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Outputs (524)

The Relationship Between Obesity and Patient-Reported Outcome Measures in People with Polymyalgia Rheumatica (2024)
Journal Article
Scott, I. C., Bajpai, R., Hider, S. L., Helliwell, T., Mallen, C. D., & Muller, S. (in press). The Relationship Between Obesity and Patient-Reported Outcome Measures in People with Polymyalgia Rheumatica. Rheumatology Advances in Practice, 8(3), Article rkae081. https://doi.org/10.1093/rap/rkae081

Objective To examine the association between obesity and patient-reported outcomes measures (PROMs) in a primary care-based cohort of people with polymyalgia rheumatica (PMR). Methods The PMR Cohort Study recruited people with incident PMR from... Read More about The Relationship Between Obesity and Patient-Reported Outcome Measures in People with Polymyalgia Rheumatica.

Exploring practice and perspectives on shared decision-making about osteoporosis medicines in Fracture Liaison Services: the iFraP development qualitative study (2024)
Journal Article
Bullock, L., Manning, F., Hawarden, A., Fleming, J., Leyland, S., Clark, E. M., …Paskins, Z. (in press). Exploring practice and perspectives on shared decision-making about osteoporosis medicines in Fracture Liaison Services: the iFraP development qualitative study. Archives of Osteoporosis, 19(1), Article 50. https://doi.org/10.1007/s11657-024-01410-6

Summary Interviews and focus groups with patients, FLS clinicians, and GPs identified challenges relating to clinical and shared decision-making about bone health and osteoporosis medicines. Findings will inform the development of the multicomponent... Read More about Exploring practice and perspectives on shared decision-making about osteoporosis medicines in Fracture Liaison Services: the iFraP development qualitative study.

Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study (2024)
Journal Article
Nakafero, G., Grainge, M. J., Card, T., Mallen, C. D., Nguyen Van-Tam, J. S., & Abhishek, A. (2024). Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study. BMJ Open Gastroenterology, 11(1), Article e001370. https://doi.org/10.1136/bmjgast-2024-001370

Objective: To investigate (1) the UK-wide inactivated influenza vaccine (IIV) uptake in adults with inflammatory bowel disease (IBD), (2) the association between vaccination against influenza and IBD flare and (3) the effectiveness of IIV in preventi... Read More about Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study.

2023 EULAR classification criteria for hand osteoarthritis. (2024)
Journal Article
Haugen, I. K., Felson, D. T., Abhishek, A., Berenbaum, F., Bierma-Zeinstra, S., Dziedzic, K. S., …Kloppenburg, M. (in press). 2023 EULAR classification criteria for hand osteoarthritis. Annals of the Rheumatic Diseases, https://doi.org/10.1136/ard-2023-225073

The objective of this study is to develop classification criteria for overall hand osteoarthritis (OA), interphalangeal OA and thumb base OA based on self-reported data and radiographic features. The classification criteria sets were developed in thr... Read More about 2023 EULAR classification criteria for hand osteoarthritis..

P021 Uptake, safety, and effectiveness of pneumococcal vaccination in adults with immune mediated inflammatory diseases: a UK wide study using data from the Clinical Practice Research Datalink (2024)
Presentation / Conference
Nakafero, G., Grainge, M. J., Mallen, C. D., Card, T., Nguyen Van-Tam, J. S., & Abhishek, A. (2024, April). P021 Uptake, safety, and effectiveness of pneumococcal vaccination in adults with immune mediated inflammatory diseases: a UK wide study using data from the Clinical Practice Research Datalink. Poster presented at British Society for Rheumatology Annual Conference 2024

Background/Aims The safety and effectiveness of pneumococcal vaccine in people with immune mediated inflammatory diseases (IMIDs) is not known, which may contribute to suboptimal uptake. We investigated UK wide pneumococcal vaccine uptake in adults w... Read More about P021 Uptake, safety, and effectiveness of pneumococcal vaccination in adults with immune mediated inflammatory diseases: a UK wide study using data from the Clinical Practice Research Datalink.

P080 Supporting shared decision-making about osteoporosis medicines: Combining multiple methods to develop the prototype iFraP intervention (2024)
Presentation / Conference
Bullock, L., Fleming, J., Clark, E. M., Leyland, S., Thomas, S., Gidlow, C., …Paskins, Z. (2024, April). P080 Supporting shared decision-making about osteoporosis medicines: Combining multiple methods to develop the prototype iFraP intervention. Poster presented at British Society for Rheumatology Annual Conference 2024

Background/Aims Shared decision-making (SDM) is a joint process in which a person and healthcare professional work together to reach decisions about care. The iFraP (Improving uptake of Fracture Prevention drug treatments) intervention comprises comp... Read More about P080 Supporting shared decision-making about osteoporosis medicines: Combining multiple methods to develop the prototype iFraP intervention.

P185 Anatomical patterns of pain in primary care patients with polymyalgia rheumatica compared to the general population (2024)
Presentation / Conference
Hammad, N., Partington, R., Hider, S., Butt, H., Helliwell, T., Mallen, C., & Muller, S. (2024, April). P185 Anatomical patterns of pain in primary care patients with polymyalgia rheumatica compared to the general population. Poster presented at British Society for Rheumatology Annual Conference 2024

Background/Aims Polymyalgia rheumatica (PMR) is common in older adults, causing severe pain and stiffness, particularly in the shoulder and hip girdles. A tapered course of glucocorticoids is recommended, but not always straightforward, with frequent... Read More about P185 Anatomical patterns of pain in primary care patients with polymyalgia rheumatica compared to the general population.

P187 Fatigue in people with polymyalgia rheumatica: a key unmet need? (2024)
Presentation / Conference
Muller, S., Belcher, J., Hider, S., Helliwell, T., & Mallen, C. D. (2024, April). P187 Fatigue in people with polymyalgia rheumatica: a key unmet need?. Poster presented at British Society for Rheumatology Annual Conference 2024

Background/Aims Polymyalgia rheumatica (PMR) is common in older adults, causing severe pain and stiffness, particularly in the shoulder and hip girdles. Glucocorticoids treatment generally focusses on reducing pain and stiffness, but there are other... Read More about P187 Fatigue in people with polymyalgia rheumatica: a key unmet need?.

Long-term outcomes of COVID-19 infection in children and young people: a systematic review and meta-analysis [version 1; peer review: awaiting peer review] (2024)
Journal Article
Twohig, H., Bajpai, R., Corp, N., Faux-Nightingale, A., Mallen, C., Robinson, T., …Burton, C. (2024). Long-term outcomes of COVID-19 infection in children and young people: a systematic review and meta-analysis [version 1; peer review: awaiting peer review]. NIHR Open Research, 4(22), https://doi.org/10.3310/nihropenres.13549.1

Background Children and young people (CYP) may experience prolonged symptoms following COVID-19, commonly termed ‘Long-COVID’. The characteristics of Long-COVID in CYP are unclear, as are the sequalae of acute COVID-19. We aimed to systematically sy... Read More about Long-term outcomes of COVID-19 infection in children and young people: a systematic review and meta-analysis [version 1; peer review: awaiting peer review].

Impact of research activity on performance of general practices: a qualitative study. (2024)
Journal Article
Kenning, C., Usher-Smith, J. A., Jamison, J., Jones, J., Boaz, A., Little, P., …Park, S. (in press). Impact of research activity on performance of general practices: a qualitative study. British Journal of General Practice Open (BJGP Open), Article BJGPO.2024.0073. https://doi.org/10.3399/BJGPO.2024.0073

There is evidence that engaging in research is directly associated with better performance. If this relationship is to be strengthened, it is necessary to understand the mechanisms which might underlie that relationship. To explore the perspectives o... Read More about Impact of research activity on performance of general practices: a qualitative study..

767 EXPLORING THE POTENTIAL EXTENDED ROLE OF COMMUNITY PHARMACY IN THE MANAGEMENT OF OSTEOARTHRITIS: SURVEYS AND INTERVIEWS WITH COMMUNITY PHARMACY STAFF AND OTHER HEALTHCARE PROFESSIONALS (2024)
Presentation / Conference
Simkins, J., Holden, M., Babatunde, O. O., White, S., Nicholls, E., Long, A., …O'Brien, N. (2024, April). 767 EXPLORING THE POTENTIAL EXTENDED ROLE OF COMMUNITY PHARMACY IN THE MANAGEMENT OF OSTEOARTHRITIS: SURVEYS AND INTERVIEWS WITH COMMUNITY PHARMACY STAFF AND OTHER HEALTHCARE PROFESSIONALS. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

768 STAKEHOLDER CO-DESIGN OF AN EXTENDED COMMUNITY PHARMACY ROLE AND SERVICE DELIVERY MODEL FOR PROVIDING OSTEOARTHRITS CARE: THE PHARMOA MODEL (2024)
Presentation / Conference
Holden, M., Stanford, C., Simkins, J., Babatunde, O. O., White, S., O'Brien, N., …Healey, E. L. (2024, April). 768 STAKEHOLDER CO-DESIGN OF AN EXTENDED COMMUNITY PHARMACY ROLE AND SERVICE DELIVERY MODEL FOR PROVIDING OSTEOARTHRITS CARE: THE PHARMOA MODEL. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

786 CHALLENGES OF IMPLEMENTING A NEW MODEL OF CARE FOR OSTEOARTHRITIS AMONG COMMUNITY PHARMACIES IN SOUTH-WESTERN NIGERIA: Focus on the Joint Implementation of Guidelines for OSteoArthritis in West-Africa (JIGSAW-A). (2024)
Presentation / Conference
Adetunji, O. A., Owoyemi, T., Alonge, I., Ogunbanjo, A., Taiwo, P., Carter, J., …Babatunde, O. O. (2024, April). 786 CHALLENGES OF IMPLEMENTING A NEW MODEL OF CARE FOR OSTEOARTHRITIS AMONG COMMUNITY PHARMACIES IN SOUTH-WESTERN NIGERIA: Focus on the Joint Implementation of Guidelines for OSteoArthritis in West-Africa (JIGSAW-A). Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

Prognostic factors for colchicine prophylaxis-related adverse events when initiating allopurinol for gout: retrospective cohort study (2024)
Journal Article
Bajpai, R., Partington, R., Muller, S., Forrester, H., Mallen, C. D., Clarson, L., …Roddy, E. (2024). Prognostic factors for colchicine prophylaxis-related adverse events when initiating allopurinol for gout: retrospective cohort study. Rheumatology, Article keae229. https://doi.org/10.1093/rheumatology/keae229

Objectives Colchicine is commonly used to prevent flares when starting urate-lowering therapy for gout. Patients with gout are frequently concurrently prescribed other medications (such as statins) that may interact with colchicine, increasing the r... Read More about Prognostic factors for colchicine prophylaxis-related adverse events when initiating allopurinol for gout: retrospective cohort study.

Characteristics of primary care practices associated with patient education during COVID-19: results of the cross-sectional PRICOV-19 study in 38 countries (2024)
Journal Article
Kirkove, D., Willems, S., Van Poel, E., Dardenne, N., Donneau, A.-F., Perrin, E., …Pétré, B. (2024). Characteristics of primary care practices associated with patient education during COVID-19: results of the cross-sectional PRICOV-19 study in 38 countries. BMC Primary Care, 24(Suppl 1), Article 285. https://doi.org/10.1186/s12875-024-02348-x

Background: In response to the COVID-19 pandemic, the World Health Organization established a number of key recommendations such as educational activities especially within primary care practices (PCPs) which are a key component of this strategy. Thi... Read More about Characteristics of primary care practices associated with patient education during COVID-19: results of the cross-sectional PRICOV-19 study in 38 countries.

Designing a primary care pharmacist-led review for people treated with opioids for persistent pain: a multi-method qualitative study (2024)
Journal Article
Woodcock, C., Cornwall, N., Dikomitis, L., Harrisson, S. A., White, S., Helliwell, T., …Jinks, C. (2024). Designing a primary care pharmacist-led review for people treated with opioids for persistent pain: a multi-method qualitative study. British Journal of General Practice Open (BJGP Open), Article BJGPO.2023.0221. https://doi.org/10.3399/BJGPO.2023.0221

Background Opioids are frequently prescribed for persistent non-cancer pain despite limited evidence of long-term effectiveness and risk of harm. Evidence-based interventions to address inappropriate opioid prescribing are lacking. Aim To explore... Read More about Designing a primary care pharmacist-led review for people treated with opioids for persistent pain: a multi-method qualitative study.

Hearing the patient voice for persistent pain intervention development: Recommendations for using a bespoke online discussion forum for qualitative data collection (2024)
Journal Article
Woodcock, C., Cornwall, N., Harrisson, S., Jinks, C., Buttery, A., Ashworth, J., …Dikomitis, L. (in press). Hearing the patient voice for persistent pain intervention development: Recommendations for using a bespoke online discussion forum for qualitative data collection. British Journal of Pain,

We discuss a bespoke online discussion forum as an innovative method for qualitative data collection in the context of developing an intervention for patients prescribed opioids for persistent pain. We discuss the following key areas: planning and de... Read More about Hearing the patient voice for persistent pain intervention development: Recommendations for using a bespoke online discussion forum for qualitative data collection.

Identifying carers in general practice (STATUS QUO): a multicentre, cross-sectional study in England (2024)
Journal Article
Lawton, S., Mallen, C., Hussain, Z., Bajpai, R., Muller, S., Holmstrom, C., …Helliwell, T. (2024). Identifying carers in general practice (STATUS QUO): a multicentre, cross-sectional study in England. BMJ Open, 14(4), Article e083816. https://doi.org/10.1136/bmjopen-2023-083816

Objectives: To determine General Practice (GP) recording of carer status and the number of patients self-identifying as carers, while self-completing an automated check-in screen prior to a GP consultation. Design: A descriptive cross-sectional st... Read More about Identifying carers in general practice (STATUS QUO): a multicentre, cross-sectional study in England.

Protocol for the development and validation of a Rheumatoid Arthritis PredIction moDel using primary care health records (RAPID) (2024)
Working Paper
Hammond, B., Baranskaya, A., Adderley, N., Zemedikun, D., d’Elia, A., Falahee, M., …Raza, K. Protocol for the development and validation of a Rheumatoid Arthritis PredIction moDel using primary care health records (RAPID)

Background Rheumatoid Arthritis (RA) is a chronic rheumatological condition which causes inflammation of both the joint lining and extra-articular sites. It affects around 1% of the UK population and, if not properly treated, can lead joint damage, d... Read More about Protocol for the development and validation of a Rheumatoid Arthritis PredIction moDel using primary care health records (RAPID).

Risk of adverse outcomes during gabapentinoid therapy and factors associated with increased risk in UK primary care using the clinical practice research datalink: a cohort study. (2024)
Journal Article
Muller, S., Bailey, J., Bajpai, R., Helliwell, T., Harrisson, S. A., Whittle, R., …Ashworth, J. (in press). Risk of adverse outcomes during gabapentinoid therapy and factors associated with increased risk in UK primary care using the clinical practice research datalink: a cohort study. PAIN, https://doi.org/10.1097/j.pain.0000000000003239

Growing evidence from pharmacovigilance data and postmortem toxicology reports highlights the misuse potential of gabapentinoids. This study aimed to investigate the risk of serious adverse outcomes (drug misuse, overdose, major trauma), and their ri... Read More about Risk of adverse outcomes during gabapentinoid therapy and factors associated with increased risk in UK primary care using the clinical practice research datalink: a cohort study..

Protocol for a trial-based economic evaluation analysis of a complex digital health intervention including a computerised decision support tool: the iFraP intervention (2024)
Journal Article
Siciliano, M., Bathers, S., Bentley, I., Bullock, L., Cherrington, A., Clark, E., …Iglesias-Urrutia, C. (in press). Protocol for a trial-based economic evaluation analysis of a complex digital health intervention including a computerised decision support tool: the iFraP intervention. NIHR Open Research, 4(15), https://doi.org/10.3310/nihropenres.13575.1

Background Digital health interventions (DHI) are associated with significant promise. In recent years, the need to assess the value of these healthcare technologies has motivated a debate regarding the suitability of existing economic evaluation me... Read More about Protocol for a trial-based economic evaluation analysis of a complex digital health intervention including a computerised decision support tool: the iFraP intervention.

A person-centred consultation intervention to improve shared decision-making about, and uptake of, osteoporosis medicines (iFraP): a pragmatic, parallel-group, individual randomised controlled trial protocol (2024)
Journal Article
Bullock, L., Nicholls, E., Cherrington, A., Butler-Walley, S., Clark, E. M., Fleming, J., …Paskins, Z. (in press). A person-centred consultation intervention to improve shared decision-making about, and uptake of, osteoporosis medicines (iFraP): a pragmatic, parallel-group, individual randomised controlled trial protocol. NIHR Open Research, 4(14), https://doi.org/10.3310/nihropenres.13571.1

Background Good quality shared decision-making (SDM) conversations involve people with, or at risk of osteoporosis and clinicians collaborating to decide, where appropriate, which evidence-based medicines best fit the person’s life, beliefs, and val... Read More about A person-centred consultation intervention to improve shared decision-making about, and uptake of, osteoporosis medicines (iFraP): a pragmatic, parallel-group, individual randomised controlled trial protocol.

The SelfSTarT intervention for low back pain patients presenting to first contact physiotherapists: A mixed methods service evaluation (2024)
Journal Article
Stevenson, K., Hadley‐Barrows, T., Evans, N., Campbell, L., Southam, J., Chudyk, A., …Hill, J. C. (2024). The SelfSTarT intervention for low back pain patients presenting to first contact physiotherapists: A mixed methods service evaluation. Musculoskeletal Care, 22(1), Article e1876. https://doi.org/10.1002/msc.1876

Introduction Globally, back pain is the leading cause of years of disability. In the United Kingdom, over 20 million people live with musculoskeletal (MSK) pain, with low back pain being one of the most common causes. National strategies promote sel... Read More about The SelfSTarT intervention for low back pain patients presenting to first contact physiotherapists: A mixed methods service evaluation.

Talking in primary care (TIP): protocol for a cluster-randomised controlled trial in UK primary care to assess clinical and cost-effectiveness of communication skills e-learning for practitioners on patients’ musculoskeletal pain and enablement (2024)
Journal Article
Bishop, F. L., Cross, N., Dewar-Haggart, R., Teasdale, E., Herbert, A., Robinson, M. E., …Everitt, H. A. (2024). Talking in primary care (TIP): protocol for a cluster-randomised controlled trial in UK primary care to assess clinical and cost-effectiveness of communication skills e-learning for practitioners on patients’ musculoskeletal pain and enablement. BMJ Open, 14(3), Article e081932. https://doi.org/10.1136/bmjopen-2023-081932

Introduction: Effective communication can help optimise healthcare interactions and patient outcomes. However, few interventions have been tested clinically, subjected to cost-effectiveness analysis or are sufficiently brief and well-described for im... Read More about Talking in primary care (TIP): protocol for a cluster-randomised controlled trial in UK primary care to assess clinical and cost-effectiveness of communication skills e-learning for practitioners on patients’ musculoskeletal pain and enablement.

Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases (2024)
Journal Article
Fuller, A., Hancox, J., Williams, H. C., Card, T., Taal, M. W., Aithal, G. P., …Abhishek, A. (2024). Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases. Rheumatology, Article keae175. https://doi.org/10.1093/rheumatology/keae175

To explore the acceptability of an individualised risk-stratified approach to monitoring for target-organ toxicity in adult patients with immune-mediated inflammatory diseases established on immune-suppressing treatment(s). Adults (≥18 years) taking... Read More about Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases.

Uptake and safety of pneumococcal vaccination in adults with immune mediated inflammatory diseases: a UK wide observational study (2024)
Journal Article
Nakafero, G., Grainge, M. J., Card, T., Mallen, C. D., Nguyen Van-Tam, J. S., & Abhishek, A. (in press). Uptake and safety of pneumococcal vaccination in adults with immune mediated inflammatory diseases: a UK wide observational study. Rheumatology, https://doi.org/10.1093/rheumatology/keae160

Objective The uptake and safety of pneumococcal vaccination in people with immune-mediated inflammatory diseases (IMIDs) is poorly understood. We investigated the UK-wide pneumococcal vaccine uptake in adults with IMIDs and explored the association... Read More about Uptake and safety of pneumococcal vaccination in adults with immune mediated inflammatory diseases: a UK wide observational study.

Barriers and facilitators in diagnosing axial spondyloarthritis: a qualitative study (2024)
Journal Article
Hay, C. A., Packham, J., Prior, J. A., Mallen, C. D., & Ryan, S. (2024). Barriers and facilitators in diagnosing axial spondyloarthritis: a qualitative study. Rheumatology International, 44, 863–884. https://doi.org/10.1007/s00296-024-05554-z

Diagnosis of axial spondyloarthritis (axSpA) is frequently delayed for years after symptom onset. However, little is known about patient and healthcare professional (HCP) perspectives on barriers and facilitators in axSpA diagnosis. This study explor... Read More about Barriers and facilitators in diagnosing axial spondyloarthritis: a qualitative study.

Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation (2024)
Journal Article
Abhishek, A., Grainge, M., Card, T., Williams, H. C., Taal, M. W., Aithal, G. P., …Riley, R. (2024). Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation. RMD Open, 10(1), Article e003980. https://doi.org/10.1136/rmdopen-2023-003980

Background: Sulfasalazine-induced cytopenia, nephrotoxicity and hepatotoxicity is uncommon during long-term treatment. Some guidelines recommend 3 monthly monitoring blood tests indefinitely during long-term treatment while others recommend stopping... Read More about Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation.

Health Literacy and Gout Characteristics in a Primary Care Cohort (2024)
Journal Article
Watson, L., Protheroe, J., Mallen, C., Muller, S., & Roddy, E. (2024). Health Literacy and Gout Characteristics in a Primary Care Cohort. Rheumatology Advances in Practice, 8(2), Article rkae034. https://doi.org/10.1093/rap/rkae034

Objectives To examine the cross-sectional association between health literacy and gout characteristics. Methods In a primary care cohort of adults living with gout, the prevalence of poor health literacy was defined using the Single-Item Literac... Read More about Health Literacy and Gout Characteristics in a Primary Care Cohort.

“We have to change our mindsets”: a qualitative study of barriers and facilitators in research collaboration across integrated care system organisations (2024)
Journal Article
Gidlow, C. J., Sams, L., Buckless, K., Ellis, N. J., Duffy, H. C., Lambley-Burke, R., …Mallen, C. D. (2024). “We have to change our mindsets”: a qualitative study of barriers and facilitators in research collaboration across integrated care system organisations. BMC Health Services Research, 24(1), Article 264. https://doi.org/10.1186/s12913-024-10760-3

The introduction of Integrated Care Systems (ICS) in England aimed to increase joint planning and delivery of health and social care, and other services, to better meet the needs of local communities. There is an associated duty to undertake collabor... Read More about “We have to change our mindsets”: a qualitative study of barriers and facilitators in research collaboration across integrated care system organisations.

Exploring the potential extended role of community pharmacy in the management of osteoarthritis: A multi‐methods study with pharmacy staff and other healthcare professionals (2024)
Journal Article
Simkins, J., Holden, M. A., Babatunde, O., White, S., Nicholls, E., Long, A., …O’Brien, N. (2024). Exploring the potential extended role of community pharmacy in the management of osteoarthritis: A multi‐methods study with pharmacy staff and other healthcare professionals. Musculoskeletal Care, 22(1), Article e1873. https://doi.org/10.1002/msc.1873

Introduction Osteoarthritis is the commonest form of chronic joint pain, which patients often self-manage before seeking healthcare advice. Patients frequently seek advice from community pharmacies, and a recent policy has recommended integrating co... Read More about Exploring the potential extended role of community pharmacy in the management of osteoarthritis: A multi‐methods study with pharmacy staff and other healthcare professionals.

Systematic Review of the Association of the Hospital Frailty Risk Score with Mortality in Patients with Cerebrovascular and Cardiovascular Disease. (2024)
Journal Article
Sokhal, B. S., Menon, S. P. K., Willes, C., Corp, N., Matetić, A., Mallen, C., & Mamas, M. (in press). Systematic Review of the Association of the Hospital Frailty Risk Score with Mortality in Patients with Cerebrovascular and Cardiovascular Disease. Current Cardiology Reviews, 20(3), Article e290224227533. https://doi.org/10.2174/011573403X276647240217112151

There is limited systematic data on the association between the Hospital Frailty Risk Score (HFRS) and characteristics and mortality in patients with cerebrovascular and cardiovascular disease (CVD). This systematic review aimed to summarise the use... Read More about Systematic Review of the Association of the Hospital Frailty Risk Score with Mortality in Patients with Cerebrovascular and Cardiovascular Disease..

Evaluating the impact of the supporting the advancement of research skills (STARS) programme on research knowledge, engagement and capacity-building in a health and social care organisation in England (2024)
Journal Article
Tajuria, G., Dobel-Ober, D., Bradley, E., Charnley, C., Lambley-Burke, R., Mallen, C., …Kingstone, T. (in press). Evaluating the impact of the supporting the advancement of research skills (STARS) programme on research knowledge, engagement and capacity-building in a health and social care organisation in England. BMC Medical Education, 24(1), Article 126. https://doi.org/10.1186/s12909-024-05059-0

Objectives To evaluate the impact a novel education programme - to improve research engagement, awareness, understanding and confidence - had on a diverse health and social care workforce. Barriers and facilitators to engagement were explored togeth... Read More about Evaluating the impact of the supporting the advancement of research skills (STARS) programme on research knowledge, engagement and capacity-building in a health and social care organisation in England.

Betwixt and between student and professional identities: UK medical students during COVID times (2024)
Journal Article
Polidano, K., Wenning, B., Mallen, C. D., & Dikomitis, L. (2024). Betwixt and between student and professional identities: UK medical students during COVID times. SN Social Sciences, 4(2), Article 53. https://doi.org/10.1007/s43545-024-00844-6

The COVID-19 pandemic lockdown in Spring 2020 brought about unprecedented disruption to medical education in the United Kingdom (UK). Medical students were encouraged to take up paid roles in the National Health Service to help with workforce shortag... Read More about Betwixt and between student and professional identities: UK medical students during COVID times.

Optimising the implementation of evidence-based osteoarthritis guidelines in primary care: Development of a knowledge mobilisation toolkit (2024)
Journal Article
Swaithes, L., Paskins, Z., Finney, A., Walsh, N., Skrybant, M., Mallen, C., & Dziedzic, K. (2024). Optimising the implementation of evidence-based osteoarthritis guidelines in primary care: Development of a knowledge mobilisation toolkit. Osteoarthritis and Cartilage, https://doi.org/10.1016/j.joca.2024.01.003

Objective Implementing clinical guidelines for osteoarthritis in primary care is complex. Whilst international guidelines detail what best practice for osteoarthritis looks like, little is known about how this is... Read More about Optimising the implementation of evidence-based osteoarthritis guidelines in primary care: Development of a knowledge mobilisation toolkit.

Co-development and testing of an extended community pharmacy model of service delivery for managing osteoarthritis: protocol for a sequential, multi-methods study (PharmOA) (2024)
Journal Article
Babatunde, O. O., Cottrell, E., White, S., Chudyk, A., Healey, E. L., Edwards, J., …Holden, M. A. (in press). Co-development and testing of an extended community pharmacy model of service delivery for managing osteoarthritis: protocol for a sequential, multi-methods study (PharmOA). BMC Musculoskeletal Disorders, 25(1), Article 54. https://doi.org/10.1186/s12891-023-07105-2

Background Osteoarthritis is a common, painful and disabling long-term condition. Delivery of high-quality guideline-informed osteoarthritis care that successfully promotes and maintains supported self-management is imperative. However, osteoarthrit... Read More about Co-development and testing of an extended community pharmacy model of service delivery for managing osteoarthritis: protocol for a sequential, multi-methods study (PharmOA).

EULAR recommendations for the non-pharmacological core management of hip and knee osteoarthritis: 2023 update. (2024)
Journal Article
Moseng, T., Vliet Vlieland, T. P. M., Battista, S., Beckwée, D., Boyadzhieva, V., Conaghan, P. G., …Østerås, N. (in press). EULAR recommendations for the non-pharmacological core management of hip and knee osteoarthritis: 2023 update. Annals of the Rheumatic Diseases, https://doi.org/10.1136/ard-2023-225041

Hip and knee osteoarthritis (OA) are increasingly common with a significant impact on individuals and society. Non-pharmacological treatments are considered essential to reduce pain and improve function and quality of life. EULAR recommendations for... Read More about EULAR recommendations for the non-pharmacological core management of hip and knee osteoarthritis: 2023 update..

Undertaking multi-centre randomised controlled trials in primary care: learnings and recommendations from the PULsE-AI trial researchers (2024)
Journal Article
Pollock, K. G., Dickerson, C., Kainth, M., Lawton, S., Hurst, M., Sugrue, D. M., …Cohen, A. T. (in press). Undertaking multi-centre randomised controlled trials in primary care: learnings and recommendations from the PULsE-AI trial researchers. BMC Primary Care, 25(1), Article 7. https://doi.org/10.1186/s12875-023-02246-8

Background Conducting effective and translational research can be challenging and few trials undertake formal reflection exercises and disseminate learnings from them. Following completion of our multicentre randomised controlled trial, which was im... Read More about Undertaking multi-centre randomised controlled trials in primary care: learnings and recommendations from the PULsE-AI trial researchers.

Impact of the COVID-19 pandemic on young people living with HIV in Lesotho: a qualitative study (2024)
Journal Article
Shepherd, T., Robinson, M. E., Ramaema, M., Rakuoane, M., Moletsane, N., Mpholo, R., …Leigh, G. (2024). Impact of the COVID-19 pandemic on young people living with HIV in Lesotho: a qualitative study. BMJ Public Health, 2(1), Article e000414. https://doi.org/10.1136/bmjph-2023-000414

Introduction: There is a growing body of research evidencing the detrimental impact of the COVID-19 pandemic on the mental health and well-being of young people. This impact may be worse in low-resource settings, especially those in sub-Saharan Afric... Read More about Impact of the COVID-19 pandemic on young people living with HIV in Lesotho: a qualitative study.

785 Co-contextualising and Implementing evidence-based care model for osteoarthritis: Nigerian case study in the Joint Implementation of Guidelines for OSteoArthritis in West-Africa (JIGSAW-A) (2024)
Presentation / Conference
Babatunde, O. O., Adetunji, O. A., Alonge, I., Owoyemi, T., Taiwo, P., Ogunbanjo, A., …Mallen, C. (2024, January). 785 Co-contextualising and Implementing evidence-based care model for osteoarthritis: Nigerian case study in the Joint Implementation of Guidelines for OSteoArthritis in West-Africa (JIGSAW-A). Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austira

Variation in UK fracture liaison service consultation conduct and content before and during the COVID pandemic: results from the iFraP-D UK survey (2023)
Journal Article
Bullock, L., Abdelmagid, S., Fleming, J., Leyland, S., Clark, E. M., Gidlow, C., …Paskins, Z. (2023). Variation in UK fracture liaison service consultation conduct and content before and during the COVID pandemic: results from the iFraP-D UK survey. Archives of Osteoporosis, 19(1), Article 5. https://doi.org/10.1007/s11657-023-01361-4

Summary We conducted a survey of FLSs’ consultation conduct and content which identified marked variation in whether FLS HCPs discussed osteoporosis medicine with patients. A review of service pro formas showed more content related to ‘investigating... Read More about Variation in UK fracture liaison service consultation conduct and content before and during the COVID pandemic: results from the iFraP-D UK survey.

Acceptability of a proposed practice pharmacist-led review for opioid-treated patients with persistent pain: A qualitative study to inform intervention development (2023)
Journal Article
Cornwall, N., Woodcock, C., Ashworth, J., Harrisson, S. A., Dikomitis, L., White, S., …on behalf of the PROMPPT team. (2023). Acceptability of a proposed practice pharmacist-led review for opioid-treated patients with persistent pain: A qualitative study to inform intervention development. British Journal of Pain, https://doi.org/10.1177/20494637231221688

Introduction Regular review of patients prescribed opioids for persistent non-cancer pain (PCNP) is recommended but not routinely undertaken. The PROMPPT (Proactive clinical Review of patients taking Opioid Medicines long-term for persistent Pain le... Read More about Acceptability of a proposed practice pharmacist-led review for opioid-treated patients with persistent pain: A qualitative study to inform intervention development.

The cost-effectiveness of adding an ultrasound corticosteroid and local anaesthetic injection to advice and education for hip osteoarthritis (2023)
Journal Article
Kigozi, J., Oppong, R., Paskins, Z., Bromley, K., Lewis, M., Hughes, G., …Roddy, E. (2023). The cost-effectiveness of adding an ultrasound corticosteroid and local anaesthetic injection to advice and education for hip osteoarthritis. Rheumatology, https://doi.org/10.1093/rheumatology/kead659

Objectives. Evidence for the comparative cost-effectiveness of intra-articular corticosteroid injection in people with hip osteoarthritis (OA) remains unclear. This study investigated the cost-effectiveness of best current treatment (BCT) comprising... Read More about The cost-effectiveness of adding an ultrasound corticosteroid and local anaesthetic injection to advice and education for hip osteoarthritis.

Management and treatment of children, young people and adults with systemic lupus erythematosus: British Society for Rheumatology guideline scope (2023)
Journal Article
Md Yusof, M. Y., Smith, E. M. D., Ainsworth, S., Armon, K., Beresford, M. W., Brown, M., …Vital, E. M. (in press). Management and treatment of children, young people and adults with systemic lupus erythematosus: British Society for Rheumatology guideline scope. Rheumatology Advances in Practice, 7(3), rkad093. https://doi.org/10.1093/rap/rkad093

Lay Summary: Systemic lupus erythematosus (SLE) is a lifelong condition in which the immune system damages the body’s own tissues, causing various symptoms including rashes, hair loss, mouth ulcers, joint pain and overwhelming tiredness. It can also... Read More about Management and treatment of children, young people and adults with systemic lupus erythematosus: British Society for Rheumatology guideline scope.

Improving the understanding and management of back pain in older adults: the BOOST research programme including RCT and OPAL cohort (2023)
Report
Williamson, E., Sanchez-Santos, M. T., Marian, I. R., Maredza, M., Srikesavan, C., Garrett, A., …Lamb, S. E. (2023). Improving the understanding and management of back pain in older adults: the BOOST research programme including RCT and OPAL cohort. NIHR

Background Back pain frequently affects older people. Knowledge about back pain in older people and evidence to inform clinical care was lacking, particularly for older people with neurogenic claudication due to spinal stenosis, which is a debilitati... Read More about Improving the understanding and management of back pain in older adults: the BOOST research programme including RCT and OPAL cohort.

Musculoskeletal disorders and pain in agricultural workers in Low- and Middle-Income Countries: a systematic review and meta-analysis (2023)
Journal Article
Shivakumar, M., Welsh, V., Bajpai, R., Helliwell, T., Mallen, C., Robinson, M., & Shepherd, T. (2024). Musculoskeletal disorders and pain in agricultural workers in Low- and Middle-Income Countries: a systematic review and meta-analysis. Rheumatology International, 44, 235–247. https://doi.org/10.1007/s00296-023-05500-5

Agricultural workers constitute two-thirds of the population of Low- and Middle-Income Countries (LMIC) and are at increased risk of developing musculoskeletal disorders (MSD) due to high-risk activities. This systematic review and meta-analysis aim... Read More about Musculoskeletal disorders and pain in agricultural workers in Low- and Middle-Income Countries: a systematic review and meta-analysis.

Pre-existing musculoskeletal pain and its association with mortality in newly diagnosed co-morbid conditions: an electronic health record cohort study (2023)
Journal Article
Marshall, M., Mason, K. J., Edwards, J. J., Mamas, M. A., Bailey, J., Heron, N., …Jordan, K. P. (2023). Pre-existing musculoskeletal pain and its association with mortality in newly diagnosed co-morbid conditions: an electronic health record cohort study. Rheumatology Advances in Practice, 8(1), Article rkad104. https://doi.org/10.1093/rap/rkad104

Objective Musculoskeletal pain is a common risk factor for co-morbid conditions and might increase the risk of poor outcomes. The objective was to determine whether patients with pre-existing musculoskeletal pain have an increased risk for mortality... Read More about Pre-existing musculoskeletal pain and its association with mortality in newly diagnosed co-morbid conditions: an electronic health record cohort study.

Cohort study investigating gout flares and management in UK general practice (2023)
Journal Article
Finnikin, S., Mallen, C. D., & Roddy, E. (in press). Cohort study investigating gout flares and management in UK general practice. BMC Primary Care, 24(1), 246. https://doi.org/10.1186/s12875-023-02201-7

Background: Gout is the most common inflammatory arthritis and is almost exclusively managed in primary care, however the course and severity of the condition is variable and poorly characterised. This research aims improve understanding about the fr... Read More about Cohort study investigating gout flares and management in UK general practice.

Trends in Cardiovascular Mortality Among Individuals with Alzheimer's Disease in the United States, 1999-2020 (2023)
Journal Article
Ranganathan, S., Abramov, D., Chew, N. W., Mallen, C., Marshall, M., Kobo, O., & Mamas, M. A. (2024). Trends in Cardiovascular Mortality Among Individuals with Alzheimer's Disease in the United States, 1999-2020. The American Journal of Cardiology, 211, Article 326-333. https://doi.org/10.1016/j.amjcard.2023.11.044

This study aimed to compare the trends in cardiovascular diseases (CVD)-related mortality in patients with Alzheimer's Disease (AD) and in the general population aged 65 and above. Data from the CDC WONDER Multiple Cause of Death da... Read More about Trends in Cardiovascular Mortality Among Individuals with Alzheimer's Disease in the United States, 1999-2020.

Discontinuation of anti-tumour necrosis factor alpha treatment owing to blood test abnormalities, and cost-effectiveness of alternate blood monitoring strategies (2023)
Journal Article
Abhishek, A., Stevenson, M. D., Nakafero, G., Grainge, M. J., Evans, I., Alabas, O., …Williams, H. C. (2024). Discontinuation of anti-tumour necrosis factor alpha treatment owing to blood test abnormalities, and cost-effectiveness of alternate blood monitoring strategies. British Journal of Dermatology, 190(4), 559–564. https://doi.org/10.1093/bjd/ljad430

Background There is no evidence base to support the use of 6-monthly monitoring blood tests for the early detection of liver, blood and renal toxicity during established anti-tumour necrosis factor alpha (TNFα) treatment. Objectives To evaluate... Read More about Discontinuation of anti-tumour necrosis factor alpha treatment owing to blood test abnormalities, and cost-effectiveness of alternate blood monitoring strategies.

Estimating the direct healthcare utilization and cost of musculoskeletal pain among people with comorbidity: a retrospective electronic health record study (2023)
Journal Article
Png, M. E., Mason, K. J., Marshall, M., Jordan, K. P., Bailey, J., Frisher, M., …Achana, F. (2023). Estimating the direct healthcare utilization and cost of musculoskeletal pain among people with comorbidity: a retrospective electronic health record study. Current Medical Research and Opinion, 1-8. https://doi.org/10.1080/03007995.2023.2271862

Objective To investigate the impact of pre-existing painful musculoskeletal conditions on healthcare utilization and costs among patients with five common conditions: acute coronary syndrome (ACS), stroke, cancer, dementia and pneumonia. Methods... Read More about Estimating the direct healthcare utilization and cost of musculoskeletal pain among people with comorbidity: a retrospective electronic health record study.

Analgesic Prescribing in Patients with Inflammatory Arthritis in England: Observational Studies in the Clinical Practice Research Datalink (2023)
Journal Article
Scott, I. C., Jordan, K. P., Twohig, H., Whittle, R., Muller, S., Hider, S. L., …Bailey, J. (2023). Analgesic Prescribing in Patients with Inflammatory Arthritis in England: Observational Studies in the Clinical Practice Research Datalink. Rheumatology, Article kead463. https://doi.org/10.1093/rheumatology/kead463

Despite little evidence that analgesics are effective in inflammatory arthritis (IA), studies report substantial opioid prescribing. The extent this applies to other analgesics is uncertain. We undertook a comprehensive evaluation of analgesic prescr... Read More about Analgesic Prescribing in Patients with Inflammatory Arthritis in England: Observational Studies in the Clinical Practice Research Datalink.

Stakeholder perceptions of preventive approaches to rheumatoid arthritis: qualitative study of healthcare professionals’ perspectives on predictive and preventive strategies (2023)
Journal Article
Wells, I., Simons, G., Kanacherril, J. P., Mallen, C. D., Raza, K., & Falahee, M. (in press). Stakeholder perceptions of preventive approaches to rheumatoid arthritis: qualitative study of healthcare professionals’ perspectives on predictive and preventive strategies. BMC Rheumatology, 7(1), Article 35. https://doi.org/10.1186/s41927-023-00361-8

Background: There is increasing research interest in the development of preventive treatment for individuals at risk of rheumatoid arthritis (RA). Previous studies have explored the perceptions of at-risk groups and patients about predictive and prev... Read More about Stakeholder perceptions of preventive approaches to rheumatoid arthritis: qualitative study of healthcare professionals’ perspectives on predictive and preventive strategies.

Safety of colchicine and NSAID prophylaxis when initiating urate-lowering therapy for gout: propensity score-matched cohort studies in the UK Clinical Practice Research Datalink (2023)
Journal Article
Roddy, E., Bajpai, R., Forrester, H., James Partington, R., D Mallen, C., Clarson, L. E., …Muller, S. (2023). Safety of colchicine and NSAID prophylaxis when initiating urate-lowering therapy for gout: propensity score-matched cohort studies in the UK Clinical Practice Research Datalink. Annals of the Rheumatic Diseases, ard-2023-224154. https://doi.org/10.1136/ard-2023-224154

Objectives: To determine the risk of adverse events associated with colchicine or non-steroidal anti-inflammatory drug (NSAID) prophylaxis when initiating allopurinol for gout. Methods: We conducted two matched retrospective cohort studies in... Read More about Safety of colchicine and NSAID prophylaxis when initiating urate-lowering therapy for gout: propensity score-matched cohort studies in the UK Clinical Practice Research Datalink.

