercise adherence: the ATEMPT (Adherence To Exercise for Musculoskeletal Pain Tool).

Experiences of living with hip osteoarthritis and of receiving advice, education and ultrasound-guided intra-articular hip injection in the hip injection trial. A qualitative study (2023)
Journal Article
Hawarden, A., Holden, M. A., Paskins, Z., Roddy, E., Mallen, C. D., Liddle, J., …Jinks, C. (2023). Experiences of living with hip osteoarthritis and of receiving advice, education and ultrasound-guided intra-articular hip injection in the hip injection trial. A qualitative study. Musculoskeletal Care, https://doi.org/10.1002/msc.1830

Objectives: The Hip Injection Trial (HIT) compared the effectiveness of adding a single ultrasound-guided intra-articular injection of either corticosteroid and local anaesthetic, or local anaesthetic alone, to advice and education among people with... Read More about Experiences of living with hip osteoarthritis and of receiving advice, education and ultrasound-guided intra-articular hip injection in the hip injection trial. A qualitative study.

Mechanisms of action of therapeutic exercise for knee and hip OA remain a black box phenomenon: an individual patient data mediation study with the OA Trial Bank (2023)
Journal Article
Runhaar, J., A Holden, M., Hattle, M., Quicke, J., Healey, E. L., van der Windt, D., …Menek, M. Y. (2023). Mechanisms of action of therapeutic exercise for knee and hip OA remain a black box phenomenon: an individual patient data mediation study with the OA Trial Bank. RMD Open, 9(3), Article e003220. https://doi.org/10.1136/rmdopen-2023-003220

Objectives: To evaluate mediating factors for the effect of therapeutic exercise on pain and physical function in people with knee/hip osteoarthritis (OA).

Methods: For Subgrouping and TargetEd Exercise pRogrammes for knee and hip OsteoArthritis (... Read More about Mechanisms of action of therapeutic exercise for knee and hip OA remain a black box phenomenon: an individual patient data mediation study with the OA Trial Bank.

Patient Preferences and Osteoarthritis Care: What Do We Know About What Patients Want from Osteoarthritis Treatment? (2023)
Journal Article
Nicolson, P. J. A., & Holden, M. A. (2023). Patient Preferences and Osteoarthritis Care: What Do We Know About What Patients Want from Osteoarthritis Treatment?. Current Treatment Options in Rheumatology, 9(3), 120-131. https://doi.org/10.1007/s40674-023-00208-w

Purpose of review: Patient-centred care for people with osteoarthritis requires shared decision making. Understanding and considering patients’ preferences for osteoarthritis treatments is central to this. In this narrative review, we present an over... Read More about Patient Preferences and Osteoarthritis Care: What Do We Know About What Patients Want from Osteoarthritis Treatment?.

Moderators of the effect of therapeutic exercise for knee and hip osteoarthritis: a systematic review and individual participant data meta-analysis (2023)
Journal Article
Holden, M. A., Hattle, M., Runhaar, J., Riley, R. D., Healey, E. L., Quicke, J., …Exercise Collaborative, O. T. B. (2023). Moderators of the effect of therapeutic exercise for knee and hip osteoarthritis: a systematic review and individual participant data meta-analysis. The Lancet Rheumatology, 5(7), e386-e400. https://doi.org/10.1016/S2665-9913%2823%2900122-4

Background
Many international clinical guidelines recommend therapeutic exercise as a core treatment for knee and hip osteoarthritis. We aimed to identify individual patient-level moderators of the effect of therapeutic exercise for reducing pain an... Read More about Moderators of the effect of therapeutic exercise for knee and hip osteoarthritis: a systematic review and individual participant data meta-analysis.

Improving the Effectiveness of Exercise Therapy for Adults With Knee Osteoarthritis: A Pragmatic Randomized Controlled Trial (BEEP Trial). (2023)
Journal Article
Foster, N. E., Nicholls, E., Holden, M. A., Healey, E. L., Hay, E. M., & trial team, T. B. (2023). Improving the Effectiveness of Exercise Therapy for Adults With Knee Osteoarthritis: A Pragmatic Randomized Controlled Trial (BEEP Trial). Archives of Rehabilitation Research and Clinical Translation, 5(2), Article 100266. https://doi.org/10.1016/j.arrct.2023.100266

To investigate whether knee osteoarthritis (OA) related pain and function can be improved by offering enhanced physical therapist-led exercise interventions. Three-arm prospectively designed pragmatic randomized controlled trial. General practices an... Read More about Improving the Effectiveness of Exercise Therapy for Adults With Knee Osteoarthritis: A Pragmatic Randomized Controlled Trial (BEEP Trial)..

Exercise Therapy Compared To Usual Care In People With Early-Stage Knee Oa: An Individual Patient Data Meta-Analysis From The Oa Trial Bank (2023)
Presentation / Conference
van Middelkoop, M., Schiphof, D., Hattle, M., Simkins, J., Bennell, K., Hinman, R., …Bierma-Zeinstra, S. (2023, March). Exercise Therapy Compared To Usual Care In People With Early-Stage Knee Oa: An Individual Patient Data Meta-Analysis From The Oa Trial Bank. Presented at 2023 OARSI World Congress on Osteoarthritis, Sheraton Denver Downtown Hotel, Denver, USA

what factors require consideration when individualising exercise interventions for people with osteoarthritis? Consensus of experts using a delphi methodology (2023)
Presentation / Conference
Yaseen, K., Zhang, W., Doherty, M., Abhishek, A., Jamtvedt, G., Martinez, M., …Hall, M. (2023, March). what factors require consideration when individualising exercise interventions for people with osteoarthritis? Consensus of experts using a delphi methodology. Poster presented at 2023 OARSI World Congress on Osteoarthritis, Sheraton Denver Downtown Hotel, Denver, USA

Evaluating Osteoarthritis Management Programs: outcome domain recommendations from the OARSI Joint Effort Initiative. (2023)
Journal Article
Allen, K., Huffman, K., Cleveland, R., van der Esch, M., Abbott, J., Abbott, A., …Hinman, R. (2023). Evaluating Osteoarthritis Management Programs: outcome domain recommendations from the OARSI Joint Effort Initiative. Osteoarthritis and Cartilage, 31(7), 954-965. https://doi.org/10.1016/j.joca.2023.02.078

Objective
To develop sets of core and optional recommended domains for describing and evaluating Osteoarthritis Management Programs (OAMPs), with a focus on hip and knee Osteoarthritis (OA).

