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Ying Yang's Outputs (99)

New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties. (2022)
Journal Article
Yang, & Wu. (2022). New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties. Scientific reports, 12, Article 5109. https://doi.org/10.1038/s41598-022-09005-2

Preterm prelabour rupture of membranes is the leading cause of preterm birth and its associated infant mortality and morbidity. However, its underlying mechanism remains unknown. We utilized two novel biomechanical assessment techniques, ball indenta... Read More about New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties..

New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties (2022)
Journal Article
Yang, & Wu. (2022). New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties. Scientific reports, 12, Article 5109. https://doi.org/10.1038/s41598-022-09005-2

Preterm prelabour rupture of membranes is the leading cause of preterm birth and its associated infant mortality and morbidity. However, its underlying mechanism remains unknown. We utilized two novel biomechanical assessment techniques, ball indenta... Read More about New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties.

Time-dependent mechanical behaviour of the aortic chronic dissection flap (2022)
Journal Article
Panpho, P., Yang, Y., Davies, H. A., Nawaytou, O., Harky, A., Torella, F., …Akhtar, R. (2022). Time-dependent mechanical behaviour of the aortic chronic dissection flap. Interactive Cardiovascular and Thoracic Surgery, 34(5), 892-901. https://doi.org/10.1093/icvts/ivac029

The transition of aortic dissection from acute to chronic is poorly understood. We examined time-dependent mechanical behaviour and biochemical properties of chronic dissection tissues.

Potential of Exosomes as Cell-Free Therapy in Articular Cartilage Regeneration: A Review (2021)
Journal Article
Ng, C. Y., Chai, J. Y., Foo, J. B., Mohamad Yahaya, N. H., Yang, Y., Ng, M. H., & Law, J. X. (in press). Potential of Exosomes as Cell-Free Therapy in Articular Cartilage Regeneration: A Review. International Journal of Nanomedicine, Volume 16, 6749-6781. https://doi.org/10.2147/ijn.s327059

Treatment of cartilage defects such as osteoarthritis (OA) and osteochondral defect (OCD) remains a huge clinical challenge in orthopedics. OA is one of the most common chronic health conditions and is mainly characterized by the degeneration of arti... Read More about Potential of Exosomes as Cell-Free Therapy in Articular Cartilage Regeneration: A Review.

Molecular dynamics simulation of peptide attachment on Al-based surfaces (2021)
Journal Article
Lou, T., Bai, X., He, X., Yang, Y., & Yuan, C. (2021). Molecular dynamics simulation of peptide attachment on Al-based surfaces. Progress in Organic Coatings, 157, 106310. https://doi.org/10.1016/j.porgcoat.2021.106310

Biofouling is a serious problem for devices or facilities working in marine environment that needs to be solved. Modifying the contact surface with antimicrobial peptides is a promised technique to inhibit biofouling. However, the attachment behavior... Read More about Molecular dynamics simulation of peptide attachment on Al-based surfaces.

The Combination of Tissue-Engineered Blood Vessel Constructs and Parallel Flow Chamber Provides a Potential Alternative to In Vivo Drug Testing Models (2021)
Journal Article
Njoroge, W., Hernández Hernández, A. C., Idris Musa, F., Butler, R., Harper, A. G. S., & Yang, Y. (2021). The Combination of Tissue-Engineered Blood Vessel Constructs and Parallel Flow Chamber Provides a Potential Alternative to In Vivo Drug Testing Models. Pharmaceutics, 13(3), Article 340. https://doi.org/10.3390/pharmaceutics13030340

Cardiovascular disease is a major cause of death globally. This has led to significant efforts to develop new anti-thrombotic therapies or re-purpose existing drugs to treat cardiovascular diseases. Due to difficulties of obtaining healthy human bloo... Read More about The Combination of Tissue-Engineered Blood Vessel Constructs and Parallel Flow Chamber Provides a Potential Alternative to In Vivo Drug Testing Models.

Quantitative measurement of mechanical properties in wound healing processes in a corneal stroma model by using vibrational optical coherence elastography (OCE) (2021)
Journal Article
Yang. (2021). Quantitative measurement of mechanical properties in wound healing processes in a corneal stroma model by using vibrational optical coherence elastography (OCE). Biomedical Optics Express, 588 - 603. https://doi.org/10.1364/BOE.404096

Corneal wound healing, caused by frequent traumatic injury to the cornea and increasing numbers of refractive surgeries, has become a vital clinical problem. In the cornea, wound healing is an extremely complicated process. However, little is known a... Read More about Quantitative measurement of mechanical properties in wound healing processes in a corneal stroma model by using vibrational optical coherence elastography (OCE).

Dose-response association between physical activity and clustering of modifiable cardiovascular risk factors among 26,093 Chinese adults (2020)
Journal Article
Shi, R., Cai, Y., Yang, Y., Yu, D., & Qin, R. (2020). Dose-response association between physical activity and clustering of modifiable cardiovascular risk factors among 26,093 Chinese adults. BMC Cardiovascular Disorders, 20, Article 347. https://doi.org/10.1186/s12872-020-01627-6

Background
There is uncertain evidence in the dose-response association between overall physical activity levels and clustering of cardiovascular diseases modifiable risk factors (CVDMRF) in Chinese adults. This study examined the hypothesis whether... Read More about Dose-response association between physical activity and clustering of modifiable cardiovascular risk factors among 26,093 Chinese adults.

