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Outputs (39)

Genetic Loss of miR-205 Causes Increased Mammary Gland Development (2023)
Journal Article
Cataldo, A., Cheung, D. G., Hagan, J. P., Fassan, M., Sandhu-Deol, S., Croce, C. M., …Iorio, M. V. (in press). Genetic Loss of miR-205 Causes Increased Mammary Gland Development. Non-Coding RNA, 10(1), Article 4. https://doi.org/10.3390/ncrna10010004

MiRNAs play crucial roles in a broad spectrum of biological processes, both physiological and pathological. Different reports implicate miR-205 in the control of breast stem cell properties. Differential miR-205 expression has been observed in differ... Read More about Genetic Loss of miR-205 Causes Increased Mammary Gland Development.

Drug Resistance in Medulloblastoma Is Driven by YB-1, ABCB1 and a Seven-Gene Drug Signature. (2023)
Journal Article
Taylor, L., Wade, P. K., Johnson, J. E., Aldighieri, M., Morlando, S., Di Leva, G., …Coyle, B. (2023). Drug Resistance in Medulloblastoma Is Driven by YB-1, ABCB1 and a Seven-Gene Drug Signature. Cancers, 15(4), Article 1086. https://doi.org/10.3390/cancers15041086

Therapy resistance represents an unmet challenge in the treatment of medulloblastoma. Accordingly, the identification of targets that mark drug-resistant cell populations, or drive the proliferation of resistant cells, may improve treatment strategie... Read More about Drug Resistance in Medulloblastoma Is Driven by YB-1, ABCB1 and a Seven-Gene Drug Signature..

Correction: MiR-34a/c-Dependent PDGFR-a/ß Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer. (2022)
Journal Article
Garofalo, M., Jeon, Y., Nuovo, G. J., Middleton, J., Secchiero, P., Joshi, P., …Croce, C. M. (2022). Correction: MiR-34a/c-Dependent PDGFR-a/ß Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer. PloS one, e0267628 - ?. https://doi.org/10.1371/journal.pone.0267628

[This corrects the article DOI: 10.1371/journal.pone.0067581.].

UC.183, UC.110, and UC.84 Ultra-Conserved RNAs Are Mutually Exclusive with miR-221 and Are Engaged in the Cell Cycle Circuitry in Breast Cancer Cell Lines. (2021)
Journal Article
Corrà, F., Crudele, F., Baldassari, F., Bianchi, N., Galasso, M., Minotti, L., …Volinia, S. (2021). UC.183, UC.110, and UC.84 Ultra-Conserved RNAs Are Mutually Exclusive with miR-221 and Are Engaged in the Cell Cycle Circuitry in Breast Cancer Cell Lines. Genes, 12(12), Article 1978. https://doi.org/10.3390/genes12121978

In the human genome, there are about 600 ultra-conserved regions (UCRs), long DNA sequences extremely conserved in vertebrates. We performed a large-scale study to quantify transcribed UCR (T-UCR) and miRNA levels in over 6000 cancer and normal tissu... Read More about UC.183, UC.110, and UC.84 Ultra-Conserved RNAs Are Mutually Exclusive with miR-221 and Are Engaged in the Cell Cycle Circuitry in Breast Cancer Cell Lines..

A KRAS-responsive long non-coding RNA controls microRNA processing (2021)
Journal Article
Shi, L., Magee, P., Fassan, M., Sahoo, S., Leong, H. S., Lee, D., …Garofalo, M. (2021). A KRAS-responsive long non-coding RNA controls microRNA processing. Nature communications, 12, Article 2038. https://doi.org/10.1038/s41467-021-22337-3

Wild-type KRAS (KRASWT) amplification has been shown to be a secondary means of KRAS activation in cancer and associated with poor survival. Nevertheless, the precise role of KRASWT overexpression in lung cancer progression is largely unexplored. Her... Read More about A KRAS-responsive long non-coding RNA controls microRNA processing.

