The TBXT rs2305089 SNP links the benign notochordal cell tumour and chordoma (2025)
Journal Article
Usher, I., O'Donnell, P., Ligammari, L., Harder, D., Brown, W., Choi, D., Cool, P., Cottone, L., & Flanagan, A. M. (2025). The TBXT rs2305089 SNP links the benign notochordal cell tumour and chordoma. The Journal of pathology, https://doi.org/10.1002/path.6427

The aim of this research was to investigate the pathogenesis of the bone cancer chordoma and the role of the germline rs2305089 SNP in TBXT. Using medical imaging and genotyping studies, we observed that benign notochordal cell tumours (BNCTs) were a... Read More about The TBXT rs2305089 SNP links the benign notochordal cell tumour and chordoma.

A deep learning framework deploying segment anything to detect pan-cancer mitotic figures from haematoxylin and eosin-stained slides (2024)
Journal Article
Shen, Z., Simard, M., Brand, D., Andrei, V., Al-Khader, A., Oumlil, F., Trevers, K., Butters, T., Haefliger, S., Kara, E., Amary, F., Tirabosco, R., Cool, P., Royle, G., Hawkins, M. A., Flanagan, A. M., & Collins-Fekete, C.-A. (in press). A deep learning framework deploying segment anything to detect pan-cancer mitotic figures from haematoxylin and eosin-stained slides. Communications Biology, 7(1), 1674. https://doi.org/10.1038/s42003-024-07398-6

Mitotic activity is an important feature for grading several cancer types. However, counting mitotic figures (cells in division) is a time-consuming and laborious task prone to inter-observer variation. Inaccurate recognition of MFs can lead to incor... Read More about A deep learning framework deploying segment anything to detect pan-cancer mitotic figures from haematoxylin and eosin-stained slides.