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The antiapoptotic RBM5/LUCA-15/H37 gene and its role in apoptosis and human cancer: Research update (2006)
Journal Article
Maarabouni, M. M., & Williams, G. T. (2006). The antiapoptotic RBM5/LUCA-15/H37 gene and its role in apoptosis and human cancer: Research update. Scientific World Journal, 1705 - 1712. https://doi.org/10.1100/tsw.2006.268

The candidate tumour-suppressor gene, LUCA-15/RBM5/H37, maps to the lung cancer tumour-suppressor locus 3p21.3. The LUCA-15 gene locus encodes at least four alternatively spliced transcripts that have been shown to function as regulators of apoptosis... Read More about The antiapoptotic RBM5/LUCA-15/H37 gene and its role in apoptosis and human cancer: Research update.

Candidate tumor suppressor LUCA-15/RBM5/H37 modulates expression of apoptosis and cell cycle genes (2006)
Journal Article
Mourtada-Maarabouni, M., Keen, J., Clark, J., Cooper, C. S., & Williams, G. T. (2006). Candidate tumor suppressor LUCA-15/RBM5/H37 modulates expression of apoptosis and cell cycle genes. Experimental Cell Research, 312(10), 1745-1752. https://doi.org/10.1016/j.yexcr.2006.02.009

RBM5 (RNA-binding motif protein 5/LUCA-15/H37) is encoded at the lung cancer tumor suppressor locus 3p21.3 and itself has several important characteristics of a tumor suppressor, including both potentiation of apoptosis and inhibition of the cell cyc... Read More about Candidate tumor suppressor LUCA-15/RBM5/H37 modulates expression of apoptosis and cell cycle genes.

Functional expression cloning reveals a central role for the receptor for activated protein kinase C 1 (RACK1) in T cell apoptosis (2005)
Journal Article
Mourtada-Maarabouni, M., Kirkham, L., Farzaneh, F., & Williams, G. T. (2005). Functional expression cloning reveals a central role for the receptor for activated protein kinase C 1 (RACK1) in T cell apoptosis. Journal of Leukocyte Biology, 78(2), 503–514. https://doi.org/10.1189/jlb.0205070

Mammalian cDNA expression cloning was used to identify novel genes that regulate apoptosis. Using a functional screen, we identified a partial cDNA for the receptor for activated protein kinase C 1 (RACK1) through selection for resistance to phytohem... Read More about Functional expression cloning reveals a central role for the receptor for activated protein kinase C 1 (RACK1) in T cell apoptosis.

Regulation of apoptosis by fau revealed by functional expression cloning and antisense expression (2004)
Journal Article
Mourtada-Maarabouni, M., Kirkham, L., Farzaneh, F., & Williams, G. T. (2004). Regulation of apoptosis by fau revealed by functional expression cloning and antisense expression. Oncogene, 23, 9419–9426. https://doi.org/10.1038/sj.onc.1208048

Functional expression cloning is a powerful strategy for identifying critical steps in biological pathways independently of prior assumptions. It is particularly suitable for the identification of molecules crucial to the control of apoptosis. Our sc... Read More about Regulation of apoptosis by fau revealed by functional expression cloning and antisense expression.

Isolation and characterization of a novel pituitary tumor apoptosis gene (2004)
Journal Article
Bahar, A., Simpson, D. J., Cutty, S. J., Bicknell, J. E., Hoban, P. R., Holley, S., Mourtada-Maarabouni, M., Williams, G. T., Clayton, R. N., & Farrell, W. E. (2004). Isolation and characterization of a novel pituitary tumor apoptosis gene. Molecular Endocrinology, 18(7), https://doi.org/10.1210/me.2004-0087

To determine mechanisms for pituitary neoplasia we used methylation-sensitive arbitrarily primed-PCR to isolate novel genes that are differentially methylated relative to normal pituitary. We report the isolation of a novel differentially methylated... Read More about Isolation and characterization of a novel pituitary tumor apoptosis gene.