Knowledge, attitudes and practice of female genital mutilation and cutting: An observational cross-sectional study in primary care (FGM/C Study) (2023)
Journal Article
Robinson, M., Prior, J., Mallen, C. D., & Shepherd, T. A. (2023). Knowledge, attitudes and practice of female genital mutilation and cutting: An observational cross-sectional study in primary care (FGM/C Study). British Journal of General Practice Open (BJGP Open), 7(3), Article BJGPO20230005. https://doi.org/10.3399/bjgpo.2023.0005

Background: Female genital mutilation and cutting (FGM/C) describes procedures involving partial or total removal of the external female genitalia or other injury to the female genital organs for non-medical reasons. Increasing migration means many c... Read More about Knowledge, attitudes and practice of female genital mutilation and cutting: An observational cross-sectional study in primary care (FGM/C Study).

Risk-stratified monitoring for thiopurine toxicity in immune-mediated inflammatory diseases: prognostic model development, validation, and, health economic evaluation. (2023)
Journal Article
Nakafero, G., Card, T., Grainge, M. J., Williams, H. C., Taal, M. W., Aithal, G. P., …Abhishek, A. (2023). Risk-stratified monitoring for thiopurine toxicity in immune-mediated inflammatory diseases: prognostic model development, validation, and, health economic evaluation. EClinicalMedicine, 64, Article 102213. https://doi.org/10.1016/j.eclinm.2023.102213

Background Patients established on thiopurines (e.g., azathioprine) are recommended to undergo three-monthly blood tests for the early detection of blood, liver, or kidney toxicity. These side-effects are uncommon during long-term treatment. We deve... Read More about Risk-stratified monitoring for thiopurine toxicity in immune-mediated inflammatory diseases: prognostic model development, validation, and, health economic evaluation..

Impact of Frailty on Emergency Department Encounters for Cardiovascular Disease: A Retrospective Cohort Study (2023)
Journal Article
Sokhal, B. S., Matetić, A., Abhishek, A., Banerjee, A., Partington, R., Roddy, E., …Mamas, M. A. (2023). Impact of Frailty on Emergency Department Encounters for Cardiovascular Disease: A Retrospective Cohort Study. American Journal of Cardiology, 206, 210-218. https://doi.org/10.1016/j.amjcard.2023.08.138

Data are limited on whether the causes of emergency department (ED) encounters for cardiovascular diseases (CVDs) and associated clinical outcomes vary by frailty status. Using the United States Nationwide ED Sample, selected CVD encounters (acute my... Read More about Impact of Frailty on Emergency Department Encounters for Cardiovascular Disease: A Retrospective Cohort Study.

The aftermath of war; mental health, substance use and their correlates with social support and resilience among adolescents in a post-conflict region of Sri Lanka (2023)
Journal Article
Dissanayake, L., Jabir, S., Shepherd, T., Helliwell, T., Selvaratnam, L., Jayaweera, K., …Sumathipala, A. (in press). The aftermath of war; mental health, substance use and their correlates with social support and resilience among adolescents in a post-conflict region of Sri Lanka. Child and Adolescent Psychiatry and Mental Health, 17(1), Article 101. https://doi.org/10.1186/s13034-023-00648-1

Background: Armed conflicts impact on the health and well-being of everyone, but its effect on adolescent mental health is a significant, yet under-explored area in global health. Mental health disorders which develop during adolescence often lead... Read More about The aftermath of war; mental health, substance use and their correlates with social support and resilience among adolescents in a post-conflict region of Sri Lanka.

Traditional healers working with primary care and mental health for early intervention in psychosis in young persons: protocol for the feasibility cluster randomised controlled trial (2023)
Journal Article
Farooq, S., Sheikh, S., Dikomitis, L., Haq, M. M. U., Khan, A. J., Sanauddin, N., …Lewis, M. (2023). Traditional healers working with primary care and mental health for early intervention in psychosis in young persons: protocol for the feasibility cluster randomised controlled trial. BMJ Open, 13(7), Article e072471. https://doi.org/10.1136/bmjopen-2023-072471

Objectives In low/middle-income countries (LMICs), more than half of patients with first-episode psychosis initially seek treatment from traditional and religious healers as their first care. This contributes to an excessively long duration of untrea... Read More about Traditional healers working with primary care and mental health for early intervention in psychosis in young persons: protocol for the feasibility cluster randomised controlled trial.

UK research data resources based on primary care electronic health records: review and summary for potential users (2023)
Journal Article
Edwards, L., Pickett, J., Ashcroft, D. M., Dambha-Miller, H., Majeed, A., Mallen, C., …MacLeod, J. (2023). UK research data resources based on primary care electronic health records: review and summary for potential users. British Journal of General Practice Open (BJGP Open), https://doi.org/10.3399/BJGPO.2023.0057

To describe the current landscape of UK electronic health record (EHR) databases and considerations of access and use of these resources relevant to researchers. Narrative review DATA SOURCES: Information was collected from the Health Data Research I... Read More about UK research data resources based on primary care electronic health records: review and summary for potential users.

Traditional healers working with primary care and mental health for early intervention in psychosis in young persons: protocol for the feasibility cluster randomised controlled trial (2023)
Journal Article
Farooq, S., Sheikh, S., Dikomitis, L., Haq, M. M. U., Khan, A. J., Sanauddin, N., …Lewis, M. (2023). Traditional healers working with primary care and mental health for early intervention in psychosis in young persons: protocol for the feasibility cluster randomised controlled trial. BMJ Open, 13(7), e072471. https://doi.org/10.1136/bmjopen-2023-072471

Objectives: In low/middle-income countries (LMICs), more than half of patients with first-episode psychosis initially seek treatment from traditional and religious healers as their first care. This contributes to an excessively long duration of untre... Read More about Traditional healers working with primary care and mental health for early intervention in psychosis in young persons: protocol for the feasibility cluster randomised controlled trial.

POS0999-HPR THE IMPACT OF THE COVID-19 PANDEMIC ON REFERRALS TO MUSCULOSKELETAL SERVICES FROM PRIMARY CARE AND SUBSEQUENT INCIDENCE OF INFLAMMATORY RHEUMATIC MUSCULOSKELETAL DISEASE: AN OBSERVATIONAL STUDY (2023)
Presentation / Conference
Bajpai, R., Burton, C., Mason, K., Bailey, J., Frisher, M., Jordan, K., …Welsh, V. (2023, May). POS0999-HPR THE IMPACT OF THE COVID-19 PANDEMIC ON REFERRALS TO MUSCULOSKELETAL SERVICES FROM PRIMARY CARE AND SUBSEQUENT INCIDENCE OF INFLAMMATORY RHEUMATIC MUSCULOSKELETAL DISEASE: AN OBSERVATIONAL STUDY. Poster presented at EULAR 2023 European Congress of Rheumatology, Milan, Italy

Background Inflammatory rheumatic and musculoskeletal diseases (iRMDs), including rheumatoid arthritis (RA) and juveneille inflammatory arthritsi (JIA), are common and cause a high disease burden globally. Early diagnosis of iRMDs and subsequent time... Read More about POS0999-HPR THE IMPACT OF THE COVID-19 PANDEMIC ON REFERRALS TO MUSCULOSKELETAL SERVICES FROM PRIMARY CARE AND SUBSEQUENT INCIDENCE OF INFLAMMATORY RHEUMATIC MUSCULOSKELETAL DISEASE: AN OBSERVATIONAL STUDY.

POS0508 A RANDOMISED CONTROLLED TRIAL COMPARING ANAKINRA VERSUS STEROIDS FOR THE TREATMENT OF GOUT ATTACKS IN PEOPLE WITH RENAL DISEASE (ASGARD): A FEASIBILITY STUDY (2023)
Presentation / Conference
Balasubramaniam, G., Almond, M., Harnett, P., Zhang, J., Turner, D., Scales, J., …Dasgupta, B. (2023, May). POS0508 A RANDOMISED CONTROLLED TRIAL COMPARING ANAKINRA VERSUS STEROIDS FOR THE TREATMENT OF GOUT ATTACKS IN PEOPLE WITH RENAL DISEASE (ASGARD): A FEASIBILITY STUDY. Paper presented at EULAR 2023 European Congress of Rheumatology, Milan, Italy

Risk stratified monitoring for methotrexate toxicity in immune mediated inflammatory diseases: prognostic model development and validation using primary care data from the UK (2023)
Journal Article
Nakafero, G., Grainge, M. J., Williams, H. C., Card, T., Taal, M. W., Aithal, G. P., …Abhishek, A. (2023). Risk stratified monitoring for methotrexate toxicity in immune mediated inflammatory diseases: prognostic model development and validation using primary care data from the UK. BMJ,

Objective To develop and validate a prognostic model to inform risk stratified decisions on frequency of monitoring blood tests during long term methotrexate treatment.

Evaluation of an electronic clinical decision support system (DeSSBack) to improve low back pain management: a pilot cluster randomized controlled trial (2023)
Journal Article
Firzara, A. M. T., Teo, C. H., Teh, S. Y., Su, J. Y., Zaini, H. S. M., Suhaimi, A., …Ng, C. J. (2023). Evaluation of an electronic clinical decision support system (DeSSBack) to improve low back pain management: a pilot cluster randomized controlled trial. Family Practice, 40(5-6), 742-752. https://doi.org/10.1093/fampra/cmad044

Background Low back pain (LBP) is a common reason for primary care consultation; yet doctors often find managing it challenging. An electronic decision support system for LBP (DeSSBack) was developed based on an evidence-based risk stratification too... Read More about Evaluation of an electronic clinical decision support system (DeSSBack) to improve low back pain management: a pilot cluster randomized controlled trial.

Trends in consultations and prescribing for rheumatic and musculoskeletal diseases: an electronic primary care records study. (2023)
Journal Article
Welsh, V. K., Mason, K. J., Bailey, J., Bajpai, R., Jordan, K. P., Mallen, C. D., & Burton, C. (2023). Trends in consultations and prescribing for rheumatic and musculoskeletal diseases: an electronic primary care records study. British Journal of General Practice (BJGP), 73(736), BJGP.2022.0648. https://doi.org/10.3399/bjgp.2022.0648

Background Rheumatic and musculoskeletal diseases (RMDs) are common and generally managed in primary care through supported self-care, physiotherapy, analgesia, and specialist referral where indicated. The COVID-19 pandemic led to abrupt changes in... Read More about Trends in consultations and prescribing for rheumatic and musculoskeletal diseases: an electronic primary care records study..

Proactive review of patients taking opioid medicines for persistent pain led by pharmacists in primary care teams (PROMPPT): A feasibility study (2023)
Presentation / Conference
Ashworth, J., Cornwall, N., Harrisson, S. A., Woodcock, C., Nicholls, E., Laing, L., …Jinks, C. (2023, May). Proactive review of patients taking opioid medicines for persistent pain led by pharmacists in primary care teams (PROMPPT): A feasibility study. Presented at BPS Annual Scientific Meeting 2023, Glasgow, Scotland, UK

Healthcare utilisation and mortality in people with osteoarthritis in the UK: findings from a national primary care database (2023)
Journal Article
Swain, S., Coupland, C., Sarmanova, A., Kuo, C. F., Mallen, C., Doherty, M., & Zhang, W. (2023). Healthcare utilisation and mortality in people with osteoarthritis in the UK: findings from a national primary care database. British Journal of General Practice (BJGP), 73(733), e615-e622. https://doi.org/10.3399/BJGP.2022.0419

The burden of osteoarthritis (OA) in UK primary care has not been investigated thoroughly. To estimate healthcare use and mortality in people with OA (overall and joint specific). A matched cohort study of adults with an incident diagnosis of OA in p... Read More about Healthcare utilisation and mortality in people with osteoarthritis in the UK: findings from a national primary care database.

P115 Healthcare professionals' perspectives on integrating predictive and emerging preventive approaches in rheumatoid arthritis care: A qualitative investigation (2023)
Presentation / Conference
Simons, G., Wells, I., Kanacherril, J. P., Mallen, C. D., Raza, K., & Falahee, M. (2023, April). P115 Healthcare professionals' perspectives on integrating predictive and emerging preventive approaches in rheumatoid arthritis care: A qualitative investigation. Poster presented at British Society for Rheumatology Annual Conference 2023, Manchester Central Convention Complex, Manchester, UK

P102 Barriers and facilitators to lifestyle change in people living with gout: a scoping review of qualitative studies (2023)
Presentation / Conference
Watson, L., Cornwall, N., Jinks, C., Bradbury, K., Goff, L., Little, P., …Roddy, E. (2023, April). P102 Barriers and facilitators to lifestyle change in people living with gout: a scoping review of qualitative studies. Poster presented at British Society for Rheumatology Annual Conference 2023, Manchester Central Convention Complex, Manchester, UK

Background/Aims Lifestyle, especially diet and alcohol, has been implicated in the causation of gout for centuries and the dietary factors which may trigger flares remain of great interest to people living with gout and their families. However, ther... Read More about P102 Barriers and facilitators to lifestyle change in people living with gout: a scoping review of qualitative studies.

E060 Testing a new prototype osteoporosis shared decision-making intervention in UK Fracture Liaison Services: patient and clinician perspectives of ‘iFraP’ (2023)
Presentation / Conference
Bullock, L., Tyler, N., Thompson, M., Ryan, S., Lefroy, J., Leyland, S., …Paskins, Z. (2023, April). E060 Testing a new prototype osteoporosis shared decision-making intervention in UK Fracture Liaison Services: patient and clinician perspectives of ‘iFraP’. Poster presented at British Society for Rheumatology Annual Conference 2023, Manchester Central Convention Complex, Manchester, UK

Shared decision-making (SDM) is a joint process in which a person and healthcare professional work together to reach decisions about care. The Improving uptake of Fracture Prevention drug treatments (iFraP) study developed a prototype theoretically-i... Read More about E060 Testing a new prototype osteoporosis shared decision-making intervention in UK Fracture Liaison Services: patient and clinician perspectives of ‘iFraP’.

P203 Comparison of coding of giant cell arteritis in primary and secondary care records: an observational feasibility study (2023)
Presentation / Conference
Padmanabhan, N., Muller, S., Bailey, J., Helliwell, T., Mackie, S. L., Mallen, C. D., & Roddy, E. (2023, April). P203 Comparison of coding of giant cell arteritis in primary and secondary care records: an observational feasibility study. Poster presented at British Society for Rheumatology Annual Conference 2023, Manchester Central Convention Complex, Manchester, UK

Giant cell arteritis (GCA) is considered a medical emergency, and relapses are common, affecting around 50% of patients. Many of the early symptoms of GCA are non-specific and highly prevalent in older people, making the diagnosis challenging. The... Read More about P203 Comparison of coding of giant cell arteritis in primary and secondary care records: an observational feasibility study.

P098 Changes in Analgesic Prescribing in Patients with Inflammatory Arthritis in England: An Observational Study in CPRD Aurum (2023)
Presentation / Conference
C Scott, I., Whittle, R., Bailey, J., Twohig, H., L Hider, S., D Mallen, C., …P Jordan, K. (2023, April). P098 Changes in Analgesic Prescribing in Patients with Inflammatory Arthritis in England: An Observational Study in CPRD Aurum. Poster presented at British Society for Rheumatology Annual Conference 2023, Manchester Central Convention Complex, Manchester, UK

Background/Aims Pain is a common symptom experienced by patients with inflammatory arthritis (IA). Emerging data indicate IA pain treatment focuses on prescribing analgesics despite an absence of evidence for long-term efficacy. Delivering optimal,... Read More about P098 Changes in Analgesic Prescribing in Patients with Inflammatory Arthritis in England: An Observational Study in CPRD Aurum.

Online Health Information Seeking for Mpox in Endemic and Nonendemic Countries: Google Trends Study (2023)
Journal Article
Shepherd, T., Robinson, M., & Mallen, C. (2023). Online Health Information Seeking for Mpox in Endemic and Nonendemic Countries: Google Trends Study. JMIR Formative Research, 7, Article e42710. https://doi.org/10.2196/42710

Background: The recent global outbreak of mpox (monkeypox) has already been declared a public health emergency of international concern by the World Health Organization. Given the health, social, and economic impacts of the COVID-19 pandemic, there... Read More about Online Health Information Seeking for Mpox in Endemic and Nonendemic Countries: Google Trends Study.

The impact of the COVID-19 pandemic on referrals to musculoskeletal services from primary care and subsequent incidence of inflammatory rheumatic musculoskeletal disease: an observational study (2023)
Journal Article
Burton, C., Mallen, C., Mason, K., Jordan, K., Welsh, V., Bajpai, R., & Bailey, J. (2023). The impact of the COVID-19 pandemic on referrals to musculoskeletal services from primary care and subsequent incidence of inflammatory rheumatic musculoskeletal disease: an observational study. Rheumatology Advances in Practice, 7(2), Article ARTN rkad044. https://doi.org/10.1093/rap/rkad044

Objectives To describe the impact of the COVID-19 pandemic upon referral patterns and incident diagnosis of inflammatory rheumatic and musculoskeletal diseases (iRMDs). Methods UK primary care data was used to describe referral patterns for pat... Read More about The impact of the COVID-19 pandemic on referrals to musculoskeletal services from primary care and subsequent incidence of inflammatory rheumatic musculoskeletal disease: an observational study.

Patient perceptions of empathy in primary care telephone consultations: A mixed methods study* (2023)
Journal Article
Vennik, J., Hughes, S., Lyness, E., McDermott, C., Smith, K. A., Steele, M., …Bishop, F. L. (2023). Patient perceptions of empathy in primary care telephone consultations: A mixed methods study*. Patient Education and Counseling, 113, Article ARTN 107748. https://doi.org/10.1016/j.pec.2023.107748

Objective Clinical empathy can enhance patient outcomes. This study examined patients’ perceptions of empathy in primary care consultations delivered by telephone. Methods A mixed methods study was nested in a larger feasibility study conducted... Read More about Patient perceptions of empathy in primary care telephone consultations: A mixed methods study*.

Association of Frailty Status on the Causes and Outcomes of Patients Admitted With Cardiovascular Disease. (2023)
Journal Article
Sokhal, B., Matetić, A., Rashid, M., Protheroe, J., Partington, R., Mallen, C., & Mamas, M. (2023). Association of Frailty Status on the Causes and Outcomes of Patients Admitted With Cardiovascular Disease. American Journal of Cardiology, 7 - 15. https://doi.org/10.1016/j.amjcard.2022.12.029

Data are limited about the contemporary association between frailty and the causes and outcomes of patients admitted with cardiovascular diseases (CVD). Using the US National Inpatient Sample, CVD admissions of interest (acute myocardial infarction,... Read More about Association of Frailty Status on the Causes and Outcomes of Patients Admitted With Cardiovascular Disease..

Predictors of the likelihood that patients with rheumatoid arthritis will communicate information about rheumatoid arthritis risk to relatives: A quantitative assessment. (2023)
Journal Article
Mallen, C., Raza, K., Falahee, M., Wells, I., Zemedikun, D., Simons, G., & Stack, R. (2023). Predictors of the likelihood that patients with rheumatoid arthritis will communicate information about rheumatoid arthritis risk to relatives: A quantitative assessment. Patient Education and Counseling, 112, Article 107713. https://doi.org/10.1016/j.pec.2023.107713

First-degree relatives (FDRs) of people with rheumatoid arthritis (RA) are increasingly recruited to prediction and prevention studies. Access to FDRs is usually via their proband with RA. Quantitative data on predictors of family risk communication... Read More about Predictors of the likelihood that patients with rheumatoid arthritis will communicate information about rheumatoid arthritis risk to relatives: A quantitative assessment..

what factors require consideration when individualising exercise interventions for people with osteoarthritis? Consensus of experts using a delphi methodology (2023)
Presentation / Conference
Yaseen, K., Zhang, W., Doherty, M., Abhishek, A., Jamtvedt, G., Martinez, M., …Hall, M. (2023, March). what factors require consideration when individualising exercise interventions for people with osteoarthritis? Consensus of experts using a delphi methodology. Poster presented at 2023 OARSI World Congress on Osteoarthritis, Sheraton Denver Downtown Hotel, Denver, USA

Symptom patterns and life with post-acute COVID-19 in children aged 8-17: a mixed methods studyprotocol. (2023)
Journal Article
Faux-Nightingale, A., Burton, C., Twohig, H., Bucknall, M., Carroll, W., Chew-Graham, C., …Welsh, V. (2023). Symptom patterns and life with post-acute COVID-19 in children aged 8-17: a mixed methods studyprotocol. British Journal of General Practice Open (BJGP Open), 7(2), Article BJGPO20220149. https://doi.org/10.3399/bjgpo.2022.0149

Background: While there is a substantial body of knowledge about acute COVID-19, less is known about long-COVID, where symptoms continue beyond 4 weeks. Aim: To describe longer-term effects of COVID-19 infection in children and young people (CYP)... Read More about Symptom patterns and life with post-acute COVID-19 in children aged 8-17: a mixed methods studyprotocol..

Musculoskeletal pain and its impact on prognosis following acute coronary syndrome or stroke: A linked electronic health record cohort study (2023)
Journal Article
Mason, K. J., Jordan, K. P., Heron, N., Edwards, J. J., Bailey, J., Achana, F. A., …Marshall, M. (2023). Musculoskeletal pain and its impact on prognosis following acute coronary syndrome or stroke: A linked electronic health record cohort study. Musculoskeletal Care, 21(3), 749-762. https://doi.org/10.1002/msc.1748

OBJECTIVE: Musculoskeletal painful conditions are a risk factor for cardiovascular disease (CVD), but less is known about whether musculoskeletal pain also worsens prognosis from CVD. The objective was to determine whether patients with musculoskelet... Read More about Musculoskeletal pain and its impact on prognosis following acute coronary syndrome or stroke: A linked electronic health record cohort study.

Sex and country differences in gout: cross-country comparison between Sweden and the UK (2023)
Journal Article
Dehlin, M., Muller, S., Mallen, C., Landgren, A., Watson, L., Jacobsson, L., & Roddy, E. (2023). Sex and country differences in gout: cross-country comparison between Sweden and the UK. Scandinavian Journal of Rheumatology, 52(6), 673-682. https://doi.org/10.1080/03009742.2023.2177383

OBJECTIVE: Compare characteristics, sex differences, and management of gout in Sweden and the UK. METHOD: The results from two separate primary care gout surveys from Sweden and the UK were compared. Participants aged =18 years with gout were sent a... Read More about Sex and country differences in gout: cross-country comparison between Sweden and the UK.

Trends in gabapentinoid prescribing in UK primary care using the Clinical Practice Research Datalink: an observational study (2023)
Journal Article
Ashworth, J., Bajpai, R., Muller, S., Bailey, J., Helliwell, T., Harrisson, S., …Mallen, C. (2023). Trends in gabapentinoid prescribing in UK primary care using the Clinical Practice Research Datalink: an observational study. The Lancet Regional Health Europe, 27, Article ARTN 100579. https://doi.org/10.1016/j.lanepe.2022.100579

Background The UK government reclassified gabapentin and pregabalin as ‘controlled drugs’ from April 2019. This study aimed to describe the trends in gabapentinoid prescribing before and immediately after reclassification, in the UK Clinical Practic... Read More about Trends in gabapentinoid prescribing in UK primary care using the Clinical Practice Research Datalink: an observational study.

The Organization of Outreach Work for Vulnerable Patients in General Practice during COVID-19: Results from the Cross-Sectional PRICOV-19 Study in 38 Countries. (2023)
Journal Article
Stark, S., Willems, S., Schaubroeck, E., Mallen, C., Murauskiene, L., Šantrić Milićević, M., …Collins, C. (2023). The Organization of Outreach Work for Vulnerable Patients in General Practice during COVID-19: Results from the Cross-Sectional PRICOV-19 Study in 38 Countries. International Journal of Environmental Research and Public Health, https://doi.org/10.3390/ijerph20043165

The COVID-19 pandemic disproportionately affected vulnerable populations' access to health care. By proactively reaching out to them, general practices attempted to prevent the underutilization of their services. This paper examined the association b... Read More about The Organization of Outreach Work for Vulnerable Patients in General Practice during COVID-19: Results from the Cross-Sectional PRICOV-19 Study in 38 Countries..

Is Vaccination Against COVID-19 Associated With Inflammatory Bowel Disease Flare? Self-Controlled Case Series Analysis Using the UK CPRD (2023)
Journal Article
Card, T. R., Nakafero, G., Grainge, M. J., Mallen, C. D., Van-Tam, J. S. N., Williams, H. C., & Abhishek, A. (2023). Is Vaccination Against COVID-19 Associated With Inflammatory Bowel Disease Flare? Self-Controlled Case Series Analysis Using the UK CPRD. American Journal of Gastroenterology, 118(8), 1388-1394. https://doi.org/10.14309/ajg.0000000000002205

INTRODUCTION: To investigate the association between vaccination against coronavirus disease 2019 (COVID-19) and inflammatory bowel disease (IBD) flare. METHODS: Patients with IBD vaccinated against COVID-19 who consulted for disease flare between De... Read More about Is Vaccination Against COVID-19 Associated With Inflammatory Bowel Disease Flare? Self-Controlled Case Series Analysis Using the UK CPRD.

Investigating the usefulness of Automated Check-in Data Collection in general practice (AC DC Study): a multicentre, cross-sectional study in England. (2023)
Journal Article
Lawton, S., Mallen, C., Muller, S., Wathall, S., & Helliwell, T. (2023). Investigating the usefulness of Automated Check-in Data Collection in general practice (AC DC Study): a multicentre, cross-sectional study in England. BMJ Open, 13(1), Article e062389. https://doi.org/10.1136/bmjopen-2022-062389

Objectives: To investigate the usefulness of using automated appointment check-in screens to collect brief research data from patients, prior to their general practice consultation. Design: A descriptive, cross-sectional study. Setting: Nine ge... Read More about Investigating the usefulness of Automated Check-in Data Collection in general practice (AC DC Study): a multicentre, cross-sectional study in England..

Systematic review of community engagement approach in research: describing partnership approaches, challenges and benefits (2023)
Journal Article
Abebe, H., Zerihun, Z., Mallen, C., Price, H., Mulugeta, A., & Taffere, G. (2023). Systematic review of community engagement approach in research: describing partnership approaches, challenges and benefits. Journal of Public Health, https://doi.org/10.1007/s10389-022-01799-9

Background Community engagement in research has gained momentum as people have realised the importance and value it brings to research. However, a lack of standardization in the engagement approach has been reported in the literature. This systemati... Read More about Systematic review of community engagement approach in research: describing partnership approaches, challenges and benefits.

Factors associated with change in health-related quality of life in people with gout: a 3-year prospective cohort study in primary care (2022)
Journal Article
Watson, L., Belcher, J., Nicholls, E., Chandratre, P., Blagojevic-Bucknall, M., Hider, S., …Roddy, E. (2022). Factors associated with change in health-related quality of life in people with gout: a 3-year prospective cohort study in primary care. Rheumatology, 62(8), 2748-2756. https://doi.org/10.1093/rheumatology/keac706

Objective To describe factors associated with change in health-related quality of life (HRQOL) in people living with gout in primary care. Methods In a UK prospective cohort study, adults with a diagnosis of gout registered with 20 general practices... Read More about Factors associated with change in health-related quality of life in people with gout: a 3-year prospective cohort study in primary care.

A Critical Evaluation of Patient Pathways and Missed Opportunities in Treatment for Heart Failure. (2022)
Journal Article
Shing Kwok, C., Satchithananda, D., Ahmed, F. Z., Chue, C. D., Barker, D., Patwala, A., …Mallen, C. D. (2022). A Critical Evaluation of Patient Pathways and Missed Opportunities in Treatment for Heart Failure. Journal of Cardiovascular Development and Disease, 9(12. Special issue Heart Failure: Clinical Diagnostics and Treatment), https://doi.org/10.3390/jcdd9120455

BACKGROUND: Heart failure (HF) is a global problem responsible for significant morbidity and mortality. METHODS: This review describes the patient pathways and missed opportunities related to treatment for patients with HF. RESULTS: The contemporary... Read More about A Critical Evaluation of Patient Pathways and Missed Opportunities in Treatment for Heart Failure..

Predictors of perceived risk in first-degree relatives of patients with rheumatoid arthritis. (2022)
Journal Article
Bunnewell, S., Wells, I., Zemedikun, D., Simons, G., Mallen, C. D., Raza, K., & Falahee, M. (2022). Predictors of perceived risk in first-degree relatives of patients with rheumatoid arthritis. RMD Open, https://doi.org/10.1136/rmdopen-2022-002606

OBJECTIVES: To define variables associated with perceived risk of developing rheumatoid arthritis (RA) in first-degree relatives (FDRs) of patients with RA. METHODS: Patients with RA and their FDRs were invited to complete cross-sectional surveys. FD... Read More about Predictors of perceived risk in first-degree relatives of patients with rheumatoid arthritis..

Has the COVID-19 Pandemic Led to Changes in the Tasks of the Primary Care Workforce? An International Survey among General Practices in 38 Countries (PRICOV-19). (2022)
Journal Article
Groenewegen, P., Van Poel, E., Spreeuwenberg, P., Mallen, C., Murauskiene, L., Pétré, B., …Peris, A. (2022). Has the COVID-19 Pandemic Led to Changes in the Tasks of the Primary Care Workforce? An International Survey among General Practices in 38 Countries (PRICOV-19). International Journal of Environmental Research and Public Health, https://doi.org/10.3390/ijerph192215329

The COVID-19 pandemic has had a large and varying impact on primary care. This paper studies changes in the tasks of general practitioners (GPs) and associated staff during the COVID-19 pandemic. Data from the PRICOV-19 study of 5093 GPs in 38 countr... Read More about Has the COVID-19 Pandemic Led to Changes in the Tasks of the Primary Care Workforce? An International Survey among General Practices in 38 Countries (PRICOV-19)..

Is Vaccination Against Covid-19 Associated with Autoimmune Rheumatic Disease Flare? Self-controlled Case Series Analysis Using Data from the Clinical Practice Research Datalink (Aurum) (2022)
Presentation / Conference
Nakafero, G., Grainge, M. J., Card, T., Mallen, C., Nguyen van Tam, J. S., Williams, H. C., & Abhishek, A. (2022, November). Is Vaccination Against Covid-19 Associated with Autoimmune Rheumatic Disease Flare? Self-controlled Case Series Analysis Using Data from the Clinical Practice Research Datalink (Aurum). Paper presented at ACR Convergence 2022, Philadelphia, PA, USA

Background/Purpose: It is unclear whether autoimmune rheumatic disease (AIRD) flares are associated with the recent prior Covid-19 vaccination, and whether the association was influenced by vaccine modality and prior Covid-19 infection. The objective... Read More about Is Vaccination Against Covid-19 Associated with Autoimmune Rheumatic Disease Flare? Self-controlled Case Series Analysis Using Data from the Clinical Practice Research Datalink (Aurum).

Data Collection Theory in Healthcare Research: The Minimum Dataset in Quantitative Studies. (2022)
Journal Article
Kwok, C., Muntean, E., Mallen, C., & Borovac, J. (2022). Data Collection Theory in Healthcare Research: The Minimum Dataset in Quantitative Studies. Clinics and Practice, 832 - 844. https://doi.org/10.3390/clinpract12060088

There is considerable interest in data analytics because of its value in informing decisions in healthcare. Data variables can be derived from routinely collected records or from primary studies. The level of detail for individual variables in quanti... Read More about Data Collection Theory in Healthcare Research: The Minimum Dataset in Quantitative Studies..

Is vaccination against COVID-19 associated with psoriasis or eczema flare? Self-controlled case series analysis using data from the Clinical Practice Research Datalink (Aurum) (2022)
Journal Article
Adams, L., Nakafero, G., Grainge, M. J., Card, T., Mallen, C. D., Van-Tam, J. S. N., …Abhishek, A. (2023). Is vaccination against COVID-19 associated with psoriasis or eczema flare? Self-controlled case series analysis using data from the Clinical Practice Research Datalink (Aurum). British Journal of Dermatology, 188(2), 297-299. https://doi.org/10.1093/bjd/ljac061

Intermediate care in caring for dementia, the point of view of general practitioners: A key informant survey across Europe. (2022)
Journal Article
Dibao-Dina, C., Oger, C., Foley, T., Torzsa, P., Lazic, V., Kreitmayer Peštiae, S., …Petrazzuoli, F. (2022). Intermediate care in caring for dementia, the point of view of general practitioners: A key informant survey across Europe. Frontiers in Medicine, https://doi.org/10.3389/fmed.2022.1016462

Background: Intermediate care is often defined as healthcare occurring somewhere between traditional primary (community) and secondary (hospital) care settings. High quality intermediate care is important in dementia, may prevent caregiver burnout an... Read More about Intermediate care in caring for dementia, the point of view of general practitioners: A key informant survey across Europe..

Rheumatoid arthritis, psoriatic arthritis, and axial spondyloarthritis epidemiology in England from 2004 to 2020: An observational study using primary care electronic health record data (2022)
Journal Article
Scott, I. C., Whittle, R., Bailey, J., Twohig, H., Hider, S., Mallen, C., …Jordan, K. (2022). Rheumatoid arthritis, psoriatic arthritis, and axial spondyloarthritis epidemiology in England from 2004 to 2020: An observational study using primary care electronic health record data. The Lancet Regional Health Europe, 23, Article 100519. https://doi.org/10.1016/j.lanepe.2022.100519

Background: Contemporary data on rheumatoid arthritis (RA), psoriatic arthritis (PsA) and axial spondyloarthritis (SpA) epidemiology in England are lacking. This knowledge is crucial to planning healthcare services. We updated algorithms defining pat... Read More about Rheumatoid arthritis, psoriatic arthritis, and axial spondyloarthritis epidemiology in England from 2004 to 2020: An observational study using primary care electronic health record data.

Management and outcomes of patients admitted with type 2 myocardial infarction with and without standard modifiable risk factors. (2022)
Journal Article
Rashid, M., Matetić, A., Lambrinou, E., Sokhal, B., Figtree, G., Moledina, S., …Velagapudi, P. (2022). Management and outcomes of patients admitted with type 2 myocardial infarction with and without standard modifiable risk factors. International Journal of Cardiology, 391-396. https://doi.org/10.1016/j.ijcard.2022.09.037

BACKGROUND: Whilst it is known patients without standard modifiable cardiovascular risk factors (SMuRF; hypertension, diabetes, hypercholesterolaemia, smoking) have worse outcomes in Type 1 acute myocardial infarction (AMI), the relationship between... Read More about Management and outcomes of patients admitted with type 2 myocardial infarction with and without standard modifiable risk factors..

Acceptability of predictive testing for ischemic heart disease in those with a family history and the impact of results on behavioural intention and behaviour change: a systematic review. (2022)
Journal Article
Wells, I., Simons, G., Davenport, C., Mallen, C., Raza, K., & Falahee, M. (2022). Acceptability of predictive testing for ischemic heart disease in those with a family history and the impact of results on behavioural intention and behaviour change: a systematic review. BMC Public Health, 22, Article 1751. https://doi.org/10.1186/s12889-022-14116-6

BACKGROUND: Tests to predict the development of chronic diseases in those with a family history of the disease are becoming increasingly available and can identify those who may benefit most from preventive interventions. It is important to understan... Read More about Acceptability of predictive testing for ischemic heart disease in those with a family history and the impact of results on behavioural intention and behaviour change: a systematic review..

Development and validation of a prediction model for self-reported mobility decline in community-dwelling older adults. (2022)
Journal Article
Sanchez-Santos, M., Williamson, E., Nicolson, P., Bruce, J., Collins, G., Mallen, C., …OPAL study team, .. (2022). Development and validation of a prediction model for self-reported mobility decline in community-dwelling older adults. Journal of Clinical Epidemiology, 70-79. https://doi.org/10.1016/j.jclinepi.2022.09.002

OBJECTIVE: To develop and validate two models to predict 2-year risk of self-reported mobility decline among community-dwelling older adults. STUDY DESIGN AND SETTING: We used data from a prospective cohort study of people aged 65 years and over... Read More about Development and validation of a prediction model for self-reported mobility decline in community-dwelling older adults..

Barriers and facilitators to vaccination uptake against COVID-19, influenza, and pneumococcal pneumonia in immunosuppressed adults with immune-mediated inflammatory diseases: A qualitative interview study during the COVID-19 pandemic. (2022)
Journal Article
Fuller, A., Hancox, J., Vedhara, K., Card, T., Mallen, C., Van-Tam, J., & Abhishek, A. (2022). Barriers and facilitators to vaccination uptake against COVID-19, influenza, and pneumococcal pneumonia in immunosuppressed adults with immune-mediated inflammatory diseases: A qualitative interview study during the COVID-19 pandemic. PloS one, 17(9), Article e0267769. https://doi.org/10.1371/journal.pone.0267769

OBJECTIVES: To explore barriers and facilitators to COVID-19, influenza, and pneumococcal vaccine uptake in immunosuppressed adults with immune-mediated inflammatory diseases (IMIDs). METHODS: Recruiting through national patient charities and a l... Read More about Barriers and facilitators to vaccination uptake against COVID-19, influenza, and pneumococcal pneumonia in immunosuppressed adults with immune-mediated inflammatory diseases: A qualitative interview study during the COVID-19 pandemic..

Is vaccination against COVID-19 associated with autoimmune rheumatic disease flare? A self-controlled case series analysis (2022)
Journal Article
Nakafero, G., Grainge, M. J., Abhishek, A., Card, T., Mallen, C. D., Nguyen Van-Tam, J. S., & Williams, H. C. (2023). Is vaccination against COVID-19 associated with autoimmune rheumatic disease flare? A self-controlled case series analysis. Rheumatology, 62(4), 1445-1450. https://doi.org/10.1093/rheumatology/keac484

AbstractObjectivesTo investigate the association between vaccination against coronavirus disease 2019 (COVID-19) and autoimmune rheumatic disease (AIRD) flare.Material and methodsPatients with AIRDs vaccinated against COVID-19 who consulted for disea... Read More about Is vaccination against COVID-19 associated with autoimmune rheumatic disease flare? A self-controlled case series analysis.

Patients’ and healthcare professionals’ perspectives on a community-based intervention for schizophrenia in Pakistan: A focus group study (2022)
Journal Article
Ishaq Khattak, M., Dikomitis, L., Firaz Khan, M., Ul Haq, M., Saeed, U., Riaz Awan, N., …Farooq, S. (2022). Patients’ and healthcare professionals’ perspectives on a community-based intervention for schizophrenia in Pakistan: A focus group study. PloS one, https://doi.org/10.1371/journal.pone.0273286

OBJECTIVE: To explore the perceptions and experiences of schizophrenia from patients, their care givers, health care providers, spiritual and traditional healers to develop a community-based intervention for improving treatment adherence for people w... Read More about Patients’ and healthcare professionals’ perspectives on a community-based intervention for schizophrenia in Pakistan: A focus group study.

Evaluating the long-term effect of allopurinol use in gout using marginal structural models: A primary care electronic health records study (2022)
Presentation / Conference
Rathod-Mistry, T., Roddy, E., Jordan, K., Mallen, C., & Blagojevic-Bucknall, M. (2022, August). Evaluating the long-term effect of allopurinol use in gout using marginal structural models: A primary care electronic health records study

Background: Allopurinol is intended to be taken for life in the treatment of gout. In UK primary care, treatment is suboptimal with up to 30% of indicated patients being treated within five years of diagnosis and once prescribed allopurinol, treatmen... Read More about Evaluating the long-term effect of allopurinol use in gout using marginal structural models: A primary care electronic health records study.

The potential role of community pharmacy staff in reducing patient delay in consulting with symptoms of rheumatoid arthritis: a qualitative study. (2022)
Journal Article
Ismail, N., Sandhu, K., Mallen, C., Stack, R., Pontefract, S., Simons, G., …Falahee, M. (2022). The potential role of community pharmacy staff in reducing patient delay in consulting with symptoms of rheumatoid arthritis: a qualitative study. BMC Rheumatology, 50 - ?. https://doi.org/10.1186/s41927-022-00280-0

BACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory arthritis which can cause joint damage and reduced quality of life. Early treatment of RA within 3 months of symptom onset is associated with improved clinical outcomes. However, this wi... Read More about The potential role of community pharmacy staff in reducing patient delay in consulting with symptoms of rheumatoid arthritis: a qualitative study..

The potential role of community pharmacy staff in reducing patient delay in consulting with symptoms of rheumatoid arthritis: a qualitative study (2022)
Journal Article
Simons, G., Ismail, N., Sandhu, K., Mallen, C. D., Stack, R. J., Pontefract, S., …Falahee, M. (in press). The potential role of community pharmacy staff in reducing patient delay in consulting with symptoms of rheumatoid arthritis: a qualitative study. BMC Rheumatology, 6, Article 50. https://doi.org/10.1186/s41927-022-00280-0

Background: Rheumatoid arthritis (RA) is a chronic inflammatory arthritis which can cause joint damage and reduced quality of life. Early treatment of RA within 3 months of symptom onset is associated with improved clinical outcomes. However, this w... Read More about The potential role of community pharmacy staff in reducing patient delay in consulting with symptoms of rheumatoid arthritis: a qualitative study.