Pre-therapeutic efficacy of the CDK inhibitor dinaciclib in medulloblastoma cells (2021)
Journal Article
Buzzetti, M., Morlando, S., Solomos, D., Mehmood, A., Cox, A. W., Chiesa, M., …Di Leva, G. (2021). Pre-therapeutic efficacy of the CDK inhibitor dinaciclib in medulloblastoma cells. Scientific reports, 11, Article 5374. https://doi.org/10.1038/s41598-021-84082-3

Medulloblastoma (MB) is the most common aggressive paediatric brain tumour and, despite the recent progress in the treatments of MB patients, there is still an urgent need of complementary or alternative therapeutic options for MB infants. Cyclin Dep... Read More about Pre-therapeutic efficacy of the CDK inhibitor dinaciclib in medulloblastoma cells.

Vulnerability of drug-resistant EML4-ALK rearranged lung cancer to transcriptional inhibition (2020)
Journal Article
Paliouras, A. R., Buzzetti, M., Shi, L., Donaldson, I. J., Magee, P., Sahoo, S., …Garofalo, M. (2020). Vulnerability of drug-resistant EML4-ALK rearranged lung cancer to transcriptional inhibition. EMBO Molecular Medicine, 12(7), Article e11099. https://doi.org/10.15252/emmm.201911099

A subset of lung adenocarcinomas is driven by the EML4-ALK translocation. Even though ALK inhibitors in the clinic lead to excellent initial responses, acquired resistance to these inhibitors due to on-target mutations or parallel pathway alterations... Read More about Vulnerability of drug-resistant EML4-ALK rearranged lung cancer to transcriptional inhibition.

Telomerase inhibition, telomere attrition and proliferation arrest of cancer cells induced by phosphorothioate ASO-NLS conjugates targeting hTERC and siRNAs targeting hTERT (2020)
Journal Article
Diala, I., Shiohama, Y., Fujita, T., Kotake, Y., Demonacos, C., Krstic-Demonacos, M., …Fujii, M. (2020). Telomerase inhibition, telomere attrition and proliferation arrest of cancer cells induced by phosphorothioate ASO-NLS conjugates targeting hTERC and siRNAs targeting hTERT. Nucleosides, Nucleotides and Nucleic Acids, 39(1-3), 407 - 425. https://doi.org/10.1080/15257770.2020.1713357

Telomerase activity has been regarded as a critical step in cellular immortalization and carcinogenesis and because of this, regulation of telomerase represents an attractive target for anti-tumor specific therapeutics. Recently, one avenue of cancer... Read More about Telomerase inhibition, telomere attrition and proliferation arrest of cancer cells induced by phosphorothioate ASO-NLS conjugates targeting hTERC and siRNAs targeting hTERT.

Heterogeneity in Circulating Tumor Cells: The Relevance of the Stem-Cell Subset (2019)
Journal Article
Agnoletto, C., Corrà, F., Minotti, L., Baldassari, F., Crudele, F., Cook, W. J. J., …Volinia, S. (2019). Heterogeneity in Circulating Tumor Cells: The Relevance of the Stem-Cell Subset. Cancers, 11(4), Article 483. https://doi.org/10.3390/cancers11040483

The release of circulating tumor cells (CTCs) into vasculature is an early event in the metastatic process. The analysis of CTCs in patients has recently received widespread attention because of its clinical implications, particularly for precision m... Read More about Heterogeneity in Circulating Tumor Cells: The Relevance of the Stem-Cell Subset.

Circulating Micrornas Predict Survival of Patients with Tumors of Glial Origin (2018)
Journal Article
Di Leva. (2018). Circulating Micrornas Predict Survival of Patients with Tumors of Glial Origin. EBioMedicine, 105 -112. https://doi.org/10.1016/j.ebiom.2018.03.022

The World Health Organization has recently introduced molecular prognostic-diagnostic biomarkers in the classification of Central Nervous System (CNS) tumors. In order to characterize subclasses of tumors that cannot find a precise location in the cu... Read More about Circulating Micrornas Predict Survival of Patients with Tumors of Glial Origin.