Functional expression cloning reveals proapoptotic role for protein phosphatase 4 (2003)
Journal Article
Mourtada-Maarabouni, M., Kirkham, L., Jenkins, B., Rayner, J., Gonda, T. J., Starr, R., Trayner, I., Farzaneh, F., & Williams, G. T. (2003). Functional expression cloning reveals proapoptotic role for protein phosphatase 4. Cell Death and Differentiation, 10, Article 1016–1024. https://doi.org/10.1038/sj.cdd.4401274

Functional expression cloning strategies are highly suitable for the analysis of the molecular control of apoptosis. This approach has two critical advantages. Firstly, it eliminates prior assumptions about the properties of the proteins involved, an... Read More about Functional expression cloning reveals proapoptotic role for protein phosphatase 4.

Effects of the Imidazoline Binding Site Ligands, Idazoxan and Efaroxan, on the Viability of Insulin-Secreting BRIN-BD11 Cells (2003)
Journal Article
Gao, H., Mourtada, M., & Morgan, N. G. (2003). Effects of the Imidazoline Binding Site Ligands, Idazoxan and Efaroxan, on the Viability of Insulin-Secreting BRIN-BD11 Cells. Journal of the Pancreas, 4(3),

Context Certain imidazoline drugs stimulate insulin secretion acutely but their longer term effects on the viability of pancreatic beta-cells are less well characterised. Indeed, some reports have suggested that imidazolines can be toxic to beta-cel... Read More about Effects of the Imidazoline Binding Site Ligands, Idazoxan and Efaroxan, on the Viability of Insulin-Secreting BRIN-BD11 Cells.

Simultaneous acceleration of the cell cycle and suppression of apoptosis by splice variant delta-6 of the candidate tumour suppressor LUCA-15/RBM5 (2003)
Journal Article
Mourtada-Maarabouni, M., Sutherland, L. C., Meredith, J. M., & Williams, G. T. (2003). Simultaneous acceleration of the cell cycle and suppression of apoptosis by splice variant delta-6 of the candidate tumour suppressor LUCA-15/RBM5. Genes to Cells, 8(2), 109-119. https://doi.org/10.1046/j.1365-2443.2003.00619.x

Background: The short arm of chromosome 3 is thought to include one or more tumour suppressor genes (TSGs), since carcinoma of various tissues display deletions in this region. Many genes mapping to this region have recently been identified, includin... Read More about Simultaneous acceleration of the cell cycle and suppression of apoptosis by splice variant delta-6 of the candidate tumour suppressor LUCA-15/RBM5.

Candidate tumour suppressor LUCA-15 can regulate multiple apoptotic pathways (2002)
Journal Article
Mourtada-Maarabouni, M., Sutherland, L., & Williams, G. (2002). Candidate tumour suppressor LUCA-15 can regulate multiple apoptotic pathways. Apoptosis, 7, 421–432. https://doi.org/10.1023/A%3A1020083008017

Functional screening of a human bone marrow cDNA library for suppressors of CD95-mediated apoptosis has led to the identification of a 326 bp fragment (Je2), which not only suppresses CD95-induced apoptosis in Jurkat T-cells, but maps to 3p21.3, to a... Read More about Candidate tumour suppressor LUCA-15 can regulate multiple apoptotic pathways.

RBM5/LUCA-15 — Tumour Suppression by Control of Apoptosis and the Cell Cycle? (2002)
Journal Article
Mourtada-Maarabouni, M., & Williams, G. T. (2002). RBM5/LUCA-15 — Tumour Suppression by Control of Apoptosis and the Cell Cycle?. Scientific World Journal, 2, https://doi.org/10.1100/tsw.2002.859

The candidate tumour suppressor gene, LUCA-15, maps to the lung cancer tumour suppressor locus 3p21.3. The LUCA-15 gene locus encodes at least four alternatively spliced transcripts, which have been shown to function as regulators of apoptosis, a fac... Read More about RBM5/LUCA-15 — Tumour Suppression by Control of Apoptosis and the Cell Cycle?.

Characterization of a K<inf>ATP</inf> channel-independent pathway involved in potentiation of insulin secretion by efaroxan (2001)
Journal Article
Chan, S. L., Mourtada, M., & Morgan, N. G. (2001). Characterization of a KATP channel-independent pathway involved in potentiation of insulin secretion by efaroxan. Diabetes, 50(2), 340–347. https://doi.org/10.2337/diabetes.50.2.340

Efaroxan, like several other imidazoline reagents, elicits a glucose-dependent increase in insulin secretion from pancreatic β-cells. This response has been attributed to efaroxan-mediated blockade of KATP channels, with the subsequent gating of volt... Read More about Characterization of a K<inf>ATP</inf> channel-independent pathway involved in potentiation of insulin secretion by efaroxan.