Design
We conducted a 3-round modified Delphi survey i... Read More about Evaluating Osteoarthritis Management Programs: outcome domain recommendations from the OARSI Joint Effort Initiative..

What should a toolkit to aid the delivery of therapeutic exercise for hip and knee osteoarthritis look like? Qualitative analysis of an international survey of 318 researchers, clinicians, and consumers by the OARSI Rehabilitation Discussion Group (2023)
Journal Article
Holden, M. A., Lawford, B. J., Master, H., Larsen, J. B., Bartholdy, C., Corrigan, P., …White, D. K. (2023). What should a toolkit to aid the delivery of therapeutic exercise for hip and knee osteoarthritis look like? Qualitative analysis of an international survey of 318 researchers, clinicians, and consumers by the OARSI Rehabilitation Discussion Group. Musculoskeletal Care, 21(2), 545-555. https://doi.org/10.1002/msc.1732

BACKGROUND: We aimed to identify important components of, and practical resources relevant for inclusion in, a toolkit to aid exercise delivery for people with hip/knee osteoarthritis. METHOD: An online international multi-disciplinary survey was con... Read More about What should a toolkit to aid the delivery of therapeutic exercise for hip and knee osteoarthritis look like? Qualitative analysis of an international survey of 318 researchers, clinicians, and consumers by the OARSI Rehabilitation Discussion Group.

Conceptualising adherence to exercise for musculoskeletal pain: A concept mapping study (2022)
Journal Article
Bailey, D., Bishop, A., Foster, N. E., & Holden, M. A. (2023). Conceptualising adherence to exercise for musculoskeletal pain: A concept mapping study. Physiotherapy Research International, 28(2), https://doi.org/10.1002/pri.1989

AbstractBackgroundThe concept of adherence to exercise for musculoskeletal (MSK) pain is poorly defined and inadequately measured. This study aimed to, (1) conceptualise adherence to exercise therapy for MSK pain, and (2) identify statements most rep... Read More about Conceptualising adherence to exercise for musculoskeletal pain: A concept mapping study.

Recommendations for the delivery of therapeutic exercise for people with knee and/or hip osteoarthritis. An international consensus study from the OARSI Rehabilitation Discussion Group (2022)
Journal Article
Holden, M., Metcalf, B., Lawford, B., Hinman, R., Boyd, M., Button, K., …Bennell, K. (2023). Recommendations for the delivery of therapeutic exercise for people with knee and/or hip osteoarthritis. An international consensus study from the OARSI Rehabilitation Discussion Group. Osteoarthritis and Cartilage, 31(3), 386-396. https://doi.org/10.1016/j.joca.2022.10.009

Objective
To develop evidence-informed recommendations to support the delivery of best practice therapeutic exercise for people with knee and/or hip osteoarthritis (OA).

Design
A multi-stage, evidence-informed, international multi-disciplinary c... Read More about Recommendations for the delivery of therapeutic exercise for people with knee and/or hip osteoarthritis. An international consensus study from the OARSI Rehabilitation Discussion Group.

Osteoarthritis year in review 2022: rehabilitation (2022)
Journal Article
Holden, M., Nicolson, P., Thomas, M., Corp, N., Hinman, R., & Bennell, K. (2023). Osteoarthritis year in review 2022: rehabilitation. Osteoarthritis and Cartilage, 31(2), 177-186. https://doi.org/10.1016/j.joca.2022.10.004

This year in review presents key highlights from research relating to osteoarthritis (OA) rehabilitation published from the 1st April 2021 to the 18th March 2022. To identify studies for inclusion in the review, an electronic database search was carr... Read More about Osteoarthritis year in review 2022: rehabilitation.

Effectiveness of a telehealth physiotherapist-delivered intensive dietary weight loss program combined with exercise in people with knee osteoarthritis and overweight or obesity: study protocol for the POWER randomized controlled trial. (2022)
Journal Article
Holden. (2022). Effectiveness of a telehealth physiotherapist-delivered intensive dietary weight loss program combined with exercise in people with knee osteoarthritis and overweight or obesity: study protocol for the POWER randomized controlled trial. BMC Musculoskeletal Disorders, 733 - ?. https://doi.org/10.1186/s12891-022-05685-z

BACKGROUND: Obesity is associated with knee osteoarthritis (OA). Weight loss, alongside exercise, is a recommended treatment for individuals with knee OA and overweight/obesity. However, many patients cannot access weight loss specialists such as die... Read More about Effectiveness of a telehealth physiotherapist-delivered intensive dietary weight loss program combined with exercise in people with knee osteoarthritis and overweight or obesity: study protocol for the POWER randomized controlled trial..

