Biotin-tagged fluorescent sensor to visualize 'mobile' Zn2+ in cancer cells

Watkinson

Abstract

A cancer cell-targeting fluorescent sensor has been developed to image mobile Zn2+ by introducing a biotin group. It shows a highly selective response to Zn2+ in vitro, no toxicity in cellulo and images 'mobile' Zn2+ specifically in cancer cells. We believe this probe has the potential to help improve our understanding of the role of Zn2+ in the processes of cancer initiation and development.

Citation

Watkinson. (2018). Biotin-tagged fluorescent sensor to visualize 'mobile' Zn2+ in cancer cells. Chemical Communications, 9619-9266. https://doi.org/10.1039/c8cc05425h

• Acceptance Date: Jul 27, 2018
• Publication Date: Sep 7, 2018
• Journal: Chemical Communications
• Print ISSN: 1359-7345
• Publisher: Royal Society of Chemistry
• Pages: 9619-9266
• DOI: https://doi.org/10.1039/c8cc05425h
• Publisher URL: http://doi.org/10.1039/c8cc05425h