The impact of polymyalgia rheumatica on intimate sexual relationships: findings from the PMR Cohort Study (2022)
Journal Article
Muller, S., Hider, S. L., Hider, S., Ranasinghe, . P., Helliwell, T., Lawton, S. A., …Mallen, C. (2022). The impact of polymyalgia rheumatica on intimate sexual relationships: findings from the PMR Cohort Study. Rheumatology Advances in Practice, 6(3), https://doi.org/10.1093/rap/rkac070

Objectives To determine the impact of polymyalgia rheumatica (PMR) on intimate and sexual relationships over time. Methods The PMR Cohort study (UKCRN ID16477) is a longitudinal study of patients with incident PMR in English primary care. Participant... Read More about The impact of polymyalgia rheumatica on intimate sexual relationships: findings from the PMR Cohort Study.

Identification of undiagnosed atrial fibrillation using a machine learning risk prediction algorithm and diagnostic testing (PULsE-AI) in primary care: cost-effectiveness of a screening strategy evaluated in a randomized controlled trial in England (2022)
Journal Article
Hill, N. R., Groves, L., Dickerson, C., Boyce, R., Lawton, S., Hurst, M., …Cohen, A. T. (2022). Identification of undiagnosed atrial fibrillation using a machine learning risk prediction algorithm and diagnostic testing (PULsE-AI) in primary care: cost-effectiveness of a screening strategy evaluated in a randomized controlled trial in England. https://doi.org/10.1080/13696998.2022.2102355

OBJECTIVE: The PULsE-AI trial sought to determine the effectiveness of a screening strategy that included a machine learning risk prediction algorithm in conjunction with diagnostic testing for identification of undiagnosed atrial fibrillation (AF) i... Read More about Identification of undiagnosed atrial fibrillation using a machine learning risk prediction algorithm and diagnostic testing (PULsE-AI) in primary care: cost-effectiveness of a screening strategy evaluated in a randomized controlled trial in England.

Risk-based stratified primary care for common musculoskeletal pain presentations (STarT MSK): a cluster-randomised, controlled trial (2022)
Journal Article
Hill, J. C., Garvin, S., Bromley, K., Saunders, B., Kigozi, J., Cooper, V., …Foster, N. E. (2022). Risk-based stratified primary care for common musculoskeletal pain presentations (STarT MSK): a cluster-randomised, controlled trial. The Lancet Rheumatology, 4(9), e591 - e602. https://doi.org/10.1016/S2665-9913%2822%2900159-X

Background Risk-based stratified care shows clinical effectiveness and cost-effectiveness versus usual primary care for non-specific low back pain but is untested for other common musculoskeletal disorders. We aimed to test the clinical effectiveness... Read More about Risk-based stratified primary care for common musculoskeletal pain presentations (STarT MSK): a cluster-randomised, controlled trial.

Influence of the Danish Co-morbidity Index Score on the Treatment and Outcomes of 2.5 Million Patients Admitted With Acute Myocardial Infarction in the United States. (2022)
Journal Article
Mamas, M., & Mallen, C. (2022). Influence of the Danish Co-morbidity Index Score on the Treatment and Outcomes of 2.5 Million Patients Admitted With Acute Myocardial Infarction in the United States. American Journal of Cardiology, https://doi.org/10.1016/j.amjcard.2022.06.008

This study aimed to determine the association between the Danish Co-morbidity Index for Acute Myocardial Infarction (DANCAMI) and restricted DANCAMI (rDANCAMI) scores and clinical outcomes in patients hospitalized with AMI. Using the National Inpatie... Read More about Influence of the Danish Co-morbidity Index Score on the Treatment and Outcomes of 2.5 Million Patients Admitted With Acute Myocardial Infarction in the United States..

Metformin use and the risk of total knee replacement among diabetic patients: a propensity-score-matched retrospective cohort study. (2022)
Journal Article
Lai, F., Yip, B., Hunter, D., Rabago, D., Mallen, C., Yeoh, E., …Sit, R. (2022). Metformin use and the risk of total knee replacement among diabetic patients: a propensity-score-matched retrospective cohort study. Scientific reports, 11571 - ?. https://doi.org/10.1038/s41598-022-15871-7

Metformin has been shown to modulate meta-inflammation, an important pathogenesis in knee osteoarthritis (OA). The study aimed to test the association between regular metformin use with total knee replacement (TKR) in patients with diabetes. This is... Read More about Metformin use and the risk of total knee replacement among diabetic patients: a propensity-score-matched retrospective cohort study..

Musculoskeletal pain and its impact on rates of hospitalisation and mortality in cancer: a linked electronic health record cohort study (MSKCOM) (2022)
Presentation / Conference
Mason, K., Bailey, J., Heron, N., Marshall, M., Achana, F., Chen, Y., …Jordan, K. (2022, July). Musculoskeletal pain and its impact on rates of hospitalisation and mortality in cancer: a linked electronic health record cohort study (MSKCOM). Paper presented at SAPC ASM 2022 - UCLan 50th Annual Scientific Meeting, University of Central Lancashire, UK

Background: Patients with painful musculoskeletal conditions have an increased risk of developing cancer, but less is known about whether this impacts on the longer-term cancer prognosis. This study aims to determine whether patients with painful mus... Read More about Musculoskeletal pain and its impact on rates of hospitalisation and mortality in cancer: a linked electronic health record cohort study (MSKCOM).

Missed Opportunities in the Diagnosis of Heart Failure: Evaluation of Pathways to Determine Sources of Delay to Specialist Evaluation. (2022)
Journal Article
Kwok, C., Burke, H., McDermott, S., Welsh, V., Barker, D., Patwala, A., …Mallen, C. (2022). Missed Opportunities in the Diagnosis of Heart Failure: Evaluation of Pathways to Determine Sources of Delay to Specialist Evaluation. Current Heart Failure Reports, https://doi.org/10.1007/s11897-022-00551-4

Missed opportunities are incidents where different actions by those involved could have resulted in more desirable events. Heart failure is a complex clinical syndrome presenting as symptoms and signs common to other diagnoses, in patients frequently... Read More about Missed Opportunities in the Diagnosis of Heart Failure: Evaluation of Pathways to Determine Sources of Delay to Specialist Evaluation..

Incidence and pattern of mycophenolate discontinuation associated with abnormal monitoring blood-test results: cohort study using data from the Clinical Practice Research Datalink Aurum (2022)
Journal Article
Nakafero, G., Grainge, M., Card, T., Mallen, C., Riley, R., van der Windt, D., …Abhishek, A. (2022). Incidence and pattern of mycophenolate discontinuation associated with abnormal monitoring blood-test results: cohort study using data from the Clinical Practice Research Datalink Aurum. Rheumatology Advances in Practice, 6(2), Article rkac046. https://doi.org/10.1093/rap/rkac046

Objective: The aim was to examine the incidence and pattern of MMF discontinuation associated with abnormal monitoring blood-test results. Methods Data from people prescribed MMF for common inflammatory conditions in the Clinical Practice Research Da... Read More about Incidence and pattern of mycophenolate discontinuation associated with abnormal monitoring blood-test results: cohort study using data from the Clinical Practice Research Datalink Aurum.

OP0228 USE OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND RISK OF COMORBIDITIES IN PEOPLE WITH AND WITHOUT OSTEOARTHRITIS - A UK PRIMARY CARE DATABASE COHORT STUDY (2022)
Journal Article
Mallen, C. (2022). OP0228 USE OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND RISK OF COMORBIDITIES IN PEOPLE WITH AND WITHOUT OSTEOARTHRITIS - A UK PRIMARY CARE DATABASE COHORT STUDY. Annals of the Rheumatic Diseases, 150 - 151. https://doi.org/10.1136/annrheumdis-2022-eular.110

BackgroundPeople with osteoarthritis (OA) are at higher risk of developing a wide array of comorbidities. Whether the use of non-steroidal anti-inflammatory drugs (NSAIDs) contributes to the increased risk of some incident comorbidities remains unkno... Read More about OP0228 USE OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND RISK OF COMORBIDITIES IN PEOPLE WITH AND WITHOUT OSTEOARTHRITIS - A UK PRIMARY CARE DATABASE COHORT STUDY.

POS1124 EVALUATION OF COMORBIDITY PATTERNS AND IDENTIFICATION OF SUB-GROUPS IN PATIENTS DIAGNOSED WITH HIP OSTEOARTHRITIS IN 94,720 PATIENTS FROM SPAIN (2022)
Journal Article
Pineda-Moncusí, M., Strauss, V., Robinson, D., Swain, S., Runhaar, J., Kamps, A., …Khalid, S. (2022). POS1124 EVALUATION OF COMORBIDITY PATTERNS AND IDENTIFICATION OF SUB-GROUPS IN PATIENTS DIAGNOSED WITH HIP OSTEOARTHRITIS IN 94,720 PATIENTS FROM SPAIN. Annals of the Rheumatic Diseases, 890.2 - 891. https://doi.org/10.1136/annrheumdis-2022-eular.3121

Background Osteoarthritis (OA) patients are more likely to have other comorbidities (Swain, Sarmanova et al. 2020). Improving the understanding of comorbidity profiles of OA patients may lead to improvement in their clinical care. Objectives To id... Read More about POS1124 EVALUATION OF COMORBIDITY PATTERNS AND IDENTIFICATION OF SUB-GROUPS IN PATIENTS DIAGNOSED WITH HIP OSTEOARTHRITIS IN 94,720 PATIENTS FROM SPAIN.

Development and psychometric evaluation of the PMR-Impact Scale: a new patient reported outcome measure for polymyalgia rheumatica. (2022)
Journal Article
Twohig, H., Mitchell, C., Mallen, C., & Muller, S. (2022). Development and psychometric evaluation of the PMR-Impact Scale: a new patient reported outcome measure for polymyalgia rheumatica. Rheumatology, https://doi.org/10.1093/rheumatology/keac317/6593480

OBJECTIVES: Polymyalgia rheumatica (PMR) causes pain, stiffness and disability in older adults. Measuring the impact of the condition from the patient's perspective is vital to high-quality research and patient-centred care, yet there are no validate... Read More about Development and psychometric evaluation of the PMR-Impact Scale: a new patient reported outcome measure for polymyalgia rheumatica..

Long-term use of glucocorticoids for polymyalgia rheumatica: follow-up of the PMR Cohort Study (2022)
Journal Article
Muller, S., Hider, S. L., Sokhal, B. S., Lawton, S. A., Helliwell, T., & Mallen, C. D. (2022). Long-term use of glucocorticoids for polymyalgia rheumatica: follow-up of the PMR Cohort Study. Rheumatology Advances in Practice, 6(2), Article rkac034. https://doi.org/10.1093/rap/rkac034

Objectives PMR is a common inflammatory condition in older adults, characterized by bilateral hip and shoulder pain and stiffness. Reducing oral glucocorticoids, classically used for

Negotiating agency and belonging during the first lockdown of the COVID-19 pandemic: an interview study among older adults in England, UK. (2022)
Journal Article
Wenning, B., Polidano, K., Mallen, C., & Dikomitis, L. (2022). Negotiating agency and belonging during the first lockdown of the COVID-19 pandemic: an interview study among older adults in England, UK. BMJ Open, e060405 - ?. https://doi.org/10.1136/bmjopen-2021-060405

OBJECTIVES: The aim of this study was to explore the agency of older adults and their strategies to restructure ways of being and belonging in a rapidly and radically changed social environment during the UK's first COVID-19 lockdown in Spring 2020.... Read More about Negotiating agency and belonging during the first lockdown of the COVID-19 pandemic: an interview study among older adults in England, UK..

P182 Health literacy and gout characteristics in a primary care cohort (2022)
Journal Article
Watson, L., Protheroe, J., Mallen, C., Muller, S., & Roddy, E. (2022). P182 Health literacy and gout characteristics in a primary care cohort. Rheumatology, 61(S1), https://doi.org/10.1093/rheumatology/keac133.181

Abstract Background/Aims Gout is the most common inflammatory arthritis, affecting 2.5% of the UK population. It is often suboptimally managed, despite the availability of effective urate-lowering therapy. Health literacy has been conceptualised to... Read More about P182 Health literacy and gout characteristics in a primary care cohort.

P145 Safety of colchicine or NSAID prophylaxis when initiating allopurinol for gout: propensity score-matched cohort studies (2022)
Journal Article
Roddy, E., Bajpai, R., Forrester, H., Partington, R., Mallen, C. D., Clarson, L., …Muller, S. (2022). P145 Safety of colchicine or NSAID prophylaxis when initiating allopurinol for gout: propensity score-matched cohort studies. Rheumatology, 61(S1), https://doi.org/10.1093/rheumatology/keac133.144

Abstract Background/Aims Initiating urate-lowering therapy for gout commonly triggers a gout flare and hence co-prescription of colchicine or non-steroidal anti-inflammatory drug (NSAID) prophylaxis is recommended. However, little is known about the... Read More about P145 Safety of colchicine or NSAID prophylaxis when initiating allopurinol for gout: propensity score-matched cohort studies.

Burnout among primary health-care professionals in low- and middle-income countries: systematic review and meta-analysis (2022)
Journal Article
Helliwell, T., Wright, T., Mughal, F., Babatunde, O., Dikomitis, L., & Mallen, C. (2022). Burnout among primary health-care professionals in low- and middle-income countries: systematic review and meta-analysis. Bulletin of the World Health Organization, 385 - 401A. https://doi.org/10.2471/blt.22.288300

Objective To estimate the prevalence of burnout among primary health-care professionals in low- and middle-income countries and to identify factors associated with burnout. Methods We systematically searched nine databases up to February 2022 to... Read More about Burnout among primary health-care professionals in low- and middle-income countries: systematic review and meta-analysis.

Treatment and Outcomes of Acute Myocardial Infarction in Patients With Polymyalgia Rheumatica With and Without Giant Cell Arteritis. (2022)
Journal Article
Sokhal, B., Matetić, A., Bharadwaj, A., Helliwell, T., Abhishek, A., Mallen, C., …Mamas, M. (2022). Treatment and Outcomes of Acute Myocardial Infarction in Patients With Polymyalgia Rheumatica With and Without Giant Cell Arteritis. American Journal of Cardiology, 12-19. https://doi.org/10.1016/j.amjcard.2022.03.034

This study analyzed the characteristics, management, and outcomes of patients with polymyalgia rheumatica (PMR) hospitalized with acute myocardial infarction (AMI), including sensitivity analysis for presence of giant cell arteritis (GCA). Using the... Read More about Treatment and Outcomes of Acute Myocardial Infarction in Patients With Polymyalgia Rheumatica With and Without Giant Cell Arteritis..

P181 Musculoskeletal pain and prognosis of acute coronary syndrome and cerebrovascular accident: a linked electronic health record cohort study (2022)
Journal Article
Mason, K. J., Jordan, K. P., Achana, F. A., Bailey, J., Chen, Y., Frisher, M., …Edwards, J. J. (2022). P181 Musculoskeletal pain and prognosis of acute coronary syndrome and cerebrovascular accident: a linked electronic health record cohort study. Rheumatology, 61(S1), https://doi.org/10.1093/rheumatology/keac133.180

Abstract Background/Aims There is some evidence of an increased risk of cardiovascular disease in patients with painful musculoskeletal conditions, but it is unclear if musculoskeletal pain also worsens its prognosis. The aim was to determine whethe... Read More about P181 Musculoskeletal pain and prognosis of acute coronary syndrome and cerebrovascular accident: a linked electronic health record cohort study.

P183 Establishing the epidemiology of rheumatoid arthritis, psoriatic arthritis, and axial spondyloarthritis in England using primary care electronic health record data (2022)
Journal Article
Scott, I. C., Whittle, R., Bailey, J., Twohig, H., Hider, S., Mallen, C., …Jordan, K. (2022). P183 Establishing the epidemiology of rheumatoid arthritis, psoriatic arthritis, and axial spondyloarthritis in England using primary care electronic health record data. Rheumatology, 61(S1), https://doi.org/10.1093/rheumatology/keac133.182

Abstract Background/Aims The substantial personal and socioeconomic costs associated with rheumatoid arthritis (RA), psoriatic arthritis (PsA), and axial spondyloarthritis (SpA) make understanding their epidemiology crucial. The Clinical Practice Re... Read More about P183 Establishing the epidemiology of rheumatoid arthritis, psoriatic arthritis, and axial spondyloarthritis in England using primary care electronic health record data.

Comorbidities in osteoarthritis (ComOA): a combined cross-sectional, case-control and cohort study using large electronic health records in four European countries. (2022)
Journal Article
Zhang, W., Runhaar, J., Dell'Isola, A., Turkiewicz, A., Swain, S., Kamps, A., …Bierma-Zeinstra, S. (2022). Comorbidities in osteoarthritis (ComOA): a combined cross-sectional, case-control and cohort study using large electronic health records in four European countries. BMJ Open, e052816 - ?. https://doi.org/10.1136/bmjopen-2021-052816

INTRODUCTION: Osteoarthritis (OA) is one of the leading chronic conditions in the older population. People with OA are more likely to have one or more other chronic conditions than those without. However, the temporal associations, clusters of the co... Read More about Comorbidities in osteoarthritis (ComOA): a combined cross-sectional, case-control and cohort study using large electronic health records in four European countries..

Clinical effectiveness of one ultrasound guided intra-articular corticosteroid and local anaesthetic injection in addition to advice and education for hip osteoarthritis (HIT trial): single blind, parallel group, three arm, randomised controlled trial (2022)
Journal Article
Paskins, Z., Bromley, K., Lewis, M., Hughes, G., Hughes, E., Hennings, S., …Mallen, C. D. (2022). Clinical effectiveness of one ultrasound guided intra-articular corticosteroid and local anaesthetic injection in addition to advice and education for hip osteoarthritis (HIT trial): single blind, parallel group, three arm, randomised controlled trial. BMJ, 377, Article ARTN e068446. https://doi.org/10.1136/bmj-2021-068446

Objectives: to compare the clinical effectiveness of best current treatment (BCT) plus single ultrasound-guided intra-articular hip injection (USGI) of 40mg triamcinolone acetonide and 4ml 1% lidocaine hydrochloride [BCT+US-Triamcinolone-Lidocaine] w... Read More about Clinical effectiveness of one ultrasound guided intra-articular corticosteroid and local anaesthetic injection in addition to advice and education for hip osteoarthritis (HIT trial): single blind, parallel group, three arm, randomised controlled trial.

A Review of the Wide Range of Indications and Uses of Implantable Loop Recorders: A Review of the Literature (2022)
Journal Article
Darlington, D., Mayer, J., Panchal, G., Zachariah, D., Phan, T., Mallen, C., …Walker, V. (2022). A Review of the Wide Range of Indications and Uses of Implantable Loop Recorders: A Review of the Literature. Hearts, https://doi.org/10.3390/hearts3020007

Implantable loop recorders (ILR) are devices that are implanted subcutaneously on the chest, which enables the continuous monitoring of arrhythmias for up to three years. These devices have an important role in helping to make a diagnosis and support... Read More about A Review of the Wide Range of Indications and Uses of Implantable Loop Recorders: A Review of the Literature.

Clinician views on optimism and empathy in primary care consultations: a qualitative interview study (2022)
Journal Article
Hughes, S., Vennik, J., Smith, K., Bostock, J., Howick, J., Mallen, C., …Everitt, H. (2022). Clinician views on optimism and empathy in primary care consultations: a qualitative interview study. British Journal of General Practice Open (BJGP Open), 6(3), Article 0221. https://doi.org/10.3399/BJGPO.2021.0221

Background: Practitioner expressions of optimism and empathy may improve treatment engagement, adherence, and patient satisfaction but are not delivered consistently amid the challenges of everyday clinical practice. Aim: To explore primary care p... Read More about Clinician views on optimism and empathy in primary care consultations: a qualitative interview study.

The impact of COVID-19 on the patient, clinician, healthcare services and society: A patient pathway review. (2022)
Journal Article
Kwok, C. S., Muntean, E., & Mallen, C. D. (2022). The impact of COVID-19 on the patient, clinician, healthcare services and society: A patient pathway review. Journal of Medical Virology, 94(8), 3634-3641. https://doi.org/10.1002/jmv.27758

The spread of COVID-19 infection has changed the world. Population-based studies of COVID-19 are limited because it is unknown why events happen or why certain outcomes occur. An alternative approach called the patient pathway review evaluates what h... Read More about The impact of COVID-19 on the patient, clinician, healthcare services and society: A patient pathway review..

Identification of undiagnosed atrial fibrillation using a machine learning risk prediction algorithm and diagnostic testing (PULsE-AI) in primary care: a multi-centre randomised controlled trial in England (2022)
Journal Article
Hill, N. R., Groves, L., Dickerson, C., Ochs, A., Pang, D., Lawton, S., …Cohen, A. T. (2022). Identification of undiagnosed atrial fibrillation using a machine learning risk prediction algorithm and diagnostic testing (PULsE-AI) in primary care: a multi-centre randomised controlled trial in England. European Heart Journal, S111 - S111. https://doi.org/10.1093/ehjdh/ztac009

The clinical effectiveness of a physiotherapy delivered physical and psychological group intervention for older adults with neurogenic claudication: the BOOST randomised controlled trial. (2022)
Journal Article
Mallen. (2022). The clinical effectiveness of a physiotherapy delivered physical and psychological group intervention for older adults with neurogenic claudication: the BOOST randomised controlled trial. The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences, https://doi.org/10.1093/gerona/glac063

BACKGROUND: Neurogenic claudication (NC) is a debilitating spinal condition affecting older adults' mobility and quality of life. METHODS: A randomised controlled trial of 438 participants evaluated the effectiveness of a physical and psychological g... Read More about The clinical effectiveness of a physiotherapy delivered physical and psychological group intervention for older adults with neurogenic claudication: the BOOST randomised controlled trial..

Diagnostic delay in axial spondyloarthritis: a systematic review (2022)
Journal Article
Hay, C., Packham, J., Ryan, S., Mallen, C., Chatzixenitidis, A., & Prior, J. (2022). Diagnostic delay in axial spondyloarthritis: a systematic review. Clinical Rheumatology, 41(1939–1950), https://doi.org/10.1007/s10067-022-06100-7

Identification of axial spondyloarthritis (axSpA) remains challenging, frequently resulting in a diagnostic delay for patients. Current benchmarks of delay are usually reported as mean data, which are typically skewed and therefore may be overestimat... Read More about Diagnostic delay in axial spondyloarthritis: a systematic review.

Development of radiographic classification criteria for hand osteoarthritis: a methodological report (Phase 2) (2022)
Journal Article
Haugen, I. K., Felson, D., Abhishek, A., Berenbaum, F., James Edwards, J., Herrero Beaumont, G., …Kloppenburg, M. (2022). Development of radiographic classification criteria for hand osteoarthritis: a methodological report (Phase 2). RMD Open, 8(1), e002024 - e002024. https://doi.org/10.1136/rmdopen-2021-002024

Objectives In Phase 1 of developing new hand osteoarthritis (OA) classification criteria, features associated with hand OA were identified in a population with hand complaints. Radiographic findings could better discriminate patients with hand OA and... Read More about Development of radiographic classification criteria for hand osteoarthritis: a methodological report (Phase 2).

Clustering of comorbidities and associated outcomes in people with osteoarthritis - a UK Clinical Practice Research Datalink study. (2022)
Journal Article
Englund, M., Prieto-Alhambra, D., Zhang, W., Doherty, M., Swain, S., Coupland, C., …Bierma-Zeinstra, S. (2022). Clustering of comorbidities and associated outcomes in people with osteoarthritis - a UK Clinical Practice Research Datalink study. Osteoarthritis and Cartilage, https://doi.org/10.1016/j.joca.2021.12.013

OBJECTIVE: To examine the clusters of chronic conditions present in people with osteoarthritis and the associated risk factors and health outcomes. METHODS: Clinical Practice Research Datalink (CPRD) GOLD was used to identify people diagnosed with in... Read More about Clustering of comorbidities and associated outcomes in people with osteoarthritis - a UK Clinical Practice Research Datalink study..

POSC125 Identification of Undiagnosed Atrial Fibrillation Using a Machine Learning Risk Prediction Algorithm and Diagnostic Testing (PULSE-AI) in Primary Care: Health Economic Impact Assessment of a UK Randomised Controlled Trial (2022)
Journal Article
Hill, N., Groves, L., Dickerson, C., Ochs, A., Lawton, S., Hurst, M., …Cohen, A. (2022). POSC125 Identification of Undiagnosed Atrial Fibrillation Using a Machine Learning Risk Prediction Algorithm and Diagnostic Testing (PULSE-AI) in Primary Care: Health Economic Impact Assessment of a UK Randomised Controlled Trial. Value in Health, 25(1), S111. https://doi.org/10.1016/j.jval.2021.11.529

Patient and practitioner priorities and concerns about primary healthcare interactions for osteoarthritis: A meta-ethnography (2022)
Journal Article
Mallen, C., Vennik, J., Hughes, S., Smith, K. A., Misurya, P., Bostock, J., …Bishop, F. L. (2022). Patient and practitioner priorities and concerns about primary healthcare interactions for osteoarthritis: A meta-ethnography. Patient Education and Counseling, 105(7), 1865-1877. https://doi.org/10.1016/j.pec.2022.01.009

OBJECTIVE: To explore primary care practitioners' (PCPs) and patients' priorities and concerns for healthcare interactions for osteoarthritis (OA) in primary care. METHODS: We searched Embase, CINAHL, Medline, PsychInfo (1990 to present) for primary... Read More about Patient and practitioner priorities and concerns about primary healthcare interactions for osteoarthritis: A meta-ethnography.

Patient pathways in cardiology: Should pharmaceutical and medical device companies care? (2022)
Journal Article
Kwok, C. S., Muntean, E., Muntean, E., Foster, W., & Mallen, C. D. (2022). Patient pathways in cardiology: Should pharmaceutical and medical device companies care?. Critical Pathways in Cardiology: A Journal of Evidence-Based Medicine, 21(1), 57-60. https://doi.org/10.1097/HPC.0000000000000278

A shared goal of patients, providers and the companies that produce new therapies is to have these therapies used according to guidelines. Health services specialize in patient care and may lack the capabilities to take a product from conception thro... Read More about Patient pathways in cardiology: Should pharmaceutical and medical device companies care?.

Prevalence of Occupational Stress among Secondary School Teachers in Public Schools in the District of Colombo, Sri Lanka (2022)
Journal Article
Wickramasinghe, E., Seneviratne, R. D. A., Gunawardana, N., Sumathipala, A., & Mallen, C. (2022). Prevalence of Occupational Stress among Secondary School Teachers in Public Schools in the District of Colombo, Sri Lanka. https://doi.org/10.22158/rhs.v7n3p12

Teacher occupational stress is increasing globally. We aimed to determine the prevalence of occupational stress among secondary teachers, to advocate policies for prevention of occupational stress among teachers in Sri Lanka. A cross-sectional study... Read More about Prevalence of Occupational Stress among Secondary School Teachers in Public Schools in the District of Colombo, Sri Lanka.

The impact of COVID-19 on primary care: insights from the National Health Service (NHS) and future recommendations (2021)
Journal Article
Mallen, C., Khunti, K., & Mughal, F. (2021). The impact of COVID-19 on primary care: insights from the National Health Service (NHS) and future recommendations. Journal of Family Medicine and Primary Care, 4345-4349. https://doi.org/10.4103/jfmpc.jfmpc_756_21

COVID-19 has changed health systems and services. In this commentary, we outline the impact COVID-19 has had on the delivery of primary health care, and on primary care teams, and describe the NHS response. We highlight the challenges of managing lon... Read More about The impact of COVID-19 on primary care: insights from the National Health Service (NHS) and future recommendations.

Misdiagnosis of aortic dissection: A systematic review of the literature (2021)
Journal Article
Mallen. (2021). Misdiagnosis of aortic dissection: A systematic review of the literature. American Journal of Emergency Medicine, https://doi.org/10.1016/j.ajem.2021.11.047

Background Aortic dissection is a rare but potentially catastrophic condition. Misdiagnosis of aortic dissection is not uncommon as symptoms can overlap with other diagnoses. Objective We conducted a systematic review to better understand the fa... Read More about Misdiagnosis of aortic dissection: A systematic review of the literature.

An evaluation of the use of investigations in a nurse-led rapid access chest pain clinic (2021)
Journal Article
Mallen. (2021). An evaluation of the use of investigations in a nurse-led rapid access chest pain clinic. British Journal of Cardiac Nursing, 1 - 14. https://doi.org/10.12968/bjca.2021.0084

Background/Aims Chest pain is a common symptom, but its presentation and cause varies widely, making diagnosis a challenge. This study describes the authors' experience of a nurse-led rapid access chest pain clinic, and associated use of investigatio... Read More about An evaluation of the use of investigations in a nurse-led rapid access chest pain clinic.

Predictors of interest in predictive testing for rheumatoid arthritis among first degree relatives of rheumatoid arthritis patients (2021)
Journal Article
Mallen, Wells, I., T Zemedikun, D., Simons, G., J Stack, R., D Mallen, C., …Falahee, M. (2022). Predictors of interest in predictive testing for rheumatoid arthritis among first degree relatives of rheumatoid arthritis patients. Rheumatology, 61(8), https://doi.org/10.1093/rheumatology/keab890

OBJECTIVES: There is increasing interest in prediction and prevention of rheumatoid arthritis (RA). It is important to understand the views of those at risk to inform the development of effective approaches. First-degree relatives (FDRs) of RA patien... Read More about Predictors of interest in predictive testing for rheumatoid arthritis among first degree relatives of rheumatoid arthritis patients.

Fragility fractures and prescriptions of medications for osteoporosis in patients with polymyalgia rheumatica: results from the PMR Cohort Study (2021)
Journal Article
Paskins, Z., Sokhal, B. S., Hider, S. L., Mallen, C. D., & Muller, S. (2021). Fragility fractures and prescriptions of medications for osteoporosis in patients with polymyalgia rheumatica: results from the PMR Cohort Study. Rheumatology Advances in Practice, Article rkab094. https://doi.org/10.1093/rap/rkab094

OBJECTIVES: PMR is a common indication for long-term glucocorticoid treatment, leading to an increased risk of osteoporosis and fragility fractures. Guidelines recommend calcium and vitamin D for all patients, in addition to anti-resorptive agents fo... Read More about Fragility fractures and prescriptions of medications for osteoporosis in patients with polymyalgia rheumatica: results from the PMR Cohort Study.

Analgesic prescribing in patients with inflammatory arthritis in England: an observational study using electronic healthcare record data (2021)
Journal Article
Scott, I. C., Bailey, J., White, C. R., Mallen, C., & Muller, S. (2022). Analgesic prescribing in patients with inflammatory arthritis in England: an observational study using electronic healthcare record data. Rheumatology, 61(8), 3201–3211. https://doi.org/10.1093/rheumatology/keab870

OBJECTIVES: International data suggest inflammatory arthritis (IA) pain management frequently involves opioid prescribing, despite little evidence of efficacy, and potential harms. We evaluated analgesia prescribing in English National Health Service... Read More about Analgesic prescribing in patients with inflammatory arthritis in England: an observational study using electronic healthcare record data.

Musculoskeletal pain and its impact on prognosis following hospitalisation for acute coronary syndrome or cerebrovascular accident: a linked electronic health record cohort study (MSKCOM) (2021)
Presentation / Conference
Mallen, Mason, Frisher, Mamas, Jordan, Marshall, …White. (2021, November). Musculoskeletal pain and its impact on prognosis following hospitalisation for acute coronary syndrome or cerebrovascular accident: a linked electronic health record cohort study (MSKCOM). Presented at SAPC North 2021, Virtual

Background: There is evidence that painful musculoskeletal conditions are associated with increased risk of cardiovascular disease, but less is known about whether this impacts on prognosis of cardiovascular disease. The aim was to determine whether... Read More about Musculoskeletal pain and its impact on prognosis following hospitalisation for acute coronary syndrome or cerebrovascular accident: a linked electronic health record cohort study (MSKCOM).

Musculoskeletal pain and its impact on prognosis following hospitalisation for acute coronary syndrome or cerebrovascular accident: a linked electronic health record cohort study (MSKCOM) (2021)
Presentation / Conference
Mason, K., Jordan, K. P., Achana, F., Bailey, J., Chen, Y., Frisher, M., …Edwards, J. J. (2021, November). Musculoskeletal pain and its impact on prognosis following hospitalisation for acute coronary syndrome or cerebrovascular accident: a linked electronic health record cohort study (MSKCOM). Paper presented at 2021 SAPC North, Virtual

Background: There is evidence that painful musculoskeletal conditions are associated with increased risk of cardiovascular disease, but less is known about whether this impacts on prognosis of cardiovascular disease. The aim was to determine whether... Read More about Musculoskeletal pain and its impact on prognosis following hospitalisation for acute coronary syndrome or cerebrovascular accident: a linked electronic health record cohort study (MSKCOM).

Musculoskeletal pain and its impact on prognosis following hospitalisation for acute coronary syndrome or cerebrovascular accident: a linked electronic health record cohort study (MSKCOM) (2021)
Presentation / Conference
Mason, K., Jordan, K., Achana, F., Bailey, J., Chen, Y., Frisher, M., …Edwards, J. (2021, November). Musculoskeletal pain and its impact on prognosis following hospitalisation for acute coronary syndrome or cerebrovascular accident: a linked electronic health record cohort study (MSKCOM). Poster presented at 2021 SAPC North, Virtual

Musculoskeletal pain and its impact on prognosis following hospitalisation for acute coronary syndrome or cerebrovascular accident: a linked electronic health record cohort study (MSKCOM) (2021)
Presentation / Conference
Mason, K., Jordan, K., Achana, F., Bailey, J., Chen, Y., Frisher, M., …Edwards, J. (2021, November). Musculoskeletal pain and its impact on prognosis following hospitalisation for acute coronary syndrome or cerebrovascular accident: a linked electronic health record cohort study (MSKCOM). Poster presented at 2021 SAPC North, Virtual

Development and validation of a prognostic model for leflunomide discontinuation with abnormal blood tests during long-term treatment: cohort study using data from the Clinical Practice Research Datalink Gold and Aurum (2021)
Journal Article
Nakafero, G., Grainge, M. J., Card, T., Taal, M. W., Aithal, G. P., Zhang, W., …Abhishek, A. (2022). Development and validation of a prognostic model for leflunomide discontinuation with abnormal blood tests during long-term treatment: cohort study using data from the Clinical Practice Research Datalink Gold and Aurum. Rheumatology, 61(7), 2783–2791. https://doi.org/10.1093/rheumatology/keab790

OBJECTIVE: To develop and validate a prognostic model for leflunomide discontinuation with abnormal blood-test results. METHODS: Data from CPRD Gold and Aurum were used for model development and external validation respectively. Participants prescrib... Read More about Development and validation of a prognostic model for leflunomide discontinuation with abnormal blood tests during long-term treatment: cohort study using data from the Clinical Practice Research Datalink Gold and Aurum.

Readmission after index hospital discharge among patients with COVID-19: Protocol for a systematic review and meta-analysis (2021)
Journal Article
AlSayegh, A., Gassan, A. A., Bajpai, R. C., Muller, S., Welsh, V., Kwok, C. S., & Mallen, C. D. (2021). Readmission after index hospital discharge among patients with COVID-19: Protocol for a systematic review and meta-analysis. Health Science Reports, 4(4), Article ARTN e417. https://doi.org/10.1002/hsr2.417

Background and Aims: Hospital readmissions among COVID-19 patients have increased the load on the healthcare systems and added more pressure to hospital capacity. This affects the ability to accommodate newly diagnosed COVID-19 patients and other non... Read More about Readmission after index hospital discharge among patients with COVID-19: Protocol for a systematic review and meta-analysis.

What non-pharmacological treatments do people with polymyalgia rheumatica try: results from the PMR Cohort Study (2021)
Journal Article
Weddell, J., Hider, S., Mallen, C., & Muller, S. (2022). What non-pharmacological treatments do people with polymyalgia rheumatica try: results from the PMR Cohort Study. Rheumatology International, 285-290. https://doi.org/10.1007/s00296-021-05036-6

Polymyalgia rheumatica (PMR) is common. The mainstay of treatment, glucocorticoids, are associated with significant adverse effects and many patients remain on high doses for a number of years. Little is known about the use of other, non-pharmacologi... Read More about What non-pharmacological treatments do people with polymyalgia rheumatica try: results from the PMR Cohort Study.

Predicting pain and function outcomes in people consulting with shoulder pain: the PANDA-S clinical cohort and qualitative study protocol (2021)
Journal Article
Wynne-Jones, G., Myers, H., Hall, A., Littlewood, C., Hennings, S., Saunders, B., …van der Windt, D. (2021). Predicting pain and function outcomes in people consulting with shoulder pain: the PANDA-S clinical cohort and qualitative study protocol. BMJ Open, 11(9), Article e052758. https://doi.org/10.1136/bmjopen-2021-052758

INTRODUCTION: People presenting with shoulder pain considered to be of musculoskeletal origin is common in primary care but diagnosing the cause of the pain is contentious, leading to uncertainty in management. To inform optimal primary care for pati... Read More about Predicting pain and function outcomes in people consulting with shoulder pain: the PANDA-S clinical cohort and qualitative study protocol.

Integrating case-finding and initial management for osteoarthritis, anxiety, and depression into primary care long-term condition reviews: results from the ENHANCE pilot trial. (2021)
Journal Article
Healey, E. L., Mallen, C. D., Chew-Graham, C. A., Nicholls, E., Lewis, M., Lawton, S. A., …Jinks, C. (2022). Integrating case-finding and initial management for osteoarthritis, anxiety, and depression into primary care long-term condition reviews: results from the ENHANCE pilot trial. Family Practice, 39(4), 592–602. https://doi.org/10.1093/fampra/cmab113

Background: Multimorbidity is increasingly the norm; however, primary care remains focused on single diseases. Osteoarthritis, anxiety, and depression are frequently comorbid with other long-term conditions (LTCs), but rarely prioritized by clinician... Read More about Integrating case-finding and initial management for osteoarthritis, anxiety, and depression into primary care long-term condition reviews: results from the ENHANCE pilot trial..

Smoking cessation after acute coronary syndrome: A systematic review and meta-analysis. (2021)
Journal Article
Mallen. (2021). Smoking cessation after acute coronary syndrome: A systematic review and meta-analysis. International Journal of Clinical Practice, https://doi.org/10.1111/ijcp.14894

BACKGROUND: Smoking cessation is an effective secondary prevention measure after acute coronary syndrome (ACS). We conducted a systematic review with the aim to better understand which patients have a greater propensity to quit smoking, and the risk... Read More about Smoking cessation after acute coronary syndrome: A systematic review and meta-analysis..

The patient pathway review: A new method of evaluating clinical practices to understand the complexities of real-world care. (2021)
Journal Article
Kwok, C. S., Muntean, E., & Mallen, C. (2021). The patient pathway review: A new method of evaluating clinical practices to understand the complexities of real-world care. Critical Pathways in Cardiology: A Journal of Evidence-Based Medicine, 20(4), 213-219. https://doi.org/10.1097/HPC.0000000000000267

Healthcare research has contributed to the good patient care that is delivered today. With the perpetual demand for higher quality, cost-effective care, the current approaches in research could be improved to answer important research questions relat... Read More about The patient pathway review: A new method of evaluating clinical practices to understand the complexities of real-world care..

Vertebral fracture as a risk factor for self-harm: A retrospective cohort study (2021)
Journal Article
Prior, J. A., Crawford-Manning, F., Whittle, R., Abdul-Sultan, A., Chew-Graham, C. A., Muller, S., …Paskins, Z. (2021). Vertebral fracture as a risk factor for self-harm: A retrospective cohort study. BMC Musculoskeletal Disorders, 22, Article 757. https://doi.org/10.1186/s12891-021-04631-9

Abstract Background The prevention of self-harm is an international public health priority. It is vital to identify at-risk populations, particularly as self-harm is a risk factor for suicide. This study aims to examine the risk of self-harm in peopl... Read More about Vertebral fracture as a risk factor for self-harm: A retrospective cohort study.

Reply (2021)
Journal Article
Hay, C. A., Mallen, C. D., Belcher, J., Roddy, E., & Prior, J. A. (2022). Reply. Arthritis Care and Research, 74(1), 161-162. https://doi.org/10.1002/acr.24777

'letter'

Social Work and Social Care: Mapping Workforce Engagement, Relevance, Experience and Interest in Research (2021)
Journal Article
Lambley-Burke, R., Wakefield, J., Lavender, S., Nixon, K., Hornby, S., Dobel-Ober, D., …Mallen, C. (2022). Social Work and Social Care: Mapping Workforce Engagement, Relevance, Experience and Interest in Research. British Journal of Social Work, 52(4), https://doi.org/10.1093/bjsw/bcab169

Evidence-based practice (EBP) has been promoted within social work/social care, with emerging evidence of benefit to practitioners and service users. Advocates argue that EBP enables practitioners to have the skills to interpret and evaluate evidence... Read More about Social Work and Social Care: Mapping Workforce Engagement, Relevance, Experience and Interest in Research.

'It's just a great muddle when it comes to food': a qualitative exploration of patient decision-making around diet and gout. (2021)
Journal Article
Hider, Watson, Mallen, & Roddy. (2021). 'It's just a great muddle when it comes to food': a qualitative exploration of patient decision-making around diet and gout. Rheumatology Advances in Practice, https://doi.org/10.1093/rap/rkab055

Objective: Our aim was to understand whether, why and how patients choose to modify their diets after developing gout. Methods: We conducted an inductive thematic secondary analysis of qualitative data from 43 interviews and four focus groups wit... Read More about 'It's just a great muddle when it comes to food': a qualitative exploration of patient decision-making around diet and gout..