Clinical effectiveness of one ultrasound guided intra-articular corticosteroid and local anaesthetic injection in addition to advice and education for hip osteoarthritis (HIT trial): single blind, parallel group, three arm, randomised controlled trial (2022)
Journal Article
Paskins, Z., Bromley, K., Lewis, M., Hughes, G., Hughes, E., Hennings, S., …Mallen, C. D. (2022). Clinical effectiveness of one ultrasound guided intra-articular corticosteroid and local anaesthetic injection in addition to advice and education for hip osteoarthritis (HIT trial): single blind, parallel group, three arm, randomised controlled trial. BMJ, 377, Article ARTN e068446. https://doi.org/10.1136/bmj-2021-068446

Objectives: to compare the clinical effectiveness of best current treatment (BCT) plus single ultrasound-guided intra-articular hip injection (USGI) of 40mg triamcinolone acetonide and 4ml 1% lidocaine hydrochloride [BCT+US-Triamcinolone-Lidocaine] w... Read More about Clinical effectiveness of one ultrasound guided intra-articular corticosteroid and local anaesthetic injection in addition to advice and education for hip osteoarthritis (HIT trial): single blind, parallel group, three arm, randomised controlled trial.

Effects of an Online Education Program on Physical Therapists' Confidence in Weight Management for People With Osteoarthritis: A Randomized Controlled Trial (2021)
Journal Article
Allison, K., Jones, S., Hinman, R. S., Briggs, A. M., Sumithran, P., Quicke, J., …Bennell, K. (2021). Effects of an Online Education Program on Physical Therapists' Confidence in Weight Management for People With Osteoarthritis: A Randomized Controlled Trial. Arthritis Care and Research, 75(4), 835-847. https://doi.org/10.1002/acr.24828

OBJECTIVE: Evaluate effects of an online education program about weight management for osteoarthritis on physiotherapists' self-reported confidence in knowledge and skills in weight management, and attitudes toward obesity.

METHOD: A two-group ran... Read More about Effects of an Online Education Program on Physical Therapists' Confidence in Weight Management for People With Osteoarthritis: A Randomized Controlled Trial.

How does hip osteoarthritis differ from knee osteoarthritis? (2021)
Journal Article
Hall, M., van der Esch, M., Hinman, R., Peat, G., de Zwart, A., Quicke, J., …Bennell, K. (2022). How does hip osteoarthritis differ from knee osteoarthritis?. Osteoarthritis and Cartilage, 30(1), 32-41. https://doi.org/10.1016/j.joca.2021.09.010

Hip and knee osteoarthritis are leading causes of global disability. Most research to date has focused on the knee, with results often extrapolated to the hip, and this extends to treatment recommendations in clinical guidelines. Extrapolating result... Read More about How does hip osteoarthritis differ from knee osteoarthritis?.

Clinical and cost-effectiveness of bracing in symptomatic knee osteoarthritis management: protocol for a multicentre, primary care, randomised, parallel-group, superiority trial. (2021)
Journal Article
Holden, M., Callaghan, M., Felson, D., Birrell, F., Nicholls, E., Jowett, S., …Peat, G. (2021). Clinical and cost-effectiveness of bracing in symptomatic knee osteoarthritis management: protocol for a multicentre, primary care, randomised, parallel-group, superiority trial. BMJ Open, 11(3), Article e048196. https://doi.org/10.1136/bmjopen-2020-048196

BACKGROUND: Brace effectiveness for knee osteoarthritis (OA) remains unclear and international guidelines offer conflicting recommendations. Our trial will determine the clinical and cost-effectiveness of adding knee bracing (matched to patients' cli... Read More about Clinical and cost-effectiveness of bracing in symptomatic knee osteoarthritis management: protocol for a multicentre, primary care, randomised, parallel-group, superiority trial..

Moderators of the effects of therapeutic exercise for people with knee and hip osteoarthritis: A systematic review of sub-group analyses from randomised controlled trials (2020)
Journal Article
Quicke, J., Runhaar, J., Van Der Windt, D., Healey, E., Foster, N., & Holden, M. (2020). Moderators of the effects of therapeutic exercise for people with knee and hip osteoarthritis: A systematic review of sub-group analyses from randomised controlled trials. Osteoarthritis and Cartilage Open, 2(4), Article 100113. https://doi.org/10.1016/j.ocarto.2020.100113

Objective
1) To identify potential moderators of the effect of therapeutic exercise explored in randomised controlled trials (RCTs) of knee and hip osteoarthritis (OA); 2) summarise the extent, strength and quality of evidence reported for moderator... Read More about Moderators of the effects of therapeutic exercise for people with knee and hip osteoarthritis: A systematic review of sub-group analyses from randomised controlled trials.

Guidance for Implementing Best Practice Therapeutic Exercise for Patients With Knee and Hip Osteoarthritis: What Does the Current Evidence Base Tell Us? (2020)
Journal Article
Holden, M. A., Button, K., Collins, N. J., Henrotin, Y., Hinman, R. S., Larsen, J. B., …Bennell, K. (2021). Guidance for Implementing Best Practice Therapeutic Exercise for Patients With Knee and Hip Osteoarthritis: What Does the Current Evidence Base Tell Us?. Arthritis Care and Research, 73(12), 1746-1753. https://doi.org/10.1002/acr.24434

Therapeutic exercise is a recommended first‐line treatment for patients with knee and hip osteoarthritis (OA); however, there is little specific advice or practical resources to guide clinicians in its implementation. As the first in a series of proj... Read More about Guidance for Implementing Best Practice Therapeutic Exercise for Patients With Knee and Hip Osteoarthritis: What Does the Current Evidence Base Tell Us?.