Loss of miR-204 expression is a key event in melanoma (2018)
Journal Article
Galasso, M., Morrison, C., Minotti, L., Corrà, F., Zerbinati, C., Agnoletto, C., …Volinia, S. (2018). Loss of miR-204 expression is a key event in melanoma. Molecular cancer, 17, Article 71. https://doi.org/10.1186/s12943-018-0819-8

Cutaneous melanoma (CM) is a malignancy with increasing occurrence. Its microRNA repertoire has been defined in a number studies, leading to candidates for biological and clinical relevance: miR-200a/b/c, miR-203, miR-205, miR-204, miR-211, miR-23b a... Read More about Loss of miR-204 expression is a key event in melanoma.

miRNAs in bone metastasis (2017)
Journal Article
Cheung, D. G., Buzzetti, M., & Di Leva, G. (2017). miRNAs in bone metastasis. Expert Review of Endocrinology and Metabolism, 12(6), 451-461. https://doi.org/10.1080/17446651.2017.1383893

INTRODUCTION: Bone metastasis is one of the most common forms of metastasis from a number of different primary carcinomas. MicroRNAs (miRNAs) are short, endogenous RNAs that negatively regulate gene expression to control essential pathways, including... Read More about miRNAs in bone metastasis.

Deregulation of miRNAs in malignant pleural mesothelioma is associated with prognosis and suggests an alteration of cell metabolism (2017)
Journal Article
De Santi, C., Melaiu, O., Bonotti, A., Cascione, L., Di Leva, G., Foddis, R., …Landi, S. (2017). Deregulation of miRNAs in malignant pleural mesothelioma is associated with prognosis and suggests an alteration of cell metabolism. Scientific reports, 7, Article ARTN 3140. https://doi.org/10.1038/s41598-017-02694-0

Malignant pleural mesothelioma (MPM) is an aggressive human cancer and miRNAs can play a key role for this disease. In order to broaden the knowledge in this field, the miRNA expression was investigated in a large series of MPM to discover new pathwa... Read More about Deregulation of miRNAs in malignant pleural mesothelioma is associated with prognosis and suggests an alteration of cell metabolism.

Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface. (2017)
Journal Article
Tang, H., Leung, L., Saturno, G., Viros, A., Smith, D., Di Leva, G., …Marais, R. (2017). Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface. Nature communications, 8, Article 14909. https://doi.org/10.1038/ncomms14909

Lysyl oxidase (LOX) remodels the tumour microenvironment by cross-linking the extracellular matrix. LOX overexpression is associated with poor cancer outcomes. Here, we find that LOX regulates the epidermal growth factor receptor (EGFR) to drive tumo... Read More about Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface..

miR-9 and miR-200 Regulate PDGFRß-Mediated Endothelial Differentiation of Tumor Cells in Triple-Negative Breast Cancer (2016)
Journal Article
D'Ippolito, E., Plantamura, I., Bongiovanni, L., Casalini, P., Baroni, S., Piovan, C., …Iorio, M. V. (2016). miR-9 and miR-200 Regulate PDGFRß-Mediated Endothelial Differentiation of Tumor Cells in Triple-Negative Breast Cancer. Cancer research, 76(18), 5562 - 5572. https://doi.org/10.1158/0008-5472.CAN-16-0140

Organization of cancer cells into endothelial-like cell-lined structures to support neovascularization and to fuel solid tumors is a hallmark of progression and poor outcome. In triple-negative breast cancer (TNBC), PDGFRß has been identified as a ke... Read More about miR-9 and miR-200 Regulate PDGFRß-Mediated Endothelial Differentiation of Tumor Cells in Triple-Negative Breast Cancer.

miRNA clusters as therapeutic targets for hormone-resistant breast cancer (2015)
Journal Article
Di Leva, G., Cheung, D. G., & Croce, C. M. (2015). miRNA clusters as therapeutic targets for hormone-resistant breast cancer. Expert Review of Endocrinology and Metabolism, 10(6), 607-617. https://doi.org/10.1586/17446651.2015.1099430

MicroRNAs are small non-coding RNAs that typically inhibit the translation and stability of messenger RNAs, controlling genes involved in cellular processes such as inflammation, cell cycle regulation, stress response, differentiation, apoptosis, and... Read More about miRNA clusters as therapeutic targets for hormone-resistant breast cancer.

Repression of Esophageal Neoplasia and Inflammatory Signaling by Anti-miR-31 Delivery In Vivo (2015)
Journal Article
Taccioli, C., Garofalo, M., Chen, H., Jiang, Y., Tagliazucchi, G. M., Di Leva, G., …Fong, L. Y. (2015). Repression of Esophageal Neoplasia and Inflammatory Signaling by Anti-miR-31 Delivery In Vivo. JNCI: Journal of the National Cancer Institute, 107(11), djv220. https://doi.org/10.1093/jnci/djv220

Background: Overexpression of microRNA-31 (miR-31) is implicated in the pathogenesis of esophageal squamous cell carcinoma (ESCC), a deadly disease associated with dietary zinc deficiency. Using a rat model that recapitulates features of human ESCC,... Read More about Repression of Esophageal Neoplasia and Inflammatory Signaling by Anti-miR-31 Delivery In Vivo.

