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All Outputs (101)

Research Progress of Antimicrobial Peptides in the Field of Marine Antifouling (2022)
Journal Article
Lou, T., Bai, X., He, X., Yang, Y., Yang, Z., & Yuan, C. (2022). Research Progress of Antimicrobial Peptides in the Field of Marine Antifouling. China Surface Engineering, 35(2), 1-11. https://doi.org/10.11933/j.issn.1007-9289.20210611001

Marine biofouling is still a problem that needs to be urgently solved. However, comprehensive studies and reports on the research progress of antimicrobial peptides in the field of marine antifouling remain scant. Three types of antimicrobial peptide... Read More about Research Progress of Antimicrobial Peptides in the Field of Marine Antifouling.

Return to Sport After Total Shoulder Arthroplasty and Hemiarthroplasty: A Systematic Review (2022)
Journal Article
Franceschetti, E., Gregori, P., Giovannetti de Sanctis, E., Palumbo, A., Paciotti, M., Maffulli, N., & Franceschi, F. (in press). Return to Sport After Total Shoulder Arthroplasty and Hemiarthroplasty: A Systematic Review. Sports Medicine and Arthroscopy Review, 31(1), 27-32. https://doi.org/10.1097/jsa.0000000000000306

Purpose: One of the most frequent concerns of the increasing number of patients undergoing shoulder arthroplasty is the possibility to resume sport after surgery. This systematic review determined the rate of return to sport after total shoulder arth... Read More about Return to Sport After Total Shoulder Arthroplasty and Hemiarthroplasty: A Systematic Review.

Activin B and Activin C Have Opposing Effects on Prostate Cancer Progression and Cell Growth (2022)
Journal Article
(2022). Activin B and Activin C Have Opposing Effects on Prostate Cancer Progression and Cell Growth. Cancers, 147 - 147. https://doi.org/10.3390/cancers15010147

Current prognostic and diagnostic tests for prostate cancer are not able to accurately distinguish between aggressive and latent cancer. Members of the transforming growth factor-ß (TGFB) family are known to be important in regulating prostate cell g... Read More about Activin B and Activin C Have Opposing Effects on Prostate Cancer Progression and Cell Growth.

Inhibition of branched-chain alpha-keto acid dehydrogenase kinase augments the sensitivity of ovarian and breast cancer cells to paclitaxel (2022)
Journal Article
Ibrahim, S. L., Abed, M. N., Mohamed, G., Price, J. C., Abdullah, M. I., & Richardson, A. (2023). Inhibition of branched-chain alpha-keto acid dehydrogenase kinase augments the sensitivity of ovarian and breast cancer cells to paclitaxel. British Journal of Cancer, 128(5), 896-906. https://doi.org/10.1038/s41416-022-02095-9

Many cancer patients who initially respond to chemotherapy eventually develop chemoresistance, and to address this, we previously conducted a RNAi screen to identify genes contributing to resistance. One of the hits from the screen was branchedcha... Read More about Inhibition of branched-chain alpha-keto acid dehydrogenase kinase augments the sensitivity of ovarian and breast cancer cells to paclitaxel.

Genotype-phenotype correlations in human diseases caused by mutations of LINC complex-associated genes: a systematic review and meta-summary (2022)
Journal Article
Fuller, H., & Storey, E. (2022). Genotype-phenotype correlations in human diseases caused by mutations of LINC complex-associated genes: a systematic review and meta-summary. Cells, https://doi.org/10.3390/cells11244065

Mutations in genes encoding proteins associated with the linker of nucleoskel-eton and cytoskeleton (LINC) complex within the nuclear envelope cause dif-ferent diseases with varying phenotypes including skeletal muscle, cardiac, metabolic, or nervous... Read More about Genotype-phenotype correlations in human diseases caused by mutations of LINC complex-associated genes: a systematic review and meta-summary.

Magnetic activation of TREK1 triggers stress signalling and regulates neuronal branching in SH-SY5Y cells. (2022)
Journal Article
Rotherham, M., Moradi, Y., Nahar, T., Mosses, D., Telling, N., & El Haj, A. (2022). Magnetic activation of TREK1 triggers stress signalling and regulates neuronal branching in SH-SY5Y cells. Frontiers in Medical Technology, 4, Article 981421. https://doi.org/10.3389/fmedt.2022.981421

TWIK-related K+ 1 (TREK1) is a potassium channel expressed in the nervous system with multiple functions including neurotransmission and is a prime pharmacological target for neurological disorders. TREK1 gating is controlled by a wide range of exter... Read More about Magnetic activation of TREK1 triggers stress signalling and regulates neuronal branching in SH-SY5Y cells..

