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An investigation into the coordination chemistry of tripodal “click” triazole ligands with Mn, Ni, Co and Zn ions (2022)
Journal Article
Chernobryva, M., Motevalli, M., Hawes, C. S., & Watkinson, M. (2022). An investigation into the coordination chemistry of tripodal “click” triazole ligands with Mn, Ni, Co and Zn ions. Journal of Molecular Structure, 1259, 132736 - 132736. https://doi.org/10.1016/j.molstruc.2022.132736

The steric influences of the triazole side chains in two tripodal chelating ligands tris[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]amine (TBTA) and tris[(1-phenyl-1H-1,2,3-triazol-4-yl)methyl]amine (TPTA) are explored through structural studies of four... Read More about An investigation into the coordination chemistry of tripodal “click” triazole ligands with Mn, Ni, Co and Zn ions.

Developments in the Chemical Synthesis of Heparin and Heparan Sulfate (2021)
Journal Article
Pongener, I., O'Shea, C., Wootton, H., Watkinson, M., & Miller, G. J. (2021). Developments in the Chemical Synthesis of Heparin and Heparan Sulfate. Chemical Record, 21(11), 3238-3255. https://doi.org/10.1002/tcr.202100173

Heparin and heparan sulfate represent key members of the glycosaminoglycan family of carbohydrates and underpin considerable repertoires of biological importance. As such, their efficiency of synthesis represents a key requirement, to further underst... Read More about Developments in the Chemical Synthesis of Heparin and Heparan Sulfate.

Protect to detect: A Golgi apparatus targeted probe to image mobile zinc through the use of a lipophilic cell-labile protecting group strategy (2021)
Journal Article
Fang, L., Crespo-Otero, R., Jones, C. R., & Watkinson, M. (2021). Protect to detect: A Golgi apparatus targeted probe to image mobile zinc through the use of a lipophilic cell-labile protecting group strategy. Sensors and Actuators B: Chemicall, 338, Article 129850. https://doi.org/10.1016/j.snb.2021.129850

The Golgi apparatus requires zinc for its normal function, but the role it plays in these processes at the sub-cellular level is not well-understood due to the lack of appropriate tools to image it. Herein, a small molecule Golgi apparatus targeted p... Read More about Protect to detect: A Golgi apparatus targeted probe to image mobile zinc through the use of a lipophilic cell-labile protecting group strategy.

Subcellular localised small molecule fluorescent probes to image mobile Zn2+ (2020)
Journal Article
Fang, L., & Watkinson, M. (2020). Subcellular localised small molecule fluorescent probes to image mobile Zn2+. Chemical Science, 11(42), 11366 - 11379. https://doi.org/10.1039/D0SC04568C

Zn2+, as the second most abundant d-block metal in the human body, plays an important role in a wide range of biological processes, and the dysfunction of its homeostasis is related to many diseases, including Type 2 diabetes, Alzheimer's disease and... Read More about Subcellular localised small molecule fluorescent probes to image mobile Zn2+.

Illuminating glycoscience: synthetic strategies for FRET-enabled carbohydrate active enzyme probes (2020)
Journal Article
Singh, M., Watkinson, M., Scanlan, E. M., & Miller, G. (2020). Illuminating glycoscience: synthetic strategies for FRET-enabled carbohydrate active enzyme probes. RSC Chemical Biology, 5(1), 352 - 368

Carbohydrates are synthesised, refined and degraded by carbohydrate active enzymes. FRET is emerging as a powerful tool to monitor and quantify their activity as well as to test inhibitors as new drug candidates and monitor disease.

A Series of Manganese(III) Salen Complexes as a Result of Team-Based Inquiry in a Transnational Education Programme. (2020)
Journal Article
Yuan, D., Cai, N., Xu, J., Miao, D., Zhang, S., Woodfine, S. E., …Watkinson, M. (2020). A Series of Manganese(III) Salen Complexes as a Result of Team-Based Inquiry in a Transnational Education Programme. ChemPlusChem, 85(6), 1210 - 1219. https://doi.org/10.1002/cplu.202000337

The development of a team-based approach to research-led transnational practical chemistry teaching is described in which a team of five Chinese students on an articulated transnational degree programme, supported by a team of academic and technical... Read More about A Series of Manganese(III) Salen Complexes as a Result of Team-Based Inquiry in a Transnational Education Programme..

Endoplasmic reticulum targeting fluorescent probes to image mobile Zn2+ (2019)
Journal Article
Fang, L., Trigiante, G., Crespo-Otero, R., Hawes, C. S., Philpott, M. P., Jones, C. R., & Watkinson, M. (2019). Endoplasmic reticulum targeting fluorescent probes to image mobile Zn2+. Chemical Science, 10(47), 10881-10887. https://doi.org/10.1039/C9SC04300D

Zn2+ plays an important role in the normal function of the endoplasmic reticulum (ER) and its deficiency can cause ER stress, which is related to a wide range of diseases. In order to provide tools to better understand the role of mobile Zn2+ in ER p... Read More about Endoplasmic reticulum targeting fluorescent probes to image mobile Zn2+.

An alternative modular 'click-SNAr-click' approach to develop subcellular localised fluorescent probes to image mobile Zn2+ (2019)
Journal Article
Watkinson, M., Fang, L., Trigiante, G., Crespo-Otero, R., Philpott, M. P., & Jones, C. R. (2019). An alternative modular 'click-SNAr-click' approach to develop subcellular localised fluorescent probes to image mobile Zn2+. Organic and Biomolecular Chemistry, 17(47), 10013-10019. https://doi.org/10.1039/c9ob01855g

Zn2+ is involved in a number of biological processes and its wide-ranging roles at the subcellular level, especially in specific organelles, have not yet been fully established due to a lack of tools to image it effectively. We report a new and effic... Read More about An alternative modular 'click-SNAr-click' approach to develop subcellular localised fluorescent probes to image mobile Zn2+.

Peptide Cross-Linked Poly(2-oxazoline) as a Sensor Material for the Detection of Proteases with a Quartz Crystal Microbalance (2019)
Journal Article
Watkinson. (2019). Peptide Cross-Linked Poly(2-oxazoline) as a Sensor Material for the Detection of Proteases with a Quartz Crystal Microbalance. Biomacromolecules, 2506-2514. https://doi.org/10.1021/acs.biomac.9b00245

Inflammatory conditions are frequently accompanied by increased levels of active proteases, and there is rising interest in methods for their detection to monitor inflammation in a point of care setting. In this work, new sensor materials for disposa... Read More about Peptide Cross-Linked Poly(2-oxazoline) as a Sensor Material for the Detection of Proteases with a Quartz Crystal Microbalance.