Molecularly Defined Glycocalyx Models Reveal AB5 Toxins Recognize Their Target Glycans Superselectively (2025)
Journal Article
Saltor Núñez, L., Kumar, V., Ross, J. F., Dolan, J. P., Srimasorn, S., Zhang, X., Richter, R. P., & Turnbull, W. B. (2025). Molecularly Defined Glycocalyx Models Reveal AB5 Toxins Recognize Their Target Glycans Superselectively. JACS Au, https://doi.org/10.1021/jacsau.5c00305

AB5 toxins are a class of bacterial toxins that recognize cell surface carbohydrates to facilitate their uptake by the target cell. Among them are cholera toxin (CT) from Vibrio cholerae that causes cholera, and Shiga toxin (STx) from Shigella dysent... Read More about Molecularly Defined Glycocalyx Models Reveal AB5 Toxins Recognize Their Target Glycans Superselectively.

A modular, reusable biocatalytic flow system for UDP-GlcNAc production (2025)
Journal Article
Roberts, T. L., Dolan, J. P., Miller, G. J., Lima, M. A. D., & Cosgrove, S. C. (2025). A modular, reusable biocatalytic flow system for UDP-GlcNAc production. Reaction Chemistry and Engineering, https://doi.org/10.1039/d5re00127g

We report here the continuous flow synthesis of a high-value sugar nucleotide. Immobilisation of enzymes onto solid carriers permitted transfer of the biocatalysts into packed bed reactors to realise a continuous biocatalytic platform for the synthes... Read More about A modular, reusable biocatalytic flow system for UDP-GlcNAc production.