Intrathecal morphine in combination with bupivacaine as pre-emptive analgesia in posterior lumbar fusion surgery: a retrospective cohort study (2022)
Journal Article
Kuiper. (2022). Intrathecal morphine in combination with bupivacaine as pre-emptive analgesia in posterior lumbar fusion surgery: a retrospective cohort study. Journal of Orthopaedic Surgery and Research, https://doi.org/10.1186/s13018-022-03124-2

Abstract Background The purpose of this study was to evaluate the efficacy of intrathecal morphine (ITM) in combination with bupivacaine as pre-emptive analgesia in patients undergoing posterior lumbar fusion surgery. This is in comparison with tradi... Read More about Intrathecal morphine in combination with bupivacaine as pre-emptive analgesia in posterior lumbar fusion surgery: a retrospective cohort study.

Pre-hospital transdermal glyceryl trinitrate in patients with stroke mimics: data from the RIGHT-2 randomised-controlled ambulance trial (2022)
Journal Article
Roffe. (2022). Pre-hospital transdermal glyceryl trinitrate in patients with stroke mimics: data from the RIGHT-2 randomised-controlled ambulance trial. BMC Emergency Medicine, https://doi.org/10.1186/s12873-021-00560-x

Background: Prehospital stroke trials will inevitably recruit patients with non-stroke conditions, so called stroke mimics. We undertook a pre-specified analysis to determine outcomes in patients with mimics in the second Rapid Intervention with Glyc... Read More about Pre-hospital transdermal glyceryl trinitrate in patients with stroke mimics: data from the RIGHT-2 randomised-controlled ambulance trial.

Remote magnetic actuation of cell signalling for tissue engineering (2022)
Journal Article
Rotherham, M., Nahar, T., Broomhall, T., Telling, N., & El Haj, A. (2022). Remote magnetic actuation of cell signalling for tissue engineering. Current Opinion in Biomedical Engineering, 24, Article 100410. https://doi.org/10.1016/j.cobme.2022.100410

Magnetic nanoparticles (MNP) are extremely versatile tools in bioengineering and medicine with diverse uses ranging from magnetic resonance contrast agents to drug delivery vehicles. Recently, MNP have been adapted to target and regulate cell signall... Read More about Remote magnetic actuation of cell signalling for tissue engineering.

An orange will do: Suspending learner disbelief in simulations (2022)
Journal Article
Richardson, C. L., Thompson, J., & Jacklin, S. (2022). An orange will do: Suspending learner disbelief in simulations. Currents in Pharmacy Teaching and Learning, 14(11), 1337-1339. https://doi.org/10.1016/j.cptl.2022.09.016

Increasingly, educators are implementing simulation to supplement teaching. Where simulation is not already integral, difficulties have arisen with the utilization of simulation due to limited resources, training requirements, and educator uncertaint... Read More about An orange will do: Suspending learner disbelief in simulations.

Use of path analysis to predict changes to community pharmacy and GP emergency hormonal contraception (EHC) provision in England (2022)
Journal Article
Thayer, N., White, S., & Frisher, M. (2022). Use of path analysis to predict changes to community pharmacy and GP emergency hormonal contraception (EHC) provision in England. BMJ Open, 12(11), Article e059039. https://doi.org/10.1136/bmjopen-2021-059039

Objectives: In 2014/2015, 46% of community pharmacies were commissioned by local authorities to provide emergency hormonal contraception (EHC) free without prescription in England. Commissioning EHC services influences EHC prescribing from General... Read More about Use of path analysis to predict changes to community pharmacy and GP emergency hormonal contraception (EHC) provision in England.