CLINICAL AND COST-EFFECTIVENESS OF ULTRASOUND-GUIDED INTRA-ARTICULAR CORTICOSTEROID AND LOCAL ANAESTHETIC INJECTION FOR HIP OSTEOARTHRITIS: A RANDOMISED CONTROLLED TRIAL (HIT) (2020)
Journal Article
Paskins, Z., Bromley, K., Lewis, M., Hughes, G., Hughes, E., Cherrington, A., …Roddy, E. (2020). CLINICAL AND COST-EFFECTIVENESS OF ULTRASOUND-GUIDED INTRA-ARTICULAR CORTICOSTEROID AND LOCAL ANAESTHETIC INJECTION FOR HIP OSTEOARTHRITIS: A RANDOMISED CONTROLLED TRIAL (HIT). Osteoarthritis and Cartilage, 28(S1), https://doi.org/10.1016/j.joca.2020.02.751

O04 Clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injection for hip OA: a randomised controlled trial (HIT) (2020)
Presentation / Conference
Paskins, Z., Bromley, K., Lewis, M., Hughes, G., Hughes, E., Cherrington, A., …Roddy, E. (2020, April). O04 Clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injection for hip OA: a randomised controlled trial (HIT). Presented at British Society for Rheumatology Annual Conference 2020, Glasgow, Scotland, UK

Background
Evidence of the effectiveness of intra-articular corticosteroid injection for hip osteoarthritis (OA) is limited. The HIT trial compared the clinical and cost-effectiveness of an ultrasound-guided intra-articular hip injection (USGI) of 4... Read More about O04 Clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injection for hip OA: a randomised controlled trial (HIT).

Qualitative findings from the Hip Injection Trial (HIT): experiences of living with hip osteoarthritis and receiving trial treatments (2020)
Journal Article
Paskins, Holden, Mallen, Jinks, Hawarden, & Roddy. (2020). Qualitative findings from the Hip Injection Trial (HIT): experiences of living with hip osteoarthritis and receiving trial treatments. Rheumatology, https://doi.org/10.1093/rheumatology/keaa111.125

Background
The HIT trial compared ultrasound-guided intra-articular hip injection (USGI) of triamcinolone acetonide and 1% lidocaine hydrochloride combined with best current treatment (BCT) with (i) BCT alone and (ii) an USGI of 1% lidocaine only co... Read More about Qualitative findings from the Hip Injection Trial (HIT): experiences of living with hip osteoarthritis and receiving trial treatments.

The hip injection trial (HIT) nested qualitative study: experiences of living with hip Osteoarthritis and receiving trial treatments. (2020)
Journal Article
Holden, M., Hawarden, A., Paskins, Z., Roddy, E., Mallen, C., Jinks, C., & Trial Team, T. H. (2020). The hip injection trial (HIT) nested qualitative study: experiences of living with hip Osteoarthritis and receiving trial treatments. Osteoarthritis and Cartilage, 28, S499. https://doi.org/10.1016/j.joca.2020.02.782

Purpose: Evidence about the effectiveness of intra-articular corticosteroid injection for hip osteoarthritis (OA) is limited. The HIT trial compared ultrasound-guided intra-articular hip injection (USGI) of triamcinolone acetonide and 1% lidocaine hy... Read More about The hip injection trial (HIT) nested qualitative study: experiences of living with hip Osteoarthritis and receiving trial treatments..

Moderators of the effects of exercise for hip and knee osteoarthritis: a systematic review of subgroup analyses from randomised controlled trials (2020)
Journal Article
Van Der Windt, Healey, & Holden. (2020). Moderators of the effects of exercise for hip and knee osteoarthritis: a systematic review of subgroup analyses from randomised controlled trials. Osteoarthritis and Cartilage, https://doi.org/10.1016/j.joca.2020.02.263

Meta-analyses of randomised controlled trials (RCTs) of exercise interventions in people with knee and hip osteoarthritis (OA) provide strong evidence of, on average, a small-to-medium effect on pain and function outcomes compared to comparison inter... Read More about Moderators of the effects of exercise for hip and knee osteoarthritis: a systematic review of subgroup analyses from randomised controlled trials.

Use of the nominal group technique to identify UK stakeholder views of the measures and domains used in the assessment of therapeutic exercise adherence for patients with musculoskeletal disorders (2020)
Journal Article
Holden, M. (2020). Use of the nominal group technique to identify UK stakeholder views of the measures and domains used in the assessment of therapeutic exercise adherence for patients with musculoskeletal disorders. BMJ Open, e031591 - ?. https://doi.org/10.1136/+bmjopen-2019-031591

OBJECTIVES: The objective was to the undertake nominal group technique (NGT) to evaluate current exercise adherence measures and isolated domains to develop stakeholder consensus on the domains to include in the measurement of therapeutic exercise ad... Read More about Use of the nominal group technique to identify UK stakeholder views of the measures and domains used in the assessment of therapeutic exercise adherence for patients with musculoskeletal disorders.

Use of the nominal group technique to identify UK stakeholder views of the measures and domains used in the assessment of therapeutic exercise adherence for patients with musculoskeletal disorders. (2020)
Journal Article
Mallett, R., McLean, S., Holden, M. A., Potia, T., Gee, M., & Haywood, K. (2020). Use of the nominal group technique to identify UK stakeholder views of the measures and domains used in the assessment of therapeutic exercise adherence for patients with musculoskeletal disorders. BMJ Open, 10(2), https://doi.org/10.1136/bmjopen-2019-031591

Objectives The objective was to the undertake nominal group technique (NGT) to evaluate current exercise adherence measures and isolated domains to develop stakeholder consensus on the domains to include in the measurement of therapeutic exercise adh... Read More about Use of the nominal group technique to identify UK stakeholder views of the measures and domains used in the assessment of therapeutic exercise adherence for patients with musculoskeletal disorders..

