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Christian Mallen's Outputs (558)

Pharmacological pain management in patients with rheumatoid arthritis: a narrative literature review (2025)
Journal Article
Cox, N., Mallen, C. D., & Scott, I. C. (in press). Pharmacological pain management in patients with rheumatoid arthritis: a narrative literature review. BMC Medicine, 23(1), Article 54. https://doi.org/10.1186/s12916-025-03870-0

Background: Pain is a major challenge for patients with rheumatoid arthritis (RA), with many people suffering chronic pain. Current RA management guidelines focus on assessing and reducing disease activity using disease-modifying anti-rheumatic drugs... Read More about Pharmacological pain management in patients with rheumatoid arthritis: a narrative literature review.

Monitoring for 5-aminosalicylate nephrotoxicity in adults with inflammatory bowel disease: prognostic model development and validation using data from the Clinical Practice Research Datalink (2025)
Journal Article
Abhishek, A., Nakafero, G., Card, T., Taal, M. W., Grainge, M. J., Aithal, G. P., …Riley, R. D. (2025). Monitoring for 5-aminosalicylate nephrotoxicity in adults with inflammatory bowel disease: prognostic model development and validation using data from the Clinical Practice Research Datalink. BMJ Open Gastroenterology, 12(1), https://doi.org/10.1136/bmjgast-2024-001627

Objective: To develop and validate a prognostic model for risk-stratified monitoring of 5-aminosalicylate nephrotoxicity. Methods: This UK retrospective cohort study used data from the Clinical Practice Research Datalink Aurum and Gold for model deve... Read More about Monitoring for 5-aminosalicylate nephrotoxicity in adults with inflammatory bowel disease: prognostic model development and validation using data from the Clinical Practice Research Datalink.

OP0074 MULTIMORBIDITY CLUSTERS, DETERMINANTS AND TRAJECTORIES IN OSTEOARTHRITIS IN THE UK: FINDINGS FROM THE CLINICAL PRACTICE RESEARCH DATALINK (2025)
Journal Article
Swain, S., Coupland, C., Strauss, V., Mallen, C., Kuo, C., Sarmanova, A., …Zhang, W. (in press). OP0074 MULTIMORBIDITY CLUSTERS, DETERMINANTS AND TRAJECTORIES IN OSTEOARTHRITIS IN THE UK: FINDINGS FROM THE CLINICAL PRACTICE RESEARCH DATALINK. Annals of the Rheumatic Diseases, 79, 49-50. https://doi.org/10.1136/annrheumdis-2020-eular.1488

Background:
Multimorbidity (≥2 chronic conditions) escalates the risk of adverse health outcomes. However, its burden in people with osteoarthritis (OA) remains largely unknown.... Read More about OP0074 MULTIMORBIDITY CLUSTERS, DETERMINANTS AND TRAJECTORIES IN OSTEOARTHRITIS IN THE UK: FINDINGS FROM THE CLINICAL PRACTICE RESEARCH DATALINK.

OP0264-HPR PERSPECTIVES ON APPROACHES TO PREDICT THE DEVELOPMENT OF RHEUMATOID ARTHRITIS: A QUANTITATIVE ASSESSMENT OF PATIENTS AND THEIR FIRST DEGREE RELATIVES (2025)
Journal Article
Wells, I., Simons, G., Stack, R., Mallen, C., Nightingale, P., Raza, K., & Falahee, M. (in press). OP0264-HPR PERSPECTIVES ON APPROACHES TO PREDICT THE DEVELOPMENT OF RHEUMATOID ARTHRITIS: A QUANTITATIVE ASSESSMENT OF PATIENTS AND THEIR FIRST DEGREE RELATIVES. Annals of the Rheumatic Diseases, 79, 165-166. https://doi.org/10.1136/annrheumdis-2020-eular.2175

Background:
There is considerable interest within the medical research community in the identification of individuals at risk of developing rheumatoid arthritis (RA), to identify those who may benefit from prevent... Read More about OP0264-HPR PERSPECTIVES ON APPROACHES TO PREDICT THE DEVELOPMENT OF RHEUMATOID ARTHRITIS: A QUANTITATIVE ASSESSMENT OF PATIENTS AND THEIR FIRST DEGREE RELATIVES.

