Development of a Three-Dimensional Pathology-Simulating Model of Neurotrauma Using a Polymer-Encapsulated Neural Cell Network (2025)
Journal Article
Wiseman, J. P., Dombros-Ryan, Z., Griffiths, J., Adams, C., & Chari, D. M. (in press). Development of a Three-Dimensional Pathology-Simulating Model of Neurotrauma Using a Polymer-Encapsulated Neural Cell Network. Gels, 11(4), Article 247. https://doi.org/10.3390/gels11040247

Penetrating traumatic injuries of the brain have a poor clinical prognosis necessitating development of new therapies to improve neurological outcomes. Laboratory research is hampered by reliance on highly invasive experimental approaches in living a... Read More about Development of a Three-Dimensional Pathology-Simulating Model of Neurotrauma Using a Polymer-Encapsulated Neural Cell Network.

A macro-transection model of brain trauma for neuromaterial testing with functional electrophysiological readouts. (2025)
Journal Article
Wiseman, J., Basit, R. H., Suto, A., Middya, S., Kabiri, B., Evans, M., George, V., Adams, C., Malliaras, G., & Chari, D. M. (in press). A macro-transection model of brain trauma for neuromaterial testing with functional electrophysiological readouts. Neural Regeneration Research, 20(12), 3539-3552. https://doi.org/10.4103/NRR.NRR-D-24-00422

Functional recovery in penetrating neurological injury is hampered by a lack of clinical regenerative therapies. Biomaterial therapies show promise as medical materials for neural repair through immunomodulation, structural support, and delivery of t... Read More about A macro-transection model of brain trauma for neuromaterial testing with functional electrophysiological readouts..

Neural Cell Interactions with a Surgical Grade Biomaterial Using a Simulated Injury in Brain Organotypic Slices (2024)
Journal Article
Wiseman, J. P., & Chari, D. M. (in press). Neural Cell Interactions with a Surgical Grade Biomaterial Using a Simulated Injury in Brain Organotypic Slices. Journal of Functional Biomaterials, 15(12), Article 362. https://doi.org/10.3390/jfb15120362

Tissue engineering research for neurological applications has demonstrated that biomaterial-based structural bridges present a promising approach for promoting regeneration. This is particularly relevant for penetrating traumatic brain injuries, wher... Read More about Neural Cell Interactions with a Surgical Grade Biomaterial Using a Simulated Injury in Brain Organotypic Slices.

Developing High-Fidelity In Vitro Models of Traumatic Brain Injury to Test Therapeutic Biomaterials (2024)
Book Chapter
Adams, C., Kabiri, B., Basit, R. H., Wiseman, J., & Chari, D. M. (2024). Developing High-Fidelity In Vitro Models of Traumatic Brain Injury to Test Therapeutic Biomaterials. In Regenerative Medicine and Brain Repair (271-315). Springer International Publishing. https://doi.org/10.1007/978-3-031-49744-5_10