Do comorbidities predict pain and function in knee osteoarthritis following an exercise intervention, and do they moderate the effect of exercise? Analyses of data from three randomized controlled trials. (2019)
Journal Article
Legha, A., Burke, D. L., Foster, N. E., Van Der Windt, D. A., Quicke, J. G., Healey, E. L., …Holden, M. A. (2020). Do comorbidities predict pain and function in knee osteoarthritis following an exercise intervention, and do they moderate the effect of exercise? Analyses of data from three randomized controlled trials. Musculoskeletal Care, 18(1), 3-11. https://doi.org/10.1002/msc.1425

BACKGROUND: Although exercise is a core treatment for people with knee osteoarthritis (OA), it is currently unknown whether those with additional comorbidities respond differently to exercise than those without. We explored whether comorbidities pred... Read More about Do comorbidities predict pain and function in knee osteoarthritis following an exercise intervention, and do they moderate the effect of exercise? Analyses of data from three randomized controlled trials..

Therapeutic alliance facilitates adherence to physiotherapy-led exercise and physical activity for older adults with knee pain: a longitudinal qualitative study (2019)
Journal Article
Moore, A. J., Holden, M. A., Foster, N. E., & Jinks, C. (2020). Therapeutic alliance facilitates adherence to physiotherapy-led exercise and physical activity for older adults with knee pain: a longitudinal qualitative study. Journal of Physiotherapy, 66(1), 45-53. https://doi.org/10.1016/j.jphys.2019.11.004

Objectives: To investigate patients’ experiences and impact of physiotherapist (physical therapist) led exercise interventions for knee pain attributable to osteoarthritis, and to explore barriers and facilitators to change in exercise and physical a... Read More about Therapeutic alliance facilitates adherence to physiotherapy-led exercise and physical activity for older adults with knee pain: a longitudinal qualitative study.

Clinical Effectiveness of Ultrasound-guided Intra-articular Corticosteroid and Local Anaesthetic Injections for Hip Osteoarthritis: A Randomised Controlled Trial (HIT) (2019)
Presentation / Conference
Paskins, Z., Bromley, K., Lewis, M., Hughes, G., Hughes, E., Cherrington, A., …Roddy, E. (2019, November). Clinical Effectiveness of Ultrasound-guided Intra-articular Corticosteroid and Local Anaesthetic Injections for Hip Osteoarthritis: A Randomised Controlled Trial (HIT). Paper presented at 2019 ACR/ARP Annual Meeting, Atlanta, GA, USA

Background/Purpose: Evidence of the effectiveness of intra-articular corticosteroid injection for hip osteoarthritis (OA) is limited and conflicting. The HIT trial compared the clinical effectiveness of an ultrasound-guided intra-articular hip inject... Read More about Clinical Effectiveness of Ultrasound-guided Intra-articular Corticosteroid and Local Anaesthetic Injections for Hip Osteoarthritis: A Randomised Controlled Trial (HIT).

Priorities for the effective implementation of osteoarthritis management programs: an OARSI international consensus exercise (2019)
Journal Article
Eyles, J. P., Hunter, D. J., Bennell, K. L., Dziedzic, K. S., Hinman, R. S., van der Esch, M., …Jinks, C. (2019). Priorities for the effective implementation of osteoarthritis management programs: an OARSI international consensus exercise. Osteoarthritis and Cartilage, 27(9), 1270-1279. https://doi.org/10.1016/j.joca.2019.05.015

Objective
The Joint Effort Initiative was endorsed by Osteoarthritis Research Society International (OARSI) in 2018 as a collaboration between international researchers and clinicians with an interest in the implementation of osteoarthritis manageme... Read More about Priorities for the effective implementation of osteoarthritis management programs: an OARSI international consensus exercise.

How do UK physiotherapists address weight loss among individuals with hip osteoarthritis? A mixed-methods study (2019)
Journal Article
Holden, M. A., Waterfield, J., Whittle, R., Bennell, K., Quicke, J. G., Chesterton, L., & Mallen, C. (2019). How do UK physiotherapists address weight loss among individuals with hip osteoarthritis? A mixed-methods study. Musculoskeletal Care, 17(1), 133-144. https://doi.org/10.1002/msc.1383

BACKGROUND
Weight loss is recommended as a core treatment for individuals with hip osteoarthritis who are overweight or obese. Physiotherapists play an important role in managing patients with hip osteoarthritis, but little is known about how they a... Read More about How do UK physiotherapists address weight loss among individuals with hip osteoarthritis? A mixed-methods study.

Identification and Evaluation of Self-Report Physical Activity Instruments in Adults With Osteoarthritis: A Systematic Review (2018)
Journal Article
Dziedzic, K., Holden, M., & Healey, E. L. (2019). Identification and Evaluation of Self-Report Physical Activity Instruments in Adults With Osteoarthritis: A Systematic Review. Arthritis Care and Research, 71(2), 237-251. https://doi.org/10.1002/acr.23787

OBJECTIVE
To identify and evaluate the measurement properties of self-report physical activity (PA) instruments suitable for those with osteoarthritis (OA).

METHODS
A comprehensive two-stage systematic review using multiple electronic databases... Read More about Identification and Evaluation of Self-Report Physical Activity Instruments in Adults With Osteoarthritis: A Systematic Review.

A mixed methods exploration of physiotherapist's approaches to analgesic use among patients with hip osteoarthritis. (2018)
Journal Article
Holden, M., Whittle, R., Waterfield, J., Chesterton, L., Cottrell, E., Quicke, J., & Mallen, C. (2019). A mixed methods exploration of physiotherapist's approaches to analgesic use among patients with hip osteoarthritis. Physiotherapy, 105(3), 328 - 337. https://doi.org/10.1016/j.physio.2018.08.003

OBJECTIVE: To explore how physiotherapists currently address analgesic use among patients with hip osteoarthritis, and their beliefs about the acceptability of prescribing for these patients. METHODS: A cross-sectional questionnaire was mailed to 312... Read More about A mixed methods exploration of physiotherapist's approaches to analgesic use among patients with hip osteoarthritis..