Synthesis of magnetic nanoparticles with an IDA or TED modified surface for purification and immobilization of poly-histidine tagged proteins (2020)
Journal Article
Yang. (2020). Synthesis of magnetic nanoparticles with an IDA or TED modified surface for purification and immobilization of poly-histidine tagged proteins. RSC advances, 11524 - 11534. https://doi.org/10.1039/C9RA10473A

Magnetic nanoparticles (MNPs) chelating with metal ions can specifically interact with poly-histidine peptides and facilitate immobilization and purification of proteins with poly-histidine tags. Fabrication of MNPs is generally complicated and time... Read More about Synthesis of magnetic nanoparticles with an IDA or TED modified surface for purification and immobilization of poly-histidine tagged proteins.

Bioactive silver phosphate/polyindole nanocomposites (2020)
Journal Article
Yang. (2020). Bioactive silver phosphate/polyindole nanocomposites. RSC advances, 11060 - 11073. https://doi.org/10.1039/D0RA01129K

Materials capable of releasing reactive oxygen species (ROS) can display antibacterial and anticancer activity, and may also have anti-oxidant capacity if they suppress intracellular ROS (e.g. nitric oxide, NO) resulting in anti-inflammatory activity... Read More about Bioactive silver phosphate/polyindole nanocomposites.

Development and evaluation of cationic nanostructured lipid carriers for ophthalmic drug delivery of besifloxacin (2019)
Journal Article
Yang. (2019). Development and evaluation of cationic nanostructured lipid carriers for ophthalmic drug delivery of besifloxacin. Journal of Drug Delivery Science and Technology, https://doi.org/10.1016/j.jddst.2019.101496

Besifloxacin hydrochloride (BSF) is a new ophthalmic antibiotic. However, its low water solubility limits its therapeutic efficacy. This article reported a novel lipid based drug delivery system to enhance ocular bioavailability of BSF. Cationic nano... Read More about Development and evaluation of cationic nanostructured lipid carriers for ophthalmic drug delivery of besifloxacin.

P1 Biomechanical Properties of the Aortic Dissection Flap in Chronic Aortic Dissection (2019)
Journal Article
Panpho, P., Davies, H., Field, M., Madine, J., Yang, Y., & Akhtar, R. (2019). P1 Biomechanical Properties of the Aortic Dissection Flap in Chronic Aortic Dissection. Artery Research, 25(Suppl 1), S43-S43. https://doi.org/10.2991/artres.k.191224.036

Background: Aortic dissection is a devastating condition, beginning with a tear through from intima to the medial layer, leading to splitting of aortic layers and creating the false and true lumen with a septum (or flap). Little is known about the pr... Read More about P1 Biomechanical Properties of the Aortic Dissection Flap in Chronic Aortic Dissection.

Cardiac Progenitor Cells from Stem Cells: Learning from Genetics and Biomaterials (2019)
Journal Article
Barreto, S., Hamel, L., Schiatti, T., Yang, Y., & George, V. (2019). Cardiac Progenitor Cells from Stem Cells: Learning from Genetics and Biomaterials. Cells, 8(12), https://doi.org/10.3390/cells8121536

Cardiac Progenitor Cells (CPCs) show great potential as a cell resource for restoring cardiac function in patients affected by heart disease or heart failure. CPCs are proliferative and committed to cardiac fate, capable of generating cells of all th... Read More about Cardiac Progenitor Cells from Stem Cells: Learning from Genetics and Biomaterials.

Maintenance and Acceleration of Pericellular Matrix Formation within 3D Cartilage Cell Culture Models (2019)
Journal Article
Owida, H. A., Kuiper, N. L., & Yang, Y. (2021). Maintenance and Acceleration of Pericellular Matrix Formation within 3D Cartilage Cell Culture Models. Cartilage, 13(2_suppl), 847S-861S. https://doi.org/10.1177/1947603519870839

In native articular cartilage, chondrocytes are surrounded by a thin pericellular matrix (PCM) forming chondrons. The PCM is exclusively rich in type VI collagen. The retention of the PCM has a significant influence on the metabolic activity of the c... Read More about Maintenance and Acceleration of Pericellular Matrix Formation within 3D Cartilage Cell Culture Models.

Regulation of endothelial cell arrangements within hMSC – HUVEC co-cultured aggregates (2019)
Journal Article
Yang. (2019). Regulation of endothelial cell arrangements within hMSC – HUVEC co-cultured aggregates. https://doi.org/10.1016/j.bj.2019.01.003

Background Micro-mass culturing or cellular aggregation is an effective method used to form mineralised bone tissue. Poor core cell viability, however, is often an impeding characteristic of large micro-mass cultures, and equally for large tissue-eng... Read More about Regulation of endothelial cell arrangements within hMSC – HUVEC co-cultured aggregates.