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Mesenchymal Stem Cell-Derived Extracellular Vesicles Reduce Disease Severity and Immune Responses in Inflammatory Arthritis (2020)
Other
Kay, A., Roach, P., Treadwell, K., Morgan, R., Lodge, R., Hyland, M., …Forsyth, N. R. (2020). Mesenchymal Stem Cell-Derived Extracellular Vesicles Reduce Disease Severity and Immune Responses in Inflammatory Arthritis

Abstract Background Novel biological therapies have revolutionised the management of Rheumatoid Arthritis (RA) but no cure currently exists. Mesenchymal stem cells (MSCs) immunomodulate inflammatory responses through paracrine signalling via growth f... Read More about Mesenchymal Stem Cell-Derived Extracellular Vesicles Reduce Disease Severity and Immune Responses in Inflammatory Arthritis.

Black hole inconsistencies? (2020)
Working Paper
Austin, J. Black hole inconsistencies?

For large enough astrophysical objects, internal pressures are insufficient to prevent gravitational collapse to sizes smaller than a critical radius where the magnitude of escape velocity is equal to the speed of light. In coordinates natural for di... Read More about Black hole inconsistencies?.

Glycosaminoglycans induce conformational change in the SARS-CoV-2 Spike S1 Receptor Binding Domain (2020)
Journal Article
Mycroft-West, C. J., Su, D., Li, Y., Guimond, S. E., Rudd, T. R., Elli, S., …Skidmore, M. A. Glycosaminoglycans induce conformational change in the SARS-CoV-2 Spike S1 Receptor Binding Domain. bioRxiv, https://doi.org/10.1101/2020.04.29.068767

The glycosaminoglycan (GAG) class of polysaccharides are utilised by a plethora of microbial pathogens as receptors for adherence and invasion. The GAG heparin prevents infection by a range of viruses when added exogenously, including the S-associate... Read More about Glycosaminoglycans induce conformational change in the SARS-CoV-2 Spike S1 Receptor Binding Domain.

SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with Low Molecular Weight Heparins (2020)
Journal Article
Mycroft-West, C. J., Su, D., Li, Y., Guimond, S. E., Rudd, T. R., Elli, S., …Skidmore, M. A. SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with Low Molecular Weight Heparins. arXiv, https://doi.org/10.1101/2020.04.29.068486

The dependence of the host on the interaction of hundreds of extracellular proteins with the cell surface glycosaminoglycan heparan sulphate (HS) for the regulation of homeostasis is exploited by many microbial pathogens as a means of adherence and i... Read More about SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with Low Molecular Weight Heparins.

The Right to Be Forgotten as a Fundamental Right in the UK After Brexit (2020)
Journal Article
Aidinlis. (2020). The Right to Be Forgotten as a Fundamental Right in the UK After Brexit. SSRN,

Will Brexit diminish digital rights protection in the UK or are domestic institutions better-placed to deliver such protection unencumbered by the oversight of EU institutions? This article scrutinises the validity of conflicting arguments about the... Read More about The Right to Be Forgotten as a Fundamental Right in the UK After Brexit.

A comparative analysis for SARS-CoV-2 (2020)
Journal Article
Misirli, G. A comparative analysis for SARS-CoV-2. Manuscript submitted for publication

COVID-19 has affected the world tremendously. It is critical that biological experiments and clinical designs are informed by computational approaches for time- and cost-effective solutions. Comparative analyses particularly can play a key role to re... Read More about A comparative analysis for SARS-CoV-2.

Improved CRISPR-based suppression gene drives mitigate resistance and impose a large reproductive load on laboratory-contained mosquito populations (2020)
Working Paper
Hammond, A. M., Kyrou, K., Gribble, M., Karlsson, X., Morianou, I., Galizi, R., …Nolan, T. Improved CRISPR-based suppression gene drives mitigate resistance and impose a large reproductive load on laboratory-contained mosquito populations

Abstract CRISPR-based genes drives bias their own inheritance and can be used to modify entire populations of insect vectors of disease as a novel form of sustainable disease control. Gene drives designed to interfere with female fertility can suppre... Read More about Improved CRISPR-based suppression gene drives mitigate resistance and impose a large reproductive load on laboratory-contained mosquito populations.