Skip to main content

Research Repository

Advanced Search

Corticosteroids delay remyelination of experimental demyelination in the rodent central nervous system

Chari, Divya M.; Zhao, Chao; Kotter, Mark R.; Blakemore, William F.; Franklin, Robin J.M.


Chao Zhao

Mark R. Kotter

William F. Blakemore

Robin J.M. Franklin


High dose corticosteroid (CS) administration is a common mode of therapy in treatment of acute relapses in multiple sclerosis (MS) but the effects of CS on remyelination and the cellular mechanisms mediating this repair process are controversial. We have examined CS effects on repair of toxin-induced demyelinating lesions in the adult rat spinal cord. Corticosteroids reduced the extent of oligodendrocyte remyelination at 1 month post lesion (whereas Schwann-cell mediated repair was unaffected). However, CS did not cause permanent impairment of remyelination as lesions were fully remyelinated at 2 months after cessation of treatment. The delay in oligodendrocyte mediated repair could be attributed to inhibition of differentiation of oligodendrocyte progenitor cells (OPCs) into oligodendrocytes, with no effect of CS treatment observed on OPC colonisation of the lesions. No differences were observed in animals treated with methylprednisolone succinate alone or with a subsequent prednisone taper indicating that CS effects occur at an early stage of repair. The potential consequences of delayed remyelination in inflammatory lesions are discussed. © 2006 Wiley-Liss, Inc.


Chari, D. M., Zhao, C., Kotter, M. R., Blakemore, W. F., & Franklin, R. J. (2006). Corticosteroids delay remyelination of experimental demyelination in the rodent central nervous system. Journal of Neuroscience Research, 83(4), 594-605.

Journal Article Type Article
Online Publication Date Jan 20, 2006
Publication Date 2006-03
Deposit Date Jun 11, 2024
Journal Journal of Neuroscience Research
Print ISSN 0360-4012
Electronic ISSN 1097-4547
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 83
Issue 4
Pages 594-605
Public URL