Negotiating agency and belonging during the first lockdown of the COVID-19 pandemic: an interview study among older adults in England, UK. (2022)
Journal Article
Wenning, B., Polidano, K., Mallen, C., & Dikomitis, L. (2022). Negotiating agency and belonging during the first lockdown of the COVID-19 pandemic: an interview study among older adults in England, UK. BMJ Open, e060405 - ?. https://doi.org/10.1136/bmjopen-2021-060405

OBJECTIVES: The aim of this study was to explore the agency of older adults and their strategies to restructure ways of being and belonging in a rapidly and radically changed social environment during the UK's first COVID-19 lockdown in Spring 2020.... Read More about Negotiating agency and belonging during the first lockdown of the COVID-19 pandemic: an interview study among older adults in England, UK..

Physoxia alters human mesenchymal stem cell secretome (2021)
Journal Article
(2021). Physoxia alters human mesenchymal stem cell secretome. Journal of Tissue Engineering, https://doi.org/10.1177/20417314211056132

The human mesenchymal stem cell (hMSC) secretome has pleiotropic effects which underpin their therapeutic potential. hMSC serum-free conditioned media (SFCM) has been determined to contain a variety of cytokines with roles in regeneration and suppres... Read More about Physoxia alters human mesenchymal stem cell secretome.

Synthetic biology open language visual (SBOL visual) version 3.0. (2021)
Journal Article
Baig, H., Myers, C., McLaughlin, J., Scott-Brown, J., Vaidyanathan, P., Gorochowski, T., …Fontanarossa, P. (2021). Synthetic biology open language visual (SBOL visual) version 3.0. Journal of Integrative Bioinformatics, https://doi.org/10.1515/jib-2021-0013

People who engineer biological organisms often find it useful to draw diagrams in order to communicate both the structure of the nucleic acid sequences that they are engineering and the functional relationships between sequence features and other mol... Read More about Synthetic biology open language visual (SBOL visual) version 3.0..

Does pre-existing morbidity influences risks and benefits of total hip replacement for osteoarthritis: a prospective study of 6682 patients from linked national datasets in England (2021)
Journal Article
Ferguson, R., Prieto-Alhambra, D., Peat, G., Delmestri, A., P Jordan, K., Y Strauss, V., …Silman, A. (2021). Does pre-existing morbidity influences risks and benefits of total hip replacement for osteoarthritis: a prospective study of 6682 patients from linked national datasets in England. BMJ Open, e046712 - ?. https://doi.org/10.1136/bmjopen-2020-046712

Total hip arthroplasty (THA) surgery for elderly people with multimorbidity increases the risk of serious health hazards including mortality. Whether such background morbidity reduces the clinical benefit is less clear. OBJECTIVE: To evaluate how pre... Read More about Does pre-existing morbidity influences risks and benefits of total hip replacement for osteoarthritis: a prospective study of 6682 patients from linked national datasets in England.

Glossary of methods and terms used in analytical spectroscopy (IUPAC Recommendations 2019) (2021)
Journal Article
Goenaga Infante, H., Warren, J., Chalmers, J., Dent, G., Todoli, J. L., Collingwood, J., …Craston, D. (2021). Glossary of methods and terms used in analytical spectroscopy (IUPAC Recommendations 2019). Pure and Applied Chemistry, 93(6), 647 - 776. https://doi.org/10.1515/pac-2019-0203

Recommendations are given concerning the terminology of concepts and methods used in spectroscopy in analytical chemistry, covering nuclear magnetic resonance spectroscopy, atomic spectroscopy, and vibrational spectroscopy.

Comparing the supine and erect pelvis radiographic examinations: an evaluation of anatomy, image quality and radiation dose. (2021)
Journal Article
(2021). Comparing the supine and erect pelvis radiographic examinations: an evaluation of anatomy, image quality and radiation dose. British Journal of Radiology, 1- 9

OBJECTIVES: Pelvis radiographs are usually acquired supine despite standing imaging reflecting functional anatomy. We compared the supine and erect radiographic examinations for anatomical features, radiation dose and image quality. METHODS: Sixty pa... Read More about Comparing the supine and erect pelvis radiographic examinations: an evaluation of anatomy, image quality and radiation dose..

International perspectives on radiography practice education (2021)
Journal Article
(2021). International perspectives on radiography practice education. Radiography, 1044-1051. https://doi.org/10.1016/j.radi.2021.04.004

Introduction
The radiography profession is built upon strong educational foundations which help ensure graduate radiographers have the required knowledge, skills, and competence to practise safely and effectively. Changing clinical practices, servic... Read More about International perspectives on radiography practice education.