A randomised controlled trial of the clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injections: the hip injection trial (HIT) protocol (2018)
Journal Article
Paskins, Z., Hughes, G., Myers, H., Hughes, E., Hennings, S., Cherrington, A., …Roddy, E. (2018). A randomised controlled trial of the clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injections: the hip injection trial (HIT) protocol. BMC Musculoskeletal Disorders, 19, Article 218. https://doi.org/10.1186/s12891-018-2153-0

BACKGROUND: Evidence on the effectiveness of intra-articular corticosteroid injection for hip osteoarthritis is limited and conflicting. The primary objective of the Hip Injection Trial (HIT) is to compare pain intensity over 6 months, in people with... Read More about A randomised controlled trial of the clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injections: the hip injection trial (HIT) protocol.

Optimal primary care management of clinical osteoarthritis and joint pain in older people: a mixed-methods programme of systematic reviews, observational and qualitative studies, and randomised controlled trials (2018)
Report
Hay, E., Dziedzic, K., Foster, N., Peat, G., van der Windt, D., Bartlam, B., …Croft, P. (2018). Optimal primary care management of clinical osteoarthritis and joint pain in older people: a mixed-methods programme of systematic reviews, observational and qualitative studies, and randomised controlled trials. NIHR. PGfAR as project number RP-PG-0407-10386. Secretary of State for Health and Social Care

<jats:sec id="abs1-1"> <jats:title>Background</jats:title> <jats:p>Osteoarthritis (OA) is the most common long-term condition managed in UK general practice. However, care is suboptimal despite evidence that primary care and community-based intervent... Read More about Optimal primary care management of clinical osteoarthritis and joint pain in older people: a mixed-methods programme of systematic reviews, observational and qualitative studies, and randomised controlled trials.

Defining adherence to therapeutic exercise for musculoskeletal pain: A systematic review (2018)
Journal Article
Holden, M. (2018). Defining adherence to therapeutic exercise for musculoskeletal pain: A systematic review. British Journal of Sports Medicine, 326-331. https://doi.org/10.1136/bjsports-2017-098742

Objective: To establish the meaning of the term ‘adherence’ (including conceptual and measurement definitions) in the context of therapeutic exercise (TE) for musculoskeletal (MSK) pain.

Design: Systematic review using a search strategy including... Read More about Defining adherence to therapeutic exercise for musculoskeletal pain: A systematic review.

Cost-utility analysis of interventions to improve effectiveness of exercise therapy for adults with knee osteoarthritis: the BEEP trial. (2018)
Journal Article
Kigozi, J., Jowett, S., Nicholls, E., Tooth, S., Hay, E., Foster, N. E., & Holden, M. (2018). Cost-utility analysis of interventions to improve effectiveness of exercise therapy for adults with knee osteoarthritis: the BEEP trial. Rheumatology Advances in Practice, rky018 - ?. https://doi.org/10.1093/rap/rky018

Objectives: Evidence regarding the cost-effectiveness of enhancing physical therapy exercise programmes in order to improve outcomes for patients with knee OA remains unclear. This study investigates the cost-effectiveness of two enhanced physical th... Read More about Cost-utility analysis of interventions to improve effectiveness of exercise therapy for adults with knee osteoarthritis: the BEEP trial..

How Do Physical Therapists in the United Kingdom Manage Patients With Hip Osteoarthritis? Results of a Cross-Sectional Survey (2018)
Journal Article
Mallen, C., & Holden, M. (2018). How Do Physical Therapists in the United Kingdom Manage Patients With Hip Osteoarthritis? Results of a Cross-Sectional Survey. Physical Therapy, 461-470. https://doi.org/10.1093/ptj/pzy013

Background: Hip osteoarthritis (OA) is common, painful and disabling. Physical therapists have an important role in managing patients with hip OA, however little is known about their current management approach and whether it aligns with clinical gui... Read More about How Do Physical Therapists in the United Kingdom Manage Patients With Hip Osteoarthritis? Results of a Cross-Sectional Survey.

Change in physical activity level and clinical outcomes in older adults with knee pain: a secondary analysis from a randomised controlled trial (2018)
Journal Article
Holden. (2018). Change in physical activity level and clinical outcomes in older adults with knee pain: a secondary analysis from a randomised controlled trial. BMC Musculoskeletal Disorders, https://doi.org/10.1186/s12891-018-1968-z

Background
Exercise interventions improve clinical outcomes of pain and function in adults with knee pain due to osteoarthritis and higher levels of physical activity are associated with lower severity of pain and higher levels of physical functioni... Read More about Change in physical activity level and clinical outcomes in older adults with knee pain: a secondary analysis from a randomised controlled trial.

Subgrouping and TargetEd Exercise pRogrammes for knee and hip OsteoArthritis (STEER OA): a systematic review update and individual participant data meta-analysis protocol. (2017)
Journal Article
Van Der Windt, Holden, & Dziedzic. (2017). Subgrouping and TargetEd Exercise pRogrammes for knee and hip OsteoArthritis (STEER OA): a systematic review update and individual participant data meta-analysis protocol. BMJ Open, e018971 - ?. https://doi.org/10.1136/bmjopen-2017-018971

INTRODUCTION: Knee and hip osteoarthritis (OA) is a leading cause of disability worldwide. Therapeutic exercise is a recommended core treatment for people with knee and hip OA, however, the observed effect sizes for reducing pain and improving physic... Read More about Subgrouping and TargetEd Exercise pRogrammes for knee and hip OsteoArthritis (STEER OA): a systematic review update and individual participant data meta-analysis protocol..