Harnessing Placebo Effects in Primary Care: Using the Person-Based Approach to Develop an Online Intervention to Enhance Practitioners' Communication of Clinical Empathy and Realistic Optimism During Consultations. (2021)
Journal Article
Mallen. (2021). Harnessing Placebo Effects in Primary Care: Using the Person-Based Approach to Develop an Online Intervention to Enhance Practitioners' Communication of Clinical Empathy and Realistic Optimism During Consultations. Frontiers in Pain Research, 721222 - ?. https://doi.org/10.3389/fpain.2021.721222

Background: Empathic communication and positive messages are important components of "placebo" effects and can improve patient outcomes, including pain. Communicating empathy and optimism to patients within consultations may also enhance the effects... Read More about Harnessing Placebo Effects in Primary Care: Using the Person-Based Approach to Develop an Online Intervention to Enhance Practitioners' Communication of Clinical Empathy and Realistic Optimism During Consultations..

Improving uptake of Fracture Prevention drug treatments: a protocol for Development of a consultation intervention (iFraP-D) (2021)
Journal Article
Paskins, Z., Bullock, L., Crawford-Manning, F., Cottrell, E., Fleming, J., Leyland, S., …Jinks, C. (2021). Improving uptake of Fracture Prevention drug treatments: a protocol for Development of a consultation intervention (iFraP-D). BMJ Open, 11(8), https://doi.org/10.1136/bmjopen-2021-048811

INTRODUCTION: Prevention of fragility fractures, a source of significant economic and personal burden, is hindered by poor uptake of fracture prevention medicines. Enhancing communication of scientific evidence and elicitation of patient medication-r... Read More about Improving uptake of Fracture Prevention drug treatments: a protocol for Development of a consultation intervention (iFraP-D).

Exploring the Impact of the First Wave of COVID-19 on Social Work Practice: A Qualitative Study in England, UK (2021)
Journal Article
Kingstone, T., Campbell, P., Andras, A., Nixon, K., Mallen, C., Dikomitis, L., …Wenning, B. (2021). Exploring the Impact of the First Wave of COVID-19 on Social Work Practice: A Qualitative Study in England, UK. British Journal of Social Work, 52(4), 2043–2062. https://doi.org/10.1093/bjsw/bcab166

The COVID-19 pandemic signalled a radical shift in health and social care services globally. In UK, many of the people with existing social care needs were identified as 'clinically vulnerable' to COVID-19. Those at greatest risk were encouraged to a... Read More about Exploring the Impact of the First Wave of COVID-19 on Social Work Practice: A Qualitative Study in England, UK.

Prevalence of osteoarthritis in lower middle- and low-income countries: a systematic review and meta-analysis (2021)
Journal Article
Yahaya, I., Wright, T., Babatunde, O., Corp, N., Helliwell, T., Dikomitis, L., & Mallen, C. (2021). Prevalence of osteoarthritis in lower middle- and low-income countries: a systematic review and meta-analysis. Rheumatology International, 41, 1221-1231. https://doi.org/10.1007/s00296-021-04838-y

Evidence from the Global Burden of Disease studies suggests that osteoarthritis (OA) is a significant cause of disability globally; however, it is less clear how much of this burden exists in low-income and lower middle-income countries. This study a... Read More about Prevalence of osteoarthritis in lower middle- and low-income countries: a systematic review and meta-analysis.

Propranolol Reduces Risk of Knee or Hip Replacement Due to Osteoarthritis: a Propensity Score Matched Cohort Study-using Data From the Clinical Practice Research Datalink. (2021)
Journal Article
Mamas, M., & Mallen, C. (2021). Propranolol Reduces Risk of Knee or Hip Replacement Due to Osteoarthritis: a Propensity Score Matched Cohort Study-using Data From the Clinical Practice Research Datalink. Research Square, https://doi.org/10.21203/rs.3.rs-670522/v1

Objectives: To examine the association between ß -blocker prescription and knee or hip total joint replacement (TJR) in a UK primary-care population with incident knee or hip osteoarthritis (OA). Methods: Cohort study using data from the Clinical P... Read More about Propranolol Reduces Risk of Knee or Hip Replacement Due to Osteoarthritis: a Propensity Score Matched Cohort Study-using Data From the Clinical Practice Research Datalink..

Mortality in Patients With Gout Treated With Allopurinol: A Systematic Review and Meta‐Analysis (2021)
Journal Article
Hay, C. A., Prior, J. A., Belcher, J., Mallen, C. D., & Roddy, E. (2021). Mortality in Patients With Gout Treated With Allopurinol: A Systematic Review and Meta‐Analysis. Arthritis Care & Research, 73(7), 1049-1054. https://doi.org/10.1002/acr.24205

ObjectiveUrate‐lowering therapy (predominantly allopurinol) is highly effective as a treatment for gout, but its wider long‐term effects remain unclear. This systematic review and meta‐analysis aimed to ascertain the association between mortality and... Read More about Mortality in Patients With Gout Treated With Allopurinol: A Systematic Review and Meta‐Analysis.

Refinement and validation of a tool for stratifying patients with musculoskeletal pain (2021)
Journal Article
Dunn, K. M., Campbell, P., Lewis, M., Hill, J. C., van der Windt, D. A., Afolabi, E., …Foster, N. E. (2021). Refinement and validation of a tool for stratifying patients with musculoskeletal pain. European Journal of Pain, 25(10), 2081-2093. https://doi.org/10.1002/ejp.1821

AbstractBackgroundPatients with musculoskeletal pain in different body sites share common prognostic factors. Using prognosis to stratify and treatment match can be clinically and cost‐effective. We aimed to refine and validate the Keele STarT MSK To... Read More about Refinement and validation of a tool for stratifying patients with musculoskeletal pain.

Missed opportunities in coronary artery disease: reflection on practice to improve patient outcomes (2021)
Journal Article
Kwok, C. S., Satchithananda, D., & Mallen, C. D. (2021). Missed opportunities in coronary artery disease: reflection on practice to improve patient outcomes. Coronary Artery Disease, 33(3), 233-238. https://doi.org/10.1097/MCA.0000000000001075

Missed opportunities refer to incidents where different actions by those involved could result in more desirable outcomes. While missed opportunities is not an established concept in coronary artery disease (CAD), they are important because CAD is co... Read More about Missed opportunities in coronary artery disease: reflection on practice to improve patient outcomes.

Missed acute myocardial infarction: an underrecognized problem that contributes to poor patient outcomes. (2021)
Journal Article
Mallen. (2021). Missed acute myocardial infarction: an underrecognized problem that contributes to poor patient outcomes. Coronary Artery Disease, 345-349. https://doi.org/10.1097/MCA.0000000000000975

Ischemic heart disease is the number one killer in the world. While improvements in the management of acute myocardial infarction (AMI) have resulted in lower mortality rates, there are still cases where AMI is missed with rates varying depending on... Read More about Missed acute myocardial infarction: an underrecognized problem that contributes to poor patient outcomes..

Misdiagnosis of heart failure: A systematic review of the literature (2021)
Journal Article
Mallen. (2021). Misdiagnosis of heart failure: A systematic review of the literature. Journal of Cardiac Failure, 925-933. https://doi.org/10.1016/j.cardfail.2021.05.014

Background Heart failure (HF) is a chronic disease associated with a significant burden to patients, families and health services. The diagnosis of HF can be easily missed due to similar symptoms with other conditions especially respiratory diseases... Read More about Misdiagnosis of heart failure: A systematic review of the literature.

Corrigendum to: comparing the use of direct observation, standardized patients and exit interviews in low- and middle-income countries: a systematic review of methods of assessing quality of primary care. (2021)
Journal Article
Mallen. (2021). Corrigendum to: comparing the use of direct observation, standardized patients and exit interviews in low- and middle-income countries: a systematic review of methods of assessing quality of primary care. Health Policy and Planning, 341-356. https://doi.org/10.1093/heapol/czab046

Metformin use and the risk of total knee replacement among diabetic patients in primary care (2021)
Presentation / Conference
Sit, R., Lai, F., Yip, B., Hunter, D., Rabago, D., Mallen, C., & Wong, S. (2021, April). Metformin use and the risk of total knee replacement among diabetic patients in primary care. Presented at Virtual 2021 OARSI World Congress on Osteoarthritis, Virtual

Purpose: Metformin, apart from its glucose lowering and weight reduction effects, has recently been shown to modulate meta-inflammation, an important pathogenesis in knee osteoarthritis (OA). We aim to study the association between regular metformin... Read More about Metformin use and the risk of total knee replacement among diabetic patients in primary care.

PREVALENCE OF FRAGILITY FRACTURES AND MEDICATION PRESCRIPTION FOR OSTEOPOROSIS IN PATIENTS WITH POLYMYALGIA RHEUMATICA: RESULTS FROM THE PMR COHORT STUDY (2021)
Journal Article
Singh Sokhal, B., Hider, S. L., Paskins, Z., Muller, S., & Mallen, C. D. (2021). PREVALENCE OF FRAGILITY FRACTURES AND MEDICATION PRESCRIPTION FOR OSTEOPOROSIS IN PATIENTS WITH POLYMYALGIA RHEUMATICA: RESULTS FROM THE PMR COHORT STUDY. Rheumatology, 60(S1), Article ARTN keab246.002. https://doi.org/10.1093/rheumatology/keab246.002

Background/Aims Polymyalgia rheumatica (PMR) is one of the commonest indications for long term glucocorticoid (GC) use, leading to an increased risk of osteoporosis and fragility fractures. Clinical guidelines recommend prescribing medication includ... Read More about PREVALENCE OF FRAGILITY FRACTURES AND MEDICATION PRESCRIPTION FOR OSTEOPOROSIS IN PATIENTS WITH POLYMYALGIA RHEUMATICA: RESULTS FROM THE PMR COHORT STUDY.

The patient, clinician and healthcare perspectives in evaluating care pathways for stable chest pain. (2021)
Journal Article
Kwok, C. S., Duckett, S., Satchithananda, D., Potluri, R., Morgan-Smith, D., Bellenger, N., …Mallen, C. D. (2021). The patient, clinician and healthcare perspectives in evaluating care pathways for stable chest pain. Critical Pathways in Cardiology: A Journal of Evidence-Based Medicine, 20(3), 143-148. https://doi.org/10.1097/HPC.0000000000000261

Chest pain is one of the most common reasons for patients to present to healthcare professionals. One of the main challenges with the management of chest pain is the wide differential diagnosis, ranging from minor chest trauma to potentially life thr... Read More about The patient, clinician and healthcare perspectives in evaluating care pathways for stable chest pain..

Assessing the severity of cardiovascular disease in 213 088 patients with coronary heart disease: a retrospective cohort study. (2021)
Journal Article
Mamas, Mallen, & Chew-Graham. (2021). Assessing the severity of cardiovascular disease in 213 088 patients with coronary heart disease: a retrospective cohort study. Open Heart, https://doi.org/10.1136/openhrt-2020-001498

OBJECTIVE: Most current cardiovascular disease (CVD) risk stratification tools are for people without CVD, but very few are for prevalent CVD. In this study, we developed and validated a CVD severity score in people with coronary heart disease (CHD)... Read More about Assessing the severity of cardiovascular disease in 213 088 patients with coronary heart disease: a retrospective cohort study..

Self-management advice, exercise and foot orthoses for plantar heel pain: the TREADON pilot and feasibility randomised trial (2021)
Journal Article
Chesterton, L. S., Thomas, M. J., Hendry, G., Chen, Y., Goddin, D., Halliday, N., …Roddy, E. (2021). Self-management advice, exercise and foot orthoses for plantar heel pain: the TREADON pilot and feasibility randomised trial. Pilot and Feasibility Studies, 7, Article 92. https://doi.org/10.1186/s40814-021-00808-0

Plantar heel pain (PHP) is common and impacts negatively on physical function and quality of life. Initial treatment usually comprises analgesia and self-management advice (SMA), with referral to a physiotherapist or podiatrist recommended only when... Read More about Self-management advice, exercise and foot orthoses for plantar heel pain: the TREADON pilot and feasibility randomised trial.

Impact of changes to national guidelines on hypertension-related workload: an interrupted time series analysis in English primary care. (2021)
Journal Article
Mallen. (2021). Impact of changes to national guidelines on hypertension-related workload: an interrupted time series analysis in English primary care. British Journal of General Practice (BJGP), e296-e302. https://doi.org/10.3399/bjgp21X714281

BACKGROUND: In 2011, National Institute for Health and Care Excellence (NICE) guidelines recommended the routine use of out-of-office blood pressure (BP) monitoring for the diagnosis of hypertension. These changes were predicted to reduce unnecessary... Read More about Impact of changes to national guidelines on hypertension-related workload: an interrupted time series analysis in English primary care..

Clinical and cost-effectiveness of bracing in symptomatic knee osteoarthritis management: protocol for a multicentre, primary care, randomised, parallel-group, superiority trial. (2021)
Journal Article
Holden, M., Callaghan, M., Felson, D., Birrell, F., Nicholls, E., Jowett, S., …Peat, G. (2021). Clinical and cost-effectiveness of bracing in symptomatic knee osteoarthritis management: protocol for a multicentre, primary care, randomised, parallel-group, superiority trial. BMJ Open, 11(3), Article e048196. https://doi.org/10.1136/bmjopen-2020-048196

BACKGROUND: Brace effectiveness for knee osteoarthritis (OA) remains unclear and international guidelines offer conflicting recommendations. Our trial will determine the clinical and cost-effectiveness of adding knee bracing (matched to patients' cli... Read More about Clinical and cost-effectiveness of bracing in symptomatic knee osteoarthritis management: protocol for a multicentre, primary care, randomised, parallel-group, superiority trial..

Developing a model Fracture Liaison Service consultation with patients, carers and clinicians: a Delphi survey to inform content of the iFraP complex consultation intervention. (2021)
Journal Article
Bullock, L., Crawford-Manning, F., Cottrell, E., Fleming, J., Leyland, S., Edwards, J., …Paskins, Z. (2021). Developing a model Fracture Liaison Service consultation with patients, carers and clinicians: a Delphi survey to inform content of the iFraP complex consultation intervention. Archives of Osteoporosis, 16, 1- 17. https://doi.org/10.1007/s11657-021-00913-w

Fracture Liaison Services are recommended to deliver best practice in secondary fracture prevention. This modified Delphi survey, as part of the iFraP (Improving uptake of Fracture Prevention drug Treatments) study, provides consensus regarding tasks... Read More about Developing a model Fracture Liaison Service consultation with patients, carers and clinicians: a Delphi survey to inform content of the iFraP complex consultation intervention..

Onset of comorbidities and flare patterns within pre-existing morbidity clusters in people with gout: 5-year primary care cohort study. (2021)
Journal Article
Bajpai, R., Muller, S., Mallen, C., Watson, L., Richette, P., Hider, S. L., & Roddy, E. (2021). Onset of comorbidities and flare patterns within pre-existing morbidity clusters in people with gout: 5-year primary care cohort study. Rheumatology, 61(1), 407-412. https://doi.org/10.1093/rheumatology/keab283

OBJECTIVE: To investigate the onset of comorbidities and pattern of flares over five years according to baseline comorbidity clusters in people with gout. METHODS: In a prospective primary-care-based cohort study, adults aged =18 years with gout, wer... Read More about Onset of comorbidities and flare patterns within pre-existing morbidity clusters in people with gout: 5-year primary care cohort study..

What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline? (2021)
Journal Article
Mallen. (2021). What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline?. Rheumatology, https://doi.org/10.1093/rheumatology/keab254

OBJECTIVES: To examine incidence of treatment changes due to abnormal blood-test results and, to explore rates of treatment changes due to liver, kidney and haematological blood-test abnormalities in autoimmune rheumatic diseases (AIRD) treated with... Read More about What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline?.

Exploring patient views of empathic optimistic communication for osteoarthritis in primary care: A qualitative interview study using vignettes (2021)
Journal Article
Mallen. (2021). Exploring patient views of empathic optimistic communication for osteoarthritis in primary care: A qualitative interview study using vignettes. British Journal of General Practice Open (BJGP Open), https://doi.org/10.3399/BJGPO.2021.0014

BACKGROUND: Osteoarthritis (OA) causes pain and disability. An empathic optimistic consultation approach can improve patient quality of life, satisfaction with care, and reduce pain. However, expressing empathic optimism may be overlooked in busy pri... Read More about Exploring patient views of empathic optimistic communication for osteoarthritis in primary care: A qualitative interview study using vignettes.

ß-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: a propensity score matched cohort study (2021)
Journal Article
Mamas, & Mallen. (2021). ß-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: a propensity score matched cohort study. Rheumatology, https://doi.org/10.1093/rheumatology/keab234

OBJECTIVES: To examine the association between ß-blocker prescription and first primary-care consultation for knee osteoarthritis (OA), hip OA, knee pain and hip pain. METHODS: Data source: Clinical Practice Research Datalink. Participants aged =40?y... Read More about ß-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: a propensity score matched cohort study.

Corrigendum to Health-related quality of life in gout in primary care: Baseline findings from a cohort study Seminars in Arthritis & Rheumatism, 48 (2018) 61-69. (2021)
Journal Article
Chandratre, P., Mallen, C., Richardson, J., Muller, S., Hider, S., Rome, K., …Roddy, E. (2022). Corrigendum to Health-related quality of life in gout in primary care: Baseline findings from a cohort study Seminars in Arthritis & Rheumatism, 48 (2018) 61-69. Seminars in Arthritis and Rheumatism, 52, Article 151800. https://doi.org/10.1016/j.semarthrit.2021.02.009

Corrigendum

Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting. (2021)
Journal Article
Mallen. (2021). Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting. Rheumatology, 4327-4339. https://doi.org/10.1093/rheumatology/keab067

OBJECTIVE: To determine the burden of comorbidities in osteoarthritis (OA) and their temporal relationships in the UK. METHODS: The Clinical Practice Research Datalink (CPRD) GOLD was used to identify people with incident OA and age, gender and pract... Read More about Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting..

Misdiagnosis of Acute Myocardial Infarction: A Systematic Review of the Literature (2021)
Journal Article
Kwok, C. S., Bennett, S., Azam, Z., Welsh, V., Potluri, R., Loke, Y. K., & Mallen, C. D. (2021). Misdiagnosis of Acute Myocardial Infarction: A Systematic Review of the Literature. Critical Pathways in Cardiology: A Journal of Evidence-Based Medicine, 20(3), 155-162. https://doi.org/10.1097/HPC.0000000000000256

Background: Despite the availability of tests to diagnose acute myocardial infarction (AMI), cases are still missed. Methods: We systematically reviewed the literature to determine how missed AMI has been defined, the reported rates of misdiagnosed A... Read More about Misdiagnosis of Acute Myocardial Infarction: A Systematic Review of the Literature.

Using Google Trends to assess the impact of Global Public Health Days on online health information-seeking behaviour in Arabian Peninsula (2021)
Journal Article
Ajbar, A., Shepherd, T. A., Robinson, M., Mallen, C. D., & Prior, J. A. (2021). Using Google Trends to assess the impact of Global Public Health Days on online health information-seeking behaviour in Arabian Peninsula. Journal of Egyptian Public Health Association, 94, Article 4. https://doi.org/10.1186/s42506-020-00063-w

BACKGROUND: Global Public Health Days (GPHD) are public health interventions which serve to improve public awareness of specific health conditions. Google Trends is a publicly available tool that allows the user to view the popularity of a searched k... Read More about Using Google Trends to assess the impact of Global Public Health Days on online health information-seeking behaviour in Arabian Peninsula.

TReatments of Exercise AnD Orthotic devices for plaNtar heel pain (TREADON) pilot and feasibility trial Self-Management Advice Booklet (2021)
Book
Thomas, Roddy, Mallen, & Lewis. (2021). TReatments of Exercise AnD Orthotic devices for plaNtar heel pain (TREADON) pilot and feasibility trial Self-Management Advice Booklet. https://doi.org/10.21252/n2y0-sr15

This record is the participant Self-Management Advice Booklet used in the TReatments of Exercise AnD Orthotic devices for plaNtar heel pain (TREADON) pilot and feasibility trial. Trial registration number: International Standard Randomised Controll... Read More about TReatments of Exercise AnD Orthotic devices for plaNtar heel pain (TREADON) pilot and feasibility trial Self-Management Advice Booklet.

Methods to disinfect and decontaminate SARS-CoV-2: a systematic review of in vitro studies (2021)
Journal Article
Mallen. (2021). Methods to disinfect and decontaminate SARS-CoV-2: a systematic review of in vitro studies. Therapeutic Advances in Infectious Disease, 2049936121998548 - ?

Background: Cleaning is a major control component for outbreaks of infection. However, for the SARS-CoV-2 pandemic, there is limited specific guidance regarding the proper disinfection methods that should be used. Methods: We conducted a systematic r... Read More about Methods to disinfect and decontaminate SARS-CoV-2: a systematic review of in vitro studies.

Survey of young people in one region of the UK on accessing COVID-19 information (SOCIAL) (2021)
Journal Article
Lawton, O. G., Lawton, S. A., Dikomitis, L., Protheroe, J., Smith, J., & Mallen, C. (2021). Survey of young people in one region of the UK on accessing COVID-19 information (SOCIAL). BMJ Paediatrics Open, e000942 - e000942. https://doi.org/10.1136/bmjpo-2020-000942

COVID-19 has significantly impacted young people’s lives yet little is known about the COVID-19 related sources of information they access. We performed a cross-sectional survey of pupils (11–16 years) in North Staffordshire, UK. 408 (23%) pupils res... Read More about Survey of young people in one region of the UK on accessing COVID-19 information (SOCIAL).

Acute Myocardial Infarction in Autoimmune Rheumatological Disease: A Nationwide Analysis of Clinical outcomes and Predictors of Management Strategy (2021)
Journal Article
Mamas, Clarson, Roddy, Mallen, & Helliwell. (2021). Acute Myocardial Infarction in Autoimmune Rheumatological Disease: A Nationwide Analysis of Clinical outcomes and Predictors of Management Strategy. Mayo Clinic Proceedings, 388-399. https://doi.org/10.1016/j.mayocp.2020.04.044

Objectives: The present study sought to examine national-level differences in management strategies and outcomes in patients with autoimmune rheumatic disease (AIRD) with acute myocardial infarction (AMI) between 2004 and 2014. Methods: All AMI hos... Read More about Acute Myocardial Infarction in Autoimmune Rheumatological Disease: A Nationwide Analysis of Clinical outcomes and Predictors of Management Strategy.

Rheumatic Conditions as Risk Factors for Self-Harm: A Retrospective Cohort Study (2021)
Journal Article
Prior, J. A., Paskins, Z., Whittle, R., Abdul-Sultan, A., Chew-Graham, C. A., Muller, S., …Mallen, C. D. (2021). Rheumatic Conditions as Risk Factors for Self-Harm: A Retrospective Cohort Study. Arthritis Care and Research, 73(1), 130-137. https://doi.org/10.1002/acr.24345

Objective To examine the risk of self-harm in rheumatological conditions Methods Retrospective cohort study using data from the Clinical Practice Research Datalink. Patients with ankylosing spondylitis, fibromyalgia, osteoarthritis or rheumatoid arth... Read More about Rheumatic Conditions as Risk Factors for Self-Harm: A Retrospective Cohort Study.

Experience of implementing and delivering group consultations in UK general practice: a qualitative study (2021)
Journal Article
Swaithes, L., Paskins, Z., Duffy, H., Evans, N., Mallen, C., Dziedzic, K., & Finney, A. (2021). Experience of implementing and delivering group consultations in UK general practice: a qualitative study. British Journal of General Practice (BJGP), 71(707), E413-E422. https://doi.org/10.3399/BJGP.2020.0856

BACKGROUND: Group consultations are a relatively new concept in UK primary care and are a suggested solution to current workload pressures in general practice. Little is known about the experience of implementing and delivering this approach from sta... Read More about Experience of implementing and delivering group consultations in UK general practice: a qualitative study.

General practitioners' deprescribing decisions in older adults with polypharmacy: a case vignette study in 31 countries (2021)
Journal Article
Mallen. (2021). General practitioners' deprescribing decisions in older adults with polypharmacy: a case vignette study in 31 countries. BMC Geriatrics, https://doi.org/10.1186/s12877-020-01953-6

BACKGROUND: General practitioners (GPs) should regularly review patients' medications and, if necessary, deprescribe, as inappropriate polypharmacy may harm patients' health. However, deprescribing can be challenging for physicians. This study invest... Read More about General practitioners' deprescribing decisions in older adults with polypharmacy: a case vignette study in 31 countries.

A pilot study of a nurse-led integrated care review (the INCLUDE review) for people with inflammatory rheumatological conditions in primary care: feasibility study findings. (2021)
Journal Article
Hider, S. L., Bucknall, M., Jinks, C., Cooke, K., Cooke, K., Ediriweera Desilva, E., …Chew-Graham, C. A. (2021). A pilot study of a nurse-led integrated care review (the INCLUDE review) for people with inflammatory rheumatological conditions in primary care: feasibility study findings. Pilot and Feasibility Studies, 7, Article 9. https://doi.org/10.1186/s40814-020-00750-7

BACKGROUND: People with inflammatory rheumatological conditions such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, polymyalgia rheumatica and giant cell arteritis are at an increased risk of common comorbidities including card... Read More about A pilot study of a nurse-led integrated care review (the INCLUDE review) for people with inflammatory rheumatological conditions in primary care: feasibility study findings..

Outcomes Measured in Polymyalgia Rheumatica and Measurement Properties of Instruments Considered for the OMERACT Core Outcome Set: A Systematic Review. (2020)
Journal Article
Twohig, H., Owen, C., Muller, S., Mallen, C., Mitchell, C., Hider, S., …Hill, C. (2021). Outcomes Measured in Polymyalgia Rheumatica and Measurement Properties of Instruments Considered for the OMERACT Core Outcome Set: A Systematic Review. Journal of Rheumatology, 48(6), 883-893. https://doi.org/10.3899/jrheum.200248

OBJECTIVE: To systematically identify the outcome measures and instruments used in clinical studies of polymyalgia rheumatica (PMR) and to evaluate evidence about their measurement properties. METHODS: Searches based on the MeSH term 'polymyalgia rhe... Read More about Outcomes Measured in Polymyalgia Rheumatica and Measurement Properties of Instruments Considered for the OMERACT Core Outcome Set: A Systematic Review..

Comparing the use of direct observation, standardized patients and exit interviews in low- and middle-income countries: a systematic review of methods of assessing quality of primary care. (2020)
Journal Article
Mallen. (2020). Comparing the use of direct observation, standardized patients and exit interviews in low- and middle-income countries: a systematic review of methods of assessing quality of primary care. Health Policy and Planning, 341-356. https://doi.org/10.1093/heapol/czaa152

Clinical records in primary healthcare settings in low- and middle-income countries (LMIC) are often lacking or of too poor quality to accurately assess what happens during the patient consultation. We examined the most common methods for assessing h... Read More about Comparing the use of direct observation, standardized patients and exit interviews in low- and middle-income countries: a systematic review of methods of assessing quality of primary care..

Understanding the uptake of a clinical innovation for osteoarthritis in primary care: a qualitative study of knowledge mobilisation using the i-PARIHS framework. (2020)
Journal Article
Swaithes, L., Dziedzic, K., Finney, A., Cottrell, E., Jinks, C., Mallen, C., …Paskins, Z. (2020). Understanding the uptake of a clinical innovation for osteoarthritis in primary care: a qualitative study of knowledge mobilisation using the i-PARIHS framework. Implementation Science, 15, Article 95. https://doi.org/10.1186/s13012-020-01055-2

BACKGROUND: Osteoarthritis is a leading cause of pain and disability worldwide. Despite research supporting best practice, evidence-based guidelines are often not followed. Little is known about the implementation of non-surgical models of care in ro... Read More about Understanding the uptake of a clinical innovation for osteoarthritis in primary care: a qualitative study of knowledge mobilisation using the i-PARIHS framework..

Identification of undiagnosed atrial fibrillation patients using a machine learning risk prediction algorithm and diagnostic testing (PULsE-AI): Study protocol for a randomised controlled trial (2020)
Journal Article
Nathan R., H., Chris, A., Lee, B., A. John, C., David, C., D. Wyn, D., …Alexander T., C. (2020). Identification of undiagnosed atrial fibrillation patients using a machine learning risk prediction algorithm and diagnostic testing (PULsE-AI): Study protocol for a randomised controlled trial. Contemporary Clinical Trials Communications, https://doi.org/10.1016/j.cct.2020.106191

Atrial fibrillation (AF) is associated with an increased risk of stroke, enhanced stroke severity, and other comorbidities. However, AF is often asymptomatic, and frequently remains undiagnosed until complications occur. Current screening approaches... Read More about Identification of undiagnosed atrial fibrillation patients using a machine learning risk prediction algorithm and diagnostic testing (PULsE-AI): Study protocol for a randomised controlled trial.

Clinical features and outcomes of adults with COVID-19: A systematic review and pooled analysis of the literature (2020)
Journal Article
Mallen. (2020). Clinical features and outcomes of adults with COVID-19: A systematic review and pooled analysis of the literature. International Journal of Clinical Practice, https://doi.org/10.1111/ijcp.13725

Background: The 2019 coronavirus disease (COVID-19) has become a global pandemic and the published literature describing the virus has grown exponentially. Methods: We conducted a systematic review of the literature to identify the symptoms, comorb... Read More about Clinical features and outcomes of adults with COVID-19: A systematic review and pooled analysis of the literature.

Cohort profile: Oxford Pain, Activity and Lifestyle (OPAL) Study, a prospective cohort study of older adults in England. (2020)
Journal Article
Mallen. (2020). Cohort profile: Oxford Pain, Activity and Lifestyle (OPAL) Study, a prospective cohort study of older adults in England. BMJ Open, https://doi.org/10.1136/bmjopen-2020-037516

PURPOSE: The 'Oxford Pain, Activity and Lifestyle' (OPAL) Cohort is a longitudinal, prospective cohort study of adults, aged 65 years and older, living in the community which is investigating the determinants of health in later life. Our focus was on... Read More about Cohort profile: Oxford Pain, Activity and Lifestyle (OPAL) Study, a prospective cohort study of older adults in England..

Latent Class Growth Analysis of Gout Flare Trajectories: A Three-Year Prospective Cohort Study in Primary Care (2020)
Journal Article
Muller, Watson, Belcher, Mallen, Roddy, & Nicholls. (2020). Latent Class Growth Analysis of Gout Flare Trajectories: A Three-Year Prospective Cohort Study in Primary Care. Arthritis and Rheumatology, 72(11), 1928-1935. https://doi.org/10.1002/art.41476

Objective To investigate the existence of distinct classes of gout flare trajectories and compare their gout-specific, comorbid, and sociodemographic characteristics. Methods In a prospective cohort study, adults with gout who were registered wi... Read More about Latent Class Growth Analysis of Gout Flare Trajectories: A Three-Year Prospective Cohort Study in Primary Care.

Mortality Among Patients With Polymyalgia Rheumatica: A Retrospective Cohort Study (2020)
Journal Article
Partington, R., Muller, S., Mallen, C. D., Abdul Sultan, A., & Helliwell, T. (2021). Mortality Among Patients With Polymyalgia Rheumatica: A Retrospective Cohort Study. Arthritis Care and Research, 73(12), 1853-1857. https://doi.org/10.1002/acr.24403

OBJECTIVE: To determine whether a diagnosis of polymyalgia rheumatica (PMR) is associated with premature mortality. METHODS: We extracted anonymised electronic medical records of patients over the age of 40 years, who were eligible for linkage with t... Read More about Mortality Among Patients With Polymyalgia Rheumatica: A Retrospective Cohort Study.

Improving Empathy in Healthcare Consultations-a Secondary Analysis of Interventions. (2020)
Journal Article
Mallen. (2020). Improving Empathy in Healthcare Consultations-a Secondary Analysis of Interventions. Journal of General Internal Medicine, https://doi.org/10.1007/s11606-020-05994-w

A recent systematic review of randomised trials suggested that empathic communication improves patient health outcomes. However, the methods for training healthcare practitioners (medical professionals; HCPs) in empathy and the empathic behaviours de... Read More about Improving Empathy in Healthcare Consultations-a Secondary Analysis of Interventions..

Managing hypertension in frail oldest-old – the role of guideline use by general practitioners from 29 countries (2020)
Journal Article
Mallen. (2020). Managing hypertension in frail oldest-old – the role of guideline use by general practitioners from 29 countries. PloS one, https://doi.org/10.1371/journal.pone.0236064

Background: The best management of hypertension in frail oldest-old (=80 years of age) remains unclear while lacking guidelines providing specific recommendations.Aim, Objectives To investigate guideline use in general practitioners (GPs) and if gui... Read More about Managing hypertension in frail oldest-old – the role of guideline use by general practitioners from 29 countries.

Managing hypertension in frail oldest-old-The role of guideline use by general practitioners from 29 countries. (2020)
Journal Article
Mallen. (2020). Managing hypertension in frail oldest-old-The role of guideline use by general practitioners from 29 countries. PloS one, https://doi.org/10.1371/journal.pone.0236064

BACKGROUND: The best management of hypertension in frail oldest-old (=80 years of age) remains unclear and we still lack guidelines that provide specific recommendations. Our study aims to investigate guideline use in general practitioners (GPs) and... Read More about Managing hypertension in frail oldest-old-The role of guideline use by general practitioners from 29 countries..

Computer-Based Stratified Primary Care for Musculoskeletal Consultations Compared With Usual Care: Study Protocol for the STarT MSK Cluster Randomized Controlled Trial. (2020)
Journal Article
Hill, J., Garvin, S., Chen, Y., Cooper, V., Wathall, S., Bartlam, B., …Foster, N. E. (2020). Computer-Based Stratified Primary Care for Musculoskeletal Consultations Compared With Usual Care: Study Protocol for the STarT MSK Cluster Randomized Controlled Trial. JMIR Research Protocols, 9(7), https://doi.org/10.2196/17939

BACKGROUND: Musculoskeletal (MSK) pain is a major cause of pain and disability. We previously developed a prognostic tool (STarT Back Tool) with demonstrated effectiveness in guiding primary care low back pain management by supporting decision-making... Read More about Computer-Based Stratified Primary Care for Musculoskeletal Consultations Compared With Usual Care: Study Protocol for the STarT MSK Cluster Randomized Controlled Trial..

Supervised treatment in outpatients for schizophrenia plus (STOPS+): protocol for a cluster randomised trial of a community-based intervention to improve treatment adherence and reduce the treatment gap for schizophrenia in Pakistan (2020)
Journal Article
Shepherd, T. A., Ul-Haq, Z., Ul-Haq, M., Firaz Khan, M., Afridi, A., Dikomitis, L., …Farooq, S. (2020). Supervised treatment in outpatients for schizophrenia plus (STOPS+): protocol for a cluster randomised trial of a community-based intervention to improve treatment adherence and reduce the treatment gap for schizophrenia in Pakistan. BMJ Open, 10(6), https://doi.org/10.1136/bmjopen-2019-034709

Introduction: There is a significant treatment gap, with only a few community-based services for people with schizophrenia in Low- and Middle-Income countries. Poor treatment adherence in schizophrenia is associated with poorer health outcomes, suici... Read More about Supervised treatment in outpatients for schizophrenia plus (STOPS+): protocol for a cluster randomised trial of a community-based intervention to improve treatment adherence and reduce the treatment gap for schizophrenia in Pakistan.

Using Google Trends to assess the impact of global public health days on online health information seeking behaviour in Central and South America (2020)
Journal Article
Havelka, E. M., Mallen, C. D., & Shepherd, T. A. (2020). Using Google Trends to assess the impact of global public health days on online health information seeking behaviour in Central and South America. Journal of Global Health, 10(1), https://doi.org/10.7189/jogh.10.010403

Background Public health awareness can help prevent illness and result in earlier intervention when it does occur. For this reason, health promotion and disease awareness campaigns have great potential to alleviate the global burden of disease. Glob... Read More about Using Google Trends to assess the impact of global public health days on online health information seeking behaviour in Central and South America.

Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction (2020)
Journal Article
Clarson, L. E., Bajpai, R., Whittle, R., Belcher, J., Abdul Sultan, A., Kwok, C. S., …Mallen, C. D. (2020). Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction. Heart, 106(12), 916-922. https://doi.org/10.1136/heartjnl-2019-315511

Objectives Despite many shared risk factors and pathophysiological pathways, the risk of ischaemic heart disease (IHD) and myocardial infarction (MI) in interstitial lung disease (ILD) remains poorly understood. This lack of data could be preventing... Read More about Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction.

Initial analgesic prescriptions for osteoarthritis in the United Kingdom, 2000-2016. (2020)
Journal Article
Mallen. (2021). Initial analgesic prescriptions for osteoarthritis in the United Kingdom, 2000-2016. Rheumatology, 60(1), 147 - 159. https://doi.org/10.1093/rheumatology/keaa244

OBJECTIVES: To examine trends in the initial prescription of commonly-prescribed analgesics and patient- as well as practice-level factors related to their selection in incident OA. METHODS: Patients consulting with incident clinical OA between 2000-... Read More about Initial analgesic prescriptions for osteoarthritis in the United Kingdom, 2000-2016..

Stratified care versus usual care for management of patients presenting with sciatica in primary care (SCOPiC): a randomised controlled trial (2020)
Journal Article
Konstantinou, K., Lewis, M., Dunn, K., Hay, E., Van Der Windt, D., Artus, M., …Foster, N. (2020). Stratified care versus usual care for management of patients presenting with sciatica in primary care (SCOPiC): a randomised controlled trial. The Lancet Rheumatology, 2(7), e401-e411. https://doi.org/10.1016/S2665-9913%2820%2930099-0

Background Sciatica has a substantial impact on individuals and society. Stratified care has been shown to lead to better outcomes among patients with non-specific low back pain, but it has not been tested for sciatica. We aimed to investigate the c... Read More about Stratified care versus usual care for management of patients presenting with sciatica in primary care (SCOPiC): a randomised controlled trial.

Stratified versus usual care for the management of primary care patients with sciatica: the SCOPiC RCT (2020)
Journal Article
Foster, N. E., Konstantinou, K., Lewis, M., Ogollah, R., Saunders, B., Kigozi, J., …Dunn, K. M. (2020). Stratified versus usual care for the management of primary care patients with sciatica: the SCOPiC RCT. Health Technology Assessment, 2(7), e401-e411. https://doi.org/10.3310/hta24490

BACKGROUND: Sciatica has a substantial impact on patients and society. Current care is 'stepped', comprising an initial period of simple measures of advice and analgesia, for most patients, commonly followed by physiotherapy, and then by more intensi... Read More about Stratified versus usual care for the management of primary care patients with sciatica: the SCOPiC RCT.

Statin use and risk of joint replacement due to osteoarthritis and rheumatoid arthritis: a propensity-score matched longitudinal cohort study. (2020)
Journal Article
Mallen. (2020). Statin use and risk of joint replacement due to osteoarthritis and rheumatoid arthritis: a propensity-score matched longitudinal cohort study. Rheumatology, https://doi.org/10.1093/rheumatology/keaa223

Objective Statins are reported to have a potential benefit on progression of OA and on disease activity in RA, but existing evidence is conflicting. Our objective was to examine whether statins associate with reduction in the risk for joint replacem... Read More about Statin use and risk of joint replacement due to osteoarthritis and rheumatoid arthritis: a propensity-score matched longitudinal cohort study..

Examining the impact of an innovative online qualitative study (netnography) in developing a clinical pharmacist-led review for persistent pain patients in primary care (PROMPPT study) (2020)
Presentation / Conference
Woodcock, C., Ashworth, J., Cornwall, N., Harrisson, S. A., Buttery, A., Jinks, C., …Dikomitis, L. (2020, June). Examining the impact of an innovative online qualitative study (netnography) in developing a clinical pharmacist-led review for persistent pain patients in primary care (PROMPPT study). Presented at ASM 2020 (CANCELLED), Chicago, Illinois

FRI0610-HPR Β-ADRENORECEPTOR BLOCKING DRUGS ASSOCIATE WITH LOWER RISK OF KNEE OSTEOARTHRITIS AND KNEE PAIN CONSULTATIONS IN PRIMARY CARE: A PROPENSITY SCORE MATCHED COHORT STUDY USING THE CLINICAL PRACTICE RESEARCH DATALINK. (2020)
Presentation / Conference
Nakafero, G., Grainge, M., Valdes, A., Townsend, N., Mallen, C., Zhang, W., …Abhishek, A. (2020, June). FRI0610-HPR Β-ADRENORECEPTOR BLOCKING DRUGS ASSOCIATE WITH LOWER RISK OF KNEE OSTEOARTHRITIS AND KNEE PAIN CONSULTATIONS IN PRIMARY CARE: A PROPENSITY SCORE MATCHED COHORT STUDY USING THE CLINICAL PRACTICE RESEARCH DATALINK

Background: The pharmacologic management of OA is centred around optimising pain control but first-line analgesics only have modest efficacy1. Findings from several studies suggest that β-adrenoreceptor blocking drugs (β-blockers) have anti-nocicepti... Read More about FRI0610-HPR Β-ADRENORECEPTOR BLOCKING DRUGS ASSOCIATE WITH LOWER RISK OF KNEE OSTEOARTHRITIS AND KNEE PAIN CONSULTATIONS IN PRIMARY CARE: A PROPENSITY SCORE MATCHED COHORT STUDY USING THE CLINICAL PRACTICE RESEARCH DATALINK..