How to Improve Information Technology to Support Healthcare to address the COVID-19 Pandemic: an International Survey with Health Informatics Experts (2021)
Journal Article
(2021). How to Improve Information Technology to Support Healthcare to address the COVID-19 Pandemic: an International Survey with Health Informatics Experts. IMIA Yearbook of Medical Informatics, https://doi.org/10.1055/s-0041-1726491

Objectives: To identify the ways in which healthcare information and communication technologies can be improved to address the challenges raised by the COVID-19 pandemic.

Methods: The study population included health informatics experts who had be... Read More about How to Improve Information Technology to Support Healthcare to address the COVID-19 Pandemic: an International Survey with Health Informatics Experts.

Impact of changes to national guidelines on hypertension-related workload: an interrupted time series analysis in English primary care. (2021)
Journal Article
Mallen. (2021). Impact of changes to national guidelines on hypertension-related workload: an interrupted time series analysis in English primary care. British Journal of General Practice (BJGP), e296-e302. https://doi.org/10.3399/bjgp21X714281

BACKGROUND: In 2011, National Institute for Health and Care Excellence (NICE) guidelines recommended the routine use of out-of-office blood pressure (BP) monitoring for the diagnosis of hypertension. These changes were predicted to reduce unnecessary... Read More about Impact of changes to national guidelines on hypertension-related workload: an interrupted time series analysis in English primary care..

Developing a model Fracture Liaison Service consultation with patients, carers and clinicians: a Delphi survey to inform content of the iFraP complex consultation intervention. (2021)
Journal Article
Bullock, L., Crawford-Manning, F., Cottrell, E., Fleming, J., Leyland, S., Edwards, J., …Paskins, Z. (2021). Developing a model Fracture Liaison Service consultation with patients, carers and clinicians: a Delphi survey to inform content of the iFraP complex consultation intervention. Archives of Osteoporosis, 16, 1- 17. https://doi.org/10.1007/s11657-021-00913-w

Fracture Liaison Services are recommended to deliver best practice in secondary fracture prevention. This modified Delphi survey, as part of the iFraP (Improving uptake of Fracture Prevention drug Treatments) study, provides consensus regarding tasks... Read More about Developing a model Fracture Liaison Service consultation with patients, carers and clinicians: a Delphi survey to inform content of the iFraP complex consultation intervention..

Sex Differences in Ischemic Stroke Outcomes in Patients With Pulmonary Hypertension. (2021)
Journal Article
Mamas. (2021). Sex Differences in Ischemic Stroke Outcomes in Patients With Pulmonary Hypertension. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, e019341 - ?. https://doi.org/10.1161/JAHA.120.019341

Background The association between systemic hypertension and cerebrovascular disease is well documented. However, the impact of pulmonary hypertension (PH) on acute ischemic stroke outcomes is unknown despite PH being recognized as a risk factor for... Read More about Sex Differences in Ischemic Stroke Outcomes in Patients With Pulmonary Hypertension..

Pre-therapeutic efficacy of the CDK inhibitor dinaciclib in medulloblastoma cells (2021)
Journal Article
Buzzetti, M., Morlando, S., Solomos, D., Mehmood, A., Cox, A. W., Chiesa, M., …Di Leva, G. (2021). Pre-therapeutic efficacy of the CDK inhibitor dinaciclib in medulloblastoma cells. Scientific reports, 11, Article 5374. https://doi.org/10.1038/s41598-021-84082-3

Medulloblastoma (MB) is the most common aggressive paediatric brain tumour and, despite the recent progress in the treatments of MB patients, there is still an urgent need of complementary or alternative therapeutic options for MB infants. Cyclin Dep... Read More about Pre-therapeutic efficacy of the CDK inhibitor dinaciclib in medulloblastoma cells.

Place and Underlying Cause of Death During the COVID-19 Pandemic: Retrospective Cohort Study of 3.5 Million Deaths in England and Wales, 2014 to 2020 (2021)
Journal Article
Wu, J., Mafham, M., Mamas, M. A., Rashid, M., Kontopantelis, E., Dean, J. E., …Gale, C. P. (2021). Place and Underlying Cause of Death During the COVID-19 Pandemic: Retrospective Cohort Study of 3.5 Million Deaths in England and Wales, 2014 to 2020. Mayo Clinic Proceedings, 96(4), 952 - 963. https://doi.org/10.1016/j.mayocp.2021.02.007

OBJECTIVE: To describe the place and cause of death during the coronavirus disease 2019 (COVID-19) pandemic to assess its impact on excess mortality.

METHODS: This national death registry included all adult (aged =18 years) deaths in England and... Read More about Place and Underlying Cause of Death During the COVID-19 Pandemic: Retrospective Cohort Study of 3.5 Million Deaths in England and Wales, 2014 to 2020.

