Synthesis and biological evaluation of 3-(4-chlorophenyl)-4-substituted pyrazole derivatives

Horrocks, P.; Pickard, M. R.; Parekh, H. H.; Patel, S. P.; Pathak, Ravindra B.

Abstract

3-(4-Chlorophenyl)-4-substituted pyrazole derivatives were synthesised and tested for their in vitro antifungal activity. Some compounds showed very good antifungal activity against four pathogenic strains of fungi. The same compounds exhibited an interesting activity against the tested strain of Mycobacterium tuberculosis H37Rv. The results suggest that 1,3,4-oxadiazoles and 5-pyrazolinones bearing a core pyrazole scaffold may be promising antifungal and antitubercular agents.

Citation

Horrocks, P., Pickard, M. R., Parekh, H. H., Patel, S. P., & Pathak, R. B. (2013). Synthesis and biological evaluation of 3-(4-chlorophenyl)-4-substituted pyrazole derivatives. Organic and Biomolecular Chemistry, 11(29), 4891. https://doi.org/10.1039/c3ob27290g

• Journal Article Type: Article
• Acceptance Date: May 31, 2013
• Online Publication Date: Jun 12, 2013
• Publication Date: 2013
• Deposit Date: Nov 30, 2023
• Journal: Organic & Biomolecular Chemistry
• Print ISSN: 1477-0520
• Electronic ISSN: 1477-0539
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 11
• Issue: 29
• Pages: 4891
• DOI: https://doi.org/10.1039/c3ob27290g
• Keywords: Organic Chemistry; Physical and Theoretical Chemistry; Biochemistry
• Public URL: https://keele-repository.worktribe.com/output/653747
• Publisher URL: https://pubs.rsc.org/en/content/articlelanding/2013/ob/c3ob27290g