Effect of application of gamma amino butyric acid at the medial preoptic area on sleep-wakefulness

Chari, Divya Maitreya; Ramesh, Vijay; John, Joshi; Mohan Kumar, Velayudhan

Abstract

Abstract: Intracerebral microinjections of gamma amino butyric acid were Given bilaterally at the medial preoptic area (mPOA) to determine the possible role of this neurotran mitter in the genesis and regulation of leep-wakefulness. GABA (50 Ilg/0.2 Ill) when administered through chronically implanted cannulae in free moving rats, did not produce any significant alterations in sleepwakefulness. This may be attributed either to the non-involvement of GABA at the level of mPOA in the regulation of sleep, or to other factors like the low dose and rapid breakdown of the injected drug.

Citation

Chari, D. M., Ramesh, V., John, J., & Mohan Kumar, V. (1995). Effect of application of gamma amino butyric acid at the medial preoptic area on sleep-wakefulness. Indian Journal of Physiology and Pharmacology, 39(3),

• Journal Article Type: Article
• Publication Date: 1995-07
• Deposit Date: Jun 11, 2024
• Journal: Indian Journal of Physiology and Pharmacology
• Print ISSN: 0019-5499
• Electronic ISSN: 2582-2799
• Publisher: Scientific Scholar
• Peer Reviewed: Peer Reviewed
• Volume: 39
• Issue: 3
• Public URL: https://keele-repository.worktribe.com/output/849035
• Publisher URL: https://ijpp.com/IJPP%20archives/1995_39_3/299-301.pdf