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Markers of dementia-related health in primary care electronic health records.

Campbell, Paul; Rathod-Mistry, Trishna; Marshall, Michelle; Bailey, James; Chew-Graham, Carolyn A.; Croft, Peter; Frisher, Martin; Hayward, Richard; Negi, Rashi; Singh, Swaran; Tantalo-Baker, Shula; Tarafdar, Suhail; Babatunde, Opeyemi O.; Robinson, Louise; Sumathipala, Athula; Thein, Nwe; Walters, Kate; Weich, Scott; Jordan, Kelvin P

Markers of dementia-related health in primary care electronic health records. Thumbnail


Trishna Rathod-Mistry

Peter Croft

Richard Hayward

Rashi Negi

Swaran Singh

Shula Tantalo-Baker

Suhail Tarafdar

Opeyemi O. Babatunde

Louise Robinson

Athula Sumathipala

Nwe Thein

Kate Walters

Scott Weich


Identifying routinely recorded markers of poor health in patients with dementia may help treatment decisions and evaluation of earlier outcomes in research. Our objective was to determine whether a set of credible markers of dementia-related health could be identified from primary care electronic health records (EHR).

The study consisted of (i) rapid review of potential measures of dementia-related health used in EHR studies; (ii) consensus exercise to assess feasibility of identifying these markers in UK primary care EHR; (iii) development of UK EHR code lists for markers; (iv) analysis of a regional primary care EHR database to determine further potential markers; (v) consensus exercise to finalise markers and pool into higher domains; (vi) determination of 12-month prevalence of domains in EHR of 2328 patients with dementia compared to matched patients without dementia.

Sixty-three markers were identified and mapped to 13 domains: Care; Home Pressures; Severe Neuropsychiatric; Neuropsychiatric; Cognitive Function; Daily Functioning; Safety; Comorbidity; Symptoms; Diet/Nutrition; Imaging; Increased Multimorbidity; Change in Dementia Drug. Comorbidity was the most prevalent recorded domain in dementia (69%). Home Pressures was the least prevalent domain (1%). Ten domains had a statistically significant higher prevalence in dementia patients, one (Comorbidity) was higher in nondementia patients, and two (Home Pressures, Diet/Nutrition) showed no association with

EHR captures important markers of dementia-related health. Further research should assess if they indicate dementia progression. These markers could provide the basis for identifying individuals at risk of faster progression and outcome measures for use in research.

Journal Article Type Article
Acceptance Date Jun 7, 2020
Online Publication Date Jun 24, 2020
Publication Date Jun 24, 2020
Publicly Available Date May 26, 2023
Journal Aging and Mental Health
Print ISSN 1360-7863
Publisher Taylor and Francis Group
Peer Reviewed Peer Reviewed
Volume 25
Issue 8
Keywords Dementia, Prognosis, Electronic Health Records, Primary Care, Outcomes
Publisher URL
PMID 32578454


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