A set of NF-?B-regulated microRNAs induces acquired TRAIL resistance in lung cancer. (2015)
Journal Article
Jeon, Y., Middleton, J., Kim, T., Laganà, A., Piovan, C., Secchiero, P., …Croce, C. M. (2015). A set of NF-?B-regulated microRNAs induces acquired TRAIL resistance in lung cancer. Proceedings of the National Academy of Sciences of the United States of America, 112(26), E3355 - E3364. https://doi.org/10.1073/pnas.1504630112

TRAIL (TNF-related apoptosis-inducing ligand) is a promising anticancer agent that can be potentially used as an alternative or complementary therapy because of its specific antitumor activity. However, TRAIL can also stimulate the proliferation of c... Read More about A set of NF-?B-regulated microRNAs induces acquired TRAIL resistance in lung cancer..

Correction: MiR-34a/c-Dependent PDGFR-α/β Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer (2015)
Journal Article
Garofalo, M., Jeon, Y., Nuovo, G. J., Middleton, J., Secchiero, P., Joshi, P., …Croce, C. M. Correction: MiR-34a/c-Dependent PDGFR-α/β Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer. PloS one, 10(6), e0131729. https://doi.org/10.1371/journal.pone.0131729

After the publication of the article, it was noticed that fragments of text in this article overlap with that from previous publications. The overlap in the text relates to the Introduction, Results and Discussion sections, where sentences were repro... Read More about Correction: MiR-34a/c-Dependent PDGFR-α/β Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer.

Erratum (2014)
Journal Article
Di Leva, G. (2014). Erratum. JNCI: Journal of the National Cancer Institute, 106(11), dju373-dju373. https://doi.org/10.1093/jnci/dju373

This is a correction to: JNCI: Journal of the National Cancer Institute, Volume 106, Issue 12, December 2014, dju324, https://doi.org/10.1093/jnci/dju324 Erratum: “Pluripotent Stem Cell miRNAs and Metastasis in Invasive Breast Cancer,” Stefano Vol... Read More about Erratum.

Pluripotent Stem Cell miRNAs and Metastasis in Invasive Breast Cancer (2014)
Journal Article
Volinia, S., Nuovo, G., Drusco, A., Costinean, S., Abujarour, R., Desponts, C., …Croce, C. M. (2014). Pluripotent Stem Cell miRNAs and Metastasis in Invasive Breast Cancer. JNCI: Journal of the National Cancer Institute, 106(12), https://doi.org/10.1093/jnci/dju324

Background The purpose of this study is to determine whether microRNA for pluripotent stem cells are also expressed in breast cancer and are associated with metastasis and outcome. Methods We studied global microRNA profiles during differentiati... Read More about Pluripotent Stem Cell miRNAs and Metastasis in Invasive Breast Cancer.

Correction for Romano et al., MiR-494 is regulated by ERK1/2 and modulates TRAIL-induced apoptosis in non–small-cell lung cancer through BIM down-regulation (2014)
Journal Article
Romano, G., Acunzo, M., Garofalo, M., Di Leva, G., Cascione, L., Zanca, C., …Croce, C. M. (2014). Correction for Romano et al., MiR-494 is regulated by ERK1/2 and modulates TRAIL-induced apoptosis in non–small-cell lung cancer through BIM down-regulation. Proceedings of the National Academy of Sciences of the United States of America, 111(28), 10389-10389. https://doi.org/10.1073/pnas.1410423111

CELL BIOLOGY Correction for “MiR-494 is regulated by ERK1/2 and modulates TRAIL-induced apoptosis in non–small-cell lung cancer through BIM down-regulation,” by Giulia Romano, Mario Acunzo, Michela Garofalo, Gianpiero Di Leva, Luciano Cascione, Ciro... Read More about Correction for Romano et al., MiR-494 is regulated by ERK1/2 and modulates TRAIL-induced apoptosis in non–small-cell lung cancer through BIM down-regulation.