OP0230 COMORBIDITIES IN PEOPLE WITH OSTEOARTHRITIS IN FOUR EUROPEAN PRIMARY CARE SETTINGS - COMPREHENSIVE EVIDENCE FROM THE ComOA STUDY (2025)
Journal Article
Swain, S., Coupland, C., Kamps, A., Runhaar, J., Dell’isola, A., Mallen, C., …Zhang, W. (in press). OP0230 COMORBIDITIES IN PEOPLE WITH OSTEOARTHRITIS IN FOUR EUROPEAN PRIMARY CARE SETTINGS - COMPREHENSIVE EVIDENCE FROM THE ComOA STUDY. Annals of the Rheumatic Diseases, 83, 119-120. https://doi.org/10.1136/annrheumdis-2024-eular.3327

Background:
Associations of osteoarthritis (OA) with different comorbidities have gained attention recently. However, there is no literature on the congruency across different large primary care settings.... Read More about OP0230 COMORBIDITIES IN PEOPLE WITH OSTEOARTHRITIS IN FOUR EUROPEAN PRIMARY CARE SETTINGS - COMPREHENSIVE EVIDENCE FROM THE ComOA STUDY.

POS1483-HPR A QUANTITATIVE ASSESSMENT OF THE LIKELIHOOD THAT PATIENTS WITH RHEUMATOID ARTHRITIS WILL COMMUNICATE INFORMATION ABOUT RHEUMATOID ARTHRITIS RISK TO RELATIVES (2025)
Journal Article
Wells, I., Nightingale, P., Simons, G., Mallen, C., Raza, K., & Falahee, M. (in press). POS1483-HPR A QUANTITATIVE ASSESSMENT OF THE LIKELIHOOD THAT PATIENTS WITH RHEUMATOID ARTHRITIS WILL COMMUNICATE INFORMATION ABOUT RHEUMATOID ARTHRITIS RISK TO RELATIVES. Annals of the Rheumatic Diseases, 80, 1026-1027. https://doi.org/10.1136/annrheumdis-2021-eular.1749

Background:
First-degree relatives (FDRs) of patients with rheumatoid arthritis (RA) are at increased risk of RA and are being recruited to studies of predictive and preventive approaches. Access to FDRs is usuall... Read More about POS1483-HPR A QUANTITATIVE ASSESSMENT OF THE LIKELIHOOD THAT PATIENTS WITH RHEUMATOID ARTHRITIS WILL COMMUNICATE INFORMATION ABOUT RHEUMATOID ARTHRITIS RISK TO RELATIVES.

POS0597 PREDICTORS OF PERCEIVED RISK IN FIRST DEGREE RELATIVES OF RHEUMATOID ARTHRITIS PATIENTS (2025)
Journal Article
Bunnewell, S., Wells, I., Zemedikun, D., Simons, G., Mallen, C., Raza, K., & Falahee, M. (in press). POS0597 PREDICTORS OF PERCEIVED RISK IN FIRST DEGREE RELATIVES OF RHEUMATOID ARTHRITIS PATIENTS. Annals of the Rheumatic Diseases, 81, 565-566. https://doi.org/10.1136/annrheumdis-2022-eular.2004

Background
Risk of rheumatoid arthritis (RA) is 3-5 times higher in first-degree relatives (FDRs). Efforts are increasing to develop preventive interventions for this at risk group. Risk perception is a key predic... Read More about POS0597 PREDICTORS OF PERCEIVED RISK IN FIRST DEGREE RELATIVES OF RHEUMATOID ARTHRITIS PATIENTS.

