Integrin adhesome axis inhibits the RPM-1 ubiquitin ligase signaling hub to regulate growth cone and axon development (2024)
Journal Article
Amezquita, J., Desbois, M., Opperman, K. J., Pak, J. S., Christensen, E. L., Nguyen, N. T., Diaz-Garcia, K., Borgen, M. A., & Grill, B. (2024). Integrin adhesome axis inhibits the RPM-1 ubiquitin ligase signaling hub to regulate growth cone and axon development. PLOS genetics, 20(12), Article e1011496. https://doi.org/10.1371/journal.pgen.1011496

Integrin signaling plays important roles in development and disease. An adhesion signaling network called the integrin adhesome has been principally defined using bioinformatics and cell-based proteomics. To date, the adhesome has not been studied us... Read More about Integrin adhesome axis inhibits the RPM-1 ubiquitin ligase signaling hub to regulate growth cone and axon development.

Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function (2024)
Journal Article
Chang, C., Banerjee, S. L., Park, S. S., Zhang, X. L., Cotnoir-White, D., Opperman, K. J., Desbois, M., Grill, B., & Kania, A. (2024). Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function. eLife, 12, Article RP89176. https://doi.org/10.7554/elife.89176

Eph receptor tyrosine kinases participate in a variety of normal and pathogenic processes during development and throughout adulthood. This versatility is likely facilitated by the ability of Eph receptors to signal through diverse cellular signallin... Read More about Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function.