Trans-ancestry genome-wide association study identifies novel genetic mechanisms in rheumatoid arthritis (2021)
Preprint / Working Paper
Ishigaki, K., Sakaue, S., Terao, C., Luo, Y., Sonehara, K., Yamaguchi, K., Amariuta, T., Lai Too, C., A Laufer, V., C Scott, I., Viatte, S., Takahashi, M., Ohmura, K., Murasawa, A., Hashimoto, M., Ito, H., Hammoudeh, M., Al Emadi, S., K Masri, B., Halabi, H., …J Carroll, R. Trans-ancestry genome-wide association study identifies novel genetic mechanisms in rheumatoid arthritis

Trans-ancestry genetic research promises to improve power to detect genetic signals, fine-mapping resolution, and performances of polygenic risk score (PRS). We here present a large-scale genome-wide association study (GWAS) of rheumatoid arthritis (... Read More about Trans-ancestry genome-wide association study identifies novel genetic mechanisms in rheumatoid arthritis.

Inter-species microbiota transplantation recapitulates microbial acquisition and persistence in mosquitoes (2021)
Preprint / Working Paper
Coon, K. L., Hegde, S., & Hughes, G. L. Inter-species microbiota transplantation recapitulates microbial acquisition and persistence in mosquitoes

Background Mosquitoes harbor microbial communities that play important roles in their growth, survival, reproduction, and ability to transmit human pathogens. Microbiome transplantation approaches are often used to study host-microbe interactions and... Read More about Inter-species microbiota transplantation recapitulates microbial acquisition and persistence in mosquitoes.

Blood biochemical parameters as predictors of disease severity and mortality in COVID-19 patients- an updated systematic review and meta-analysis (2021)
Other
Majid, A., Mishra, P., Parveen, R., Bajpai, R., Khan, M., & Agarwal, N. (2021). Blood biochemical parameters as predictors of disease severity and mortality in COVID-19 patients- an updated systematic review and meta-analysis

<h4>ABSTRACT</h4> <h4>Background</h4> The outbreak of coronavirus disease 2019 (COVID-19) has been rapidly spreading across the globe and poses a great risk to human health. Patients with abnormalities in laboratory parameters are more susceptible to... Read More about Blood biochemical parameters as predictors of disease severity and mortality in COVID-19 patients- an updated systematic review and meta-analysis.

Propranolol Reduces Risk of Knee or Hip Replacement Due to Osteoarthritis: a Propensity Score Matched Cohort Study-using Data From the Clinical Practice Research Datalink. (2021)
Journal Article
Mamas, M., & Mallen, C. (2021). Propranolol Reduces Risk of Knee or Hip Replacement Due to Osteoarthritis: a Propensity Score Matched Cohort Study-using Data From the Clinical Practice Research Datalink. Research Square, https://doi.org/10.21203/rs.3.rs-670522/v1

<h4>Objectives: </h4> To examine the association between ß -blocker prescription and knee or hip total joint replacement (TJR) in a UK primary-care population with incident knee or hip osteoarthritis (OA). <h4>Methods: </h4> Cohort study using data f... Read More about Propranolol Reduces Risk of Knee or Hip Replacement Due to Osteoarthritis: a Propensity Score Matched Cohort Study-using Data From the Clinical Practice Research Datalink..

Novel HumanMethylatyion450 Analyses Reveal DNA Methylation Predictors of Future Diabetes Onset in Women With Polycystic Ovarian Syndrome (2021)
Journal Article
Kitchen, M., Manzur, A., Fryer, A., & Wu, P. (in press). Novel HumanMethylatyion450 Analyses Reveal DNA Methylation Predictors of Future Diabetes Onset in Women With Polycystic Ovarian Syndrome. Research Square, https://doi.org/10.21203/rs.3.rs-637359/v1

Aims.
Polycystic ovarian syndrome (PCOS) is a common endocrine disorder characterised by ovarian morphological, systemic biochemical, and menstrual changes. Women with PCOS are at significantly increased risk of raised fasting glucose, impaired gluc... Read More about Novel HumanMethylatyion450 Analyses Reveal DNA Methylation Predictors of Future Diabetes Onset in Women With Polycystic Ovarian Syndrome.

Dystrophin regulates peripheral circadian SRF signalling (2021)
Other
Betts, C. A., Jagannath, A., van Westering, T. L., Bowerman, M., Banerjee, S., Meng, J., Falzarano, M. S., Cravo, L., McClorey, G., Meijboom, K. E., Bhomra, A., Fang Lim, W., Rinaldi, C., Counsell, J. R., Chwalenia, K., O’Donovan, E., Saleh, A. F., Gait, M. J., Morgan, J. E., Ferlini, A., …Wood, M. J. (2021). Dystrophin regulates peripheral circadian SRF signalling

Dystrophin is a sarcolemmal protein essential for muscle contraction and maintenance, absence of which leads to the devastating muscle wasting disease Duchenne muscular dystrophy (DMD)[1, 2]. Dystrophin has an actin-binding domain [3–5], which specif... Read More about Dystrophin regulates peripheral circadian SRF signalling.