Demographic trends of motor neurone disease-associated mortality from 1999-2020 in the United States [version 1; peer review: awaiting peer review] (2024)
Journal Article
Imantalab, D., Singh Sokhal, B., Prasanna Kumar Menon, S., Kalra, S., Muller, S., & Mallen, C. (2024). Demographic trends of motor neurone disease-associated mortality from 1999-2020 in the United States [version 1; peer review: awaiting peer review]. NIHR Open Research, 1-14. https://doi.org/10.3310/nihropenres.13786.1

Motor Neurone Disease (MND) is a neurodegenerative condition affecting motor neurons in spinal cord and brainstem, leading to a reduced life expectancy. This study describes demographic trends in MND-associated mortality in the United States over a 2... Read More about Demographic trends of motor neurone disease-associated mortality from 1999-2020 in the United States [version 1; peer review: awaiting peer review].

Gabapentinoid use and the risk of fractures in patients with inflammatory arthritis: nested case–control study in the Clinical Practice Research Datalink Aurum (2024)
Journal Article
Scott, I. C., Daud, N., Bailey, J., Twohig, H., Hider, S. L., Mallen, C. D., …Muller, S. (2024). Gabapentinoid use and the risk of fractures in patients with inflammatory arthritis: nested case–control study in the Clinical Practice Research Datalink Aurum. BMC Medicine, 22(1), 575. https://doi.org/10.1186/s12916-024-03774-5

Background: Gabapentinoids are increasingly prescribed in inflammatory arthritis (IA), despite no trial evidence for efficacy at managing pain in this population. Observational studies in non-IA populations suggest gabapentinoids are associated with... Read More about Gabapentinoid use and the risk of fractures in patients with inflammatory arthritis: nested case–control study in the Clinical Practice Research Datalink Aurum.

Everyday living with osteoarthritis in the global South: A qualitative focus group inquiry in Nigeria. (2024)
Journal Article
Owoyemi, T., Alonge, I., Adetunji, O., Ogbu, E., Ogunbanjo, A., White, S., …Dziedzic, K. (2025). Everyday living with osteoarthritis in the global South: A qualitative focus group inquiry in Nigeria. Osteoarthritis and Cartilage Open, 7(1), Article 100555. https://doi.org/10.1016/j.ocarto.2024.100555

Objective
Africa contributes significantly to the increasing global prevalence (>37%), unmet need and treatment burden for people with osteoarthritis. Despite this, little research has examined the expressed needs of patients with osteoarthritis (OA... Read More about Everyday living with osteoarthritis in the global South: A qualitative focus group inquiry in Nigeria..

Incidence of Side Effects Associated With Acetaminophen in People Aged 65 Years or More: A Prospective Cohort Study Using Data From the Clinical Practice Research Datalink (2024)
Journal Article
Kaur, J., Nakafero, G., Abhishek, A., Mallen, C., Doherty, M., & Zhang, W. (2024). Incidence of Side Effects Associated With Acetaminophen in People Aged 65 Years or More: A Prospective Cohort Study Using Data From the Clinical Practice Research Datalink. Arthritis Care & Research, https://doi.org/10.1002/acr.25471

Objective The main objective of this study is to examine the safety of oral acetaminophen at its therapeutic dose in adults aged 65 years or more. Methods This population‐based cohort study used the Clinical Practice Research Datalink‐Gold data. Part... Read More about Incidence of Side Effects Associated With Acetaminophen in People Aged 65 Years or More: A Prospective Cohort Study Using Data From the Clinical Practice Research Datalink.

Pain management in people with inflammatory arthritis: British Society for Rheumatology guideline scope (2024)
Journal Article
Scott, I. C., Babatunde, O., Barker, C., Beesley, R., Beesley, R., Birkinshaw, H., …Shenker, N. G. (in press). Pain management in people with inflammatory arthritis: British Society for Rheumatology guideline scope. Rheumatology Advances in Practice, 8(4), Article rkae128. https://doi.org/10.1093/rap/rkae128

Lay Summary: What does this mean for patients? Inflammatory arthritis includes conditions causing swollen and painful joints. The main types are rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis and juvenile idiopathic arthritis. It... Read More about Pain management in people with inflammatory arthritis: British Society for Rheumatology guideline scope.

