Skip to main content

Research Repository

Advanced Search

Outputs (1202)

Semiochemical mediated oviposition and mating in Phlebotomus argentipes (Diptera: Psychodidae) sand flies
Thesis
Yaman, K. (2016). Semiochemical mediated oviposition and mating in Phlebotomus argentipes (Diptera: Psychodidae) sand flies

Phlebotomus argentipes (Diptera: Psychodidae) is an important vector responsible for the transmission of Leishmania donovani that causes visceral leishmaniasis (VL) or kala-azar, in the sub-continent of India. The aims of this study were to investiga... Read More about Semiochemical mediated oviposition and mating in Phlebotomus argentipes (Diptera: Psychodidae) sand flies.

A spatial and temporal analysis of Plasmodium falciparum transcription
Thesis
Russell, K. (2014). A spatial and temporal analysis of Plasmodium falciparum transcription

Developmentally-linked gene expression is critical to the success of the human malaria parasite Plasmodium alciparum in ensuring colonisation, adaptation, replication and transmission during its complex life cycle as well as the manifestation of dise... Read More about A spatial and temporal analysis of Plasmodium falciparum transcription.

Structural studies of surfactant protein D in complex with bacterial lipopolysaccharide ligands
Thesis
bacterial lipopolysaccharide ligands

This work is focused on the recognition of natural lipopolysaccharide (LPS) by the innate immune protein human lung surfactant protein D (hSP-D) in the form of a biologically active recombinant fragment (rfhSP-D), containing the a-helical coiled-coil... Read More about Structural studies of surfactant protein D in complex with bacterial lipopolysaccharide ligands.

Aedes aegyptigut transcriptomes respond differently to microbiome transplants from field-caught or laboratory-reared mosquitoes
Journal Article
Hegde, S., Brettell, L. E., Quek, S., Etebari, K., Saldaña, M. A., Asgari, S., …Hughes, G. L. Aedes aegyptigut transcriptomes respond differently to microbiome transplants from field-caught or laboratory-reared mosquitoes. arXiv, https://doi.org/10.1101/2023.03.16.532926

The mosquito microbiome is critical for host development and plays a major role in many aspects of mosquito biology. While the microbiome is commonly dominated by a small number of genera, there is considerable variation in composition among mosquito... Read More about Aedes aegyptigut transcriptomes respond differently to microbiome transplants from field-caught or laboratory-reared mosquitoes.

Inter-species microbiota transplantation recapitulates microbial acquisition and persistence in mosquitoes
Journal Article
Coon, K. L., Hegde, S., & Hughes, G. L. Inter-species microbiota transplantation recapitulates microbial acquisition and persistence in mosquitoes. arXiv, https://doi.org/10.1101/2021.10.06.463328

Background Mosquitoes harbor microbial communities that play important roles in their growth, survival, reproduction, and ability to transmit human pathogens. Microbiome transplantation approaches are often used to study host-microbe interactions and... Read More about Inter-species microbiota transplantation recapitulates microbial acquisition and persistence in mosquitoes.

Microbial interactions in the mosquito gut determine Serratia colonization and blood feeding propensity.
Journal Article
Kozlova, E. V., Hegde, S., Roundy, C. M., Golovko, G., A Saldana, M., Hart, C. E., …Hughes, G. L. Microbial interactions in the mosquito gut determine Serratia colonization and blood feeding propensity. arXiv, https://doi.org/10.1101/2020.04.14.039701

How microbe-microbe interactions dictate microbial complexity in the mosquito gut is unclear. Previously we found that Serratia, a gut symbiont that alters vector competence and is being considered for vector control, poorly colonized Aedes aegypti y... Read More about Microbial interactions in the mosquito gut determine Serratia colonization and blood feeding propensity..

Gut-associated bacteria invade the midgut epithelium of Aedes aegypti and stimulate innate immunity and suppress Zika virus infection in cells
Journal Article
Hegde, S., Voronin, D., Casas-Sanchez, A., Saldaña, M. A., Heinz, E., Acosta-Serrano, A., …Hughes, G. L. Gut-associated bacteria invade the midgut epithelium of Aedes aegypti and stimulate innate immunity and suppress Zika virus infection in cells. arXiv, https://doi.org/10.1101/866897

Microbiota within mosquitoes influence nutrition, immunity, fecundity, and the capacity to transmit pathogens. Despite their importance, we have a limited understanding of host-microbiota interactions, especially at the cellular level. It is evident... Read More about Gut-associated bacteria invade the midgut epithelium of Aedes aegypti and stimulate innate immunity and suppress Zika virus infection in cells.