Trends in Incidence and Prevalence of Osteoarthritis in the United Kingdom: Findings from the Clinical Practice Research Datalink (CPRD) (2020)
Journal Article
Mallen. (2020). Trends in Incidence and Prevalence of Osteoarthritis in the United Kingdom: Findings from the Clinical Practice Research Datalink (CPRD). Osteoarthritis and Cartilage, 792-801. https://doi.org/10.1016/j.joca.2020.03.004

Objective: This study aimed to explore the incidence and prevalence of OA in the UK in 2017 and their trends from 1997 to 2017 using a large nationally representative primary care database. Design: The UK Clinical Practice Research Datalink (CPRD)... Read More about Trends in Incidence and Prevalence of Osteoarthritis in the United Kingdom: Findings from the Clinical Practice Research Datalink (CPRD).

Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction. (2020)
Journal Article
Mallen, C., Belcher, J., Mamas, M., Clarson, L., Welsh, V., & Bajpai, R. (2020). Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction. Heart, 916-922. https://doi.org/10.1136/heartjnl-2019-315511

OBJECTIVES: Despite many shared risk factors and pathophysiological pathways, the risk of ischaemic heart disease (IHD) and myocardial infarction (MI) in interstitial lung disease (ILD) remains poorly understood. This lack of data could be preventing... Read More about Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction..

Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction (2020)
Journal Article
Elise Clarson, L., Bajpai, R., Whittle, R., Belcher, J., Abdul Sultan, A., Shing Kwok, C., …Mallen, C. D. (2020). Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction. Heart, Article 12. https://doi.org/10.1136/heartjnl-2019-315511

Objectives Despite many shared risk factors and pathophysiological pathways, the risk of ischaemic heart disease (IHD) and myocardial infarction (MI) in interstitial lung disease (ILD) remains poorly understood. This lack of data could be preventing... Read More about Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction.

Comorbidities in patients with polymyalgia rheumatica prior to and following diagnosis: A case control and cohort study (2020)
Journal Article
Partington, R., Muller, S., Mallen, C. D., Abdul Sultan, A., & Helliwell, T. (2020). Comorbidities in patients with polymyalgia rheumatica prior to and following diagnosis: A case control and cohort study. Seminars in Arthritis and Rheumatism, 50(4), 663-672. https://doi.org/10.1016/j.semarthrit.2020.05.003

Objectives: To determine the burden of comorbidities, including glucocorticoid (GC) related adverse effects, in patients with polymyalgia rheumatica (PMR) before and after diagnosis. Methods: We extracted anonymised electronic medical records of p... Read More about Comorbidities in patients with polymyalgia rheumatica prior to and following diagnosis: A case control and cohort study.

Development and validation of the DIabetes Severity SCOre (DISSCO) in 139 626 individuals with type 2 diabetes: a retrospective cohort study. (2020)
Journal Article
Mamas, Chew-Graham, & Mallen. (2020). Development and validation of the DIabetes Severity SCOre (DISSCO) in 139 626 individuals with type 2 diabetes: a retrospective cohort study. BMJ Open Diabetes Research and Care, https://doi.org/10.1136/bmjdrc-2019-000962

OBJECTIVE: Clinically applicable diabetes severity measures are lacking, with no previous studies comparing their predictive value with glycated hemoglobin (HbA1c). We developed and validated a type 2 diabetes severity score (the DIabetes Severity SC... Read More about Development and validation of the DIabetes Severity SCOre (DISSCO) in 139 626 individuals with type 2 diabetes: a retrospective cohort study..

Family medicine in times of 'COVID-19': A generalists' voice. (2020)
Journal Article
Mallen. (2020). Family medicine in times of 'COVID-19': A generalists' voice. European Journal of General Practice, 58 - 60. https://doi.org/10.1080/13814788.2020.1757312

The novel coronavirus epidemic is transforming the world in which we live. This pandemic will bring sweeping changes everywhere, not least in the field of primary care medicine. Like one of our colleagues said: ‘after this crisis, perhaps even our c... Read More about Family medicine in times of 'COVID-19': A generalists' voice..

THE RELATIONSHIP BETWEEN OBESITY AND OUTCOMES IN PATIENTS WITH POLYMYALGIA RHEUMATICA (2020)
Journal Article
Helliwell, T., Mallen, C. D., Scott, I. C., Bajpai, R., Muller, S., & Hider, S. L. (2020). THE RELATIONSHIP BETWEEN OBESITY AND OUTCOMES IN PATIENTS WITH POLYMYALGIA RHEUMATICA. Rheumatology, 59, 18-18. https://doi.org/10.1093/RHEUMATOLOGY/KEAA110.037

Background Obesity predisposes to a pro-inflammatory state. Studies have reported worse clinical outcomes in patients with inflammatory arthritis who are obese. The relationship between obesity and outcomes in patients with polymyalgia rheumatica (P... Read More about THE RELATIONSHIP BETWEEN OBESITY AND OUTCOMES IN PATIENTS WITH POLYMYALGIA RHEUMATICA.

Qualitative findings from the Hip Injection Trial (HIT): experiences of living with hip osteoarthritis and receiving trial treatments (2020)
Journal Article
Paskins, Holden, Mallen, Jinks, Hawarden, & Roddy. (2020). Qualitative findings from the Hip Injection Trial (HIT): experiences of living with hip osteoarthritis and receiving trial treatments. Rheumatology, https://doi.org/10.1093/rheumatology/keaa111.125

Background The HIT trial compared ultrasound-guided intra-articular hip injection (USGI) of triamcinolone acetonide and 1% lidocaine hydrochloride combined with best current treatment (BCT) with (i) BCT alone and (ii) an USGI of 1% lidocaine only co... Read More about Qualitative findings from the Hip Injection Trial (HIT): experiences of living with hip osteoarthritis and receiving trial treatments.

CLINICAL AND COST-EFFECTIVENESS OF ULTRASOUND-GUIDED INTRA-ARTICULAR CORTICOSTEROID AND LOCAL ANAESTHETIC INJECTION FOR HIP OSTEOARTHRITIS: A RANDOMISED CONTROLLED TRIAL (HIT) (2020)
Journal Article
Paskins, Z., Bromley, K., Lewis, M., Hughes, G., Hughes, E., Cherrington, A., …Roddy, E. (2020). CLINICAL AND COST-EFFECTIVENESS OF ULTRASOUND-GUIDED INTRA-ARTICULAR CORTICOSTEROID AND LOCAL ANAESTHETIC INJECTION FOR HIP OSTEOARTHRITIS: A RANDOMISED CONTROLLED TRIAL (HIT). Osteoarthritis and Cartilage, 28(S1), https://doi.org/10.1016/j.joca.2020.02.751

Undertaking an integrated nurse led review (INCLUDE) for patients with inflammatory conditions: does it change management of morbidities? (2020)
Journal Article
Healey, E., Chew-Graham, C., Finney, A., Cooke, K., Wathall, S., Mallen, C., …Jinks, C. (2020). Undertaking an integrated nurse led review (INCLUDE) for patients with inflammatory conditions: does it change management of morbidities?. Rheumatology, https://doi.org/10.1093/rheumatology/keaa111.141

Background People with inflammatory rheumatological conditions (IRCs), including rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriatic arthritis (PsA), polymyalgia rheumatica (PMR) and giant cell arteritis (GCA), are at an increased risk... Read More about Undertaking an integrated nurse led review (INCLUDE) for patients with inflammatory conditions: does it change management of morbidities?.

P148 Gastrointestinal symptoms and proton pump inhibitor use in patients with polymyalgia rheumatica: results from the PMR Cohort study (2020)
Presentation / Conference
Feddah, H., Muller, S., Hider, S., Hay, C., & Mallen, C. (2020, April). P148 Gastrointestinal symptoms and proton pump inhibitor use in patients with polymyalgia rheumatica: results from the PMR Cohort study. Poster presented at British Society for Rheumatology Annual Conference 2020, - Cancelled -

Background Polymyalgia Rheumatica (PMR) is a common disorder of older adults, characterised by pain and stiffness in the shoulders and hips. PMR is one of the commonest indications for long-term glucocorticoid use. Because of the well-recognised sid... Read More about P148 Gastrointestinal symptoms and proton pump inhibitor use in patients with polymyalgia rheumatica: results from the PMR Cohort study.

The hip injection trial (HIT) nested qualitative study: experiences of living with hip Osteoarthritis and receiving trial treatments. (2020)
Journal Article
Holden, M., Hawarden, A., Paskins, Z., Roddy, E., Mallen, C., Jinks, C., & Trial Team, T. H. (2020). The hip injection trial (HIT) nested qualitative study: experiences of living with hip Osteoarthritis and receiving trial treatments. Osteoarthritis and Cartilage, 28, S499. https://doi.org/10.1016/j.joca.2020.02.782

Purpose: Evidence about the effectiveness of intra-articular corticosteroid injection for hip osteoarthritis (OA) is limited. The HIT trial compared ultrasound-guided intra-articular hip injection (USGI) of triamcinolone acetonide and 1% lidocaine hy... Read More about The hip injection trial (HIT) nested qualitative study: experiences of living with hip Osteoarthritis and receiving trial treatments..

Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the United Kingdom primary care setting (2020)
Journal Article
Swain, S., Coupland, C., Mallen, C., Kuo, C. F., Sarmanova, A., Doherty, M., & Zhang, W. (2020). Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the United Kingdom primary care setting. Osteoarthritis and Cartilage, 28, S72-S73. https://doi.org/10.1016/j.joca.2020.02.110

Purpose: To determine the temporal relationship between osteoarthritis (OA) and comorbidities. Methods: During a 20 years period (1997-2017), we identified 222,290 incident OA cases and 222,290 age (+/-2 years), sex and practice matched controls (... Read More about Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the United Kingdom primary care setting.

O04 Clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injection for hip OA: a randomised controlled trial (HIT) (2020)
Presentation / Conference
Paskins, Z., Bromley, K., Lewis, M., Hughes, G., Hughes, E., Cherrington, A., …Roddy, E. (2020, April). O04 Clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injection for hip OA: a randomised controlled trial (HIT). Presented at British Society for Rheumatology Annual Conference 2020, Glasgow, Scotland, UK

Background Evidence of the effectiveness of intra-articular corticosteroid injection for hip osteoarthritis (OA) is limited. The HIT trial compared the clinical and cost-effectiveness of an ultrasound-guided intra-articular hip injection (USGI) of 4... Read More about O04 Clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injection for hip OA: a randomised controlled trial (HIT).

The relationship between obesity and outcomes in patients with polymyalgia rheumatica (2020)
Presentation / Conference
Scott, I. C., Bajpai, R., Mallen, C., Muller, S., Helliwell, T., & Hider, S. (2020, April). The relationship between obesity and outcomes in patients with polymyalgia rheumatica. Presented at British Society for Rheumatology Annual Conference 2020, Scottish Event Campus (SEC), Scotland, UK

Background Obesity predisposes to a pro-inflammatory state. Studies have reported worse clinical outcomes in patients with inflammatory arthritis who are obese. The relationship between obesity and outcomes in patients with polymyalgia rheumatica (P... Read More about The relationship between obesity and outcomes in patients with polymyalgia rheumatica.

P142 Factors associated with change in health-related quality of life in people living with gout: a three-year prospective cohort study in primary care (2020)
Journal Article
Watson, L., Belcher, J., Nicholls, E., Chandratre, P., Blagojevic-Bucknall, M., Hider, S., …Roddy, E. (2020). P142 Factors associated with change in health-related quality of life in people living with gout: a three-year prospective cohort study in primary care. Rheumatology, 59(Supplement_2), https://doi.org/10.1093/rheumatology/keaa111.137

Background Gout affects 2.5% of adults in the UK but is often poorly managed. It can impair health-related quality of life (HRQOL), yet little is known about which people with gout are at risk of worse outcomes. We investigated factors associated wi... Read More about P142 Factors associated with change in health-related quality of life in people living with gout: a three-year prospective cohort study in primary care.

P197 Analgesic prescribing in patients with inflammatory arthritis in the NHS (2020)
Journal Article
Scott, I. C., Bailey, J., White, C., Mallen, C. D., & Muller, S. (2020). P197 Analgesic prescribing in patients with inflammatory arthritis in the NHS. Rheumatology, 59(Supplement_2), https://doi.org/10.1093/rheumatology/keaa111.192

Background There is little evidence analgesics improve pain in inflammatory arthritis (IA), and substantial evidence they have significant harms. Excepting NSAIDs in ankylosing spondylitis (AS), their long-term use is not recommended in guidelines.... Read More about P197 Analgesic prescribing in patients with inflammatory arthritis in the NHS.

Cardiovascular risk factors and outcomes in early rheumatoid arthritis: a population-based study (2020)
Journal Article
Mallen. (2020). Cardiovascular risk factors and outcomes in early rheumatoid arthritis: a population-based study. Heart, https://doi.org/10.1136/heartjnl-2019-316193

Objective To assess the burden of cardiovascular disease (CVD) at and prior to diagnosis in people with early rheumatoid arthritis (RA) and subsequent CVD in these patients. Methods A retrospective case–control study using a large English primary... Read More about Cardiovascular risk factors and outcomes in early rheumatoid arthritis: a population-based study.

Trends in incidence and prevalence of osteoarthritis in the United Kingdom: findings from the Clinical Practice Research Datalink (CPRD). (2020)
Journal Article
Mallen. (2020). Trends in incidence and prevalence of osteoarthritis in the United Kingdom: findings from the Clinical Practice Research Datalink (CPRD). Osteoarthritis and Cartilage, https://doi.org/10.1016/j.joca.2020.03.004

OBJECTIVE: This study aimed to explore the incidence and prevalence of OA in the UK in 2017 and their trends from 1997 to 2017 using a large nationally representative primary care database. DESIGN: The UK Clinical Practice Research Datalink (CPRD) co... Read More about Trends in incidence and prevalence of osteoarthritis in the United Kingdom: findings from the Clinical Practice Research Datalink (CPRD)..

Statin use and risk of joint replacement due to osteoarthritis and rheumatoid arthritis: a propensity-score matched cohort study (2020)
Journal Article
Mallen. (2020). Statin use and risk of joint replacement due to osteoarthritis and rheumatoid arthritis: a propensity-score matched cohort study. Rheumatology, https://doi.org/10.1093/rheumatology/keaa044

Objective Statins are reported to have a potential benefit on progression of OA and on disease activity in RA, but existing evidence is conflicting. Our objective was to examine whether statins associate with reduction in the risk for joint replacem... Read More about Statin use and risk of joint replacement due to osteoarthritis and rheumatoid arthritis: a propensity-score matched cohort study.

Stratified primary care versus non-stratified care for musculoskeletal pain: findings from the STarT MSK feasibility and pilot cluster randomized controlled trial (2020)
Journal Article
Hill, J., Garvin, S., Chen, Y., Cooper, V., Wathall, S., Saunders, B., …Foster, N. E. (2020). Stratified primary care versus non-stratified care for musculoskeletal pain: findings from the STarT MSK feasibility and pilot cluster randomized controlled trial. BMC Family Practice, 21, Article 30. https://doi.org/10.1186/s12875-019-1074-9

Background: Musculoskeletal (MSK) pain from the five most common presentations to primary care (back, neck, shoulder, knee or multi-site pain), where the majority of patients are managed, is a costly global health challenge. At present, first-line de... Read More about Stratified primary care versus non-stratified care for musculoskeletal pain: findings from the STarT MSK feasibility and pilot cluster randomized controlled trial.

The Hospital Frailty Risk Score and its association with in-hospital mortality, cost, length of stay and discharge location in patients with heart failure (2020)
Journal Article
Shing Kwok, C., Zieroth, S., Van Spall, H. G. C., Helliwell, T., Clarson, L., Mohamed, M., …Mamas, M. A. (2020). The Hospital Frailty Risk Score and its association with in-hospital mortality, cost, length of stay and discharge location in patients with heart failure. International Journal of Cardiology, 184-190. https://doi.org/10.1016/j.ijcard.2019.09.064

Background: Little is known about frailty amongst patients hospitalized with heart failure (HF) on a national level. Methods: We conducted a retrospective cohort study of patients admitted to hospital for HF in the United States. We examined how... Read More about The Hospital Frailty Risk Score and its association with in-hospital mortality, cost, length of stay and discharge location in patients with heart failure.

The impact of changes to national hypertension guidelines on hypertension management and outcomes in the UK (2020)
Journal Article
Mallen. (2020). The impact of changes to national hypertension guidelines on hypertension management and outcomes in the UK. Hypertension, 356-364. https://doi.org/10.1161/HYPERTENSIONAHA.119.13926

In recent years, national and international guidelines have recommended the use of out-of-office blood pressure monitoring for diagnosing hypertension. Despite evidence of cost effectiveness, critics expressed concerns this would increase cardiovascu... Read More about The impact of changes to national hypertension guidelines on hypertension management and outcomes in the UK.

Correction to: The comorbidity burden of type 2 diabetes mellitus: patterns, clusters and predictions from a large English primary care cohort. (2020)
Journal Article
Chew-Graham, Mallen, & Mamas. (2020). Correction to: The comorbidity burden of type 2 diabetes mellitus: patterns, clusters and predictions from a large English primary care cohort. BMC Medicine, https://doi.org/10.1186/s12916-020-1492-5

The original article [1] contains an omitted grant acknowledgement and affiliation as relates to the contribution of co-author, Rafael Perera-Salazar. As such, the following two amendments should apply to the original article.

Investigating multisite pain as a predictor of self-reported falls and falls requiring health care use in an older population: A prospective cohort study. (2019)
Journal Article
Welsh, V., Mallen, C., Ogollah, R., Wilkie, R., & McBeth, J. (2019). Investigating multisite pain as a predictor of self-reported falls and falls requiring health care use in an older population: A prospective cohort study. PloS one, -. https://doi.org/10.1371/journal.pone.0226268

Older people are continuing to fall despite fall prevention guidelines targeting known falls' risk factors. Multisite pain is a potential novel falls' risk factor requiring further exploration. This study hypothesises that: (1) an increasing number o... Read More about Investigating multisite pain as a predictor of self-reported falls and falls requiring health care use in an older population: A prospective cohort study..

Naproxen or low-dose colchicine for gout flares in primary care? Response to: 'Open-label randomised pragmatic trial (CONTACT) comparing naproxen and low-dose colchicine for the treatment of gout flares in primary care' by Parperis et al. (2019)
Journal Article
Roddy, E., & Mallen, C. (2019). Naproxen or low-dose colchicine for gout flares in primary care? Response to: 'Open-label randomised pragmatic trial (CONTACT) comparing naproxen and low-dose colchicine for the treatment of gout flares in primary care' by Parperis et al. Annals of the Rheumatic Diseases, https://doi.org/10.1136/annrheumdis-2019-216671

Correspondence response.

Longitudinal clusters of pain and stiffness in polymyalgia rheumatica: 2-year results from the PMR Cohort Study (2019)
Journal Article
Muller, S., Whittle, R., Hider, S. L., Belcher, J., Helliwell, T., Morton, C., …Mallen, C. D. (2020). Longitudinal clusters of pain and stiffness in polymyalgia rheumatica: 2-year results from the PMR Cohort Study. Rheumatology, 59(8), 1906-1915. https://doi.org/10.1093/rheumatology/kez533

Objectives. To investigate potential subgroups of primary care diagnosed patients with polymyalgia rheumatica (PMR) based on self-reported pain and stiffness severity over time. Methods. 652 people with an incident PMR diagnosis were recruited fro... Read More about Longitudinal clusters of pain and stiffness in polymyalgia rheumatica: 2-year results from the PMR Cohort Study.

Clinical Effectiveness of Ultrasound-guided Intra-articular Corticosteroid and Local Anaesthetic Injections for Hip Osteoarthritis: A Randomised Controlled Trial (HIT) (2019)
Presentation / Conference
Paskins, Z., Bromley, K., Lewis, M., Hughes, G., Hughes, E., Cherrington, A., …Roddy, E. (2019, November). Clinical Effectiveness of Ultrasound-guided Intra-articular Corticosteroid and Local Anaesthetic Injections for Hip Osteoarthritis: A Randomised Controlled Trial (HIT). Paper presented at 2019 ACR/ARP Annual Meeting, Atlanta, GA, USA

Background/Purpose: Evidence of the effectiveness of intra-articular corticosteroid injection for hip osteoarthritis (OA) is limited and conflicting. The HIT trial compared the clinical effectiveness of an ultrasound-guided intra-articular hip inject... Read More about Clinical Effectiveness of Ultrasound-guided Intra-articular Corticosteroid and Local Anaesthetic Injections for Hip Osteoarthritis: A Randomised Controlled Trial (HIT).

"If It Was Unicorn Dust I'd Have It Again." Patient Experiences of Hip Osteoarthritis and Treatments in the Hip Injection Trial (2019)
Conference Proceeding
Jinks, C., Hawarden, A., Roddy, E., Paskins, Z., Mallen, C., & Holden, M. (2019). "If It Was Unicorn Dust I'd Have It Again." Patient Experiences of Hip Osteoarthritis and Treatments in the Hip Injection Trial.

Background/Purpose: Evidence of the effectiveness of intra-articular corticosteroid injection for hip osteoarthritis (OA) is limited and conflicting. The HIT trial compared the clinical effectiveness of an ultrasound-guided intra-articular hip inject... Read More about "If It Was Unicorn Dust I'd Have It Again." Patient Experiences of Hip Osteoarthritis and Treatments in the Hip Injection Trial.

Open-label randomised pragmatic trial (CONTACT) comparing naproxen and low-dose colchicine for the treatment of gout flares in primary care (2019)
Journal Article
Roddy, E., Clarkson, K., Bucknall, M., Mehta, R., Oppong, R., Avery, A., …Mallen, C. (2019). Open-label randomised pragmatic trial (CONTACT) comparing naproxen and low-dose colchicine for the treatment of gout flares in primary care. Annals of the Rheumatic Diseases, 79(2), https://doi.org/10.1136/annrheumdis-2019-216154

OBJECTIVES: To compare the effectiveness and safety of naproxen and low-dose colchicine for treating gout flares in primary care. METHODS: This was a multicentre open-label randomised trial. Adults with a gout flare recruited from 100 general prac... Read More about Open-label randomised pragmatic trial (CONTACT) comparing naproxen and low-dose colchicine for the treatment of gout flares in primary care.

Protocol for establishing a child and adolescent twin register for mental health research and capacity building in Sri Lanka and other low and middle-income countries in South Asia (2019)
Journal Article
Jayaweera, K., M Craig, J., M S Zavos, H., Abeysinghe, N., De Alwis, S., Andras, A., …Sumathipala, A. (2019). Protocol for establishing a child and adolescent twin register for mental health research and capacity building in Sri Lanka and other low and middle-income countries in South Asia. BMJ Open, 9(10), Article e029332. https://doi.org/10.1136/bmjopen-2019-029332

INTRODUCTION: Worldwide, 10%-20% of children and adolescents experience mental health conditions. However, most such disorders remain undiagnosed until adolescence or adulthood. Little is known about the factors that influence mental health in childr... Read More about Protocol for establishing a child and adolescent twin register for mental health research and capacity building in Sri Lanka and other low and middle-income countries in South Asia.

Prognostic value of comorbidity indices and lung diseases in early rheumatoid arthritis: a UK population-based study (2019)
Journal Article
Mallen. (2019). Prognostic value of comorbidity indices and lung diseases in early rheumatoid arthritis: a UK population-based study. Rheumatology, 1296-1305. https://doi.org/10.1093/rheumatology/kez409

We assessed comorbidity burden in people with RA at diagnosis and early disease (3 years) and its association with early mortality and joint destruction. The association between lung disease and mortality in RA is not well studied; we also explored t... Read More about Prognostic value of comorbidity indices and lung diseases in early rheumatoid arthritis: a UK population-based study.

The association between gravidity, parity and the risk of developing rheumatoid arthritis: A systematic review and meta-analysis. (2019)
Journal Article
Chen, W. M., Subesinghe, S., Muller, S., Hider, S. L., Mallen, C. D., & Scott, I. C. (2019). The association between gravidity, parity and the risk of developing rheumatoid arthritis: A systematic review and meta-analysis. Seminars in Arthritis and Rheumatism, 50(2), 252-260. https://doi.org/10.1016/j.semarthrit.2019.09.003

OBJECTIVE: To establish if gravidity and parity associate with the development of rheumatoid arthritis (RA), and to establish if this effect is influenced by the time elapsed since pregnancy/childbirth, the number of pregnancies/childbirths, and sero... Read More about The association between gravidity, parity and the risk of developing rheumatoid arthritis: A systematic review and meta-analysis..

DIabetes Severity SCOre (DISSCO) improves hospitalisation and mortality prediction: model development and validation in 139,626 people with type 2 diabetes (2019)
Presentation / Conference
Zghebi, S., Mamas, M., Ashcroft, D. M., Salisbury, C., Mallen, C., Chew-Graham, C., …Kontopantelis, E. (2019, September). DIabetes Severity SCOre (DISSCO) improves hospitalisation and mortality prediction: model development and validation in 139,626 people with type 2 diabetes. Paper presented at 55th EASD Annual Meeting of the European Association for the Study of Diabetes, Barcelona, Spain

Haematological abnormalities in new onset rheumatoid arthritis and risk of common infections: a population-based study (2019)
Journal Article
Nikiphorou, E., de Lusignan, S., Mallen, C., Khavandi, K., Roberts, J., Buckley, C. D., …Raza, K. (2020). Haematological abnormalities in new onset rheumatoid arthritis and risk of common infections: a population-based study. Rheumatology, 59(5), 997-1005. https://doi.org/10.1093/rheumatology/kez344

Objectives To describe the prevalence of haematological abnormalities in individuals with rheumatoid arthritis (RA) at the point of diagnosis in primary care, and the associations between haematological abnormalities, vaccinations and subsequent risk... Read More about Haematological abnormalities in new onset rheumatoid arthritis and risk of common infections: a population-based study.

Patient Characteristics and General Practitioners' Advice to Stop Statins in Oldest-Old Patients: a Survey Study Across 30 Countries. (2019)
Journal Article
Mallen. (2019). Patient Characteristics and General Practitioners' Advice to Stop Statins in Oldest-Old Patients: a Survey Study Across 30 Countries. Journal of General Internal Medicine, 1751-1757. https://doi.org/10.1007/s11606-018-4795-x

BACKGROUND: Statins are widely used to prevent cardiovascular disease (CVD). With advancing age, the risks of statins might outweigh the potential benefits. It is unclear which factors influence general practitioners' (GPs) advice to stop statins i... Read More about Patient Characteristics and General Practitioners' Advice to Stop Statins in Oldest-Old Patients: a Survey Study Across 30 Countries..

Dietary components and risk of cardiovascular disease and all-cause mortality: A review of evidence from meta-analyses (2019)
Journal Article
Watson, L., Loke, Y., Mallen, C., Mamas, M., Gulati, M., Kwok, C., …Wu, P. (2019). Dietary components and risk of cardiovascular disease and all-cause mortality: A review of evidence from meta-analyses. European Journal of Preventive Cardiology, 26(13), 1415-1429. https://doi.org/10.1177/2047487319843667

Aims The optimal diet for cardiovascular health is controversial. The aim of this review is to summarize the highest level of evidence and rank the risk associated with each individual component of diet within its food group. Methods and results... Read More about Dietary components and risk of cardiovascular disease and all-cause mortality: A review of evidence from meta-analyses.

Early Unplanned Readmissions after Admission to Hospital with Heart Failure (2019)
Journal Article
Helliwell, T., Clarson, L., Mallen, C., & Mamas, M. (2019). Early Unplanned Readmissions after Admission to Hospital with Heart Failure. American Journal of Cardiology, 736-745. https://doi.org/10.1016/j.amjcard.2019.05.053

Hospital readmissions remain a continued challenge in the care of patients with heart failure (HF). This study aims to examine the rates, temporal trends, predictors and causes of 30-day unplanned readmissions after admission with HF. Patients hospit... Read More about Early Unplanned Readmissions after Admission to Hospital with Heart Failure.

Characteristics of patients with giant cell arteritis who experience visual symptoms (2019)
Journal Article
Shen Chean, C., Prior, J., Helliwell, T., Belcher, J., Mackie, S. L., Hider, S., …Mallen, C. (2019). Characteristics of patients with giant cell arteritis who experience visual symptoms. Rheumatology International, 39, 1789-1796. https://doi.org/10.1007/s00296-019-04422-5

Permanent vision loss is one of the most serious complications of giant cell arteritis (GCA) and therefore prompt diagnosis is paramount. However, diagnosis of GCA remains challenging due to its frequently non-specific presentation. Our aim was to id... Read More about Characteristics of patients with giant cell arteritis who experience visual symptoms.

Antibiotic use and the risk of rheumatoid arthritis: a population-based case-control study (2019)
Journal Article
Mallen, Muller, Hider, & Helliwell. (2019). Antibiotic use and the risk of rheumatoid arthritis: a population-based case-control study. BMC Medicine, https://doi.org/10.1186/s12916-019-1394-6

Background Antibiotic-induced disturbances of the human microbiota have been implicated in the development of chronic autoimmune conditions. This study aimed to assess whether antibiotic use is associated with the onset of rheumatoid arthritis (RA).... Read More about Antibiotic use and the risk of rheumatoid arthritis: a population-based case-control study.

Do ß-adrenoreceptor blocking drugs associate with reduced risk of symptomatic osteoarthritis and total joint replacement in the general population? A primary care-based, prospective cohort study using the Clinical Practice Research Datalink. (2019)
Journal Article
Mallen, & Mamas. (2019). Do ß-adrenoreceptor blocking drugs associate with reduced risk of symptomatic osteoarthritis and total joint replacement in the general population? A primary care-based, prospective cohort study using the Clinical Practice Research Datalink. BMJ Open, e032050 - ?. https://doi.org/10.1136/bmjopen-2019-032050

INTRODUCTION: To investigate if ß-adrenoreceptor blocking drug (ß-blocker) prescription reduces the risk of knee or hip osteoarthritis, total joint replacement and analgesic prescription. SETTING: Primary care. METHODS AND ANALYSIS: This is a cohort... Read More about Do ß-adrenoreceptor blocking drugs associate with reduced risk of symptomatic osteoarthritis and total joint replacement in the general population? A primary care-based, prospective cohort study using the Clinical Practice Research Datalink..

Association between inactivated influenza vaccine and primary care consultations for autoimmune rheumatic disease flares: a self-controlled case series study using data from the Clinical Practice Research Datalink. (2019)
Journal Article
Mallen. (2019). Association between inactivated influenza vaccine and primary care consultations for autoimmune rheumatic disease flares: a self-controlled case series study using data from the Clinical Practice Research Datalink. Annals of the Rheumatic Diseases, 1122 - 1126. https://doi.org/10.1136/annrheumdis-2019-215086

Objectives: To examine the association between inactivated influenza vaccine (IIV) administration and primary care consultation for joint pain, rheumatoid arthritis (RA) flare, corticosteroid prescription, vasculitis and unexplained fever in people... Read More about Association between inactivated influenza vaccine and primary care consultations for autoimmune rheumatic disease flares: a self-controlled case series study using data from the Clinical Practice Research Datalink..

Suspected very early inflammatory rheumatic diseases in primary care. (2019)
Journal Article
Mallen, & Hider. (2019). Suspected very early inflammatory rheumatic diseases in primary care. https://doi.org/10.1016/j.berh.2019.06.00

As primary care clinicians are typically the first point of contact for patients with musculoskeletal problems, they are crucial to the early diagnosis and treatment of patients with an incident inflammatory arthritis, like rheumatoid arthritis. Curr... Read More about Suspected very early inflammatory rheumatic diseases in primary care..

The comorbidity burden of type 2 diabetes mellitus: patterns, clusters and predictions from a large English primary care cohort. (2019)
Journal Article
Nowakowska, M., Zghebi, S. S., Ashcroft, D. M., Buchan, I., Chew-Graham, C., Holt, T., …Kontopantelis, E. (2019). The comorbidity burden of type 2 diabetes mellitus: patterns, clusters and predictions from a large English primary care cohort. BMC Medicine, https://doi.org/10.1186/s12916-019-1373-y

BACKGROUND: The presence of additional chronic conditions has a significant impact on the treatment and management of type 2 diabetes (T2DM). Little is known about the patterns of comorbidities in this population. The aims of this study are to quanti... Read More about The comorbidity burden of type 2 diabetes mellitus: patterns, clusters and predictions from a large English primary care cohort..

Subgrouping patients with sciatica in primary care for matched care pathways: development of a subgrouping algorithm (2019)
Journal Article
Konstantinou, K., Dunn, K., Windt, D., Ogollah, R., Jasani, V., & Foster, N. (2019). Subgrouping patients with sciatica in primary care for matched care pathways: development of a subgrouping algorithm. BMC Musculoskeletal Disorders, https://doi.org/10.1186/s12891-019-2686-x

Background Sciatica is a painful condition managed by a stepped care approach for most patients. Currently, there are no decision-making tools to guide matching care pathways for patients with sciatica without evidence of serious pathology, early in... Read More about Subgrouping patients with sciatica in primary care for matched care pathways: development of a subgrouping algorithm.

Gender-specific risk factors for gout: a systematic review of cohort studies (2019)
Journal Article
Evans, P. L., Prior, J. A., Belcher, J., Hay, C. A., Mallen, C. D., & Roddy, E. (2019). Gender-specific risk factors for gout: a systematic review of cohort studies. Advances in Rheumatology, 59, Article 24. https://doi.org/10.1186/s42358-019-0067-7

BACKGROUND: Though gout is more prevalent in men than women, it remains unclear whether gender influences risk factors for incident gout. We aimed to systematically review all cohort studies examining risk factors for the development of gout by gend... Read More about Gender-specific risk factors for gout: a systematic review of cohort studies.

Incidence of infections associated with oral glucocorticoid dose in people diagnosed with polymyalgia rheumatica or giant cell arteritis: a cohort study in England (2019)
Journal Article
Mallen. (2019). Incidence of infections associated with oral glucocorticoid dose in people diagnosed with polymyalgia rheumatica or giant cell arteritis: a cohort study in England. Canadian Medical Association Journal, E680 - E688. https://doi.org/10.1503/cmaj.190178

BACKGROUND: Most patients with polymyalgia rheumatica or giant cell arteritis are treated with glucocorticoid therapy in primary care. We estimated dose-response risks of infection for this population in England. METHODS: We conducted a retrospect... Read More about Incidence of infections associated with oral glucocorticoid dose in people diagnosed with polymyalgia rheumatica or giant cell arteritis: a cohort study in England.

OP0267 INACTIVATED INFLUENZA VACCINATION DOES NOT ASSOCIATE WITH DISEASE FLARES IN AUTOIMMUNE RHEUMATIC DISEASES: A SELF-CONTROLLED CASE SERIES STUDY USING DATA FROM THE CLINICAL PRACTICE RESEARCH DATALINK (2019)
Presentation / Conference
Nakafero, G., Grainge, M., Myles, P., Mallen, C., Zhang, W., Doherty, M., …Abhishek, A. (2019, June). OP0267 INACTIVATED INFLUENZA VACCINATION DOES NOT ASSOCIATE WITH DISEASE FLARES IN AUTOIMMUNE RHEUMATIC DISEASES: A SELF-CONTROLLED CASE SERIES STUDY USING DATA FROM THE CLINICAL PRACTICE RESEARCH DATALINK. Paper presented at Annual European Congress of Rheumatology, EULAR 2019, Madrid, 12–15 June 2019

2018 updated European League Against Rheumatism evidence-based recommendations for the diagnosis of gout. (2019)
Journal Article
Richette, P., Doherty, M., Pascual, E., Barskova, V., Becce, F., Castaneda, J., …Bardin, T. (2019). 2018 updated European League Against Rheumatism evidence-based recommendations for the diagnosis of gout. Annals of the Rheumatic Diseases, 79(1), 31 - 38. https://doi.org/10.1136/annrheumdis-2019-215315

Although gout is the most common inflammatory arthritis, it is still frequently misdiagnosed. New data on imaging and clinical diagnosis have become available since the first EULAR recommendations for the diagnosis of gout in 2006. This prompted a sy... Read More about 2018 updated European League Against Rheumatism evidence-based recommendations for the diagnosis of gout..

Venous thromboembolism in patients with gout and the impact of hospital admission, disease duration and urate-lowering therapy. (2019)
Journal Article
Mallen, C., Roddy, E., Clarson, L., & Muller, S. (2019). Venous thromboembolism in patients with gout and the impact of hospital admission, disease duration and urate-lowering therapy. Canadian Medical Association Journal, 191(22), E597 - E603. https://doi.org/10.1503/cmaj.180717

BACKGROUND: Systemic inflammatory diseases have been associated with increased risk of venous thromboembolism. We aimed to quantify the risk of venous thromboembolism in patients with gout, the most common inflammatory arthritis, and to assess how di... Read More about Venous thromboembolism in patients with gout and the impact of hospital admission, disease duration and urate-lowering therapy..

Matching treatment options for risk sub-groups in musculoskeletal pain: a consensus groups study (2019)
Journal Article
Protheroe, J., Saunders, B., Bartlam, B., Dunn, K., Cooper, V., Campbell, P., …Foster, N. (2019). Matching treatment options for risk sub-groups in musculoskeletal pain: a consensus groups study. BMC Musculoskeletal Disorders, https://doi.org/10.1186/s12891-019-2587-z

Background Musculoskeletal (MSK) pain represents a considerable worldwide healthcare burden. This study aimed to gain consensus from practitioners who work with MSK pain patients, on the most appropriate primary care treatment options for subgroups... Read More about Matching treatment options for risk sub-groups in musculoskeletal pain: a consensus groups study.

Assessing the Severity of Type 2 Diabetes Using Clinical Data Based Measures: a Systematic Review (2019)
Journal Article
Mallen, Chew-Graham, & Mamas. (2019). Assessing the Severity of Type 2 Diabetes Using Clinical Data Based Measures: a Systematic Review. Diabetic Medicine, 688-701. https://doi.org/10.1111/dme.13905

Aims To identify and critically appraise measures that use clinical data to grade the severity of Type 2 diabetes. Methods We searched MEDLINE, Embase and PubMed between inception and June 2018. Studies reporting on clinical data-based diabetes-... Read More about Assessing the Severity of Type 2 Diabetes Using Clinical Data Based Measures: a Systematic Review.

The association of pain and stiffness with fatigue in incident polymyalgia rheumatica: baseline results from the polymyalgia rheumatica cohort study (2019)
Report
Prior, J., Muller, S., Helliwell, T., Hider, S., Barraclough, K., Dasgupta, B., & Mallen, C. (2019). The association of pain and stiffness with fatigue in incident polymyalgia rheumatica: baseline results from the polymyalgia rheumatica cohort study

We aimed to examine the association between pain, stiffness and fatigue in newly diagnosed polymyalgia rheumatica (PMR) patients using baseline data from a prospective cohort study. Fatigue is a known, but often ignored symptom of PMR. Newly diagnose... Read More about The association of pain and stiffness with fatigue in incident polymyalgia rheumatica: baseline results from the polymyalgia rheumatica cohort study.

Symptoms associated with inflammatory arthritis are common in the primary care population: results from the Joint Symptoms Survey (2019)
Journal Article
Hider, S. L., Muller, S., Helliwell, T., Prior, J. A., Scott, I., Lawton, S. A., …Mallen, C. D. (2019). Symptoms associated with inflammatory arthritis are common in the primary care population: results from the Joint Symptoms Survey. Rheumatology, 58(11), 2009-2014. https://doi.org/10.1093/rheumatology/kez184

Objectives: To describe the prevalence of self-reported inflammatory joint symptoms, such as joint pain, stiffness and swelling in UK primary care patients consulting for both musculoskeletal (MSK) and non-musculoskeletal (non-MSK) complaints. Met... Read More about Symptoms associated with inflammatory arthritis are common in the primary care population: results from the Joint Symptoms Survey.

Temporal relationships between systemic lupus erythematosus and comorbidities (2019)
Journal Article
Mallen. (2019). Temporal relationships between systemic lupus erythematosus and comorbidities. Rheumatology, 840-848. https://doi.org/10.1093/rheumatology/key335

Objective To examine the burden of comorbidities prior to and after the diagnosis of SLE and its impact on mortality. Methods We identified 1605 incident cases of SLE and 6284 matched controls from the UK primary care. The risks of comorbidities... Read More about Temporal relationships between systemic lupus erythematosus and comorbidities.

Effectiveness of inactivated influenza vaccine in autoimmune rheumatic diseases treated with disease modifying anti-rheumatic drugs. (2019)
Journal Article
Mallen. (2019). Effectiveness of inactivated influenza vaccine in autoimmune rheumatic diseases treated with disease modifying anti-rheumatic drugs. Annals of the Rheumatic Diseases, https://doi.org/10.1136/annrheumdis-2019-215086

Objectives To examine the association between inactivated influenza vaccine (IIV) administration and primary care consultation for joint pain, rheumatoid arthritis (RA) flare, corticosteroid prescription, vasculitis and unexplained fever in people w... Read More about Effectiveness of inactivated influenza vaccine in autoimmune rheumatic diseases treated with disease modifying anti-rheumatic drugs..

O27 Long-term effect of allopurinol use on serum uric acid levels, mortality and comorbidities in gout patients: an electronic health record cohort study (2019)
Journal Article
Rathod-Mistry, T., Roddy, E., Jordan, K., Mallen, C. D., & Blagojevic-Bucknall, M. (2019). O27 Long-term effect of allopurinol use on serum uric acid levels, mortality and comorbidities in gout patients: an electronic health record cohort study. Rheumatology, 58(Supplement_3), https://doi.org/10.1093/rheumatology/kez105.026

202 Gout attack trajectories in a 3-year cohort study in primary care (2019)
Journal Article
Watson, L., Belcher, J., Mallen, C. D., & Roddy, E. (2019). 202 Gout attack trajectories in a 3-year cohort study in primary care. Rheumatology, 58(Supplement_3), https://doi.org/10.1093/rheumatology/kez107.018

Background: Gout affects 2.5% of adults in the UK but is often poorly managed. Whilst the hallmark of gout is recurrent sudden-onset attacks of acute joint pain and swelling, little is known about the pattern (trajectory) of attacks over time. We aim... Read More about 202 Gout attack trajectories in a 3-year cohort study in primary care.