Attitudes, beliefs and common practices of hand therapists for base of thumb osteoarthritis in Australia (The ABC Thumb Study) (2017)
Journal Article
Duong, V., Bennell, K. L., Deveza, L. A., Eyles, J. P., Hodges, P. W., Holden, M. A., …Robbins, S. R. (2018). Attitudes, beliefs and common practices of hand therapists for base of thumb osteoarthritis in Australia (The ABC Thumb Study). Hand Therapy, 23(1), 19-27. https://doi.org/10.1177/1758998317731437

Introduction
The purpose of this study was to identify attitudes, beliefs and common practices of hand therapists in Australia regarding assessment and management of base of thumb osteoarthritis.
Methods
Monthly emails with a link to a 57-item cro... Read More about Attitudes, beliefs and common practices of hand therapists for base of thumb osteoarthritis in Australia (The ABC Thumb Study).

Quality and acceptability of measures of exercise adherence in musculoskeletal settings: a systematic review. (2016)
Journal Article
McLean, S., Holden, M. A., Potia, T., Gee, M., Mallett, R., Bhanbhro, S., …Haywood, K. (2016). Quality and acceptability of measures of exercise adherence in musculoskeletal settings: a systematic review. Rheumatology, 426-438. https://doi.org/10.1093/rheumatology/kew422

OBJECTIVE: To recommend robust and relevant measures of exercise adherence for application in the musculoskeletal field. METHOD: A systematic review of measures was conducted in two phases. Phase 1 sought to identify all reproducible measures used to... Read More about Quality and acceptability of measures of exercise adherence in musculoskeletal settings: a systematic review..

Evaluating acupuncture and standard care for pregnant women and back pain: the EASE back pilot randomised controlled trial ((ISRCTN49955124) (2016)
Journal Article
Bishop, A., Ogollah, R., Bartlam, B., Barlas, P., Holden, M. A., Ismail, K. M., …Foster, N. E. (2016). Evaluating acupuncture and standard care for pregnant women and back pain: the EASE back pilot randomised controlled trial ((ISRCTN49955124). Pilot and Feasibility Studies, 2, Article 72. https://doi.org/10.1186/s40814-016-0107-6

Background
Low back pain (LBP) and pelvic girdle pain (PGP) during pregnancy are common and often accepted as a ‘normal’ part of pregnancy. Many women receive little in the way of treatment, and yet pain interferes with sleep, daily activities and w... Read More about Evaluating acupuncture and standard care for pregnant women and back pain: the EASE back pilot randomised controlled trial ((ISRCTN49955124).

Content and Evaluation of the Benefits of Effective Exercise for Older Adults With Knee Pain Trial Physiotherapist Training Program (2016)
Journal Article
Holden, M. A., Whittle, R., Healey, E. L., Hill, S., Mullis, R., Roddy, E., …Foster, N. E. (2017). Content and Evaluation of the Benefits of Effective Exercise for Older Adults With Knee Pain Trial Physiotherapist Training Program. Archives of Physical Therapy and Rehabilitation, 98(5), https://doi.org/10.1016/j.apmr.2016.10.017

Objective
To explore whether participating in the Benefits of Effective Exercise for knee Pain (BEEP) trial training program increased physiotherapists' self-confidence and changed their intended clinical behavior regarding exercise for knee pain in... Read More about Content and Evaluation of the Benefits of Effective Exercise for Older Adults With Knee Pain Trial Physiotherapist Training Program.

Content and evaluation of the Benefits of Effective Exercise for Older Adults with Knee Pain trial physiotherapist training programme (2016)
Journal Article
Holden, Roddy, & Healey. (2016). Content and evaluation of the Benefits of Effective Exercise for Older Adults with Knee Pain trial physiotherapist training programme. Archives of Physical Medicine and Rehabilitation, 866-873. https://doi.org/10.1016/j.apmr.2016.10.017

Objective
To explore whether participating in the Benefits of Effective Exercise for knee Pain (BEEP) trial training program increased physiotherapists' self-confidence and changed their intended clinical behavior regarding exercise for knee pain in... Read More about Content and evaluation of the Benefits of Effective Exercise for Older Adults with Knee Pain trial physiotherapist training programme.

Content and Evaluation of the Benefits of Effective Exercise for Older Adults With Knee Pain Trial Physiotherapist Training Program (2016)
Journal Article
Holden, M. A., Whittle, R., Healey, E. L., Hill, S., Mullis, R., Roddy, E., …Foster, N. E. (2017). Content and Evaluation of the Benefits of Effective Exercise for Older Adults With Knee Pain Trial Physiotherapist Training Program. Archives of Physical Medicine and Rehabilitation, 98(5), 866-873. https://doi.org/10.1016/j.apmr.2016.10.017

Objective
To explore whether participating in the Benefits of Effective Exercise for knee Pain (BEEP) trial training program increased physiotherapists' self-confidence and changed their intended clinical behavior regarding exercise for knee pain in... Read More about Content and Evaluation of the Benefits of Effective Exercise for Older Adults With Knee Pain Trial Physiotherapist Training Program.

Relationship between attitudes, beliefs and physical activity in older adults with knee pain: secondary analysis of a randomised controlled trial (2016)
Journal Article
Quicke, J. G., Foster, N. E., Ogollah, R. O., Croft, P. R., & Holden, M. (2016). Relationship between attitudes, beliefs and physical activity in older adults with knee pain: secondary analysis of a randomised controlled trial. Arthritis Care and Research, 1192-2000. https://doi.org/10.1002/acr.23104

Objective
To investigate how attitudes and beliefs about exercise relate to physical activity behavior in older adults with knee pain attributable to osteoarthritis (OA).

Methods
We conducted secondary data analyses of a randomized controlled tr... Read More about Relationship between attitudes, beliefs and physical activity in older adults with knee pain: secondary analysis of a randomised controlled trial.

