Skip to main content

Research Repository

Advanced Search

Mesenchymal Stem Cell-Derived Extracellular Vesicles Reduce Disease Severity and Immune Responses in Inflammatory Arthritis (2020)
Other
Kay, A., Roach, P., Treadwell, K., Morgan, R., Lodge, R., Hyland, M., Piccinini, A. M., Kehoe, O., & Forsyth, N. R. (2020). Mesenchymal Stem Cell-Derived Extracellular Vesicles Reduce Disease Severity and Immune Responses in Inflammatory Arthritis

Abstract Background Novel biological therapies have revolutionised the management of Rheumatoid Arthritis (RA) but no cure currently exists. Mesenchymal stem cells (MSCs) immunomodulate inflammatory responses through paracrine signalling via growth f... Read More about Mesenchymal Stem Cell-Derived Extracellular Vesicles Reduce Disease Severity and Immune Responses in Inflammatory Arthritis.

Diversity Crisis in UK Geoscience Research Training (2020)
Other
Joanne Dowey, N., Barclay, J., Fernando, B., Giles, S., Houghton, J., Aiden-Lee Jackson, C., Mills, K., Newton, A., Rogers, S. L., & Williams, R. (2020). Diversity Crisis in UK Geoscience Research Training

Lack of sufficient public space can limit the effectiveness of COVID-19’s social distancing measures (2020)
Preprint / Working Paper
Nobajas, A., Ganau i Casas, J., Paül i Agustí, D., & Peacock, A. Lack of sufficient public space can limit the effectiveness of COVID-19’s social distancing measures

One of the primary strategies of slowing down the COVID-19 pandemic has been the establishment of social distancing rules that recommend keeping a buffer distance between individuals, and this has proven effective in helping in reducing the basic rep... Read More about Lack of sufficient public space can limit the effectiveness of COVID-19’s social distancing measures.

Black hole inconsistencies? (2020)
Preprint / Working Paper
Austin, J. Black hole inconsistencies?

For large enough astrophysical objects, internal pressures are insufficient to prevent gravitational collapse to sizes smaller than a critical radius where the magnitude of escape velocity is equal to the speed of light. In coordinates natural for di... Read More about Black hole inconsistencies?.

Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin (2020)
Preprint / Working Paper
Mycroft-West, C. J., Su, D., Pagani, I., Rudd, T. R., Elli, S., Guimond, S. E., Miller, G., Meneghetti, M. C. Z., Nader, H. B., Li, Y., Nunes, Q. M., Procter, P., Mancini, N., Clementi, M., Bisio, A., Forsyth, N. R., Turnbull, J. E., Guerrini, M., Fernig, D. G., Vicenzi, E., …Skidmore, M. A. Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin

Glycosaminoglycans induce conformational change in the SARS-CoV-2 Spike S1 Receptor Binding Domain (2020)
Journal Article
Mycroft-West, C. J., Su, D., Li, Y., Guimond, S. E., Rudd, T. R., Elli, S., Miller, G., Nunes, Q. M., Procter, P., Bisio, A., Forsyth, N. R., Turnbull, J. E., Guerrini, M., Fernig, D. G., Yates, E. A., Lima, M. A., & Skidmore, M. A. Glycosaminoglycans induce conformational change in the SARS-CoV-2 Spike S1 Receptor Binding Domain. bioRxiv, https://doi.org/10.1101/2020.04.29.068767

The glycosaminoglycan (GAG) class of polysaccharides are utilised by a plethora of microbial pathogens as receptors for adherence and invasion. The GAG heparin prevents infection by a range of viruses when added exogenously, including the S-associate... Read More about Glycosaminoglycans induce conformational change in the SARS-CoV-2 Spike S1 Receptor Binding Domain.

SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with Low Molecular Weight Heparins (2020)
Journal Article
Mycroft-West, C. J., Su, D., Li, Y., Guimond, S. E., Rudd, T. R., Elli, S., Miller, G., Nunes, Q. M., Procter, P., Bisio, A., Forsyth, N. R., Turnbull, J. E., Guerrini, M., Fernig, D. G., Yates, E. A., Lima, M. A., & Skidmore, M. A. SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with Low Molecular Weight Heparins. arXiv, https://doi.org/10.1101/2020.04.29.068486

The dependence of the host on the interaction of hundreds of extracellular proteins with the cell surface glycosaminoglycan heparan sulphate (HS) for the regulation of homeostasis is exploited by many microbial pathogens as a means of adherence and i... Read More about SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with Low Molecular Weight Heparins.

Microbial interactions in the mosquito gut determine Serratia colonization and blood feeding propensity. (2020)
Preprint / Working Paper
Kozlova, E. V., Hegde, S., Roundy, C. M., Golovko, G., A Saldana, M., Hart, C. E., Anderson, E. R., Hornett, E. A., Khanipov, K., Popov, V. L., Pimenova, M., Zhou, Y., Fovanov, Y., Weaver, S. C., Routh, A. L., Heinz, E., & Hughes, G. L. Microbial interactions in the mosquito gut determine Serratia colonization and blood feeding propensity

How microbe-microbe interactions dictate microbial complexity in the mosquito gut is unclear. Previously we found that Serratia, a gut symbiont that alters vector competence and is being considered for vector control, poorly colonized Aedes aegypti y... Read More about Microbial interactions in the mosquito gut determine Serratia colonization and blood feeding propensity..

The Right to Be Forgotten as a Fundamental Right in the UK After Brexit (2020)
Journal Article
Aidinlis. (2020). The Right to Be Forgotten as a Fundamental Right in the UK After Brexit. SSRN,

Will Brexit diminish digital rights protection in the UK or are domestic institutions better-placed to deliver such protection unencumbered by the oversight of EU institutions? This article scrutinises the validity of conflicting arguments about the... Read More about The Right to Be Forgotten as a Fundamental Right in the UK After Brexit.

A comparative analysis for SARS-CoV-2 (2020)
Journal Article
Misirli, G. A comparative analysis for SARS-CoV-2. Manuscript submitted for publication

COVID-19 has affected the world tremendously. It is critical that biological experiments and clinical designs are informed by computational approaches for time- and cost-effective solutions. Comparative analyses particularly can play a key role to re... Read More about A comparative analysis for SARS-CoV-2.