216 Characteristics of patients with prevalent giant cell arteritis in UK primary care (2019)
Journal Article
Twomlow, E. L., Prior, J. A., Mackie, S. L., Helliwell, T., Hider, S. L., Belcher, J., …Mallen, C. D. (2019). 216 Characteristics of patients with prevalent giant cell arteritis in UK primary care. Rheumatology, 58(Supplement_3), https://doi.org/10.1093/rheumatology/kez107.032

Background: Giant cell arteritis (GCA) is a rare, but serious condition affecting older people. Prompt diagnosis remains challenging due to non-specific presentations. Furthermore, there are marked variations in GP referral and management approaches.... Read More about 216 Characteristics of patients with prevalent giant cell arteritis in UK primary care.

E042 Predicting duration of glucocorticoid therapy in an inception cohort of patients with polymyalgia rheumatica (2019)
Journal Article
Morton, C., Muller, S., Hider, S., Belcher, J., Mallen, C. D., & Helliwell, T. (2019). E042 Predicting duration of glucocorticoid therapy in an inception cohort of patients with polymyalgia rheumatica. Rheumatology, 58(Supplement_3), https://doi.org/10.1093/rheumatology/kez110.041

Background: Extended duration of glucocorticoid (GC) therapy can be considered a poor outcome in people with polymyalgia rheumatica (PMR). Being able to predict the likelihood of extended GC therapy at diagnosis would enable earlier specialist referr... Read More about E042 Predicting duration of glucocorticoid therapy in an inception cohort of patients with polymyalgia rheumatica.

A systematic review of measures using clinical data for assessing the severity of Type 2 diabetes (2019)
Presentation / Conference
Zghebi, S., Panagioti, M., Rutter, M., Ashcroft, D., van Marwijk, H., Salisbury, C., …Kontopantelis, E. (2019, March). A systematic review of measures using clinical data for assessing the severity of Type 2 diabetes. Poster presented at Diabetes UK Professional Conference 2019, ACC Liverpool, Liverpool, UK

Background/Aims: The assessment of disease severity in people with diabetes enables identification of patients in need for intensive and targeted therapies, and could help optimise the allocation of healthcare resources. We aimed to identify and appr... Read More about A systematic review of measures using clinical data for assessing the severity of Type 2 diabetes.

Delays between the onset of symptoms and first rheumatology consultation in patients with rheumatoid arthritis in the UK: an observational study. (2019)
Journal Article
Jayne Stack, R., Nightingale, P., Jinks, C., Shaw, K., Herron-Marx, S., Horne, R., …Raza, K. (2019). Delays between the onset of symptoms and first rheumatology consultation in patients with rheumatoid arthritis in the UK: an observational study. BMJ Open, 9(3), Article e024361. https://doi.org/10.1136/bmjopen-2018-024361

OBJECTIVE: To investigate delays from symptom onset to rheumatology assessment for patients with a new onset of rheumatoid arthritis (RA) or unclassified arthritis. METHODS: Newly presenting adults with either RA or unclassified arthritis were recrui... Read More about Delays between the onset of symptoms and first rheumatology consultation in patients with rheumatoid arthritis in the UK: an observational study..

Multisite pain and self-reported falls in older people: systematic review and meta-analysis. (2019)
Journal Article
Welsh, V., Clarson, L. E., Mallen, C., & McBeth, J. (2019). Multisite pain and self-reported falls in older people: systematic review and meta-analysis. Arthritis Research and Therapy, 67 - ?. https://doi.org/10.1186/s13075-019-1847-5

BACKGROUND: Multisite pain and falls are common in older people, and isolated studies have identified multisite pain as a potential falls risk factor. This study aims to synthesise published literature to further explore the relationship between mu... Read More about Multisite pain and self-reported falls in older people: systematic review and meta-analysis..

Musculoskeletal symptoms and non-prescribed treatments are common in an urban African population of people living with HIV. (2019)
Journal Article
Mallen. (2019). Musculoskeletal symptoms and non-prescribed treatments are common in an urban African population of people living with HIV. Rheumatology International, 285-291. https://doi.org/10.1007/s00296-018-4188-9

There are no data from West Africa reporting musculoskeletal (MSK) disease in people living with HIV (PLWH). Our primary outcome was to measure the prevalence of MSK symptoms in PLWH in urban West Africa. Our secondary outcomes were to describe the d... Read More about Musculoskeletal symptoms and non-prescribed treatments are common in an urban African population of people living with HIV..

How do UK physiotherapists address weight loss among individuals with hip osteoarthritis? A mixed-methods study (2019)
Journal Article
Holden, M. A., Waterfield, J., Whittle, R., Bennell, K., Quicke, J. G., Chesterton, L., & Mallen, C. (2019). How do UK physiotherapists address weight loss among individuals with hip osteoarthritis? A mixed-methods study. Musculoskeletal Care, 17(1), 133-144. https://doi.org/10.1002/msc.1383

BACKGROUND Weight loss is recommended as a core treatment for individuals with hip osteoarthritis who are overweight or obese. Physiotherapists play an important role in managing patients with hip osteoarthritis, but little is known about how they a... Read More about How do UK physiotherapists address weight loss among individuals with hip osteoarthritis? A mixed-methods study.

Examining management and research priorities in patients with polymyalgia rheumatica: a primary care questionnaire survey. (2019)
Journal Article
Mallen, Muller, Hider, & Bucknall. (2019). Examining management and research priorities in patients with polymyalgia rheumatica: a primary care questionnaire survey. Clinical Rheumatology, 38, 1767-1772. https://doi.org/10.1007/s10067-018-04405-0

INTRODUCTION/OBJECTIVES: Polymyalgia rheumatica (PMR) is a common inflammatory disorder that is usually managed with oral glucocorticoids, which although effective can cause significant adverse events. Support group survey data suggests length of g... Read More about Examining management and research priorities in patients with polymyalgia rheumatica: a primary care questionnaire survey..

INCREASED RISK OF SELF-HARM IN PATIENTS WITH OSTEOPOROSIS: A UK POPULATION STUDY (2018)
Presentation / Conference
Prior, J., Whittle, R., Abdul-Sultan, A., Chew-Graham, C., Sumathipala, A., Sheperd, T., …Paskins, Z. (2018, December). INCREASED RISK OF SELF-HARM IN PATIENTS WITH OSTEOPOROSIS: A UK POPULATION STUDY. Poster presented at Osteoporosis Conference 2018, Birmingham, UK

Background: Prevention of self-harm, as a key risk factor for suicide, is an international public health priority. The World Health Organization recommends that clinicians should assess the potential for self-harm in patients in high-risk groups e.g.... Read More about INCREASED RISK OF SELF-HARM IN PATIENTS WITH OSTEOPOROSIS: A UK POPULATION STUDY.

Development and validation of a clinical rule for recognition of early inflammatory arthritis (2018)
Journal Article
Mallen, C., & Hider, S. (2018). Development and validation of a clinical rule for recognition of early inflammatory arthritis. BMJ Open, https://doi.org/10.1136/bmjopen-2018-023552

Objectives National and international guidelines recommend prompt referral of patients presenting with inflammatory arthritis (IA), but general practitioners (GPs) feel uncertain in their proficiency to detect synovitis through joint examination, th... Read More about Development and validation of a clinical rule for recognition of early inflammatory arthritis.

Gout severity, socioeconomic status and work absence: a cross-sectional study in primary care (2018)
Journal Article
Mallen, Roddy, & Muller. (2018). Gout severity, socioeconomic status and work absence: a cross-sectional study in primary care. Arthritis Care and Research, 1822-1828. https://doi.org/10.1002/acr.23562

Objective To examine the association between gout severity and socioeconomic status (SES) and gout severity and work absence. Methods Postal questionnaires were sent to adult patients who were registered with 20 general practices and who had co... Read More about Gout severity, socioeconomic status and work absence: a cross-sectional study in primary care.

Support available for and perceived priorities of people with polymyalgia rheumatica and giant cell arteritis: results of the PMRGCAuk members’ survey 2017 (2018)
Journal Article
Muller, S., O'Brien, A., Helliwell, T., Hay, C. A., Gilbert, K., Mallen, C. D., & Busby, K. (2018). Support available for and perceived priorities of people with polymyalgia rheumatica and giant cell arteritis: results of the PMRGCAuk members’ survey 2017. Clinical Rheumatology, 3411-3418. https://doi.org/10.1007/s10067-018-4220-1

Polymyalgia rheumatica and giant cell arteritis are relatively common, but under research inflammatory rheumatological conditions. This survey aimed to ascertain the matters in which patients feel they need support with these conditions and appraise... Read More about Support available for and perceived priorities of people with polymyalgia rheumatica and giant cell arteritis: results of the PMRGCAuk members’ survey 2017.

Comorbidities in polymyalgia rheumatica: a systematic review (2018)
Journal Article
Partington, R., Helliwell, T., Muller, S., Abdul Sultan, A., & Mallen, C. (2018). Comorbidities in polymyalgia rheumatica: a systematic review. Arthritis Research and Therapy, 258 -?. https://doi.org/10.1186/s13075-018-1757-y

BACKGROUND AND AIM: Comorbidities are known to exist in many rheumatological conditions. Polymyalgia rheumatica (PMR) is a common inflammatory rheumatological condition affecting older people which, prior to effective treatment, causes severe disabil... Read More about Comorbidities in polymyalgia rheumatica: a systematic review.

Risk of chronic kidney disease in patients with gout and the impact of urate lowering therapy: a population-based cohort study (2018)
Journal Article
Mallen, Roddy, Belcher, Clarson, & Muller. (2018). Risk of chronic kidney disease in patients with gout and the impact of urate lowering therapy: a population-based cohort study. Arthritis Research and Therapy, 20, Article 243. https://doi.org/10.1186/s13075-018-1746-1

BACKGROUND: An association between gout and renal disease is well-recognised but few studies have examined whether gout is a risk factor for subsequent chronic kidney disease (CKD). Additionally, the impact of urate-lowering therapy (ULT) on developm... Read More about Risk of chronic kidney disease in patients with gout and the impact of urate lowering therapy: a population-based cohort study.

The extra-articular impacts of rheumatoid arthritis: moving towards holistic care (2018)
Journal Article
Scott, I., Machin, A., Mallen, C., & Hider, S. (2018). The extra-articular impacts of rheumatoid arthritis: moving towards holistic care. BMC Rheumatology, 2, Article 32. https://doi.org/10.1186/s41927-018-0039-2

Although treat-to-target has revolutionised the outcomes of patients with rheumatoid arthritis (RA) there is emerging evidence that attaining the target of remission is insufficient to normalise patients' quality of life, and ameliorate the extra-art... Read More about The extra-articular impacts of rheumatoid arthritis: moving towards holistic care.

Challenges of diagnosing and managing polymyalgia rheumatica: a multi-methods study in UK general practice (2018)
Journal Article
Hider, S., Lawton, S., Muller, S., Helliwell, T., Zwierska, I., Mallen, C., & Richardson, J. (2018). Challenges of diagnosing and managing polymyalgia rheumatica: a multi-methods study in UK general practice. British Journal of General Practice (BJGP), 68(676), E783-E793. https://doi.org/10.3399/bjgp18X699557

BACKGROUND: Polymyalgia rheumatica (PMR) is one of the most common inflammatory arthritic disorders seen in older individuals. Most patients with PMR are diagnosed and managed exclusively in general practice, yet primary care-focused research is lack... Read More about Challenges of diagnosing and managing polymyalgia rheumatica: a multi-methods study in UK general practice.

Development and validation of prediction models to estimate risk of primary total hip and knee replacements using data from the UK: two prospective open cohorts using the UK Clinical Practice Research Datalink (2018)
Journal Article
Yu, D., Jordan, K. P., Snell, K. I. E., Riley, R. D., Bedson, J., Edwards, J. J., …Peat, G. (2018). Development and validation of prediction models to estimate risk of primary total hip and knee replacements using data from the UK: two prospective open cohorts using the UK Clinical Practice Research Datalink. Annals of the Rheumatic Diseases, https://doi.org/10.1136/annrheumdis-2018-213894

Objectives The ability to efficiently and accurately predict future risk of primary total hip and knee replacement (THR/TKR) in earlier stages of osteoarthritis (OA) has potentially important applications. We aimed to develop and validate two models... Read More about Development and validation of prediction models to estimate risk of primary total hip and knee replacements using data from the UK: two prospective open cohorts using the UK Clinical Practice Research Datalink.

Inactivated Influenza Vaccine Prevents Respiratory Infections and Improves All-Cause and Cause-Specific Mortality in Immunosuppressed People with Autoimmune Rheumatic Diseases: Propensity Score Adjusted Cohort Study Using Data from Clinical Practice Research Datalink (2018)
Presentation / Conference
Nakafero, G., Grainge, M., Myles, P., Mallen, C., Zhang, W., Doherty, M., …Abhishek, A. (2018, October). Inactivated Influenza Vaccine Prevents Respiratory Infections and Improves All-Cause and Cause-Specific Mortality in Immunosuppressed People with Autoimmune Rheumatic Diseases: Propensity Score Adjusted Cohort Study Using Data from Clinical Practice Research Datalink. Paper presented at 2018 ACR/ARHP Annual Meeting, Chicago, IL, USA

Risk of Dementia in Patients with Gout and the Impact of Urate-Lowering Therapies: A Large Population-Based Cohort Study (2018)
Presentation / Conference
Crowley, L., Abdul Sultan, A., Roddy, E., Mallen, C., Protheroe, J., & Clarson, L. (2018, October). Risk of Dementia in Patients with Gout and the Impact of Urate-Lowering Therapies: A Large Population-Based Cohort Study. Poster presented at 2018 ACR/ARHP Annual Meeting

Background/Purpose: Evidence is conflicting concerning dementia risk in gout patients, with hyperuricaemia proposed to exert a neuroprotective effect. Serum urate (sUA) targets guiding urate-lowering therapies (ULT) are poorly evidenced-based and th... Read More about Risk of Dementia in Patients with Gout and the Impact of Urate-Lowering Therapies: A Large Population-Based Cohort Study.

Better Outcomes for Older people with Spinal Trouble (BOOST) Trial: a randomised controlled trial of a combined physical and psychological intervention for older adults with neurogenic claudication, a protocol. (2018)
Journal Article
Mallen. (2018). Better Outcomes for Older people with Spinal Trouble (BOOST) Trial: a randomised controlled trial of a combined physical and psychological intervention for older adults with neurogenic claudication, a protocol. BMJ Open, e022205 - ?. https://doi.org/10.1136/bmjopen-2018-022205

INTRODUCTION: Neurogenic claudication due to spinal stenosis is common in older adults. The effectiveness of conservative interventions is not known. The aim of the study is to estimate the clinical and cost-effectiveness of a physiotherapist-deliver... Read More about Better Outcomes for Older people with Spinal Trouble (BOOST) Trial: a randomised controlled trial of a combined physical and psychological intervention for older adults with neurogenic claudication, a protocol..

Development and validation of prediction models to estimate risk of primary total hip and knee replacements using data from the UK: two prospective open cohorts using the UK Clinical Practice Research Datalink (2018)
Journal Article
Yu, D., Jordan, K. P., Snell, K. I. E., Riley, R. D., Bedson, J., James Edwards, J., …Peat, G. (2018). Development and validation of prediction models to estimate risk of primary total hip and knee replacements using data from the UK: two prospective open cohorts using the UK Clinical Practice Research Datalink. Annals of the Rheumatic Diseases, https://doi.org/10.1136/annrheumdis-2018-213894

Abstract Objectives The ability to efficiently and accurately predict future risk of primary total hip and knee replacement (THR/TKR) in earlier stages of osteoarthritis (OA) has potentially important applications. We aimed to develop and validate t... Read More about Development and validation of prediction models to estimate risk of primary total hip and knee replacements using data from the UK: two prospective open cohorts using the UK Clinical Practice Research Datalink.

Incidence, prevalence and treatment burden of Polymyalgia Rheumatica in the UK over two decades: a population-based study (2018)
Journal Article
Partington, R., Muller, S., Helliwell, T., Mallen, C., & Abdul Sultan, A. (2018). Incidence, prevalence and treatment burden of Polymyalgia Rheumatica in the UK over two decades: a population-based study. Annals of the Rheumatic Diseases, 77(12), 1750-1756. https://doi.org/10.1136/annrheumdis-2018-213883

Objective Polymyalgia rheumatica (PMR) is the most common inflammatory rheumatic disease in older people. Contemporary estimates of the incidence and prevalence are lacking, and no previous study has assessed treatment patterns at a population level... Read More about Incidence, prevalence and treatment burden of Polymyalgia Rheumatica in the UK over two decades: a population-based study.

Predictors and temporal trend of flu vaccination in auto-immune rheumatic diseases in the UK: a nationwide prospective cohort study (2018)
Journal Article
Mallen. (2018). Predictors and temporal trend of flu vaccination in auto-immune rheumatic diseases in the UK: a nationwide prospective cohort study. Rheumatology, 1726-1734. https://doi.org/10.1093/rheumatology/key156

Objectives To examine temporal trend in uptake of seasonal influenza vaccine (SIV) in the UK and explore disease and demographic factors associated with vaccination. Methods From the Clinical Practice Research Datalink, 32 751 people with auto-i... Read More about Predictors and temporal trend of flu vaccination in auto-immune rheumatic diseases in the UK: a nationwide prospective cohort study.

The Risk of Gout Among Patients With Sleep Apnea: A Matched Cohort Study (2018)
Journal Article
Blagojevic‐Bucknall, M., Mallen, C., Muller, S., Hayward, R., West, S., Choi, H., & Roddy, E. (2019). The Risk of Gout Among Patients With Sleep Apnea: A Matched Cohort Study. Arthritis & Rheumatology, 71(1), 154-160. https://doi.org/10.1002/art.40662

Objective Obstructive sleep apnea (OSA) is associated with a range of serious comorbidities. This study investigates whether people with OSA are more likely to develop gout than those without OSA in both short and long term. Methods A matched ret... Read More about The Risk of Gout Among Patients With Sleep Apnea: A Matched Cohort Study.

A mixed methods exploration of physiotherapist's approaches to analgesic use among patients with hip osteoarthritis. (2018)
Journal Article
Holden, M., Whittle, R., Waterfield, J., Chesterton, L., Cottrell, E., Quicke, J., & Mallen, C. (2019). A mixed methods exploration of physiotherapist's approaches to analgesic use among patients with hip osteoarthritis. Physiotherapy, 105(3), 328 - 337. https://doi.org/10.1016/j.physio.2018.08.003

OBJECTIVE: To explore how physiotherapists currently address analgesic use among patients with hip osteoarthritis, and their beliefs about the acceptability of prescribing for these patients. METHODS: A cross-sectional questionnaire was mailed to 312... Read More about A mixed methods exploration of physiotherapist's approaches to analgesic use among patients with hip osteoarthritis..

The availability of health information to patients with newly diagnosed polymyalgia rheumatica: results from the PMR Cohort study (2018)
Journal Article
Helliwell, T., Hider, S., Mallen, C., & Muller, S. (2018). The availability of health information to patients with newly diagnosed polymyalgia rheumatica: results from the PMR Cohort study. Primary Health Care Research and Development, https://doi.org/10.1017/S1463423618000543

Aim To assess the provision of information to, and seeking of, information by patients newly diagnosed with polymyalgia rheumatica (PMR) in primary care. Background Polymyalgia rheumatica (PMR) is an inflammatory rheumatological condition of ol... Read More about The availability of health information to patients with newly diagnosed polymyalgia rheumatica: results from the PMR Cohort study.

Comorbidity clusters in people with gout: an observational cohort study with linked medical record review (2018)
Journal Article
Mallen, Roddy, Bucknall, & Hider. (2018). Comorbidity clusters in people with gout: an observational cohort study with linked medical record review. Rheumatology, 1358-1363. https://doi.org/10.1002/acr.23562

Objective. To investigate how comorbid conditions cluster in patients with gout in a UK primary care population. Methods. A cross-sectional study was performed using baseline data from a primary-care-based prospective observational cohort of peop... Read More about Comorbidity clusters in people with gout: an observational cohort study with linked medical record review.

Health-related quality of life in gout in primary care: baseline findings from a cohort study (2018)
Journal Article
Roddy, Mallen, Bucknall, Muller, & Hider. (2018). Health-related quality of life in gout in primary care: baseline findings from a cohort study. Seminars in Arthritis and Rheumatism, 61-69. https://doi.org/10.1016/j.semarthrit.2017.12.005

Objectives: To examine gout-related, comorbid, and sociodemographic characteristics associated with generic and disease-specific health-related quality of life (HRQOL) in gout. Methods: Adults with gout from 20 general practices were mailed a que... Read More about Health-related quality of life in gout in primary care: baseline findings from a cohort study.

A randomised controlled trial of the clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injections: the hip injection trial (HIT) protocol (2018)
Journal Article
Paskins, Z., Hughes, G., Myers, H., Hughes, E., Hennings, S., Cherrington, A., …Roddy, E. (2018). A randomised controlled trial of the clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injections: the hip injection trial (HIT) protocol. BMC Musculoskeletal Disorders, 19, Article 218. https://doi.org/10.1186/s12891-018-2153-0

BACKGROUND: Evidence on the effectiveness of intra-articular corticosteroid injection for hip osteoarthritis is limited and conflicting. The primary objective of the Hip Injection Trial (HIT) is to compare pain intensity over 6 months, in people with... Read More about A randomised controlled trial of the clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injections: the hip injection trial (HIT) protocol.

Obesity, hypertension and diuretic use as risk factors for incident gout: a systematic review and meta-analysis of cohort studies (2018)
Journal Article
Evans, P. L., Prior, J. A., Belcher, J., Mallen, C., Hay, C. A., & Roddy, E. (2018). Obesity, hypertension and diuretic use as risk factors for incident gout: a systematic review and meta-analysis of cohort studies. Arthritis Research and Therapy, 20, Article 136. https://doi.org/10.1186/s13075-018-1612-1

BACKGROUND: Gout treatment remains suboptimal. Identifying populations at risk of developing gout may provide opportunities for prevention. Our aim was to assess the risk of incident gout associated with obesity, hypertension and diuretic use. METHOD... Read More about Obesity, hypertension and diuretic use as risk factors for incident gout: a systematic review and meta-analysis of cohort studies.

Platelet-rich plasma (PRP) therapy for knee arthritis: a feasibility study in primary care. (2018)
Journal Article
Mallen. (2018). Platelet-rich plasma (PRP) therapy for knee arthritis: a feasibility study in primary care. Pilot and Feasibility Studies, 93 - ?. https://doi.org/10.1186/s40814-018-0288-2

Background: Platelet-rich plasma (PRP) is a concentrate of autologous blood growth factors which has been shown to provide some symptomatic relief in early osteoarthritis (OA) of the knee. The objective of this study was to test the feasibility and e... Read More about Platelet-rich plasma (PRP) therapy for knee arthritis: a feasibility study in primary care..

Risk of fragility fracture among patients with late-onset psoriasis: a United Kingdom population-based study (2018)
Journal Article
Mallen, Roddy, Bucknall, Muller, Hider, Helliwell, & Paskins. (2018). Risk of fragility fracture among patients with late-onset psoriasis: a United Kingdom population-based study. Osteoporosis International, 1659-1664. https://doi.org/10.1007/s00198-018-4491-z

This study aimed to examine fracture risk in patients with late-onset psoriasis. A cohort study was conducted using primary care records from the Clinical Practice Research Datalink. Psoriasis patients had a 10% increased risk of fracture compared to... Read More about Risk of fragility fracture among patients with late-onset psoriasis: a United Kingdom population-based study.

Optimal primary care management of clinical osteoarthritis and joint pain in older people: a mixed-methods programme of systematic reviews, observational and qualitative studies, and randomised controlled trials (2018)
Report
Hay, E., Dziedzic, K., Foster, N., Peat, G., van der Windt, D., Bartlam, B., …Croft, P. (2018). Optimal primary care management of clinical osteoarthritis and joint pain in older people: a mixed-methods programme of systematic reviews, observational and qualitative studies, and randomised controlled trials. NIHR. PGfAR as project number RP-PG-0407-10386. Secretary of State for Health and Social Care

Background Osteoarthritis (OA) is the most common long-term condition managed in UK general practice. However, care is suboptimal despite evidence that primary care and community-based interventions can reduce OA pain and disability. Objectives Th... Read More about Optimal primary care management of clinical osteoarthritis and joint pain in older people: a mixed-methods programme of systematic reviews, observational and qualitative studies, and randomised controlled trials.

Using electronic health records to quantify and stratify the severity of type 2 diabetes in primary care in England: rationale and cohort study design (2018)
Journal Article
Mamas, Chew-Graham, & Mallen. (2018). Using electronic health records to quantify and stratify the severity of type 2 diabetes in primary care in England: rationale and cohort study design. BMJ Open, https://doi.org/10.1136/bmjopen-2017-020926

Introduction: The increasing prevalence of type 2 diabetes (T2DM) presents a significant burden on affected individuals and health-care systems internationally. There is, however, no agreed validated measure to infer diabetes severity from electronic... Read More about Using electronic health records to quantify and stratify the severity of type 2 diabetes in primary care in England: rationale and cohort study design.

Searching for a prodrome for rheumatoid arthritis in the primary care record: A case-control study in the clinical practice research datalink (2018)
Journal Article
Muller, S., Hider, S., Machin, A., Stack, R., Hayward, R. A., Raza, K., & Mallen, C. (2019). Searching for a prodrome for rheumatoid arthritis in the primary care record: A case-control study in the clinical practice research datalink. Seminars in Arthritis and Rheumatism, 48(5), 815-820. https://doi.org/10.1016/j.semarthrit.2018.06.008

Background Rheumatoid arthritis (RA) has articular and non-articular manifestations. Early, intensive treatment has substantial benefit for both. This requires patients be identified as soon as symptoms develop. Objectives To determine whether s... Read More about Searching for a prodrome for rheumatoid arthritis in the primary care record: A case-control study in the clinical practice research datalink.

PREDICTORS AND TEMPORAL TREND OF SEASONAL INFLUENZA VACCINATION IN AUTO-IMMUNE RHEUMATIC DISEASES IN THE UK: A NATIONWIDE PROSPECTIVE COHORT STUDY (2018)
Presentation / Conference
Nakafero, G., Grainge, M., Myles, P., Mallen, C., Zhang, W., Doherty, M., …Abhishek, A. (2018, June). PREDICTORS AND TEMPORAL TREND OF SEASONAL INFLUENZA VACCINATION IN AUTO-IMMUNE RHEUMATIC DISEASES IN THE UK: A NATIONWIDE PROSPECTIVE COHORT STUDY. Poster presented at Annual European Congress of Rheumatology

Background: Autoimmune rheumatic diseases (AIRDs) are associated with an increased risk of influenza and its complications which may be compounded by the use of potent disease modifying anti-rheumatic drugs (DMARDs). In the United Kingdom, seasonal i... Read More about PREDICTORS AND TEMPORAL TREND OF SEASONAL INFLUENZA VACCINATION IN AUTO-IMMUNE RHEUMATIC DISEASES IN THE UK: A NATIONWIDE PROSPECTIVE COHORT STUDY.

AB0212 Diagnostic delay for rheumatoid arthritis: a systematic review (2018)
Presentation / Conference
Hay, C., Prior, J., Scott, I., Raza, K., Hider, S., & Mallen, C. (2018, June). AB0212 Diagnostic delay for rheumatoid arthritis: a systematic review. Paper presented at Annual European Congress of Rheumatology, EULAR 2018, Amsterdam, Netherlands

Background Rheumatoid arthritis (RA) is a common inflammatory condition, affecting 1% of the population and causing pain, stiffness and swelling, leading to significant disability and loss of function[.1 Delays in the diagnosis and treatment of RA ca... Read More about AB0212 Diagnostic delay for rheumatoid arthritis: a systematic review.

How common is depression in patients with polymyalgia rheumatica? (2018)
Journal Article
Mallen, Bucknall, Belcher, & Hider. (2018). How common is depression in patients with polymyalgia rheumatica?. Clinical Rheumatology, 1633 - 1638. https://doi.org/10.1007/s10067-017-3691-9

Depression is common in inflammatory disorders such as rheumatoid arthritis and systemic lupus erythematosus and negatively impacts on outcomes. Given the long-term nature of polymyalgia rheumatica (PMR) and its glucocorticoid treatment, these patien... Read More about How common is depression in patients with polymyalgia rheumatica?.

Rheumatoid arthritis and excess mortality: down but not out. A primary care cohort study using data from Clinical Practice Research Datalink. (2018)
Journal Article
Mallen. (2018). Rheumatoid arthritis and excess mortality: down but not out. A primary care cohort study using data from Clinical Practice Research Datalink. Rheumatology, 977 - 981. https://doi.org/10.1093/rheumatology/key013

Objectives: To examine temporal trends in all-cause and cause-specific mortality in RA. Methods: Data from the Clinical Practice Research Datalink were used. Incident RA cases and four age-, sex- and general practice-matched controls were identified... Read More about Rheumatoid arthritis and excess mortality: down but not out. A primary care cohort study using data from Clinical Practice Research Datalink..

Risk of fragility fracture among patients with gout and the effect of urate-lowering therapy (2018)
Journal Article
Paskins, Mallen, Bucknall, Hider, Muller, Helliwell, & Roddy. (2018). Risk of fragility fracture among patients with gout and the effect of urate-lowering therapy. Canadian Medical Association Journal, E581 -E587. https://doi.org/10.1503/cmaj.170806

BACKGROUND: Previous studies that quantified the risk of fracture among patients with gout and assessed the potential effect of urate-lowering therapy have provided conflicting results. Our study aims to provide better estimates of risk by minimizing... Read More about Risk of fragility fracture among patients with gout and the effect of urate-lowering therapy.

Relationship of anxiety with joint pain and its management: A population survey (2018)
Journal Article
Barnett, L. A., Pritchard, M. G., Edwards, J. J., Afolabi, E. K., Jordan, K. P., Healey, E. L., …Dziedzic, K. S. (2018). Relationship of anxiety with joint pain and its management: A population survey. Musculoskeletal Care, 16(3), 353-362. https://doi.org/10.1002/msc.1243

Objectives The aims of the present study was to examine the associations between the severity of pain and anxiety in a community population reporting joint pain, and to investigate the management of joint pain in the presence of comorbid anxiety.... Read More about Relationship of anxiety with joint pain and its management: A population survey.

A mixed methods exploration of how UK physical therapists address weight loss among individuals with hip osteoarthritis (2018)
Conference Proceeding
Holden, M., Waterfield, J., Whittle, R., Bennell, K., Chesterton, L., Quicke, J., & Mallen, C. (2018). A mixed methods exploration of how UK physical therapists address weight loss among individuals with hip osteoarthritis. . https://doi.org/10.1016/j.joca.2018.02.645

Hip osteoarthritis (OA) is a common painful and disabling condition. Clinical guidelines recommend weight loss as a core treatment for individuals with hip OA who are overweight or obese. However, in the UK, support for weight loss is often lacking.... Read More about A mixed methods exploration of how UK physical therapists address weight loss among individuals with hip osteoarthritis.

Primary care challenges in diagnosing and referring patients with suspected rheumatoid arthritis: a national cross-sectional gp survey (2018)
Journal Article
Hider, & Mallen. (2018). Primary care challenges in diagnosing and referring patients with suspected rheumatoid arthritis: a national cross-sectional gp survey. Rheumatology Advances in Practice, https://doi.org/10.1093/rap/rky012

Objectives National guidelines advocate referring patients with persistent synovitis to rheumatology within 3 working days of presentation to primary care. This infrequently occurs. We aimed to identify modifiable barriers to early referral of suspe... Read More about Primary care challenges in diagnosing and referring patients with suspected rheumatoid arthritis: a national cross-sectional gp survey.

UK-South Asian patients' experiences of and satisfaction toward receiving information about biologics in rheumatoid arthritis (2018)
Journal Article
Mallen. (2018). UK-South Asian patients' experiences of and satisfaction toward receiving information about biologics in rheumatoid arthritis. Patient Preference and Adherence, 489 -497. https://doi.org/10.2147/ppa.s153741

Background: Rheumatoid arthritis (RA) causes painful joint inflammation and is incurable, but treatments control RA. Drug regimens are complex, and patients often do not take their medication as expected. Poor medication adherence can lead to poorly... Read More about UK-South Asian patients' experiences of and satisfaction toward receiving information about biologics in rheumatoid arthritis.

Cost-Utility Analysis of Routine Anxiety and Depression Screening in Patients Consulting for Osteoarthritis: Results From a Clinical, Randomized Controlled Trial (2018)
Journal Article
Kigozi, J., Jowett, S., Nicholl, B. I., Lewis, M., Bartlam, B., Green, D., …Mallen, C. D. (2018). Cost-Utility Analysis of Routine Anxiety and Depression Screening in Patients Consulting for Osteoarthritis: Results From a Clinical, Randomized Controlled Trial. Arthritis Care and Research, 70(12), 1787-1794. https://doi.org/10.1002/acr.23568

OBJECTIVE: To investigate the cost-effectiveness (cost-utility) of introducing general practitioner screening for anxiety and depression in patients consulting with osteoarthritis (OA). METHODS: A cluster-randomised trial-based economic evaluation to... Read More about Cost-Utility Analysis of Routine Anxiety and Depression Screening in Patients Consulting for Osteoarthritis: Results From a Clinical, Randomized Controlled Trial.

315 Searching for a prodrome for rheumatoid arthritis in the primary care record: a clinical practice research datalink study (2018)
Journal Article
Muller, S., Hider, S., Machin, A., Stack, R., Hayward, R., Raza, K., & Mallen, C. (2018). 315 Searching for a prodrome for rheumatoid arthritis in the primary care record: a clinical practice research datalink study. Rheumatology, 57(suppl_3), https://doi.org/10.1093/rheumatology/key075.539

Background: Outcomes in rheumatoid arthritis (RA) are improved by early treatment with disease modifying anti-rheumatic drugs (DMARD). This requires prompt recognition of symptoms when patients present to their general practitioner (GP) in order to i... Read More about 315 Searching for a prodrome for rheumatoid arthritis in the primary care record: a clinical practice research datalink study.

The real evidence for polymyalgia rheumatica as a paraneoplastic syndrome. (2018)
Journal Article
Muller, S., Hider, S., Helliwell, T., Partington, R., & Mallen, C. (2018). The real evidence for polymyalgia rheumatica as a paraneoplastic syndrome. Reumatismo, 23 - 34. https://doi.org/10.4081/reumatismo.2018.1031

The aim of this study was to systematically consider the evidence for polymyalgia rheumatica (PMR) as a paraneoplastic disease. A systematic review of Medline and Embase was conducted from their inception to February 2017. Risk of bias was assessed u... Read More about The real evidence for polymyalgia rheumatica as a paraneoplastic syndrome..

Severity domains for quantifying the severity of Type 2 diabetes using primary care data and linked hospitalisation records from England (2018)
Presentation / Conference
ZGHEBI, S., Rutter, M., Ashcroft, D., Van Marwijk, H., Mallen, C., Chew-Graham, C. A., …Kontopantelis, E. (2018, March). Severity domains for quantifying the severity of Type 2 diabetes using primary care data and linked hospitalisation records from England. Poster presented at Diabetes UK Professional Conference 2018, London ExCeL, London, UK

Aims: Despite the increasing prevalence of Type 2 diabetes, which presents a significant burden on healthcare resources, there is no agreed validated UK measure to infer Type 2 diabetes severity from electronic health records (EHRs). This study aimed... Read More about Severity domains for quantifying the severity of Type 2 diabetes using primary care data and linked hospitalisation records from England.

How Do Physical Therapists in the United Kingdom Manage Patients With Hip Osteoarthritis? Results of a Cross-Sectional Survey (2018)
Journal Article
Mallen, C., & Holden, M. (2018). How Do Physical Therapists in the United Kingdom Manage Patients With Hip Osteoarthritis? Results of a Cross-Sectional Survey. Physical Therapy, 461-470. https://doi.org/10.1093/ptj/pzy013

Background: Hip osteoarthritis (OA) is common, painful and disabling. Physical therapists have an important role in managing patients with hip OA, however little is known about their current management approach and whether it aligns with clinical gui... Read More about How Do Physical Therapists in the United Kingdom Manage Patients With Hip Osteoarthritis? Results of a Cross-Sectional Survey.

Burden of cardiovascular disease across 29 countries and GPs' decision to treat hypertension in oldest-old. (2018)
Journal Article
Mallen. (2018). Burden of cardiovascular disease across 29 countries and GPs' decision to treat hypertension in oldest-old. Scandinavian Journal of Primary Health Care, 89 - 98. https://doi.org/10.1080/02813432.2018.1426142

OBJECTIVES: We previously found large variations in general practitioner (GP) hypertension treatment probability in oldest-old (>80 years) between countries. We wanted to explore whether differences in country-specific cardiovascular disease (CVD) bu... Read More about Burden of cardiovascular disease across 29 countries and GPs' decision to treat hypertension in oldest-old..

Challenges of diagnosis and management of giant cell arteritis in general practice: a multimethods study (2018)
Journal Article
Helliwell, T., Muller, S., Hider, S. L., Prior, J. A., Richardson, J. C., & Mallen, C. D. (2018). Challenges of diagnosis and management of giant cell arteritis in general practice: a multimethods study. BMJ Open, 8(2), Article e019320. https://doi.org/10.1136/bmjopen-2017-019320

BACKGROUND: In the UK, general practitioners (GPs) are usually the first medical contact for patients with suspected giant cell arteritis (GCA). While rare, it is critical not to miss, as delayed treatment can lead to significant complications includ... Read More about Challenges of diagnosis and management of giant cell arteritis in general practice: a multimethods study.

Risk of fracture among patients with polymyalgia rheumatica and giant cell arteritis: a population-based study (2018)
Journal Article
Mallen, Roddy, Bucknall, Hider, Muller, Paskins, & Helliwell. (2018). Risk of fracture among patients with polymyalgia rheumatica and giant cell arteritis: a population-based study. BMC Medicine, https://doi.org/10.1186/s12916-017-0987-1

Background Glucocorticoids are associated with increased fracture risk and are the mainstay of treatment in polymyalgia rheumatica (PMR) and giant cell arteritis (GCA). However, fracture risk in these conditions has not been previously quantified. T... Read More about Risk of fracture among patients with polymyalgia rheumatica and giant cell arteritis: a population-based study.

The INCLUDE study: INtegrating and improving Care for patients with infLammatory rheUmatological DisordErs in the community; identifying multimorbidity: Protocol for a pilot randomized controlled trial. (2018)
Journal Article
Healey, E., Herron, D., Hider, S., Bucknall, M., Cooke, K., Finney, A., …Chew-Graham, C. (2018). The INCLUDE study: INtegrating and improving Care for patients with infLammatory rheUmatological DisordErs in the community; identifying multimorbidity: Protocol for a pilot randomized controlled trial. Journal of Comorbidity, 8(1), https://doi.org/10.1177/2235042X18792373

Background: Patients with inflammatory rheumatic conditions such as rheumatoid arthritis, polymyalgia rheumatica and ankylosing spondylitis are at increased risk of common comorbidities such as cardiovascular disease, osteoporosis and anxiety and dep... Read More about The INCLUDE study: INtegrating and improving Care for patients with infLammatory rheUmatological DisordErs in the community; identifying multimorbidity: Protocol for a pilot randomized controlled trial..

Possible giant cell arteritis symptoms are common in newly diagnosed patients with Polymyalgia Rheumatica: results from an incident primary care PMR cohort (2017)
Journal Article
Masson, W., Muller, S., Whittle, R., Prior, J., Helliwell, T., Mallen, C., & Hider, S. (2017). Possible giant cell arteritis symptoms are common in newly diagnosed patients with Polymyalgia Rheumatica: results from an incident primary care PMR cohort. BMC Rheumatology, 1, Article 7. https://doi.org/10.1186/s41927-017-0007-2

Background: To examine the frequency of possible giant cell arteritis (GCA) symptoms (including headache, temporal/scalp tenderness, jaw claudication and visual symptoms) in newly diagnosed polymyalgia rheumatica (PMR) patients in UK primary care. Me... Read More about Possible giant cell arteritis symptoms are common in newly diagnosed patients with Polymyalgia Rheumatica: results from an incident primary care PMR cohort.

Applying quantitative bias analysis to estimate the plausible effects of selection bias in a cluster randomised controlled trial: secondary analysis of the Primary care Osteoarthritis Screening Trial (POST). (2017)
Journal Article
Barnett, L., Mallen, C., Lewis, A., & Peat, G. (2017). Applying quantitative bias analysis to estimate the plausible effects of selection bias in a cluster randomised controlled trial: secondary analysis of the Primary care Osteoarthritis Screening Trial (POST). Trials, 18, 585 - ?. https://doi.org/10.1186/s13063-017-2329-1

BACKGROUND: Selection bias is a concern when designing cluster randomised controlled trials (c-RCT). Despite addressing potential issues at the design stage, bias cannot always be eradicated from a trial design. The application of bias analysis prese... Read More about Applying quantitative bias analysis to estimate the plausible effects of selection bias in a cluster randomised controlled trial: secondary analysis of the Primary care Osteoarthritis Screening Trial (POST)..