Should all people starting urate-lowering therapy for gout receive anti-inflammatory prophylaxis? (2024)
Journal Article
Roddy, E., Prior, J. A., & Mallen, C. D. (2024). Should all people starting urate-lowering therapy for gout receive anti-inflammatory prophylaxis?. Exploration of Musculoskeletal Diseases, 2, 521-528. https://doi.org/10.37349/emd.2024.00076

Co-prescription of anti-inflammatory prophylaxis with colchicine, non-steroidal anti-inflammatory drugs (NSAIDs), or corticosteroids when initiating urate-lowering therapy (ULT) for gout is recommended in clinical guidelines to prevent ULT-induced fl... Read More about Should all people starting urate-lowering therapy for gout receive anti-inflammatory prophylaxis?.

Protocol for a mixed methods process evaluation for a randomised controlled trial to improve shared decision-making about, and uptake of, osteoporosis medicines: the iFraP study (2024)
Journal Article
Bullock, L., Cherrington, A., Clark, E. M., Fleming, J., Bentley, I., Nicholls, E., …Paskins, Z. (in press). Protocol for a mixed methods process evaluation for a randomised controlled trial to improve shared decision-making about, and uptake of, osteoporosis medicines: the iFraP study. NIHR Open Research, 4, 70. https://doi.org/10.3310/nihropenres.13751.1

Background
High quality shared decision-making (SDM) conversations involve people with or at risk of osteoporosis and clinicians working together to decide, where appropriate, which evidence-based medicines best fit the person’s life, beliefs, and v... Read More about Protocol for a mixed methods process evaluation for a randomised controlled trial to improve shared decision-making about, and uptake of, osteoporosis medicines: the iFraP study.

Patient safety in general practice during COVID-19: a descriptive analysis in 38 countries (PRICOV-19) (2024)
Journal Article
Van Poel, E., Vanden Bussche, P., Collins, C., Lagaert, S., Ares-Blanco, S., Astier-Pena, M. P., …Willems, S. (in press). Patient safety in general practice during COVID-19: a descriptive analysis in 38 countries (PRICOV-19). Family Practice, 1-9. https://doi.org/10.1093/fampra/cmae059

Background This article aims to examine patient safety in general practice during COVID-19. Methods In total, 5489 GP practices from 37 European countries and Israel filled in the online self-reported PRICOV-19 survey between November 2020 and Decemb... Read More about Patient safety in general practice during COVID-19: a descriptive analysis in 38 countries (PRICOV-19).

Measles and Pertussis outbreaks in England and Wales: a time-series analysis (2024)
Journal Article
Shepherd, T., & Mallen, C. (2024). Measles and Pertussis outbreaks in England and Wales: a time-series analysis. NIHR Open Research, 4, 56. https://doi.org/10.3310/nihropenres.13607.1

Background
Vaccine coverage for common infectious diseases such as Measles and Pertussis (also known as whooping cough) have been declining in England and Wales since 2014. Consequently, significant increases in Measles and Pertussis cases are obser... Read More about Measles and Pertussis outbreaks in England and Wales: a time-series analysis.

Association of air pollution from a landfill site with primary care consultation (2024)
Working Paper
Jordan, K. P., Muller, S., Usman, M., Bailey, J., Burton, C., Lawton, S. A., …van der Windt, D. A. Association of air pollution from a landfill site with primary care consultation

Background Waste landfill sites are associated with gaseous emissions and this air pollution can cause unpleasant smells (“malodour”). This causes concerns about its impact on the health of the local population. This study assessed change in general... Read More about Association of air pollution from a landfill site with primary care consultation.