The Role of Qualitative Research in Clinical Trial Development: The EASE Back Study (2016)
Journal Article
Holden. (2016). The Role of Qualitative Research in Clinical Trial Development: The EASE Back Study. Journal of Mixed Methods Research, 325-343. https://doi.org/10.1177/1558689816656740

This article outlines the rationale for adopting a mixed methods approach within randomized controlled trials (RCTs) and explores challenges associated in doing so. Taking the example of the EASE Back feasibility and pilot study (Evaluating Acupunctu... Read More about The Role of Qualitative Research in Clinical Trial Development: The EASE Back Study.

Evaluating Acupuncture and Standard carE for pregnant women with Back pain (EASE Back): a feasibility study and pilot randomised trial. (2016)
Journal Article
Foster, N. E., Bishop, A., Bartlam, B., Ogollah, R., Barlas, P., Holden, M., …Young, J. (2016). Evaluating Acupuncture and Standard carE for pregnant women with Back pain (EASE Back): a feasibility study and pilot randomised trial. Health Technology Assessment, 20(33), 1 - 236. https://doi.org/10.3310/hta20330

BACKGROUND: Many pregnant women experience low back pain. Acupuncture appears to be a safe, promising intervention but evidence is needed about its clinical effectiveness and cost-effectiveness. OBJECTIVES: To assess the feasibility of a future large... Read More about Evaluating Acupuncture and Standard carE for pregnant women with Back pain (EASE Back): a feasibility study and pilot randomised trial..

Barriers and Facilitators to Exercise Participation in People with Hip and/or Knee Osteoarthritis: Synthesis of the Literature Using Behavior Change Theory. (2016)
Journal Article
Holden, M. (2016). Barriers and Facilitators to Exercise Participation in People with Hip and/or Knee Osteoarthritis: Synthesis of the Literature Using Behavior Change Theory. American Journal of Physical Medicine & Rehabilitation, 372 - 389. https://doi.org/10.1097/PHM.0000000000000448

Exercise is recommended for hip and knee osteoarthritis (OA). Patient initiation of, and adherence to, exercise is key to the success of managing symptoms. This study aimed to (1) identify modifiable barriers and facilitators to participation in inte... Read More about Barriers and Facilitators to Exercise Participation in People with Hip and/or Knee Osteoarthritis: Synthesis of the Literature Using Behavior Change Theory..

THU0457 Long Term Barriers and Facilitators to Exercise and Physical Activity in Older Adults with Knee Pain: The Beep Longitudinal Qualitative Study (2015)
Presentation / Conference
Jinks, C., Moore, A., Holden, M., & Foster, N. (2015, June). THU0457 Long Term Barriers and Facilitators to Exercise and Physical Activity in Older Adults with Knee Pain: The Beep Longitudinal Qualitative Study. Poster presented at EULAR 2015 - Annual European Congress of Rheumatology, Rome, Italy

Background Exercise is recommended for managing older adults with osteoarthritis (OA) related knee pain. However, the majority of older adults with OA do not meet physical activity recommendations. It remains unclear how exercise is best delivered to... Read More about THU0457 Long Term Barriers and Facilitators to Exercise and Physical Activity in Older Adults with Knee Pain: The Beep Longitudinal Qualitative Study.

OP0105 Improving the Effectiveness of Exercise Therapy for Older Adults with Knee Osteoarthritis: A Pragmatic Randomised Controlled Trial (The Beep Trial) (2015)
Journal Article
Foster, N., Nicholls, E., Holden, M., Healey, E., Kigozi, J., Jowett, S., …Hay, E. (2015). OP0105 Improving the Effectiveness of Exercise Therapy for Older Adults with Knee Osteoarthritis: A Pragmatic Randomised Controlled Trial (The Beep Trial). Annals of the Rheumatic Diseases, 74(Suppl 2), 108.2-108. https://doi.org/10.1136/annrheumdis-2015-eular.1454

Is long term physical activity safe for older adults with knee pain: a systematic review (2015)
Journal Article
Quicke, J., Foster, N., Thomas, M., & Holden, M. (2015). Is long term physical activity safe for older adults with knee pain: a systematic review. Osteoarthritis and Cartilage, 23(9), 1445-1456. https://doi.org/10.1016/j.joca.2015.05.002

Objective
To determine whether long-term physical activity is safe for older adults with knee pain.

Design
A comprehensive systematic review and narrative synthesis of existing literature was conducted using multiple electronic databases from in... Read More about Is long term physical activity safe for older adults with knee pain: a systematic review.

Content and evaluation of the BEEP trial (Benefits of Effective Exercise for Knee Pain) physical therapist training programme: did it change clinical practice? (2014)
Journal Article
Holden, M., Case, R., Healey, E., Hill, S., Mullis, R., Roddy, E., …Foster, N. (2014). Content and evaluation of the BEEP trial (Benefits of Effective Exercise for Knee Pain) physical therapist training programme: did it change clinical practice?. Osteoarthritis and Cartilage, 22, S201-S202. https://doi.org/10.1016/j.joca.2014.02.385

SAT0344 Measurement Properties of Self-Reported Physical Activity Instruments Suitable for Osteoarthritis (OA) or Joint Pain Populations: A Systematic Review. (2013)
Journal Article
Smith, R. D., Healey, E. L., McHugh, G. A., Holden, M. A., & Dziedzic, K. S. (2013). SAT0344 Measurement Properties of Self-Reported Physical Activity Instruments Suitable for Osteoarthritis (OA) or Joint Pain Populations: A Systematic Review. Annals of the Rheumatic Diseases, 72(Suppl 3), A700.1-A700. https://doi.org/10.1136/annrheumdis-2013-eular.2069