Knee osteoarthritis, joint laxity and PROMs following conservative management versus surgical reconstruction for ACL rupture: a meta-analysis (2022)
Journal Article
Migliorini, F., Oliva, F., Eschweiler, J., Torsiello, E., Hildebrand, F., & Maffulli, N. (2023). Knee osteoarthritis, joint laxity and PROMs following conservative management versus surgical reconstruction for ACL rupture: a meta-analysis. British Medical Bulletin, 145(1), 72-87. https://doi.org/10.1093/bmb/ldac029

AbstractIntroductionPatients whose rupture of the anterior cruciate ligament (ACL) can be managed conservatively or undergo reconstruction surgery.Source of dataCurrent scientific literature published in Web of Science, PubMed and Scopus.Areas of agr... Read More about Knee osteoarthritis, joint laxity and PROMs following conservative management versus surgical reconstruction for ACL rupture: a meta-analysis.

Ossification of the posterior capitellum: description of a new pathology and its radiological appearance (2022)
Journal Article
Schneider, M. M., Hollinger, B., Zimmerer, A., Nietschke, R., Michaely, H., Migliorini, F., …Burkhart, K. J. (2023). Ossification of the posterior capitellum: description of a new pathology and its radiological appearance. Archives of Orthopaedic and Trauma Surgery, 143(7), 4019-4029. https://doi.org/10.1007/s00402-022-04689-7

Background: Boxer elbow and handball goalkeeper elbow are causes of impingement characterized by osteophytes formation at the olecranon and coronoid tip as well as their corresponding fossae. Herein, we present another distinct pathology in these pat... Read More about Ossification of the posterior capitellum: description of a new pathology and its radiological appearance.

Does femoroacetabular impingement syndrome affect range of motion? A systematic review with meta-analysis (2022)
Journal Article
Albertoni, D. B., Gianola, S., Bargeri, S., Hoxhaj, I., Munari, A., Maffulli, N., & Castellini, G. (2023). Does femoroacetabular impingement syndrome affect range of motion? A systematic review with meta-analysis. British Medical Bulletin, 145(1), 45-59. https://doi.org/10.1093/bmb/ldac027

AbstractBackgroundIt is unclear whether femoroacetabular impingement syndrome (FAIS) affect hip range of motion (ROM).Sources of dataWe performed a systematic review with meta-analysis searching six electronic databases from inception to March 21, 20... Read More about Does femoroacetabular impingement syndrome affect range of motion? A systematic review with meta-analysis.

Chondrocyte Isolation and Expansion (2022)
Book Chapter
Harrison, P., Hopkins, T., Hulme, C., McCarthy, H., & Wright, K. Chondrocyte Isolation and Expansion. In Cartilage Tissue Engineering (9-19). Springer. https://doi.org/10.1007/978-1-0716-2839-3_2

Chondrocyte isolation requires a combination of enzymatic and mechanical digestion of cartilaginous tissues in order to release the chondrocytes. Extracted primary chondrocytes will then adhere to standard tissue culture plastics, typically in small... Read More about Chondrocyte Isolation and Expansion.

Directional control of neurite outgrowth: emerging technologies for Parkinson's disease using magnetic nanoparticles and magnetic field gradients. (2022)
Journal Article
Dhillon, K., Aizel, K., Broomhall, T., Secret, E., Goodman, T., Rotherham, M., …Gates, M. (2022). Directional control of neurite outgrowth: emerging technologies for Parkinson's disease using magnetic nanoparticles and magnetic field gradients. Journal of the Royal Society. Interface, 19(196), https://doi.org/10.1098/rsif.2022.0576

A challenge in current stem cell therapies for Parkinson's disease (PD) is controlling neuronal outgrowth from the substantia nigra towards the targeted area where connectivity is required in the striatum. Here we present progress towards controlling... Read More about Directional control of neurite outgrowth: emerging technologies for Parkinson's disease using magnetic nanoparticles and magnetic field gradients..

Human Mesenchymal Stem Cell Secretome Driven T Cell Immunomodulation Is IL-10 Dependent (2022)
Journal Article
Shephard, M., Merkhan, M., & Forsyth, N. (2022). Human Mesenchymal Stem Cell Secretome Driven T Cell Immunomodulation Is IL-10 Dependent. International Journal of Molecular Sciences, https://doi.org/10.3390/ijms232113596

The Human Mesenchymal Stem Cell (hMSC) secretome has pleiotropic effects underpinning its therapeutic potential. hMSC serum-free conditioned media (SFCM) contains a variety of cytokines, with previous studies linking a changed secretome composition t... Read More about Human Mesenchymal Stem Cell Secretome Driven T Cell Immunomodulation Is IL-10 Dependent.