MicroRNA Profiles Discriminate among Colon Cancer Metastasis (2014)
Journal Article
Drusco, A., Nuovo, G. J., Zanesi, N., Di Leva, G., Pichiorri, F., Volinia, S., …Croce, C. M. (in press). MicroRNA Profiles Discriminate among Colon Cancer Metastasis. PloS one, 9(6), Article e96670. https://doi.org/10.1371/journal.pone.0096670

MicroRNAs are being exploited for diagnosis, prognosis and monitoring of cancer and other diseases. Their high tissue specificity and critical role in oncogenesis provide new biomarkers for the diagnosis and classification of cancer as well as predic... Read More about MicroRNA Profiles Discriminate among Colon Cancer Metastasis.

microRNAs as Anti-Cancer Therapy (2014)
Journal Article
Garofalo, M., Di Leva, G., & Croce, C. (2014). microRNAs as Anti-Cancer Therapy. Current Pharmaceutical Design, 20(33), 5328-5335. https://doi.org/10.2174/1381612820666140128211346

MicroRNAs (miRNAs) are endogenously expressed and evolutionarily conserved small non-coding RNAs, which regulate gene expression. Several studies have shown that they are involved in fundamental biological processes, such as proliferation and apoptos... Read More about microRNAs as Anti-Cancer Therapy.

MicroRNAs in Cancer (2014)
Journal Article
Di Leva, G., Garofalo, M., & Croce, C. M. (2014). MicroRNAs in Cancer. Annual Review of Pathology: Mechanisms of Disease, 9(1), 287-314. https://doi.org/10.1146/annurev-pathol-012513-104715

MicroRNAs (miRNAs) are small noncoding RNAs that typically inhibit the translation and stability of messenger RNAs (mRNAs), controlling genes involved in cellular processes such as inflammation, cell-cycle regulation, stress response, differentiation... Read More about MicroRNAs in Cancer.

Idiopathic pulmonary fibrosis is strongly associated with productive infection by herpesvirus saimiri (2014)
Journal Article
Folcik, V. A., Garofalo, M., Coleman, J., Donegan, J. J., Rabbani, E., Suster, S., …Nuovo, G. J. (2014). Idiopathic pulmonary fibrosis is strongly associated with productive infection by herpesvirus saimiri. Modern Pathology, 27(6), 851-862. https://doi.org/10.1038/modpathol.2013.198

Idiopathic pulmonary fibrosis is a fatal disease without effective therapy or diagnostic test. To investigate a potential role for ?-herpesviruses in this disease, 21 paraffin-embedded lung biopsies from patients diagnosed with idiopathic pulmonary f... Read More about Idiopathic pulmonary fibrosis is strongly associated with productive infection by herpesvirus saimiri.

Abstract A085: miR-222/221 in aggressive breast cancer (2013)
Journal Article
Di Leva, G., Piovan, C., Cheung, D., Briskin, D., Kumar, A., Nuovo, G., …Croce, C. (2013). Abstract A085: miR-222/221 in aggressive breast cancer. Molecular Cancer Research, 11(10_Supplement), A085-A085. https://doi.org/10.1158/1557-3125.advbc-a085

MicroRNAs (miRNAs) are small non coding RNAs that regulate gene expression at post-transcriptional level through translational inhibition and/or degradation of mRNA target genes. Recent evidence points to a widespread role for miRNAs in the initiatio... Read More about Abstract A085: miR-222/221 in aggressive breast cancer.

MiR-34a/c-Dependent PDGFR-a/ß Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer. (2013)
Journal Article
Di Leva, G., Garofalo, M., Jeon, Y., Nuovo, G. J., Middleton, J., Secchiero, P., …Croce, C. M. (2013). MiR-34a/c-Dependent PDGFR-a/ß Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer. PloS one, 8(6), e67581 - ?. https://doi.org/10.1371/journal.pone.0067581

Lung cancer is the leading cause of cancer mortality in the world today. Although some advances in lung cancer therapy have been made, patient survival is still poor. MicroRNAs (miRNAs) can act as oncogenes or tumor-suppressor genes in human malignan... Read More about MiR-34a/c-Dependent PDGFR-a/ß Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer..

