A modular, reusable biocatalytic flow system for UDP-GlcNAc production (2025)
Journal Article
Roberts, T. L., Dolan, J. P., Miller, G. J., Lima, M. A. D., & Cosgrove, S. C. (2025). A modular, reusable biocatalytic flow system for UDP-GlcNAc production. Reaction Chemistry and Engineering, https://doi.org/10.1039/d5re00127g

We report here the continuous flow synthesis of a high-value sugar nucleotide. Immobilisation of enzymes onto solid carriers permitted transfer of the biocatalysts into packed bed reactors to realise a continuous biocatalytic platform for the synthes... Read More about A modular, reusable biocatalytic flow system for UDP-GlcNAc production.

Bacterial polysaccharide lyase family 33: Specificity from an evolutionarily conserved binding tunnel (2025)
Journal Article
Loiodice, M., Drula, E., McIver, Z., Antonyuk, S., Baslé, A., Lima, M., Yates, E. A., Byrne, D. P., Coughlan, J., Leech, A., Mesdaghi, S., Rigden, D. J., Drouillard, S., Helbert, W., Henrissat, B., Terrapon, N., Wright, G. S. A., Couturier, M., & Cartmell, A. (2025). Bacterial polysaccharide lyase family 33: Specificity from an evolutionarily conserved binding tunnel. Proceedings of the National Academy of Sciences, 122(7), e2421623122. https://doi.org/10.1073/pnas.2421623122

Acidic glycans are essential for the biology of multicellular eukaryotes. To utilize them, microbial life including symbionts and pathogens has evolved polysaccharide lyases (PL) that cleave their 1,4 glycosidic linkages via a β-elimination mechanism... Read More about Bacterial polysaccharide lyase family 33: Specificity from an evolutionarily conserved binding tunnel.