Factors Influencing Allopurinol Initiation in Primary Care. (2017)
Journal Article
Roddy, Mallen, Clarson, Belcher, & Hider. (2017). Factors Influencing Allopurinol Initiation in Primary Care. Annals of Family Medicine, 15(6), 557 - 560. https://doi.org/10.1370/afm.213

Despite guidance on appropriate initiation, urate-lowering therapy is prescribed for only a minority of patients with gout. Electronic health records for 8,142 patients with gout were used to investigate the effect of age, sex, comorbidities, number... Read More about Factors Influencing Allopurinol Initiation in Primary Care..

The OMERACT Core Domain Set for Outcome Measures for Clinical Trials in Polymyalgia Rheumatica (2017)
Journal Article
Mackie, S., Neill, L., Harrison, E., Black, R., Kermani, T., Simon, L., …Twohig, H. (2017). The OMERACT Core Domain Set for Outcome Measures for Clinical Trials in Polymyalgia Rheumatica. Journal of Rheumatology, 1515-1521. https://doi.org/10.3899/jrheum.161109

OBJECTIVE To inform development of a core domain set for outcome measures for clinical trials in polymyalgia rheumatica (PMR), we conducted patient consultations, a systematic review, a Delphi study, and 2 qualitative studies. METHODS Domains i... Read More about The OMERACT Core Domain Set for Outcome Measures for Clinical Trials in Polymyalgia Rheumatica.

Feasibility randomised multicentre, double-blind, double-dummy controlled trial of anakinra, an interleukin-1 receptor antagonist versus intramuscular methylprednisolone for acute gout attacks in patients with chronic kidney disease (ASGARD): protocol st… (2017)
Journal Article
Mallen, & Roddy. (2017). Feasibility randomised multicentre, double-blind, double-dummy controlled trial of anakinra, an interleukin-1 receptor antagonist versus intramuscular methylprednisolone for acute gout attacks in patients with chronic kidney disease (ASGARD): protocol st…. BMJ Open, https://doi.org/10.1136/bmjopen-2017-017121

Introduction Acute gout occurs in people with chronic kidney disease, who are commonly older people with comorbidities such as hypertension, heart disease and diabetes. Potentially harmful treatments are administered to these vulnerable patients due... Read More about Feasibility randomised multicentre, double-blind, double-dummy controlled trial of anakinra, an interleukin-1 receptor antagonist versus intramuscular methylprednisolone for acute gout attacks in patients with chronic kidney disease (ASGARD): protocol st….

What is the impact of giant cell arteritis on patients’ lives? A UK qualitative study (2017)
Journal Article
Liddle, J., Bartlam, R., Mallen, C. D., Mackie, S. L., Prior, J. A., Helliwell, T., & Richardson, J. C. (2017). What is the impact of giant cell arteritis on patients’ lives? A UK qualitative study. BMJ Open, 7(8), e017073 -?. https://doi.org/10.1136/bmjopen-2017-017073

OBJECTIVES: Clinical management of giant cell arteritis (GCA) involves balancing the risks and burdens arising from the disease with those arising from treatment, but there is little research on the nature of those burdens. We aimed to explore the im... Read More about What is the impact of giant cell arteritis on patients’ lives? A UK qualitative study.

The British Society for Rheumatology Guideline for the Management of Gout (2017)
Journal Article
Mallen, C., & Roddy, E. (2017). The British Society for Rheumatology Guideline for the Management of Gout. Rheumatology, 56(7), E1-E20. https://doi.org/10.1093/rheumatology/kex156

OBJECTIVES: We previously found large variations in general practitioner (GP) hypertension treatment probability in oldest-old (>80 years) between countries. We wanted to explore whether differences in country-specific cardiovascular disease (CVD) bu... Read More about The British Society for Rheumatology Guideline for the Management of Gout.

Assessment of the face validity. feasibility and utility of a patient-completed questionnaire for polymyalgia rheumatica: a postal survey using the QQ-10 questionnaire (2017)
Journal Article
Twohig, H., Jones, G., Mackie, S., Mallen, C., & Mitchell, C. (2017). Assessment of the face validity. feasibility and utility of a patient-completed questionnaire for polymyalgia rheumatica: a postal survey using the QQ-10 questionnaire. Pilot and Feasibility Studies, https://doi.org/10.1186/s40814-017-0150-y

Background The development of a patient-reported outcome measure (PROM) for polymyalgia rheumatica (PMR), a condition that causes pain, stiffness and disability, is necessary as there is no current validated disease-specific measure. Initial literat... Read More about Assessment of the face validity. feasibility and utility of a patient-completed questionnaire for polymyalgia rheumatica: a postal survey using the QQ-10 questionnaire.

Current physiotherapy practice and assessment in Polymyalgia Rheumatica: a UK cross-sectional survey. (2017)
Presentation / Conference
O'Brien, A. V., Liddle, J., Muller, S., Lawton, S., Whittle, R., Mason, E., & Mallen, C. D. (2017, July). Current physiotherapy practice and assessment in Polymyalgia Rheumatica: a UK cross-sectional survey. Paper presented at World Congress of Physiotherapy 2017 - Cape Town, South Africa, Cape Town, South Africa

Background: Polymyalgia Rheumatica (PMR) is the commonest inflammatory musculoskeletal disorder affecting older adults. Whilst physiotherapy interventions are recommended by international guidelines, the supporting evidence base is limited and of poo... Read More about Current physiotherapy practice and assessment in Polymyalgia Rheumatica: a UK cross-sectional survey..

Diagnostic delay for giant cell arteritis – a systematic review and meta-analysis (2017)
Journal Article
Prior, J. A., Ranjbar, H., Belcher, J., Mackie, S. L., Helliwell, T., Liddle, J., & Mallen, C. D. (2017). Diagnostic delay for giant cell arteritis – a systematic review and meta-analysis. BMC Medicine, 15, Article 120. https://doi.org/10.1186/s12916-017-0871-z

BACKGROUND: Giant cell arteritis (GCA), if untreated, can lead to blindness and stroke. The study's objectives were to (1) determine a new evidence-based benchmark of the extent of diagnostic delay for GCA and (2) examine the role of GCA-specific cha... Read More about Diagnostic delay for giant cell arteritis – a systematic review and meta-analysis.

Association between characteristics of pain and stiffness and the functional status of patients with incident polymyalgia rheumatica from primary care (2017)
Journal Article
Cawley, A., Prior, J., Muller, S., Helliwell, T., Hider, S., Dasgupta, B., …Mallen, C. (2017). Association between characteristics of pain and stiffness and the functional status of patients with incident polymyalgia rheumatica from primary care. Clinical Rheumatology, 37(6), 1639-1644. https://doi.org/10.1007/s10067-017-3730-6

This paper aims to examine the relationship between different characteristics of pain and stiffness and the functional status of patients with newly diagnosed polymyalgia rheumatica (PMR). Baseline analysis of an inception cohort study was conducted.... Read More about Association between characteristics of pain and stiffness and the functional status of patients with incident polymyalgia rheumatica from primary care.

Integrating case finding and initial management for osteoarthritis, anxiety and depression into routine primary care nurse-led long-term condition reviews: results from the enhance pilot trial (2017)
Journal Article
Jinks, C., Nicholls, E., Liddle, J., Healey, E., Evans, A., Chew-Graham, C., …Team, E. (2017). Integrating case finding and initial management for osteoarthritis, anxiety and depression into routine primary care nurse-led long-term condition reviews: results from the enhance pilot trial. Annals of the Rheumatic Diseases, 76(S2), 1433-1433. https://doi.org/10.1136/annrheumdis-2017-eular.2473

Background Co-morbid osteoarthritis (OA), anxiety and depression are undermanaged in primary care yet have significant impact on pain, disability and outcomes of other long-term conditions (LTCs). Objectives To test the feasibility and acceptabili... Read More about Integrating case finding and initial management for osteoarthritis, anxiety and depression into routine primary care nurse-led long-term condition reviews: results from the enhance pilot trial.

The pathway to consultation for rheumatoid arthritis: exploring anticipated actions between the onset of symptoms and face-to-face encounter with a healthcare professional. (2017)
Journal Article
Mallen. (2017). The pathway to consultation for rheumatoid arthritis: exploring anticipated actions between the onset of symptoms and face-to-face encounter with a healthcare professional. BMC Musculoskeletal Disorders, 258 -?. https://doi.org/10.1186/s12891-017-1619-9

BACKGROUND: When people first experience symptoms of rheumatoid arthritis (RA) they often delay seeking medical attention resulting in delayed diagnosis and treatment. This research assesses behaviours people might engage in prior to, or instead of,... Read More about The pathway to consultation for rheumatoid arthritis: exploring anticipated actions between the onset of symptoms and face-to-face encounter with a healthcare professional..

SAT0672 Risk of fragility fracture among patients with psoriasis: a population based matched cohort study from the united kingdom (2017)
Presentation / Conference
Paskins, Z., Whittle, R., Sultan, A. A., Muller, S., Helliwell, T., Blagojevic-Bucknall, M., …Mallen, C. (2017, June). SAT0672 Risk of fragility fracture among patients with psoriasis: a population based matched cohort study from the united kingdom. Poster presented at Annual European Congress of Rheumatology, 14–17 June, 2017

SAT0708 Symptoms indicative of inflammatory arthritis are common in the primary care population: findings from the symptoms in persons at risk of rheumatoid arthritis survey (2017)
Presentation / Conference
Hider, S., Muller, S., Prior, J., Helliwell, T., Schaardenburg, D. V., Mil, A. V. D. H., …Mallen, C. (2017, June). SAT0708 Symptoms indicative of inflammatory arthritis are common in the primary care population: findings from the symptoms in persons at risk of rheumatoid arthritis survey. Paper presented at Annual European Congress of Rheumatology, 14–17 June, 2017

Gout and subsequent erectile dysfunction: a population-based cohort study from England (2017)
Journal Article
Abdul Sultan, A., Mallen, C., Hayward, R., Muller, S., Whittle, R., Hotston, M., & Roddy, E. (2017). Gout and subsequent erectile dysfunction: a population-based cohort study from England. Arthritis Research and Therapy, 19, Article 123. https://doi.org/10.1186/s13075-017-1322-0

BACKGROUND: An association has been suggested between gout and erectile dysfunction (ED), however studies quantifying the risk of ED amongst gout patients are lacking. We aimed to precisely determine the population-level absolute and relative rate of... Read More about Gout and subsequent erectile dysfunction: a population-based cohort study from England.

Improving management of gout in primary care: a new UK management guideline. (2017)
Journal Article
Mallen, & Roddy. (2017). Improving management of gout in primary care: a new UK management guideline. British Journal of General Practice (BJGP), 284 - 285. https://doi.org/10.3399/bjgp17X691313

Gout is the most prevalent inflammatory arthritis, affecting 2.5% of adults in the UK.1 Despite its prevalence and the availability of potentially ‘curative’ urate-lowering therapies (ULT) such as allopurinol, gout remains undertreated in both primar... Read More about Improving management of gout in primary care: a new UK management guideline..

Des caractéristiques de la goutte associées à la dépression mais pas à l’anxiété en soins primaires : conclusions initiales d’une étude de cohorte prospective (2017)
Journal Article
Mallen, Prior, Roddy, & Muller. (2017). Des caractéristiques de la goutte associées à la dépression mais pas à l’anxiété en soins primaires : conclusions initiales d’une étude de cohorte prospective. Revue du Rhumatisme, 84(5), 423-429. https://doi.org/10.1016/j.rhum.2017.05.004

Objectifs Déterminer la prévalence de l’anxiété et de la dépression dans le contexte de la goutte, examiner les liens entre certaines caractéristiques de la goutte et ces comorbidités et identifier le rôle de l’allopurinol dans ces relations. Mét... Read More about Des caractéristiques de la goutte associées à la dépression mais pas à l’anxiété en soins primaires : conclusions initiales d’une étude de cohorte prospective.

Exploring discrepancies between long-term condition review consultation audio-recordings and computer template data (the ENHANCE pilot trial) (2017)
Presentation / Conference
Liddle, J., Lawton, S. A., Chew-Graham, C. A., Healey, E. L., Mallen, C. D., & Jinks, C. (2017, May). Exploring discrepancies between long-term condition review consultation audio-recordings and computer template data (the ENHANCE pilot trial). Presented at 4th International Clinical Trials Methodology Conference (ICTMC) and the 38th Annual Meeting of the Society for Clinical Trials, Liverpool, UK

The clinical and cost-effectiveness of stratified care for patients with sciatica: the SCOPiC randomised controlled trial protocol (ISRCTN75449581). (2017)
Journal Article
Foster, N. E., Konstantinou, K., Lewis, M., Ogollah, R., Dunn, K. M., van der Windt, D., …Hay, E. M. (2017). The clinical and cost-effectiveness of stratified care for patients with sciatica: the SCOPiC randomised controlled trial protocol (ISRCTN75449581). BMC Musculoskeletal Disorders, 18, Article 172. https://doi.org/10.1186/s12891-017-1513-5

BACKGROUND: Sciatica has a substantial impact on patients, and is associated with high healthcare and societal costs. Although there is variation in the clinical management of sciatica, the current model of care usually involves an initial period of... Read More about The clinical and cost-effectiveness of stratified care for patients with sciatica: the SCOPiC randomised controlled trial protocol (ISRCTN75449581)..

SO LOOKING AT THIS, YOU LOOK LIKE YOU'VE GOT SOME ISSUES GOING ON WITH YOUR JOINTS: EXPLORING CASE-FINDING IN LONG-TERM CONDITION REVIEW CONSULTATIONS-THE ENHANCE PILOT TRIAL (2017)
Presentation / Conference
Liddle, J., Chew-Graham, C. A., Mallen, C. D., Healey, E. L., Jinks, C., & Dikomitis, L. (2017, April). SO LOOKING AT THIS, YOU LOOK LIKE YOU'VE GOT SOME ISSUES GOING ON WITH YOUR JOINTS: EXPLORING CASE-FINDING IN LONG-TERM CONDITION REVIEW CONSULTATIONS-THE ENHANCE PILOT TRIAL. Poster presented at Rheumatology 2017, Birmingham ICC, England, UK

183. GOUT AS A CONSEQUENCE OF SLEEP APNOEA: A MATCHED COHORT STUDY (2017)
Journal Article
Blagojevic-Bucknall, M., Mallen, C., Muller, S., Hayward, R., West, S., Choi, H., & Roddy, E. (2017). 183. GOUT AS A CONSEQUENCE OF SLEEP APNOEA: A MATCHED COHORT STUDY. Rheumatology, 56(suppl_2), https://doi.org/10.1093/rheumatology/kex062.184

Background: Gout and obstructive sleep apnoea are both common problems in primary care and associated with considerable co-morbidity. Serum uric acid levels are frequently elevated in sleep apnoea patients and one previous cohort study found that peo... Read More about 183. GOUT AS A CONSEQUENCE OF SLEEP APNOEA: A MATCHED COHORT STUDY.

Variation in GP decisions on antihypertensive treatment in oldest-old and frail individuals across 29 countries (2017)
Journal Article
Mallen. (2017). Variation in GP decisions on antihypertensive treatment in oldest-old and frail individuals across 29 countries. BMC Geriatrics, 93 -?. https://doi.org/10.1186/s12877-017-0486-4

BACKGROUND: In oldest-old patients (>80), few trials showed efficacy of treating hypertension and they included mostly the healthiest elderly. The resulting lack of knowledge has led to inconsistent guidelines, mainly based on systolic blood pressure... Read More about Variation in GP decisions on antihypertensive treatment in oldest-old and frail individuals across 29 countries.

The effects of implementing a point-of-care electronic template to prompt routine anxiety and depression screening in patients consulting for osteoarthritis (the Primary Care Osteoarthritis Trial): A cluster randomised trial in primary care (2017)
Journal Article
Mallen, C. D., Nicholl, B. I., Lewis, M., Bartlam, B., Green, D., Jowett, S., …Peat, G. (2017). The effects of implementing a point-of-care electronic template to prompt routine anxiety and depression screening in patients consulting for osteoarthritis (the Primary Care Osteoarthritis Trial): A cluster randomised trial in primary care. PLoS Medicine, e1002273 -?. https://doi.org/10.1371/journal.pmed.1002273

BACKGROUND: This study aimed to evaluate whether prompting general practitioners (GPs) to routinely assess and manage anxiety and depression in patients consulting with osteoarthritis (OA) improves pain outcomes. METHODS AND FINDINGS: We conducted a... Read More about The effects of implementing a point-of-care electronic template to prompt routine anxiety and depression screening in patients consulting for osteoarthritis (the Primary Care Osteoarthritis Trial): A cluster randomised trial in primary care.

Incident acute pseudogout and prior bisphosphonate use: matched case-control study in the UK-Clinical Practice Research Datalink (2017)
Journal Article
Roddy, E., Muller, S., Paskins, Z., Hider, S., Blagojevic-Bucknall, M., & Mallen, C. (2017). Incident acute pseudogout and prior bisphosphonate use: matched case-control study in the UK-Clinical Practice Research Datalink. Medicine, https://doi.org/10.1097/MD.0000000000006177

Oral bisphosphonates are the most commonly used drugs to treat postmenopausal osteoporosis. Acute pseudogout is anecdotally reported to occur following bisphosphonate initiation but empirical data are lacking. We investigated whether treatment with o... Read More about Incident acute pseudogout and prior bisphosphonate use: matched case-control study in the UK-Clinical Practice Research Datalink.

Prognosis research ideally should measure time-varying predictors at their intended moment of use (2017)
Journal Article
Whittle, R., Royle, K., Jordan, K. P., Riley, R. D., Mallen, C. D., & Peat, G. (2017). Prognosis research ideally should measure time-varying predictors at their intended moment of use. Diagnostic and Prognostic Research, 1, Article 1. https://doi.org/10.1186/s41512-016-0006-6

Background Prognosis research studies (e.g. those deriving prognostic models or examining potential predictors of outcome) often collect information on time-varying predictors after their intended moment of use, sometimes using a measurement method... Read More about Prognosis research ideally should measure time-varying predictors at their intended moment of use.

Patients' views on the causes of their polymyalgia rheumatica: a content analysis of data from the PMR Cohort Study (2017)
Journal Article
Tshimologo, M., Saunders, B., Muller, S., Mallen, C. D., & Hider, S. L. (2017). Patients' views on the causes of their polymyalgia rheumatica: a content analysis of data from the PMR Cohort Study. BMJ Open, e014301 -?. https://doi.org/10.1136/bmjopen-2016-014301

OBJECTIVE: To explore primary care polymyalgia rheumatica (PMR) patient beliefs about the causes of their PMR. DESIGN: Qualitative content analysis was conducted on patients' written responses to the question of what they thought had caused their PMR... Read More about Patients' views on the causes of their polymyalgia rheumatica: a content analysis of data from the PMR Cohort Study.

Generic prognostic factors for musculoskeletal pain in primary care: a systematic review. (2017)
Journal Article
Artus, M., Campbell, P., Mallen, C., Dunn, K., & van der Windt, D. (2017). Generic prognostic factors for musculoskeletal pain in primary care: a systematic review. BMJ Open, e012901 - ?. https://doi.org/10.1136/bmjopen-2016-012901

OBJECTIVES: To summarise the evidence for generic prognostic factors across a range of musculoskeletal (MSK) conditions. SETTING: primary care. METHODS AND OUTCOMES: Comprehensive systematic literature review. MEDLINE, CINAHL, PsychINFO and EMBASE we... Read More about Generic prognostic factors for musculoskeletal pain in primary care: a systematic review..

Rheumatoid arthritis is getting less frequent: results of a nationwide population based cohort study (2017)
Journal Article
Mallen, C. (2017). Rheumatoid arthritis is getting less frequent: results of a nationwide population based cohort study. Rheumatology, 736-744. https://doi.org/10.1093/rheumatology/kew468

Abstract Objectives: The objectives of this study were to examine changes in incidence and prevalence of RA between 1990 and 2014, and to explore if there is any geographic variation in incidence and prevalence of RA in the UK Methods: Design Prospec... Read More about Rheumatoid arthritis is getting less frequent: results of a nationwide population based cohort study.

Predicting Mortality from Change-over-time in the Charlson Comorbidity Index: A retrospective cohort study in a data-intensive UK health system (2016)
Journal Article
Mamas, M., & Mallen, C. (2016). Predicting Mortality from Change-over-time in the Charlson Comorbidity Index: A retrospective cohort study in a data-intensive UK health system. Medicine, e4973. https://doi.org/10.1097/md.0000000000004973

Multimorbidity is common among older people and presents a major challenge to health systems worldwide. Metrics of multimorbidity are, however, crude: focusing on measuring comorbid conditions at single time-points rather than reflecting the longitud... Read More about Predicting Mortality from Change-over-time in the Charlson Comorbidity Index: A retrospective cohort study in a data-intensive UK health system.

Keele Aches and Pains Study protocol: validity, acceptability, and feasibility of the Keele STarT MSK tool for subgrouping musculoskeletal patients in primary care. (2016)
Journal Article
Campbell, P., Hill, J., Protheroe, J., Afolabi, E., Lewis, M., Beardmore, R., …Dunn, K. (2016). Keele Aches and Pains Study protocol: validity, acceptability, and feasibility of the Keele STarT MSK tool for subgrouping musculoskeletal patients in primary care. Journal of Pain Research, 2016(9), 807 -818. https://doi.org/10.2147/JPR.S116614

Musculoskeletal conditions represent a considerable burden worldwide, and are predominantly managed in primary care. Evidence suggests that many musculoskeletal conditions share similar prognostic factors. Systematically assessing patient’s prognosis... Read More about Keele Aches and Pains Study protocol: validity, acceptability, and feasibility of the Keele STarT MSK tool for subgrouping musculoskeletal patients in primary care..

Illness perceptions of gout patients and the use of allopurinol in primary care: baseline findings from a prospective cohort study (2016)
Journal Article
Walsh, C. P., Prior, J., Chandratre, P., Belcher, J., Mallen, C., & Roddy, E. (2016). Illness perceptions of gout patients and the use of allopurinol in primary care: baseline findings from a prospective cohort study. BMC Musculoskeletal Disorders, 17, Article 394. https://doi.org/10.1186/s12891-016-1252-z

Background Patients’ perceptions of their illness are dynamic and can directly influence aspects of management. Our aim was to examine the illness perceptions of gout patients in UK primary care and associations with allopurinol use. Methods A h... Read More about Illness perceptions of gout patients and the use of allopurinol in primary care: baseline findings from a prospective cohort study.

Characterising those with incident polymyalgia rheumatica in primary care: results from the PMR Cohort Study. (2016)
Journal Article
Muller, S., Hider, S. L., Helliwell, T., Lawton, S., Barraclough, K., Dasgupta, B., …Mallen, C. D. (2016). Characterising those with incident polymyalgia rheumatica in primary care: results from the PMR Cohort Study. Arthritis Research and Therapy, https://doi.org/10.1186/s13075-016-1097-8

BACKGROUND: The aim was to characterise the sociodemographic, general health and polymyalgia rheumatica (PMR)-specific features of participants in a large inception cohort of patients with PMR diagnosed in UK primary care. METHODS: Patients (n?=?739)... Read More about Characterising those with incident polymyalgia rheumatica in primary care: results from the PMR Cohort Study..

Prevalence of cardiovascular-related comorbidity in ankylosing spondylitis, psoriatic arthritis and psoriasis in primary care: a matched retrospective cohort study. (2016)
Report
Ahmed, N., Prior, J., Chen, Y., Hayward, R., Mallen, C., & Hider, S. (2016). Prevalence of cardiovascular-related comorbidity in ankylosing spondylitis, psoriatic arthritis and psoriasis in primary care: a matched retrospective cohort study

The aim of this study is to compare the prevalence of cardiovascular (CVD)-related comorbidities in patients with ankylosing spondylitis (AS), psoriatic arthritis (PsA) or psoriasis (Ps) in UK primary care against matched cohorts. Matched retrospecti... Read More about Prevalence of cardiovascular-related comorbidity in ankylosing spondylitis, psoriatic arthritis and psoriasis in primary care: a matched retrospective cohort study..

2016 updated EULAR evidence-based recommendations for the management of gout. (2016)
Journal Article
Richette, P., Doherty, M., Pascual, E., Barskova, V., Becce, F., Castañeda-Sanabria, J., …Bardin, T. (2016). 2016 updated EULAR evidence-based recommendations for the management of gout. Annals of the Rheumatic Diseases, 76(1), 29 - 42. https://doi.org/10.1136/annrheumdis-2016-209707

BACKGROUND: New drugs and new evidence concerning the use of established treatments have become available since the publication of the first European League Against Rheumatism (EULAR) recommendations for the management of gout, in 2006. This situatio... Read More about 2016 updated EULAR evidence-based recommendations for the management of gout..

Symptom recognition and perceived urgency of help-seeking for rheumatoid arthritis and other diseases in the general public: A mixed method approach. (2016)
Journal Article
Simons, G., Belcher, J., Morton, C., Kumar, K., Falahee, M., Mallen, C. D., …Raza, K. (2017). Symptom recognition and perceived urgency of help-seeking for rheumatoid arthritis and other diseases in the general public: A mixed method approach. Arthritis Care and Research, 69(5), 633-641. https://doi.org/10.1002/acr.22979

OBJECTIVE: Clinical outcomes in rheumatoid arthritis (RA) are improved if the disease is treated early. However, treatment is often significantly delayed as a result of delayed help-seeking by patients who fail to recognise its symptoms or the need f... Read More about Symptom recognition and perceived urgency of help-seeking for rheumatoid arthritis and other diseases in the general public: A mixed method approach..

DIAGNOSTIC DELAY FOR GIANT CELL ARTERITIS (GCA). A SYSTEMATIC REVIEW AND META-ANALYSIS (2016)
Journal Article
Prior, J. A., Ranjbar, H., Belcher, J., Mackie, S., & Mallen, C. D. (2016). DIAGNOSTIC DELAY FOR GIANT CELL ARTERITIS (GCA). A SYSTEMATIC REVIEW AND META-ANALYSIS. Annals of the Rheumatic Diseases, 75(S2), 1092-1092. https://doi.org/10.1136/annrheumdis-2016-eular.2639

Background The diagnosis of giant cell arteritis (GCA) remains difficult, with patients often presenting with non-specific and atypical symptoms. Such ambiguity can lead to delays in the diagnosis of GCA, which in-turn may result in the patient exper... Read More about DIAGNOSTIC DELAY FOR GIANT CELL ARTERITIS (GCA). A SYSTEMATIC REVIEW AND META-ANALYSIS.

PATIENT PRIORITIES FOR PMR RESEARCH: A PRIMARY CARE SURVEY (2016)
Journal Article
Hider, S., Morton, C., Muller, S., Belcher, J., Gilbert, K., Bucknall, M., & Mallen, C. (2016). PATIENT PRIORITIES FOR PMR RESEARCH: A PRIMARY CARE SURVEY. Annals of the Rheumatic Diseases, 75, 169-169. https://doi.org/10.1136/annrheumdis-2016-eular.5915

Background Polymyalgia rheumatica (PMR) is a common inflammatory disorder of older (>50 years) adults, frequently managed in primary care. PMR remains under-researched despite the significant impact this condition has on patient's quality of life. Ex... Read More about PATIENT PRIORITIES FOR PMR RESEARCH: A PRIMARY CARE SURVEY.

SYMPTOM RECOGNITION AND ITS EFFECT ON HELP-SEEKING IN RHEUMATOID ARTHRITIS, BOWEL CANCER AND ANGINA: A MIXED METHODS APPROACH (2016)
Presentation / Conference
Simons, G., Belcher, J., Morton, C., Kumar, K., Falahee, M., Mallen, C. D., …Raza, K. (2016, June). SYMPTOM RECOGNITION AND ITS EFFECT ON HELP-SEEKING IN RHEUMATOID ARTHRITIS, BOWEL CANCER AND ANGINA: A MIXED METHODS APPROACH. Poster presented at EULAR 2016, London, UK

Background Rheumatoid arthritis (RA) requires treatment in its earliest stages in order to reduce the likelihood of permanent joint damage and disability. However, this therapeutic window is often missed as a result of delayed help-seeking by patient... Read More about SYMPTOM RECOGNITION AND ITS EFFECT ON HELP-SEEKING IN RHEUMATOID ARTHRITIS, BOWEL CANCER AND ANGINA: A MIXED METHODS APPROACH.

A joint effort over a period of time: factors affecting use of urate-lowering therapy for long-term treatment of gout (2016)
Journal Article
Richardson, J. C., Liddle, J., Mallen, C. D., Roddy, E., Hider, S., Prinjha, S., & Ziebland, S. (2016). A joint effort over a period of time: factors affecting use of urate-lowering therapy for long-term treatment of gout. BMC Musculoskeletal Disorders, https://doi.org/10.1186/s12891-016-1117-5

Background Although international guidelines encourage urate lowering therapy (ULT) for people who have more than two attacks of gout, only 30 % of patients are prescribed it and only 40 % of those adhere to the treatment. The aim was to explore rea... Read More about A joint effort over a period of time: factors affecting use of urate-lowering therapy for long-term treatment of gout.

O21 The Impact of Symptom Recognition on Help-Seeking: A Comparison Between Rheumatoid Arthritis, Bowel Cancer and Angina (2016)
Presentation / Conference
Simons, G., Belcher, J., Kumar, K., Falahee, M., Mallen, C. D., Stack, R., & Raza, K. (2016, April). O21 The Impact of Symptom Recognition on Help-Seeking: A Comparison Between Rheumatoid Arthritis, Bowel Cancer and Angina. Presented at Rheumatology 2016, SECC Glasgow, UK

Background: RA requires early treatment to reduce the risk of joint damage and disability. However, due to delays at various points in the patient’s journey following symptom onset, this therapeutic window is often missed. Patients themselves are an... Read More about O21 The Impact of Symptom Recognition on Help-Seeking: A Comparison Between Rheumatoid Arthritis, Bowel Cancer and Angina.

Gout characteristics associate with depression, but not anxiety, in primary care: Baseline findings from a prospective cohort study (2016)
Journal Article
Prior, J. A., Mallen, C., Chandratre, P., Muller, S., Richardson, J., & Roddy, E. (2016). Gout characteristics associate with depression, but not anxiety, in primary care: Baseline findings from a prospective cohort study. Joint Bone Spine, 83(5), 553-558. https://doi.org/10.1016/j.jbspin.2015.10.008

OBJECTIVES: To determine the prevalence of anxiety and depression in gout, examine associations between gout characteristics and these comorbidities and determine the role of allopurinol in any such relationships. METHOD: As part of a prospective coh... Read More about Gout characteristics associate with depression, but not anxiety, in primary care: Baseline findings from a prospective cohort study.

Qualitative exploration of illness perceptions of Rheumatoid Arthritis in the General Public (2016)
Journal Article
Mallen. (2016). Qualitative exploration of illness perceptions of Rheumatoid Arthritis in the General Public. Musculoskeletal Care, 13-22. https://doi.org/10.1002/msc.1135

Treating patients with rheumatoid arthritis (RA) within three months of symptom onset leads to significantly improved outcomes. However, many people delay seeking medical attention. In order to understand the reasons for this delay, it is important t... Read More about Qualitative exploration of illness perceptions of Rheumatoid Arthritis in the General Public.

Development of a Provisional Core Domain Set for Polymyalgia Rheumatica: Report from the OMERACT 12 Polymyalgia Rheumatica Working Group. (2016)
Journal Article
Mallen, & Helliwell. (2016). Development of a Provisional Core Domain Set for Polymyalgia Rheumatica: Report from the OMERACT 12 Polymyalgia Rheumatica Working Group. Journal of Rheumatology, 182 - 186. https://doi.org/10.3899/jrheum.141179

OBJECTIVE: The Outcome Measures in Rheumatology (OMERACT) polymyalgia rheumatica (PMR) working group aims to develop a core set of outcome measures to be used in clinical trials for PMR. Previous reports from OMERACT 11 included a qualitative study o... Read More about Development of a Provisional Core Domain Set for Polymyalgia Rheumatica: Report from the OMERACT 12 Polymyalgia Rheumatica Working Group..

The development and initial validation of a questionnaire to measure help-seeking behaviour in patients with new onset rheumatoid arthritis (2015)
Journal Article
Stack, R. J., Mallen, C., Deighton, C., Kiely, P., Shaw, K. L., Booth, A., …Raza, K. (2015). The development and initial validation of a questionnaire to measure help-seeking behaviour in patients with new onset rheumatoid arthritis. Health Expectations, 18(6), 2340-2355. https://doi.org/10.1111/hex.12203

BACKGROUND: Early treatment for rheumatoid arthritis (RA) is vital. However, people often delay in seeking help at symptom onset. An assessment of the reasons behind patient delay is necessary to develop interventions to promote rapid consultation. O... Read More about The development and initial validation of a questionnaire to measure help-seeking behaviour in patients with new onset rheumatoid arthritis.

"Why me? I don't fit the mould...I am a freak of nature": a qualitative study of women's experience of gout (2015)
Journal Article
Richardson, J. C., Liddle, J., Mallen, C. D., Roddy, E., Prinjha, S., Ziebland, S., & Hider, S. (2015). "Why me? I don't fit the mould...I am a freak of nature": a qualitative study of women's experience of gout. BMC Women's Health, Article 122. https://doi.org/10.1186/s12905-015-0277-z

Background Gout is more common in men, and is often perceived by both patients and health practitioners to be a disorder of men, but its prevalence in women is increasing. Little is known about women’s experience of gout and the impact it has on the... Read More about "Why me? I don't fit the mould...I am a freak of nature": a qualitative study of women's experience of gout.

Improving the care of people with long-term conditions in primary care: (2015)
Journal Article
Healey, E. L., Jinks, C., Tan, V. A., Chew-Graham, C. A., Lawton, S. A., Nicholls, E., …Mallen, C. D. (2015). Improving the care of people with long-term conditions in primary care:. Journal of Comorbidity, 2015(5), 135-149. https://doi.org/10.15256/joc.2015.5.60

Background Long-term conditions (LTCs) are important determinants of quality of life and healthcare expenditure worldwide. Whilst multimorbidity is increasingly the norm in primary care, clinical guidelines and the delivery of care remain focused on... Read More about Improving the care of people with long-term conditions in primary care:.

Impact of gout on the risk of atrial fibrillation. (2015)
Journal Article
Mallen. (2015). Impact of gout on the risk of atrial fibrillation. Rheumatology, 721 - 728. https://doi.org/10.1093/rheumatology/kev418

OBJECTIVES: To examine the risk of atrial fibrillation (AF) at the time of first diagnosis of gout compared with matched controls and to follow incident gout patients and their matched controls after diagnosis to compare their subsequent risk of AF.... Read More about Impact of gout on the risk of atrial fibrillation..

Effect of allopurinol on all-cause mortality in adults with incident gout: propensity score-matched landmark analysis. (2015)
Journal Article
Mallen. (2015). Effect of allopurinol on all-cause mortality in adults with incident gout: propensity score-matched landmark analysis. https://doi.org/10.1093/rheumatology/kev246

OBJECTIVE: To examine the association between allopurinol use and all-cause mortality for patients with incident gout. METHODS: We compared all-cause mortality in incident gout patients who received allopurinol for at least 6 months within the exposu... Read More about Effect of allopurinol on all-cause mortality in adults with incident gout: propensity score-matched landmark analysis..

Physician's prescribing preference as an instrumental variable: exploring assumptions using survey data (2015)
Journal Article
Mallen, C. (2015). Physician's prescribing preference as an instrumental variable: exploring assumptions using survey data. Epidemiology, 276-283. https://doi.org/10.1097/EDE.0000000000000425

Background: Physician's prescribing preference is increasingly used as an instrumental variable in studies of therapeutic effects. However, differences in prescribing patterns among physicians may reflect differences in preferences or in case-mix. Fu... Read More about Physician's prescribing preference as an instrumental variable: exploring assumptions using survey data.

The triple whammy anxiety depression and osteoarthritis in long-term conditions (2015)
Journal Article
Jinks, Chew-Graham, Mallen, & Healey. (2015). The triple whammy anxiety depression and osteoarthritis in long-term conditions. BMC Family Practice, Article 163. https://doi.org/10.1186/s12875-015-0346-2

Improving the management of people with long-term conditions is a key priority of the UK National Health Service. Whilst the coexistence of two or more long-term conditions in one person is increasingly the norm in primary care, guidelines and delive... Read More about The triple whammy anxiety depression and osteoarthritis in long-term conditions.

Discussing prognosis with patients with osteoarthritis: a cross-sectional survey in general practice. (2015)
Journal Article
Mallen. (2015). Discussing prognosis with patients with osteoarthritis: a cross-sectional survey in general practice. Clinical Rheumatology, https://doi.org/10.1186/1471-2296-10-50

Osteoarthritis is a leading cause of chronic pain and disability and one of the most common conditions diagnosed and managed in primary care. Despite the evidence that patients would value discussions about the course of osteoarthritis to help them m... Read More about Discussing prognosis with patients with osteoarthritis: a cross-sectional survey in general practice..

Discussing prognosis with patients with osteoarthritis: a cross-sectional survey in general practice (2015)
Journal Article
Clarson, L. E., Nicholl, B. I., Bishop, A., Daniel, R., & Mallen, C. D. (2016). Discussing prognosis with patients with osteoarthritis: a cross-sectional survey in general practice. Clinical Rheumatology, 35(4), 1011-1017. https://doi.org/10.1007/s10067-015-3094-8

Osteoarthritis is a leading cause of chronic pain and disability and one of the most common conditions diagnosed and managed in primary care. Despite the evidence that patients would value discussions about the course of osteoarthritis to help them m... Read More about Discussing prognosis with patients with osteoarthritis: a cross-sectional survey in general practice.

Mapping patients experiences from initial symptoms to gout diagnosis: a qualitative exploration (2015)
Journal Article
Roddy, Mallen, & Hider. (2015). Mapping patients experiences from initial symptoms to gout diagnosis: a qualitative exploration. BMJ Open, https://doi.org/10.1136/bmjopen-2015-008323

Objective To explore patients’ experiences from initial symptoms to receiving a diagnosis of gout. Design Data from in-depth semistructured interviews were used to construct themes to describe key features of patients’ experiences of gout diagnosi... Read More about Mapping patients experiences from initial symptoms to gout diagnosis: a qualitative exploration.

2015 Recommendations for the management of polymyalgia rheumatica: a European League Against Rheumatism/American College of Rheumatology collaborative initiative. (2015)
Journal Article
Dejaco, C., Singh, Y. P., Perel, P., Hutchings, A., Camellino, D., Mackie, S., …Dasgupta, B. (2015). 2015 Recommendations for the management of polymyalgia rheumatica: a European League Against Rheumatism/American College of Rheumatology collaborative initiative. Annals of the Rheumatic Diseases, 74(10), 1799 - 1807. https://doi.org/10.1136/annrheumdis-2015-207492

Therapy for polymyalgia rheumatica (PMR) varies widely in clinical practice as international recommendations for PMR treatment are not currently available. In this paper, we report the 2015 European League Against Rheumatism (EULAR)/American College... Read More about 2015 Recommendations for the management of polymyalgia rheumatica: a European League Against Rheumatism/American College of Rheumatology collaborative initiative..

2015 recommendations for the management of polymyalgia rheumatica: a European League Against Rheumatism/American College of Rheumatology collaborative initiative. (2015)
Journal Article
Dejaco, C., Singh, Y. P., Perel, P., Hutchings, A., Camellino, D., Mackie, S., …Dasgupta, B. (2015). 2015 recommendations for the management of polymyalgia rheumatica: a European League Against Rheumatism/American College of Rheumatology collaborative initiative. Arthritis & Rheumatology, 2569 - 2580. https://doi.org/10.1002/art.39333

Therapy for polymyalgia rheumatica (PMR) varies widely in clinical practice as international recommendations for PMR treatment are not currently available. In this paper, we report the 2015 European League Against Rheumatism (EULAR)/American College... Read More about 2015 recommendations for the management of polymyalgia rheumatica: a European League Against Rheumatism/American College of Rheumatology collaborative initiative..

An Economic Evaluation of TENS in Addition to Usual Primary Care Management for the Treatment of Tennis Elbow: Results from the TATE Randomized Controlled Trial (2015)
Journal Article
Lewis, M., Chesterton, L., Sim, J., Hay, E., Mallen, C., & Van Der Windt, D. (2015). An Economic Evaluation of TENS in Addition to Usual Primary Care Management for the Treatment of Tennis Elbow: Results from the TATE Randomized Controlled Trial. PloS one, https://doi.org/10.1371/journal.pone.0135460

Background The TATE trial was a multicentre pragmatic randomized controlled trial of supplementing primary care management (PCM)–consisting of a GP consultation followed by information and advice on exercises–with transcutaneous electrical nerve sti... Read More about An Economic Evaluation of TENS in Addition to Usual Primary Care Management for the Treatment of Tennis Elbow: Results from the TATE Randomized Controlled Trial.

You want to get on with the rest of your life: a qualitative study of health-related quality of life in gout (2015)
Journal Article
Chandratre, P., Mallen, C. D., Roddy, E., Liddle, J., & Richardson, J. (2015). You want to get on with the rest of your life: a qualitative study of health-related quality of life in gout. Clinical Rheumatology, 35, 1197-1205. https://doi.org/10.1007/s10067-015-3039-2

The objective of the study is to examine the impact of gout and its treatments on health-related quality of life (HRQOL) using focus group interviews. From the baseline phase of a cohort study of HRQOL in gout, 17 participants (15 males, mean age 71... Read More about You want to get on with the rest of your life: a qualitative study of health-related quality of life in gout.