Quantitative measurement of mechanical properties in wound healing processes in a corneal stroma model by using vibrational optical coherence elastography (OCE) (2021)
Journal Article
Yang. (2021). Quantitative measurement of mechanical properties in wound healing processes in a corneal stroma model by using vibrational optical coherence elastography (OCE). Biomedical Optics Express, 588 - 603. https://doi.org/10.1364/BOE.404096

Corneal wound healing, caused by frequent traumatic injury to the cornea and increasing numbers of refractive surgeries, has become a vital clinical problem. In the cornea, wound healing is an extremely complicated process. However, little is known a... Read More about Quantitative measurement of mechanical properties in wound healing processes in a corneal stroma model by using vibrational optical coherence elastography (OCE).

Compassion fatigue and the effectiveness of support structures for diagnostic radiographers in oncology. (2020)
Journal Article
(2020). Compassion fatigue and the effectiveness of support structures for diagnostic radiographers in oncology. Journal of Medical Imaging and Radiation Sciences, 22-28. https://doi.org/10.1016/j.jmir.2020.11.008

INTRODUCTION: Diagnostic radiographers working in oncology will have frequent contact with the same patients over a prolonged period. This can be mentally exhausting for the radiographer. Compassion fatigue (CF) occurs after repeated exposure to stre... Read More about Compassion fatigue and the effectiveness of support structures for diagnostic radiographers in oncology..

characterizing ischaemic tolerance in rat pheochromocytoma (PC12) cells and primary rat neurons (2020)
Journal Article
Singh, A., Chow, O., Jenkins, S., Zhu, L., Rose, E., Astbury, K., & Chen, R. (2021). characterizing ischaemic tolerance in rat pheochromocytoma (PC12) cells and primary rat neurons. Neuroscience, 453, Article 17-31. https://doi.org/10.1016/j.neuroscience.2020.11.008

Preconditioning tissue with sublethal ischaemia or hypoxia can confer tolerance (protection) against subsequent ischaemic challenge. In vitro ischaemic preconditioning (IPC) is typically achieved through oxygen glucose deprivation (OGD), whereas hypo... Read More about characterizing ischaemic tolerance in rat pheochromocytoma (PC12) cells and primary rat neurons.

Is it time for biocatalysis in fragment-based drug discovery? (2020)
Journal Article
Cosgrove. (2020). Is it time for biocatalysis in fragment-based drug discovery?. Chemical Science, 11104 - 11112. https://doi.org/10.1039/D0SC04103C

The use of biocatalysts for fragment-based drug discovery has yet to be fully investigated, despite the promise enzymes hold for the synthesis of poly-functional, non-protected small molecules. Here we analyze products of the biocatalysis literature... Read More about Is it time for biocatalysis in fragment-based drug discovery?.

Age-related changes in the biophysical and morphological characteristics of mouse cochlear outer hair cells. (2020)
Journal Article
(2020). Age-related changes in the biophysical and morphological characteristics of mouse cochlear outer hair cells. Journal of Physiology, 3891 - 3910. https://doi.org/10.1113/JP279795

KEY POINTS: Age-related hearing loss (ARHL) is a very heterogeneous disease, resulting from cellular senescence, genetic predisposition and environmental factors (e.g. noise exposure). Currently, we know very little about age-related changes occurrin... Read More about Age-related changes in the biophysical and morphological characteristics of mouse cochlear outer hair cells..

Wearable epilepsy seizure monitor user interface evaluation (2020)
Conference Proceeding
Rukasha, T., Woolley, S. I., & Collins, T. (in press). Wearable epilepsy seizure monitor user interface evaluation. . https://doi.org/10.1145/3410530.3414382

Wearable health devices have the potential to incentivize individuals in health-promoting behaviors and to assist in the monitoring of health conditions. Wearable epilepsy seizure monitoring devices are now evolving that can support individuals and t... Read More about Wearable epilepsy seizure monitor user interface evaluation.

Mechanical thrombectomy: can it be safely delivered out of hours in the UK? (2020)
Journal Article
Weddell, J., Parr, E., Knight, S., Muddegowda, G., Natarajan, I., Chembala, J., …Roffe, C. (2020). Mechanical thrombectomy: can it be safely delivered out of hours in the UK?. BMC Neurology, 20, Article 326. https://doi.org/10.1186/s12883-020-01909-8

BACKGROUND: Mechanical thrombectomy was approved by NICE as a treatment for stroke in 2016. However, most of the evidence is from studies conducted during working hours. Only few centres in the UK perform thrombectomies out-of-hours. The Royal Stoke... Read More about Mechanical thrombectomy: can it be safely delivered out of hours in the UK?.