Imidazoline compounds protect against interleukin 1beta-induced beta-cell apoptosis. (2001)
Journal Article
Zaitsev, S. V., Appelskog, I. B., Kapelioukh, I. L., Yang, S. N., Köhler, M., Efendic, S., Berggren, P. O., & Maarabouni, M. (2001). Imidazoline compounds protect against interleukin 1beta-induced beta-cell apoptosis. Diabetes, 50(suppl_1), Article S70. https://doi.org/10.2337/diabetes.50.2007.s70

Imidazoline compounds have been considered for the treatment of type 2 diabetes. We have now investigated the effects of imidazolines on interleukin (IL)-1beta-induced beta-cell apoptosis and the signal transduction pathways involved. Inhibition of C... Read More about Imidazoline compounds protect against interleukin 1beta-induced beta-cell apoptosis..

Effects of imidazoline binding site ligands on the growth and viability of clonal pancreatic β-cells (2000)
Journal Article
Mourtada, M., Elliott, J., Smith, S., & Morgan, N. (2000). Effects of imidazoline binding site ligands on the growth and viability of clonal pancreatic β-cells. Naunyn-Schmiedeberg's Archives of Pharmacology, 361, 146–154. https://doi.org/10.1007/s002109900158

Pancreatic β-cells express imidazoline binding sites which play a role in the regulation of insulin secretion, but it is not known whether ligands for these sites also affect other aspects of β-cell physiology. In the present study, we have investiga... Read More about Effects of imidazoline binding site ligands on the growth and viability of clonal pancreatic β-cells.

Imidazolines and pancreatic hormone secretion (1999)
Journal Article
MORGAN, N. G., CHAN, S. L., MOURTADA, M., MONKS, L. K., & RAMSDEN, C. A. (1999). Imidazolines and pancreatic hormone secretion. Annals of the New York Academy of Sciences, 881(1), 217-228. https://doi.org/10.1111/j.1749-6632.1999.tb09364.x

A range of imidazoline derivatives are known to be effective stimulators of insulin secretion, and this response correlates with closure of ATP-sensitive potassium channels in the pancreatic β-cell. However, mounting evidence indicates that potassium... Read More about Imidazolines and pancreatic hormone secretion.

Effector systems involved in the insulin secretory responses to efaroxan and RX871024 in rat islets of Langerhans (1998)
Journal Article
Mourtada, M., Smith, S. A., & Morgan, N. G. (1998). Effector systems involved in the insulin secretory responses to efaroxan and RX871024 in rat islets of Langerhans. European Journal of Pharmacology, 350(2-3), 251-258. https://doi.org/10.1016/S0014-2999%2898%2900245-3

One component of the mechanism by which imidazoline compounds promote insulin secretion involves closure of ATP-sensitive K+ channels in the β-cell plasma membrane. Recently, however, it has also been proposed that these compounds may exert important... Read More about Effector systems involved in the insulin secretory responses to efaroxan and RX871024 in rat islets of Langerhans.

Insulin secretagogues with an imidazoline structure inhibit arginine-induced glucagon secretion from isolated rat islets of langerhans (1997)
Journal Article
Mourtada, M., Smith, S. A., & Morgan, N. G. (1997). Insulin secretagogues with an imidazoline structure inhibit arginine-induced glucagon secretion from isolated rat islets of langerhans. Biochemical and Biophysical Research Communications, 236(1), 162-166. https://doi.org/10.1006/bbrc.1997.6922

It is well documented that imidazoline compounds such as efaroxan and phentolamine act as potent insulin secretagogues bothin vivoandin vitro,an effect which is mediated principally by blockade of ATP-sensitive potassium channels in the pancreatic B-... Read More about Insulin secretagogues with an imidazoline structure inhibit arginine-induced glucagon secretion from isolated rat islets of langerhans.