Foot problems in people with gout in primary care: baseline findings from a prospective cohort study (2015)
Journal Article
Bucknall, Roddy, Mallen, Hider, & Muller. (2015). Foot problems in people with gout in primary care: baseline findings from a prospective cohort study. Journal of Foot and Ankle Research, 31 - ?. https://doi.org/10.1186/s13047-015-0090-9

BACKGROUND: Foot problems are common in people with gout yet the prevalence of current foot problems in people with gout and the burden they present to healthcare systems is not known. This cross-sectional study aimed to determine the prevalence and... Read More about Foot problems in people with gout in primary care: baseline findings from a prospective cohort study.

Effect of allopurinol on all-cause mortality in adults with incident gout: propensity score-matched landmark analysis (2015)
Journal Article
Kuo, C., Grainge, M. J., Mallen, C., Zhang, W., & Doherty, M. (2015). Effect of allopurinol on all-cause mortality in adults with incident gout: propensity score-matched landmark analysis. Rheumatology, 54(12), 2145-2150. https://doi.org/10.1093/rheumatology/kev246

Objective. To examine the association between allopurinol use and all-cause mortality for patients with incident gout. Methods. We compared all-cause mortality in incident gout patients who received allopurinol for at least 6 months within the exposu... Read More about Effect of allopurinol on all-cause mortality in adults with incident gout: propensity score-matched landmark analysis.

The ‘ENHANCE’ long-term condition review: Identifying co-morbid joint pain, depression and anxiety in patients with long-term conditions (2015)
Presentation / Conference
Tan, V., Jinks, C., Porcheret, M., Chew-Graham, C. A., Cooper, V., Healey, E. L., …Finney, A. G. (2015, July). The ‘ENHANCE’ long-term condition review: Identifying co-morbid joint pain, depression and anxiety in patients with long-term conditions. Presented at Health Service Research Network conference (HSRN) Conference (Nottingham), Nottingham Conference Centre, Burton Street, Nottingham, UK

AB0843 Case-Finding for Joint Pain and Anxiety and Depression: the Enhance Study (2015)
Journal Article
Jinks, C., Morden, A., Chew-Graham, C., Porcheret, M., Finney, A., Dziedzic, K., …Mallen, C. (2015). AB0843 Case-Finding for Joint Pain and Anxiety and Depression: the Enhance Study. Annals of the Rheumatic Diseases, 74(Suppl 2), 1182.2-1182. https://doi.org/10.1136/annrheumdis-2015-eular.2270

Background Osteoarthritis (OA) related joint pain and mental health problems are common and often co-exist in patients with other long term conditions (LTCs), but are under-detected and sub-optimally managed in primary care. The ENHANCE study aims to... Read More about AB0843 Case-Finding for Joint Pain and Anxiety and Depression: the Enhance Study.

One-year trajectories of depression and anxiety symptoms in older patients presenting in general practice with musculoskeletal pain: A latent class growth analysis. (2015)
Journal Article
Rzewuska, M., Mallen, C. D., Strauss, V. Y., Belcher, J., & Peat, G. (2015). One-year trajectories of depression and anxiety symptoms in older patients presenting in general practice with musculoskeletal pain: A latent class growth analysis. Journal of Psychosomatic Research, 79(3), 195 - 201. https://doi.org/10.1016/j.jpsychores.2015.05.016

OBJECTIVE: Distinguishing transient from persistent anxiety and depression symptoms in older people presenting to general practice with musculoskeletal pain is potentially important for effective management. This study sought to identify distinct pos... Read More about One-year trajectories of depression and anxiety symptoms in older patients presenting in general practice with musculoskeletal pain: A latent class growth analysis..

046. Integrating Care for Joint Pain and Anxiety and Depression into Reviews for Long-Term Conditions: The Enhance Study (2015)
Journal Article
Jinks, C., Morden, A., Chew-Graham, C., Porcheret, M., Finney, A., Dziedzic, K., …Mallen, C. (2015). 046. Integrating Care for Joint Pain and Anxiety and Depression into Reviews for Long-Term Conditions: The Enhance Study. Rheumatology, 54(S1), https://doi.org/10.1093/rheumatology/kev088.046

Joint pain and mental health problems are common and often co-exist with other long-term conditions (LTCs), but are under-detected and sub-optimally managed in primary care. The aim of the ENHANCE study is to develop and test the feasibility and acc... Read More about 046. Integrating Care for Joint Pain and Anxiety and Depression into Reviews for Long-Term Conditions: The Enhance Study.

O31. Gout and Risk of Subsequent Vascular Event: A Discrete-Time Event History Analysis in the Clinical Practice Research Datalink (2015)
Journal Article
Clarson, L. E., Hider, S. L., Belcher, J., Roddy, E., Heneghan, C., & Mallen, C. D. (2015). O31. Gout and Risk of Subsequent Vascular Event: A Discrete-Time Event History Analysis in the Clinical Practice Research Datalink. Rheumatology, 54(S1), https://doi.org/10.1093/rheumatology/kev084.001

Background: Current evidence suggests that gout is an independent risk factor for excess cardiovascular morbidity and mortality; yet, suboptimal care for patients with gout in primary care persists. We aimed to identify risk factors specific to these... Read More about O31. Gout and Risk of Subsequent Vascular Event: A Discrete-Time Event History Analysis in the Clinical Practice Research Datalink.

306. How Do General Practitioners Manage Suspected Giant Cell Arteritis (2015)
Journal Article
Helliwell, T., Muller, S., Hider, S. L., Richardson, J., & Mallen, C. (2015). 306. How Do General Practitioners Manage Suspected Giant Cell Arteritis. Rheumatology, 54(S1), https://doi.org/10.1093/rheumatology/kev090.071

Background: Background: GCA is the commonest large vessel vasculitis yet a full time UK general practitioner (GP) can expect to see just one case, at most every 1–2 years. Untreated GCA can lead to permanent visual loss, thus it is essential GPs reco... Read More about 306. How Do General Practitioners Manage Suspected Giant Cell Arteritis.

A qualitative investigation of the barriers to help-seeking among members of the public presented with symptoms of new-onset rheumatoid arthritis. (2015)
Journal Article
Mallen. (2015). A qualitative investigation of the barriers to help-seeking among members of the public presented with symptoms of new-onset rheumatoid arthritis. Journal of Rheumatology, 585 - 592. https://doi.org/10.3899/jrheum.140913

OBJECTIVE: Treating patients with rheumatoid arthritis (RA) within 3 months of symptom onset leads to significantly improved clinical outcomes. However, many people with RA symptoms wait a long time before seeking medical attention. To develop effect... Read More about A qualitative investigation of the barriers to help-seeking among members of the public presented with symptoms of new-onset rheumatoid arthritis..

Prevalence of genital prolapse symptoms in primary care: a cross-sectional survey. (2015)
Journal Article
Cooper, J., Annappa, M., Dracocardos, D., Cooper, W., Muller, S., & Mallen, C. (2015). Prevalence of genital prolapse symptoms in primary care: a cross-sectional survey. International Urogynecology Journal, 505 - 510. https://doi.org/10.1007/s00192-014-2556-x

INTRODUCTION AND HYPOTHESIS: The aim of our study was to determine the prevalence of pelvic organ prolapse (POP) symptoms in a community-dwelling population in the United Kingdom. METHODS: All women over the age of 18 from a community practice were s... Read More about Prevalence of genital prolapse symptoms in primary care: a cross-sectional survey..

Rising burden of gout in the UK but continuing suboptimal management: a nationwide population study. (2015)
Journal Article
Mallen. (2015). Rising burden of gout in the UK but continuing suboptimal management: a nationwide population study. Annals of the Rheumatic Diseases, 661 - 667. https://doi.org/10.1136/annrheumdis-2013-204463

OBJECTIVES: To describe trends in the epidemiology of gout and patterns of urate-lowering treatment (ULT) in the UK general population from 1997 to 2012. METHODS: We used the Clinical Practice Research Datalink to estimate the prevalence and incidenc... Read More about Rising burden of gout in the UK but continuing suboptimal management: a nationwide population study..

Gout and risk of chronic kidney disease and nephrolithiasis: meta-analysis of observational studies (2015)
Journal Article
Mallen, Roddy, & Belcher. (2015). Gout and risk of chronic kidney disease and nephrolithiasis: meta-analysis of observational studies. Arthritis Research and Therapy, 17, Article 90. https://doi.org/10.1186/s13075-015-0610-9

ntroduction To determine the prevalence of chronic kidney disease and nephrolithiasis in people with gout, and the association between gout and prevalent or incident chronic kidney disease and nephrolithiasis. Methods Systematic review and meta-... Read More about Gout and risk of chronic kidney disease and nephrolithiasis: meta-analysis of observational studies.

Increased cardiovascular mortality associated with gout: a systematic review and meta-analysis (2015)
Journal Article
Roddy, Mallen, Belcher, Clarson, & Hider. (2015). Increased cardiovascular mortality associated with gout: a systematic review and meta-analysis. European Journal of Preventive Cardiology, 22(3), 335 -343. https://doi.org/10.1177/2047487313514895

BACKGROUND: Hyperuricaemia, the biochemical precursor to gout, has been shown to be an independent risk factor for mortality from cardiovascular disease (CVD), although studies examining the clinical phenomenon of gout and risk of CVD mortality repor... Read More about Increased cardiovascular mortality associated with gout: a systematic review and meta-analysis.

International variation in GP treatment strategies for subclinical hypothyroidism in older adults: a case-based survey. (2015)
Journal Article
Mallen. (2015). International variation in GP treatment strategies for subclinical hypothyroidism in older adults: a case-based survey. British Journal of General Practice (BJGP), e121 - e132. https://doi.org/10.3399/bjgp15X683569

BACKGROUND: There is limited evidence about the impact of treatment for subclinical hypothyroidism, especially among older people. AIM: To investigate the variation in GP treatment strategies for older patients with subclinical hypothyroidism dependi... Read More about International variation in GP treatment strategies for subclinical hypothyroidism in older adults: a case-based survey..

Improving the care of people with long-term conditions in primary care: protocol for the ENHANCE pilot trial (2015)
Journal Article
Healey, E. L., Jinks, C., Tan, V. A., Chew-Graham, C. A., Lawton, S. A., Nicholls, E., …Mallen, C. D. (2015). Improving the care of people with long-term conditions in primary care: protocol for the ENHANCE pilot trial. Journal of Comorbidity, 5(1), 135 -149. https://doi.org/10.15256/joc.2015.5.60

Background: Long-term conditions (LTCs) are important determinants of quality of life and healthcare expenditure worldwide. Whilst multimorbidity is increasingly the norm in primary care, clinical guidelines and the delivery of care remain focused o... Read More about Improving the care of people with long-term conditions in primary care: protocol for the ENHANCE pilot trial.

Increased risk of vascular disease associated with gout: a retrospective, matched cohort study in the UK clinical practice research datalink (2015)
Journal Article
Roddy, Mallen, Belcher, & Hider. (2015). Increased risk of vascular disease associated with gout: a retrospective, matched cohort study in the UK clinical practice research datalink. Annals of the Rheumatic Diseases, 642 - 647. https://doi.org/10.1136/annrheumdis-2014-206432

OBJECTIVES: To determine whether gout increases risk of incident coronary heart disease (CHD), cerebrovascular (CVD) and peripheral vascular disease (PVD) in a large cohort of primary care patients with gout, since there have been no such large studi... Read More about Increased risk of vascular disease associated with gout: a retrospective, matched cohort study in the UK clinical practice research datalink.

"I suddenly felt I'd aged": a qualitative study of patient experiences of polymyalgia rheumatica (PMR). (2015)
Journal Article
Twohig, H., Mitchell, C., Mallen, C., Adebajo, A., & Mathers, N. (2015). "I suddenly felt I'd aged": a qualitative study of patient experiences of polymyalgia rheumatica (PMR). Patient Education and Counseling, 98(5), 645 - 650. https://doi.org/10.1016/j.pec.2014.12.013

OBJECTIVES: To explore patient experiences of living with, and receiving treatment for, PMR. METHODS: Semi-structured qualitative interviews, with 22 patients with PMR recruited from general practices in South Yorkshire. Thematic analysis using a con... Read More about "I suddenly felt I'd aged": a qualitative study of patient experiences of polymyalgia rheumatica (PMR)..

An algorithm to identify rheumatoid arthritis in primary care: a Clinical Practice Research Datalink study. (2015)
Journal Article
Muller, S., Hider, S. L., Raza, K., Stack, R. J., Hayward, R. A., & Mallen, C. D. (2015). An algorithm to identify rheumatoid arthritis in primary care: a Clinical Practice Research Datalink study. BMJ Open, 5(12), Article e009309. https://doi.org/10.1136/bmjopen-2015-009309

OBJECTIVE: Rheumatoid arthritis (RA) is a multisystem, inflammatory disorder associated with increased levels of morbidity and mortality. While much research into the condition is conducted in the secondary care setting, routinely collected primary c... Read More about An algorithm to identify rheumatoid arthritis in primary care: a Clinical Practice Research Datalink study..

The Ariadne principles: how to handle multimorbidity in primary care consultations. (2014)
Journal Article
Mallen. (2014). The Ariadne principles: how to handle multimorbidity in primary care consultations. BMC Medicine, 223 - ?. https://doi.org/10.1186/s12916-014-0223-1

Multimorbidity is a health issue mostly dealt with in primary care practice. As a result of their generalist and patient-centered approach, long-lasting relationships with patients, and responsibility for continuity and coordination of care, family p... Read More about The Ariadne principles: how to handle multimorbidity in primary care consultations..

Repeated primary care consultations for non-specific physical symptoms in children in UK: a cohort study (2014)
Journal Article
Bucknall, M., Mallen, C. D., & Dunn, K. M. (2014). Repeated primary care consultations for non-specific physical symptoms in children in UK: a cohort study. BMC Family Practice, 195 - ?. https://doi.org/10.1186/s12875-014-0195-4

BackgroundNon-specific physical symptoms (NSPS), such as headache and abdominal pain, are common reasons for children to consult primary care. NSPS represent a significant burden not only on society, but also on health care services, through frequent... Read More about Repeated primary care consultations for non-specific physical symptoms in children in UK: a cohort study.

Comorbidities in patients with gout prior to and following diagnosis: case-control study. (2014)
Journal Article
Mallen. (2014). Comorbidities in patients with gout prior to and following diagnosis: case-control study. Annals of the Rheumatic Diseases, 210 - 217. https://doi.org/10.1136/annrheumdis-2014-206410

OBJECTIVES: To determine the burden of comorbidities in patients with gout at diagnosis and the risk of developing new comorbidities post diagnosis. METHODS: There were 39 111 patients with incident gout and 39 111 matched controls identified from th... Read More about Comorbidities in patients with gout prior to and following diagnosis: case-control study..

Bisphosphonates and Risk of Acute Pseudogout: A Case-Control Study in the Clinical Practice Research Datalink (CPRD). (2014)
Presentation / Conference
Muller, S., Paskins, Z., Hider, S., Mallen, C., Roddy, E., & Bucknall, M. (2014, November). Bisphosphonates and Risk of Acute Pseudogout: A Case-Control Study in the Clinical Practice Research Datalink (CPRD). Poster presented at 2014 ACR/ARHP Annual Meeting, Boston, MA, usa

Background/Purpose: Acute pseudogout is the most dramatic clinical manifestation of calcium pyrophosphate crystal deposition (CPPD). CPPD is most commonly sporadic and age-related but can rarely occur secondary to metabolic diseases or a familial tra... Read More about Bisphosphonates and Risk of Acute Pseudogout: A Case-Control Study in the Clinical Practice Research Datalink (CPRD)..

Fatigue as a precursor to polymyalgia rheumatica: an explorative retrospective cohort study. (2014)
Journal Article
Mallen, Hider, & Muller. (2014). Fatigue as a precursor to polymyalgia rheumatica: an explorative retrospective cohort study. Scandinavian Journal of Rheumatology, 219 - 223. https://doi.org/10.3109/03009742.2014.959047

OBJECTIVES: Polymyalgia rheumatica (PMR) is the commonest inflammatory disorder of older adults. Although not part of the recently published classification criteria, patients with PMR frequently complain of fatigue. We compared consultation for fatig... Read More about Fatigue as a precursor to polymyalgia rheumatica: an explorative retrospective cohort study..

Transcutaneous electrical nerve stimulation as adjunct to primary care management for tennis elbow: (2014)
Journal Article
Chesterton, L. S., Lewis, A. M., Sim, J., Mallen, C. D., Mason, E. E., Hay, E. M., & van der Windt, D. A. (2014). Transcutaneous electrical nerve stimulation as adjunct to primary care management for tennis elbow:. British Journal of Sports Medicine, 1458 - ?. https://doi.org/10.1136/bjsports-2013-f5160rep

Can transcutaneous electrical nerve stimulation (TENS), as a patient controlled adjunct to primary care management for tennis elbow, provide superior pain relief to primary care management alone.

Prevalence of female urinary incontinence and its impact on quality of life in a cluster population in the United Kingdom (UK): a community survey. (2014)
Journal Article
Mallen. (2014). Prevalence of female urinary incontinence and its impact on quality of life in a cluster population in the United Kingdom (UK): a community survey. Primary Health Care Research and Development, 377 - 382. https://doi.org/10.1017/S1463423614000371

AIM: To ascertain the prevalence of urinary incontinence and lower urinary tract symptoms, impact on quality of life and help-seeking behaviour. BACKGROUND: Urinary incontinence is common and will affect more individuals as the population ages. Estim... Read More about Prevalence of female urinary incontinence and its impact on quality of life in a cluster population in the United Kingdom (UK): a community survey..

The association between GP consultations for non-specific physical symptoms in children and parents: a case-control study (2014)
Journal Article
Bucknall, M., Shraim, M., Mallen, C. D., & Dunn, K. M. (2014). The association between GP consultations for non-specific physical symptoms in children and parents: a case-control study. PloS one, e108039 -?. https://doi.org/10.1371/journal.pone.0108039

BACKGROUND: Non-specific physical symptoms (NSPS) such as abdominal pain, headache and musculoskeletal pain are widespread in the community, and are common reasons for visiting a general practitioner (GP). Causes of NSPS are multifactorial, but may i... Read More about The association between GP consultations for non-specific physical symptoms in children and parents: a case-control study.

Risk of vascular events in patients with polymyalgia rheumatica. (2014)
Journal Article
Hancock, A. T., Mallen, C. D., Muller, S., Belcher, J., Roddy, E., Helliwell, T., & Hider, S. L. (2014). Risk of vascular events in patients with polymyalgia rheumatica. Canadian Medical Association Journal, 186(13), E495 - E501. https://doi.org/10.1503/cmaj.140266

BACKGROUND: Polymyalgia rheumatica is one of the most common inflammatory rheumatologic conditions in older adults. Other inflammatory rheumatologic disorders are associated with an excess risk of vascular disease. We investigated whether polymyalgia... Read More about Risk of vascular events in patients with polymyalgia rheumatica..

Symptom complexes in patients with seropositive arthralgia and in patients newly diagnosed with rheumatoid arthritis: a qualitative exploration of symptom development. (2014)
Journal Article
Mallen. (2014). Symptom complexes in patients with seropositive arthralgia and in patients newly diagnosed with rheumatoid arthritis: a qualitative exploration of symptom development. https://doi.org/10.1093/rheumatology/keu159

OBJECTIVE: The aim of this study was to explore symptoms and symptom development during the earliest phases of RA in patients with seropositive arthralgia and patients newly diagnosed with RA. METHODS: Interviews were conducted with 15 seropositive p... Read More about Symptom complexes in patients with seropositive arthralgia and in patients newly diagnosed with rheumatoid arthritis: a qualitative exploration of symptom development..

Increased risk of vascular disease associated with gout: a retrospective, matched cohort study in the UK Clinical Practice Research Datalink (2014)
Journal Article
Clarson, L. E., Hider, S. L., Belcher, J., Heneghan, C., Roddy, E., & Mallen, C. D. (2014). Increased risk of vascular disease associated with gout: a retrospective, matched cohort study in the UK Clinical Practice Research Datalink. Annals of the Rheumatic Diseases, 74(4), 642-647. https://doi.org/10.1136/annrheumdis-2014-205252

Objectives To determine whether gout increases risk of incident coronary heart disease (CHD), cerebrovascular (CVD) and peripheral vascular disease (PVD) in a large cohort of primary care patients with gout, since there have been no such large studie... Read More about Increased risk of vascular disease associated with gout: a retrospective, matched cohort study in the UK Clinical Practice Research Datalink.

Is cancer associated with polymyalgia rheumatica?: A cohort study in the General Practice Research Database (2014)
Journal Article
Muller, S., Hider, S. L., Belcher, J., Helliwell, T., & Mallen, C. D. (2014). Is cancer associated with polymyalgia rheumatica?: A cohort study in the General Practice Research Database. Annals of the Rheumatic Diseases, 73(10), 1769 -1773. https://doi.org/10.1136/annrheumdis-2013-203465

OBJECTIVE: To investigate the incidence of new cancer diagnoses in a community sample of patients with polymyalgia rheumatica (PMR). METHODS: All incident cases of PMR in the UK General Practice Research Database (GPRD) (1987-99), without pre-existin... Read More about Is cancer associated with polymyalgia rheumatica?: A cohort study in the General Practice Research Database.

Improving Care for People with Long-Term Conditions: The ENHANCE study (2014)
Presentation / Conference
Finney, A. . G., Jinks, C., Chew-Graham, C. . A., Crabtree, V., Jordan, J., Healey, E. . L., …Mallen, C. . D. (2014, June). Improving Care for People with Long-Term Conditions: The ENHANCE study. Paper presented at Health Service Research Network Conference (HSRN), Nottingham Conference Centre, Nottingham, UK

The ‘ENHANCE’ long-term condition review: Identifying co-morbid joint pain, depression and anxiety in patients with long-term conditions (2014)
Presentation / Conference
Tan, V., Jinks, C., Porcheret, M., Chew-Graham, C. A., Cooper, V., Healey, E. L., …Finney, A. G. (2014, June). The ‘ENHANCE’ long-term condition review: Identifying co-morbid joint pain, depression and anxiety in patients with long-term conditions. Paper presented at HEALTH SERVICES RESEARCH NETWORK SYMPOSIUM 2014, Nottingham Conference Centre, Nottingham, England, UK

HOW DO GENERAL PRACTITIONERS IDENTIFY GIANT CELL ARTERITIS (GCA)? (2014)
Journal Article
Helliwell, T., Muller, S., Hider, S. L., Richardson, J., & Mallen, C. (2014). HOW DO GENERAL PRACTITIONERS IDENTIFY GIANT CELL ARTERITIS (GCA)?. Annals of the Rheumatic Diseases, 73(S2), 1004-1004. https://doi.org/10.1136/annrheumdis-2014-eular.4634

Background Giant Cell Arteritis (GCA) is the commonest large vessel vasculitis yet a full time UK general practitioner (GP) can expect to see just 1 case every 1-2 years [Barraclough]. GCA may be difficult to identify, particularly in atypical cases.... Read More about HOW DO GENERAL PRACTITIONERS IDENTIFY GIANT CELL ARTERITIS (GCA)?.

Association of polymyalgia rheumatica with socioeconomic status in primary care: a cross-sectional observational study. (2014)
Journal Article
Mallen, Roddy, Hider, & Muller. (2014). Association of polymyalgia rheumatica with socioeconomic status in primary care: a cross-sectional observational study. Arthritis Care and Research, 956 - 960. https://doi.org/10.1002/acr.22276

OBJECTIVE: Polymyalgia rheumatica (PMR) is an inflammatory musculoskeletal condition predominantly diagnosed and managed in the community. Socioeconomic status (SES) is known to be associated with many inflammatory rheumatologic conditions, but has n... Read More about Association of polymyalgia rheumatica with socioeconomic status in primary care: a cross-sectional observational study..

Impact of pain intensity on relationship quality between couples where one has back pain (2014)
Journal Article
Vivekanantham, A., Campbell, P., Mallen, C., & Dunn, K. (2014). Impact of pain intensity on relationship quality between couples where one has back pain. Pain Medicine, 832 - 841. https://doi.org/10.1111/pme.12366

OBJECTIVES: To investigate associations of pain intensity in those with long-term back pain, with their partners' rating of key constructs of relationship quality: cohesion (activities together), consensus (affection, sexual relations), satisfaction... Read More about Impact of pain intensity on relationship quality between couples where one has back pain.

Extending the authority for sickness certification beyond the medical profession: the importance of 'boundary work' (2014)
Journal Article
Welsh, V., Sanders, T., Richardson, J., Wynne-Jones, G., Jinks, C., & Mallen, C. (2014). Extending the authority for sickness certification beyond the medical profession: the importance of 'boundary work'. BMC Family Practice, 100 -?. https://doi.org/10.1186/1471-2296-15-100

BACKGROUND: The study aimed to explore the views of general practitioners (GPs), nurses and physiotherapists towards extending the role of sickness certification beyond the medical profession in primary care. METHODS: Fifteen GPs, seven nurses and si... Read More about Extending the authority for sickness certification beyond the medical profession: the importance of 'boundary work'.

195. Does Intra-Articular Corticosteroid Injection in the Pre-Operative Period Increase the Risk of Joint Infection Following Hip or Knee Arthroplasty? A Systematic Review and Meta-Analysis (2014)
Journal Article
Ellerby, N., Hider, S., Mallen, C., Belcher, J., & Roddy, E. (2014). 195. Does Intra-Articular Corticosteroid Injection in the Pre-Operative Period Increase the Risk of Joint Infection Following Hip or Knee Arthroplasty? A Systematic Review and Meta-Analysis. Rheumatology, 53(suppl_1), i132-i132. https://doi.org/10.1093/rheumatology/keu112.003

Background: OA is the commonest arthritis, and is increasing in prevalence. NICE OA guidelines include IA corticosteroid injections as an adjunctive treatment. There are theoretical concerns that their use prior to joint replacement surgery may incre... Read More about 195. Does Intra-Articular Corticosteroid Injection in the Pre-Operative Period Increase the Risk of Joint Infection Following Hip or Knee Arthroplasty? A Systematic Review and Meta-Analysis.

General practitioners' perspectives on campaigns to promote rapid help-seeking behaviour at the onset of rheumatoid arthritis. (2014)
Journal Article
Mallen. (2014). General practitioners' perspectives on campaigns to promote rapid help-seeking behaviour at the onset of rheumatoid arthritis. Scandinavian Journal of Primary Health Care, 37 - 43. https://doi.org/10.3109/02813432.2014.900239

OBJECTIVE: To explore general practitioners' (GPs') perspectives on public health campaigns to encourage people with the early symptoms of rheumatoid arthritis (RA) to seek medical help rapidly. DESIGN: Nineteen GPs participated in four semi-structur... Read More about General practitioners' perspectives on campaigns to promote rapid help-seeking behaviour at the onset of rheumatoid arthritis..

Symptom complexes at the earliest phases of rheumatoid arthritis: a synthesis of the qualitative literature. (2013)
Journal Article
Mallen. (2013). Symptom complexes at the earliest phases of rheumatoid arthritis: a synthesis of the qualitative literature. Arthritis Care & Research, 1916 - 1926. https://doi.org/10.1002/acr.22097

OBJECTIVE: Understanding the features and patterns of symptoms that characterize the earliest stages of rheumatoid arthritis (RA) is of considerable importance if patients are to be identified and started on treatment early. However, little is known... Read More about Symptom complexes at the earliest phases of rheumatoid arthritis: a synthesis of the qualitative literature..

Cardiovascular screening in rheumatoid arthritis: a cross-sectional primary care database study (2013)
Journal Article
Monk, H. L., Muller, S., Mallen, C. D., & Hider, S. L. (2013). Cardiovascular screening in rheumatoid arthritis: a cross-sectional primary care database study. BMC Family Practice, 14, Article ARTN 150. https://doi.org/10.1186/1471-2296-14-150

Background Patients with rheumatoid arthritis (RA) are known to be at increased risk of vascular disease. It is not known whether screening for vascular risk factors occurs in primary care. The aim of this study was to determine whether guidance adv... Read More about Cardiovascular screening in rheumatoid arthritis: a cross-sectional primary care database study.

Transcutaneous electrical nerve stimulation as adjunct to primary care management for tennis elbow: pragmatic randomised controlled trial (TATE trial) (2013)
Journal Article
Chesterton, L. S., Lewis, A. M., Sim, J., Mallen, C. D., Mason, E. E., Hay, E. M., & van der Windt, D. A. (2013). Transcutaneous electrical nerve stimulation as adjunct to primary care management for tennis elbow: pragmatic randomised controlled trial (TATE trial). BMJ, 347(sep02 4), f5160-f5160. https://doi.org/10.1136/bmj.f5160

Musculoskeletal pain in older adults at the end-of-life: a systematic search and critical review of the literature with priorities for future research (2013)
Journal Article
Lillie, A. K., Read, S., Mallen, C., Croft, P., & McBeth, J. (2013). Musculoskeletal pain in older adults at the end-of-life: a systematic search and critical review of the literature with priorities for future research. BMC Palliative Care, 12, Article ARTN 27. https://doi.org/10.1186/1472-684X-12-27

Background Pain is an important issue in end of life care. Although musculoskeletal pain is common in older adults, it is rarely associated with the cause of death and may be overlooked as death approaches. Hence a major target for improving quality... Read More about Musculoskeletal pain in older adults at the end-of-life: a systematic search and critical review of the literature with priorities for future research.

OP0298-PC How General Practitioners Diagnose Polymyalgia Rheumatica (2013)
Journal Article
Helliwell, T., Muller, S., Hider, S. L., & Mallen, C. D. (2013). OP0298-PC How General Practitioners Diagnose Polymyalgia Rheumatica. Annals of the Rheumatic Diseases, 72(Suppl 3), A155.1-A155. https://doi.org/10.1136/annrheumdis-2013-eular.503

Background The initial diagnosis of polymyalgia rheumatica (PMR) is often made in primary care. Given the non-specific nature of PMR symptoms, diagnosis can be challenging especially as many disorders can mimic the symptoms of PMR. Although guideline... Read More about OP0298-PC How General Practitioners Diagnose Polymyalgia Rheumatica.

A Prognostic Approach to Defining Chronic Pain Across a Range of Musculoskeletal Pain Sites (2013)
Journal Article
Muller, S., Thomas, E., Dunn, K. M., & Mallen, C. D. (2013). A Prognostic Approach to Defining Chronic Pain Across a Range of Musculoskeletal Pain Sites. The Clinical Journal of Pain, 29(5), 411-416. https://doi.org/10.1097/ajp.0b013e318257099e

Objectives: To test whether the prognostic definition of chronic pain, which has previously been applied in specific anatomic areas, performed well in a cohort of older adults with a range of musculoskeletal pain sites. Methods: Data are taken... Read More about A Prognostic Approach to Defining Chronic Pain Across a Range of Musculoskeletal Pain Sites.

Should there be a Quality and Outcomes Framework domain for osteoarthritis? A cross-sectional survey in general practice (2013)
Journal Article
Clarson, L. E., Nicholl, B. I., Bishop, A., Edwards, J., Daniel, R., & Mallen, C. (2013). Should there be a Quality and Outcomes Framework domain for osteoarthritis? A cross-sectional survey in general practice. Quality in Primary Care, 21(2), 97-103

BackgroundDespite being a chronic condition with a high prevalence and significant associated morbidity that is managed predominantly in primary care, osteoarthritis (OA) does not feature in the Quality and Outcomes Framework (QOF) component of theUK... Read More about Should there be a Quality and Outcomes Framework domain for osteoarthritis? A cross-sectional survey in general practice.

Point-of-Care Prognosis for Common Musculoskeletal Pain in Older Adults (2013)
Journal Article
Mallen, C. D., Thomas, E., Belcher, J., Rathod, T., Croft, P., & Peat, G. (2013). Point-of-Care Prognosis for Common Musculoskeletal Pain in Older Adults. JAMA Internal Medicine, 173(12), 1119-1125. https://doi.org/10.1001/jamainternmed.2013.962

Importance Many site-specific, multivariable risk models for predicting the outcome of musculoskeletal pain problems have been published. The overlapping content in these models suggests a common set of generic indicators suitable for use in primary... Read More about Point-of-Care Prognosis for Common Musculoskeletal Pain in Older Adults.

GP consultations for medically unexplained physical symptoms in parents and their children: a systematic review (2013)
Journal Article
Shraim, M., Mallen, C. D., & Dunn, K. M. (2013). GP consultations for medically unexplained physical symptoms in parents and their children: a systematic review. British Journal of General Practice (BJGP), e318 - e325. https://doi.org/10.3399/bjgp13X667178

BACKGROUND: There is evidence of an association of medically unexplained physical symptoms (MUPS) between parents and children, but it is unclear whether this association is also present for GP consultations. AIM: To review the literature investigati... Read More about GP consultations for medically unexplained physical symptoms in parents and their children: a systematic review.

O30. The Risk of a Subsequent Cancer Diagnosis after PMR: A Primary Care Database Study (2013)
Presentation / Conference
Muller, S., Mallen, C. D., Belcher, J., Helliwell, T., & Hider, S. L. (2013, April). O30. The Risk of a Subsequent Cancer Diagnosis after PMR: A Primary Care Database Study. Presented at Annual Meeting of the British Society for Rheumatology and British Health Professionals in Rheumatology, Birmingham, ENGLAND

Background: PMR is the commonest inflammatory rheumatological disorder managed in primary care. Other inflammatory conditions such as RA and psoriasis have been associated with an increased incidence of cancer, specifically haematological malignancie... Read More about O30. The Risk of a Subsequent Cancer Diagnosis after PMR: A Primary Care Database Study.

The association of gout with sleep disorders: a cross-sectional study in primary care (2013)
Journal Article
Mallen, Roddy, & Muller. (2013). The association of gout with sleep disorders: a cross-sectional study in primary care. BMC Musculoskeletal Disorders, 119 -?. https://doi.org/10.1186/1471-2474-14-119

BACKGROUND: Both gout and sleep apnoea are associated with the metabolic syndrome. Hyperuricaemia is also prevalent in sleep apnoea syndrome. The objective of this study was to examine the association between gout and sleep apnoea and other sleep dis... Read More about The association of gout with sleep disorders: a cross-sectional study in primary care.

Monitoring Osteoarthritis: A Cross-sectional Survey in General Practice. (2013)
Journal Article
Clarson, L., Nicholl, B. I., Bishop, A., Edwards, J. J., Daniel, R., & Mallen, C. (2013). Monitoring Osteoarthritis: A Cross-sectional Survey in General Practice. Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders, 85 - 91. https://doi.org/10.4137/CMAMD.S12606

BACKGROUND: Despite being a highly prevalent chronic condition managed predominantly in primary care and unlike other chronic conditions, osteoarthritis (OA) care is delivered on an ad hoc basis rather than through routine structured review. Evidence... Read More about Monitoring Osteoarthritis: A Cross-sectional Survey in General Practice..

The association of anxiety and depression with future dementia diagnosis: a case-control study in primary care. (2012)
Journal Article
Burton, C., Campbell, P., Jordan, K., Strauss, V., & Mallen, C. (2013). The association of anxiety and depression with future dementia diagnosis: a case-control study in primary care. Family Practice, 30(1), 25-30. https://doi.org/10.1093/fampra/cms044

Background. Depression is identified as a risk factor for dementia. Little research has been carried out on the importance of anxiety, despite strong evidence of co-morbidity with depression. Objective. To examine the association of anxiety and... Read More about The association of anxiety and depression with future dementia diagnosis: a case-control study in primary care..

The epidemiology of polymyalgia rheumatica in primary care: a research protocol (2012)
Journal Article
Roddy, Mallen, Muller, Hider, & Helliwell. (2012). The epidemiology of polymyalgia rheumatica in primary care: a research protocol. BMC Musculoskeletal Disorders, 102 - ?. https://doi.org/10.1186/1471-2474-13-102

BACKGROUND: Polymyalgia Rheumatica (PMR) is the commonest inflammatory condition seen in older patients in primary care. To date, however, research has been focused on secondary care cohorts rather than primary care where many patients are exclusivel... Read More about The epidemiology of polymyalgia rheumatica in primary care: a research protocol.

Association between polymyalgia rheumatica and vascular disease: A systematic review (2012)
Journal Article
Hancock, A. T., Mallen, C. D., Belcher, J., & Hider, S. L. (2012). Association between polymyalgia rheumatica and vascular disease: A systematic review. Arthritis Care and Research, 64(9), 1301-1305. https://doi.org/10.1002/acr.21712

Objective To systematically identify and appraise the existing literature on the association between polymyalgia rheumatica (PMR) and vascular disease. Methods The Medline, Embase, CINAHL, and Cochrane databases were searched from inception to S... Read More about Association between polymyalgia rheumatica and vascular disease: A systematic review.

Self-reported pain interference and symptoms of anxiety and depression in community-dwelling older adults: Can a temporal relationship be determined? (2010)
Journal Article
Arola, H., Nicholls, E., Mallen, C., & Thomas, E. (2010). Self-reported pain interference and symptoms of anxiety and depression in community-dwelling older adults: Can a temporal relationship be determined?. European Journal of Pain, 14(9), 966-971. https://doi.org/10.1016/j.ejpain.2010.02.012

Pain and symptoms of depression and anxiety have been observed to co-exist in the community-dwelling elderly. While depression and pain have been suggested to be predictive of one another temporally, the longitudinal associations between anxiety and... Read More about Self-reported pain interference and symptoms of anxiety and depression in community-dwelling older adults: Can a temporal relationship be determined?.

An intercalated research Masters in primary care: a pilot programme. (2010)
Journal Article
Mallen. (2010). An intercalated research Masters in primary care: a pilot programme. Education for Primary Care, 208 - 211. https://doi.org/10.1080/14739879.2010.11493909

Academic medicine is said by some to be in decline and primary care in particular struggles to recruit to academic general practice posts at all levels. Intercalated degrees are often described as being a stepping-stone to an academic career, yet a B... Read More about An intercalated research Masters in primary care: a pilot programme..

Transcutaneous electrical nerve stimulation for the management of tennis elbow: a pragmatic randomized controlled trial: the TATE trial (ISRCTN 87141084) (2009)
Journal Article
Chesterton, L. S., van der Windt, D. A., Sim, J., Lewis, M., Mallen, C. D., Mason, E. E., …Hay, E. M. (2009). Transcutaneous electrical nerve stimulation for the management of tennis elbow: a pragmatic randomized controlled trial: the TATE trial (ISRCTN 87141084). BMC Musculoskeletal Disorders, 10(1), https://doi.org/10.1186/1471-2474-10-156

Discussing prognosis with older people with musculoskeletal pain: a cross-sectional study in general practice (2009)
Journal Article
David Mallen, C., & Peat, G. (2009). Discussing prognosis with older people with musculoskeletal pain: a cross-sectional study in general practice. BMC Family Practice, 50 -?. https://doi.org/10.1186/1471-2296-10-50

Prognosis has been described as an important but neglected branch of clinical science. While patients' views have been sought in the context of life-threatening illness, similar research is lacking for patients presenting with common, non-life-threat... Read More about Discussing prognosis with older people with musculoskeletal pain: a cross-sectional study in general practice.

The impact of musculoskeletal conditions on outcomes of other illnesses (the MSKCOM study): a linked electronic health record study - Code lists
Dataset
Marshall, M., Mason, K., Bailey, J., Heron, N., Achanca, F., Chen, Y., …Jordan, K. (2022). The impact of musculoskeletal conditions on outcomes of other illnesses (the MSKCOM study): a linked electronic health record study - Code lists. [Dataset]

Marshall M, Mason K, Bailey J, Heron N, Achana F, Chen Y, Edwards J, Frisher M, Huntley A, Mallen C, Mamas M, Png ME, Tatton S, White S, Jordan KP. MSKCOM: main Public Output: The impact of musculoskeletal conditions on outcomes of other illnesses: a... Read More about The impact of musculoskeletal conditions on outcomes of other illnesses (the MSKCOM study): a linked electronic health record study - Code lists.

THU0650 Early help seeking or self-management: a quantitative assessment in the context of rheumatoid arthritis
Journal Article
Simons, G., Belcher, J., Kumar, K., Falahee, M., Mallen, C., Stack, R., & Raza, K. (2018). THU0650 Early help seeking or self-management: a quantitative assessment in the context of rheumatoid arthritis. Annals of the Rheumatic Diseases, 77(2), https://doi.org/10.1136/annrheumdis-2018-eular.2529

Background Rheumatoid arthritis (RA) should be treated with DMARDs in its earliest stages to reduce the likelihood of permanent joint damage and disability1. This therapeutic window is often missed. One important cause is delayed help seeking by pati... Read More about THU0650 Early help seeking or self-management: a quantitative assessment in the context of rheumatoid arthritis.

042 Challenges Faced in Primary Care During the Early Stages of Rheumatoid Arthritis: A Cross-Sectional Survey of General Practitioners
Presentation / Conference
Mangat, N. S., Raza, K., Clarkson, K., Stack, R., Mallen, C., Belcher, J., & Hider, S. 042 Challenges Faced in Primary Care During the Early Stages of Rheumatoid Arthritis: A Cross-Sectional Survey of General Practitioners. Poster presented at Rheumatology 2016

Background: Early treatment can reduce morbidity and mortality in patients with RA. However, identifying early RA can be challenging, in part because many of its initial symptoms are non-specific. Delays in recognising RA and referral to secondary ca... Read More about 042 Challenges Faced in Primary Care During the Early Stages of Rheumatoid Arthritis: A Cross-Sectional Survey of General Practitioners.