The Role of microRNAs in the Tumorigenesis of Ovarian Cancer. (2013)
Journal Article
Di Leva, G., & Croce, C. M. (2013). The Role of microRNAs in the Tumorigenesis of Ovarian Cancer. Frontiers in oncology, 3, 153 - ?. https://doi.org/10.3389/fonc.2013.00153

Epithelial ovarian cancer (EOC) is a complex disease, with multiple histological subtypes recognized. There have been major advances in the understanding of the cellular and molecular biology of this human malignancy, however the survival rate of wom... Read More about The Role of microRNAs in the Tumorigenesis of Ovarian Cancer..

Editorial (2013)
Journal Article
Di Leva, G., & Croce, C. M. (2013). Editorial. Clinical Biochemistry, 46(10-11), 840-841. https://doi.org/10.1016/j.clinbiochem.2013.05.060

After their discovery in mammalians, more than 20,000 publications about microRNAs have been recorded in Pubmed over the last 11 years. Although some aspects of their biology are still unknown and need some clarifications, it is now clear that microR... Read More about Editorial.

Abstract LB-244: MiR-34a/c-dependent PDGFR-α/β reduction inhibits tumorigenesis and sensitizes TRAIL-induced apoptosis in lung cancer. (2013)
Journal Article
Jeon, Y., Nuovo, G. J., Midddleton, J., Joshi, P., Nazaryan, N., Di Leva, G., …Croce, C. M. (2013). Abstract LB-244: MiR-34a/c-dependent PDGFR-α/β reduction inhibits tumorigenesis and sensitizes TRAIL-induced apoptosis in lung cancer. Cancer Research, 73(8_Supplement), LB-244-LB-244. https://doi.org/10.1158/1538-7445.am2013-lb-244

Lung cancer is the most common cause of cancer death worldwide. Despite years of research, the prognosis for patients with lung cancer remains dismal. The most frequent type, non-small cell lung cancer (NSCLC) (85%), shows an overall five year surviv... Read More about Abstract LB-244: MiR-34a/c-dependent PDGFR-α/β reduction inhibits tumorigenesis and sensitizes TRAIL-induced apoptosis in lung cancer..

Abstract LB-241: Silencing of microRNA-31 prevents esophageal neoplasia in zinc deficient rats. (2013)
Journal Article
Taccioli, C., Chen, H., Garofalo, M., Jiang, Y., Di Leva, G., Alder, H., …Fong, L. Y. Y. (2013). Abstract LB-241: Silencing of microRNA-31 prevents esophageal neoplasia in zinc deficient rats. Cancer Research, 73(8_Supplement), LB-241-LB-241. https://doi.org/10.1158/1538-7445.am2013-lb-241

Dietary zinc deficiency (ZD) is implicated in the pathogenesis of human esophageal squamous cell carcinoma (ESCC). microRNA-31 (miR-31) is overexpressed in human ESCC. In the rat a ZD diet promotes esophageal carcinogenesis by inducing cellular proli... Read More about Abstract LB-241: Silencing of microRNA-31 prevents esophageal neoplasia in zinc deficient rats..

Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status. (2013)
Journal Article
Di Leva, G., Piovan, C., Gasparini, P., Ngankeu, A., Taccioli, C., Briskin, D., …Croce, C. M. (2013). Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status. PLOS genetics, 9(3), Article ARTN e1003311. https://doi.org/10.1371/journal.pgen.1003311

MicroRNAs (miRNAs), single-stranded non-coding RNAs, influence myriad biological processes that can contribute to cancer. Although tumor-suppressive and oncogenic functions have been characterized for some miRNAs, the majority of microRNAs have not b... Read More about Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status..

miRNA profiling of cancer (2013)
Journal Article
Di Leva, G., & Croce, C. M. (2013). miRNA profiling of cancer. Current Opinion in Genetics and Development, 23(1), 3-11. https://doi.org/10.1016/j.gde.2013.01.004

A steadily growing number of studies have shown that microRNAs have key roles in the regulation of cellular processes and that their dysregulation is essential to keep the malignant phenotype of cancer cells. The distorted and unique expression profi... Read More about miRNA profiling of cancer.

Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer. (2012)
Journal Article
Di Leva. (2012). Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer. Molecular Oncology, 458 - 472. https://doi.org/10.1016/j.molonc.2012.03.003

An increasing body of evidence highlights an intriguing interaction between microRNAs and transcriptional factors involved in determining cell fate, including the well known "genome guardian" p53. Here we show that miR-205, oncosuppressive microRNA l... Read More about Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer..